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Review
Functional disorder Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective
Amal Arifi Hidayat1orcid, Langgeng Agung Waskito2,3orcid, Titong Sugihartono4orcid, Hafeza Aftab5orcid, Yudith Annisa Ayu Rezkitha3,6orcid, Ratha-korn Vilaichone4,7orcid, Muhammad Miftahussurur3,4,orcid
Intestinal Research 2024;22(3):286-296.
DOI: https://doi.org/10.5217/ir.2023.00199
Published online: March 26, 2024

1Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

2Department of Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

3Helicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia

4Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

5Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh

6Department of Internal Medicine, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia

7Center of Excellence in Digestive Diseases and Gastroenterology Unit, Department of Medicine, Thammasat University, Pathumthani, Thailand

Correspondence to Muhammad Miftahussurur, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60132, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya, Indonesia. Tel: +62-31-5020251, Fax: +62-31-5915551, E-mail: muhammad-m@fk.unair.ac.id
• Received: December 20, 2023   • Revised: February 6, 2024   • Accepted: February 15, 2024

© 2024 Korean Association for the Study of Intestinal Diseases.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder associated with substantial impairment which considerably burdens healthcare systems worldwide. Research on IBS has largely been conducted in high-income countries posing barriers to the application of diagnostic strategies in low- and middle-income countries (LMICs) due to differences in disease characteristics, healthcare resources, and socioeconomic factors. This review discusses the diagnostic issues associated with LMICs. We present a concise overview of the relevant approaches and propose a diagnostic strategy based on the latest evidence. A positive diagnostic strategy that relies on appropriate symptom-based criteria is crucial within the diagnostic framework. A combination of complete blood count, fecal occult blood test, and complete stool test may reliably identify individuals with suspected IBS who are more likely to have organic diseases, thus justifying the necessity for a colonoscopy. Eventually, we developed a diagnostic algorithm based on a limited setting perspective that summarizes the available evidence and may be applied in LMICs.
  • Keywords: Irritable bowel syndrome; Diagnosis; Developing countries; Human and disease
Irritable bowel syndrome (IBS) is one of the most prevalent and well-known disorders of gut-brain interactions (previously called functional gastrointestinal disorders) worldwide. By applying the Rome III criteria, the global prevalence of IBS was estimated to be 9.2%. In comparison, the prevalence of IBS was reported to be 3.8% based on the Rome IV criteria [1]. Prevalence rates varied significantly between regions, with rates as high as 17.5% in Latin America, 9.6% in Asia, 7.1% in North America, Europe, Australia, and New Zealand, as well as 5.5% in the Middle East and Africa [2]. This data suggests that the prevalence of IBS tends to be higher in low- and middle-income countries (LMICs) than in high-income countries (HICs). Individual countries, such as Nigeria (33%) [3] and Mexico (35.5%) [4], have considerably higher IBS prevalence than the regional average. Since developing countries tend to adopt a more Westernized diet and lifestyle, which may be associated with a higher risk of IBS, the prevalence of IBS may continue to rise [5].
IBS accounts for 15% of primary care referrals to gastroenterologists and imposes a substantial burden on the healthcare system [6]. Excluding prescriptions and over-the-counter medications, the direct medical costs associated with IBS in the United States are estimated to be as high as $1.5–10 billion annually [7]. The large expense of IBS is mainly due to excessive healthcare resource utilization, testing that is often unnecessary or performed too frequently, and wide variation in regional testing and treatment [8,9]. A cost-analysis study conducted in Iran, a representative of LMICs, reported that the annual cost per patient for IBS was approximately $90 [10]. Besides its economic burden, IBS symptoms have a significant impact on the quality of life of patients [11]. IBS patients have been demonstrated to have a lower quality of life than that of healthy individuals, which correlates significantly with symptom severity [12,13]. Additionally, patients with IBS report being less spontaneous because of their unpredictable symptoms. Moreover, they are stigmatized by family, friends, and even their own physicians, who may not fully understand the substantial daily-living implications of their symptoms [14]. An instantaneous cure was valued more than a longer lifespan by IBS patients, as reported by a study [15]. Individuals with IBS would be even willing to take on a 1% risk of sudden death if a hypothetical drug could treat their illness [16]. Patients with IBS often have trouble focusing at work because of their symptoms, so they may take more time off, which is called absenteeism. Additionally, they struggle to achieve their best performance, a concept called presenteeism [17]. In terms of decreased work productivity, the indirect costs of absenteeism and presenteeism are significant and comparable to those of other chronic diseases. Absenteeism costs employers an average of $901 per employee with IBS versus $528 per employee without IBS annually [18]. Moreover, patients who are unable to work due to IBS symptoms and claim sickness may incur additional costs to society.
The majority of IBS research has been conducted in North America and Europe, with far fewer studies conducted in and relevant to LMICs. Inadequate progress has been made in closing the gap between the generation and application of IBS knowledge in LMICs, particularly in diagnostic strategies, in which a number of challenges have arisen. The diagnostic strategies applied in Western countries are frequently irrelevant in LMICs because of differences in disease characteristics, healthcare resources, socioeconomic factors, and biological diversity among ethnic groups. Research on health systems is highly context-dependent, as resources, facilities, and sociocultural values vary substantially between HICs and LMICs and even within countries. This review focuses on the diagnostic challenges faced by LMIC. We provide a summary of relevant strategies and suggest a diagnostic approach based on the latest evidence from an LMIC perspective.
Despite its high prevalence, an accurate diagnosis of IBS remains challenging. Due to a lack of reliable biological markers for IBS, clinicians may depend heavily on patient symptoms when establishing the diagnosis. IBS symptoms are generally difficult to objectively evaluate and may vary among patients. Additionally, a variety of organic gastrointestinal disorders can mimic IBS [19]. Clinicians and patients are typically concerned about overlooking other possible diagnoses, such as inflammatory bowel disease, microscopic colitis, infectious colitis, celiac disease, and colon cancer. Owing to this uncertainty, many practitioners approach IBS as a diagnosis of exclusion by performing a considerable number of unnecessary, expensive, and invasive tests. According to a survey, 72% of community providers endorsed IBS as an exclusionary criterion. This perspective was also shared by 42% of gastroenterologists, 76% of general internal medicine practitioners, and 8% of IBS experts [20]. The dilemma for providers that there is no endpoint for establishing a positive diagnostic entity is not considered in the strategy of exclusion. This paradigm delays the initiation of the appropriate IBS treatment. On average, it takes 4 years for a patient to receive an accurate diagnosis of IBS. The stigma associated with an IBS diagnosis can leave many patients believing that their physicians may not treat them seriously and that they are unable to access effective treatment [21]. Furthermore, it has been revealed that providers who believe IBS to be an exclusionary diagnosis are likely to order 1.6 more tests and spend $364 more than are those who do not [20]. To our knowledge, no single LMIC has published a similar survey or report on the direct cost of diagnosing IBS using an exclusionary approach yet.
Despite the lack of a validated definition, a positive diagnostic strategy entails acquiring a detailed history, performing careful physical examinations, and applying a standard definition along with limited diagnostic tests to establish an accurate diagnosis of IBS [22]. A study conducted in a primary care setting compared a positive diagnosis strategy to an exclusion strategy and found that neither was inferior in terms of health-related quality of life. There were no differences in gastrointestinal symptoms or patient satisfaction between the 2 groups; however, the positive diagnosis group had nearly 40% lower overall healthcare costs ($5,075 per year vs. $3,160 per year). No cases of inflammatory bowel disease, celiac disease, or malignancy were identified using a diagnostic approach, indicating the cost-effectiveness of the positive strategy [23]. Furthermore, a provider who delivers a convincingly positive diagnosis of IBS with limited testing is more likely to shorten the time to treatment initiation by involving the patient in a joint decision [24]. The American Gastroenterology College (ACG) recommends initiating empiric treatment as soon as possible to further reduce unnecessary diagnostic tests despite the low quality of data supporting this practice [16].
The positive diagnostic strategy for IBS is largely based on symptom-based criteria. Although its complete pathophysiology has not yet been elucidated, IBS is widely accepted as a real medical disorder. Therefore, it is acceptable to employ positive symptom criteria to identify patients with this condition. This approach has been widely applied in psychiatry, where diagnostic entities (e.g., post-traumatic stress disorder or anorexia nervosa) have been established using symptom-based criteria that are true across clinical studies and cultures [25,26]. In the 1970s, Manning et al. [27] initiated the first attempt to establish a diagnostic criteria for IBS. Patients with abdominal pain who were subsequently confirmed to have or not have organic disease were compared to develop the Manning criteria. Over the past three decades, the Rome Foundation has generated and updated the diagnostic criteria for IBS with the help of local experts. The Rome symptom criteria were first developed in the 1990s and have been updated 3 times, most recently in 2016 with the Rome IV criteria [28]. Although these criteria provide a positive diagnosis, they are unwieldy and unreliable [29,30]. Up to 8.6% of patients who fulfill the clinically defined criteria for IBS turn out to have celiac disease, inflammatory bowel disease, or colorectal cancer (CRC) [31-36]. Furthermore, recent meta-analyses have revealed that the prevalence of various non-malignant treatable organic gastrointestinal disorders in patients meeting the IBS symptom criteria is significantly higher than that in healthy individuals. In patients with typical IBS symptoms, the prevalence of bile acid diarrhea, lactose malabsorption, fructose malabsorption, microscopic colitis, pancreatic exocrine insufficiency, and small intestinal bacterial overgrowth with lactulose and glucose were 41%, 54%, 43%, 3%, 4.6%, 49%, and 19%, respectively [37]. Therefore, effective treatment is not possible if these disorders are not excluded.
1. Key Features of IBS Symptom Criteria
The Rome criteria are the most universally endorsed diagnostic criteria for defining IBS worldwide. Compared to the previous version, Rome III utilized more evidence-based data rather than consensus-based data [38]. Rome IV, the most recent revision, published in May 2016, is a compilation of scientific evidence that has accumulated since Rome III was released a decade ago [28]. Due to its ambiguity, the term “discomfort” was removed from Rome IV. Discomfort refers to an uncomfortable, but not painful sensation [39]. However, the perceptions of discomfort in patients varied widely, with some equating it with mild pain and others associating it with symptoms like urgency or bloating. Abdominal pain is required at least once per week on average in Rome IV, up from the lower threshold of 3 times per month in Rome III. Rome IV has a less specific temporal association with abdominal pain, defecation, and stool characteristics. In contrast to Rome III, which requires that abdominal pain be alleviated after defecation, Rome IV only requires that pain occur either before, during, or shortly after defecation. Additionally, while Rome III requires that a change in stool frequency or consistency follows the onset of abdominal pain, Rome IV merely requires that the two occur simultaneously (Table 1) [41].
A recent study conducted in the UK Kingdom demonstrated that Rome IV was more specific than Rome III was for the diagnosis of IBS. The positive likelihood ratio of Rome IV was 4.82 compared to 2.45 for Rome III, although its clinical relevance remains unclear. This study also found that patients with constipation (IBS-C) or mixed bowel habits (IBS-M) were more accurately diagnosed using the Rome IV criteria than were those with predominant diarrhea (IBS-D) [42]. IBS is also characterized by the relapsing and remitting nature of its symptoms. In population-based studies, the proportion of patients reporting symptom resolution ranged between 17% and 55%. The transition between IBS subtypes in the same individual appears to be significant and is not solely associated with medication [43,44]. The comparison of symptom stability between Rome IV and Rome III in patients with IBS has been investigated in a recent study. At 12 months follow-up, 29.4% of patients meeting the Rome IV criteria for IBS at baseline had shifted to another functional bowel disorder. The percentage of patients who later transitioned to a different functional bowel disorder was lower (16.5%) among those who initially met Rome III criteria. This result indicates that Rome IV is less stable than Rome III [44].
2. Implementing Symptom Criteria of IBS in LMICs
According to the Rome IV criteria, IBS is characterized by abdominal pain related to bowel movements [28]. However, problems may arise when applying these criteria to LMICs, which are largely non-Western countries, as they are developed based on Western studies and clinical experience. The Rome criteria have also been adopted as the standard for determining the eligibility for IBS clinical trials. Although this method reduces bias by recruiting a more homogeneous trial population and facilitating comparisons between trials, it may limit the applicability of the findings to non-Western populations. In India, general practitioners are unfamiliar with the Rome criteria, and many gastroenterologists assume that these criteria may not be suitable as 30% of IBS patients demonstrate neither pain nor discomfort [45]. A multicenter study involving 1,618 subjects diagnosed with IBS using 5 symptom-based criteria. The research group discovered that the Manning criteria had the highest sensitivity (91.2%), followed by the Asian criteria (74.5%), Rome I (67.9%), Rome III (52.5%), and Rome II (40.1%) criteria [46]. One possible explanation for these discrepancies is that abdominal pain was not required for IBS diagnosis using either the Manning or Asian criteria (Table 1). Abdominal bloating was considered along with abdominal pain or discomfort according to the Asian criteria [40]. Similar data have been reported in Romania, where 60% of patients with IBS rated bloating as their most troublesome symptom [47]. According to studies conducted in India and Bangladesh, the frequency and/or severity of abdominal pain in IBS patients may not be as prevalent, ranging from 33.0% to 70.0%, resulting in a low prevalence of Rome IV IBS in these countries [48]. Therefore, the latest Asian consensus on IBS suggests that the pain component should be de-emphasized in Asia and that abdominal bloating should be added to the diagnostic criteria for IBS [49]. The same level of nociceptive intensity can manifest as pain in one individual but as mere discomfort in another. Furthermore, because the pathophysiology of IBS involves complex interplay between biological and psychosocial components, its expression may differ between cultural backgrounds. It is important to note that while the Asian continent currently has the highest number of LMICs, further research is needed to explore the clinical characteristics of IBS symptom perception at the regional level in order to develop local guidelines.
A major challenge in diagnosing IBS is that it relies heavily on symptom criteria, leaving it at risk because of inherent ambiguities in how patients express and how clinicians interpret symptoms [50]. Due to language barriers and cultural variations, subjective reports of discomfort in patients with IBS may indicate an extensive spectrum of symptoms, including mild pain, bloating, distention, and fullness. Consequently, the Rome Foundation conducted a multinational survey of this issue in 2014. However, they discovered that none of these terms had a universally agreed-upon definition in either English- or non-English-speaking countries [51]. A recent study found that the majority of patients with IBS who met the Rome IV criteria also met the Rome III criteria. In fact, it revealed that they represent a subgroup of Rome III-positive patients with more severe symptoms [52]. The change in the threshold for abdominal pain frequency accounts for most of the differences between Rome III and IV [53]. In a study conducted in India and Bangladesh, Rome IV criteria were less sensitive than Rome III criteria. The application of the Rome IV criteria led to a shift from IBS to other disorders of gut-brain interaction in patients who met the Rome III criteria [54]. We believe that abdominal discomfort and pain are part of a continuum of nociceptive sensation severity. Assuming that a wide variety of patients are diagnosed and treated, an inclusive approach using less stringent diagnostic criteria, such as the Rome III criteria, may be effective. The Rome IV criteria continue to play a role in identifying individuals with IBS who experience more severe symptoms and may require a more intensive treatment approach.
Colonoscopy is commonly regarded as a reliable method for ruling out organic diseases in patients with suspected IBS [55]. However, several international guidelines recommend a cautious approach in selecting IBS patients for colonoscopy in accordance with a positive diagnostic strategy endorsement [22,55]. The concept of red flag or alarm symptoms/signs enhances the accuracy of distinguishing between patients with a high likelihood of having structural disease and those with a low likelihood of having such disease among those who meet symptombased criteria. These symptoms include rectal bleeding, positive fecal occult blood test (FOBT) results, anemia, fever, nocturnal symptoms, unintended weight loss within the past 3 months, onset age > 50 years, and family history of CRC, inflammatory bowel disease, or celiac disease [28,35,56,57]. The presence of such features in patients with suspected IBS indicates the necessity for further investigation, particularly colonoscopy, according to several guidelines [22,55]. The diagnostic accuracy of IBS based solely on symptom-based criteria is moderate in patients with a low likelihood of organic disease, that is without alarming symptoms. The Manning, Rome I, and Rome II criteria have been reported to have specificities of 0.69, 0.70, and 0.66, respectively, in patients with IBS with no alarming symptoms. The Manning, Rome I, and Rome II criteria were found to have a sensitivity of 0.67, 0.72, and 0.69, respectively [58]. However, a recent study reported that colonoscopy had no diagnostic yield in patients without red flag [59]. This finding supports the preference for a positive diagnostic strategy over an exclusionary one when investigating IBS symptoms.
It has been reported that alarm symptoms and signs are highly prevalent among patients with IBS. A previous survey indicated that 70% of patients who fulfilled the Rome III criteria for IBS had at least one red flag [57]. Furthermore, the performance of red flags in detecting organic gastrointestinal diseases in formally diagnosed patients with IBS only yields a positive predictive value ranging from 7% to 9% [60]. Given this evidence, the incorporation of red flags into the Rome criteria may not improve sensitivity and may result in a substantial number of IBS cases being overlooked. Thus, a substantial proportion of patients presenting with alarm symptoms may not require colonoscopy for diagnostic purposes. A recent study involving patients with IBS defined according to the Rome IV criteria reported a similar incidence of alarming symptoms (75.3%). Interestingly, they discovered that anemia, fecal occult blood, and unintended weight loss have high predictive values for organic diseases. The positive predictive value of the combination of these 3 red flags was comparable to that of all alarm symptoms (92.2% vs. 91.7%, respectively). However, the combination of these 3 red flags led to a substantially lower rate of missed IBS diagnoses (34.1% vs. 74.8%) [61]. These results imply that these red flags may be useful in identifying patients requiring colonoscopy, but are not recommended as criteria for the exclusion of IBS. In LMICs, where endoscopy systems are limited, there is a need to refine referral prioritization for colonoscopies in IBS patients showing alarm symptoms. Based on the evidence suggesting that anemia and fecal occult blood are among the top 3 indicators for detecting organic disease, we propose that the complete blood count (CBC) and FOBT are the most valuable diagnostic tests for identifying IBS patients who would benefit from a colonoscopy. Additionally, we prefer fecal immunochemical tests over traditional guaiac FOBTs for FOBT testing due to their higher sensitivity and cost-effectiveness [62].
Parasitic infections may result in chronic symptoms such as bloating, diarrhea, and abdominal pain, resembling those of IBS, in contrast to the acute nature of bacterial and viral gastroenteritis [63]. However, a study conducted in the United States reported that the prevalence of parasitic infections among patients with suspected IBS is very low (2%) [64]. Consequently, the ACG does not recommend routine stool testing for enteric pathogens in all patients with IBS [22]. In LMICs, the environment is often characterized as nonsterile, exposing a significant portion of the population to both acute and chronic gastrointestinal infections [65]. A population-based study in Nicaragua revealed that stool examinations of 16.6% of IBS patients were positive for parasites, with the most prevalent species being Entamoeba spp., followed by Giardia lamblia, Ascaris lumbricoides, and Trichuris trichiura [66]. A separate study conducted in Iran found that those who met the symptom criteria for IBS had a higher rate of parasitic infections, specifically Blastocystis hominis and G. lamblia, compared to the healthy individuals [67]. Therefore, it is crucial to test for parasitic infections in IBS, as it aids in identifying the underlying cause of the symptoms and facilitates the implementation of more efficient treatment strategies. These findings support the inclusion of a complete stool test as a standard diagnostic procedure for patients with suspected IBS in LMICs. Microscopic analysis of stool tests, specifically the presence of parasites and egg worms, will be the key indicator in excluding parasitic infection and helminthiasis.
Clinicians should also consider the IBS subtypes when deciding whether additional diagnostic tests should be performed. In a study of 352 patients with IBS, the subtype IBS-D had the highest prevalence of organic disease (17%), followed by IBS-M (9%) and IBS-C (6%). Microscopic colitis, and not inflammatory bowel disease or CRC, explains the higher incidence of organic diseases detected by colonoscopy in diarrheal IBS than in constipation IBS [59]. Microscopic colitis is a chronic inflammatory bowel disease that primarily affects older individuals, particularly women aged 60 years or older [68]. Therefore, a colonoscopy may be justified to exclude microscopic colitis in elderly women with suspected IBS-D. Furthermore, some patients with IBS symptoms require special consideration during CRC screening. However, colonoscopy screening age criteria vary across guidelines. A study in Thailand, an LMIC, demonstrated that colonoscopy screening for CRC starting at 50 years of age is cost-effective and can prevent the development of both the early and late stages of the disease [69]. Given the existing evidence in LMICs, we maintain the view that when a patient aged 50 years or older is suspected of having IBS but has never had a colonoscopy for CRC screening, the decision to perform one should be based exclusively on the patient’s age, irrespective of their symptoms. It is crucial to acknowledge that the implementation of screening program must consider and adapt to variations in the healthcare systems, economy, and infrastructure. Further investigation is required at the regional level to precisely determine the specific age thresholds. In addition, it is generally accepted that patients with a family history of CRC who are suspected of having IBS should undergo a screening colonoscopy based on their average risk [70]. It is important to highlight that if symptoms persist despite receiving the standard treatment for IBS, it may be justifiable to consider performing a colonoscopy to clarify the ambiguity. Fig. 1 summarizes our proposed diagnostic algorithm for IBS in LMICs.
Guidelines for IBS have been developed by experts with the potential for a translational gap in daily practice. Approximately one-third of general practitioners routinely use the Rome criteria to diagnose IBS, whereas gastroenterologists use them infrequently [71]. In Mexico, the Rome criteria are widely accepted and regarded as the reference standard for defining IBS [72]. However, clinicians lack familiarity with the different versions of it. In a survey, 64.6%, 11%, 0.8%, and 23.6% of the providers were found to employ the Rome III criteria, Rome II criteria, Rome I criteria, and their experience in practice, respectively; none reported using the Manning criteria. Nevertheless, those who met the Rome III criteria were more likely to establish an accurate diagnosis than were those who did not (72.0% vs. 33.3%, P< 0.05) [73]. The diagnosis and subtype classification of IBS relies heavily on the patient’s description of symptoms to the clinician. To accurately diagnose IBS, it is essential to have an in-depth understanding of patients’ perceptions and interpretations of their symptoms. Cultural factors significantly shape the expression of symptoms among individuals from diverse ethnic backgrounds. The development of the Rome III/IV diagnostic questionnaire for IBS can provide clinicians with a standardized tool for assessing patient symptoms, aiding in the diagnosis of IBS and the classification of its subtypes [53,74]. Therefore, it is imperative to conduct studies on the translation and validation of diagnostic questionnaires into the languages used in each country.
Laboratory tests such as CBC, FOBT, and complete stool test are typically accessible in primary, secondary, and tertiary healthcare settings. On the other hand, colonoscopy is a costly procedure that is typically available only in specialized tertiary healthcare facilities. A survey of 15 LMICs revealed the significant burden of access to endoscopy services. Malawi and Rwanda, as extreme examples, had only one medically trained gastroenterologist and fewer than 11 endoscopy centers. Despite having a greater number of endoscopic services, other LMICs reported more centers in the private sector than in the public sector, with the majority located in urban areas [75]. Moreover, the majority of LMICs do not have a single universal national health insurance scheme. A low level of public funding and a high burden of out-of-pocket expenses characterize the healthcare landscape, which is marked by regional variations in access, insurance coverage, and health outcome [76]. The commitment of each nation’s stakeholders is crucial in resolving this issue. The diagnostic algorithm proposed in this study provides insights into the optimal utilization of resources based on existing evidence.
IBS is a prevalent gastrointestinal disorder that causes significant impairment and imposes an enormous burden on the global healthcare system. Research on IBS is primarily conducted in HICs, making it challenging to implement diagnostic strategies in LMICs due to differences in disease characteristics, healthcare resources, and socioeconomic factors. A positive diagnostic strategy that relies on symptom-based criteria and minimal routine tests is safer and more cost-effective than an exclusionary approach. Rome III may be more suitable for populations with LMICs than Rome IV is because of its higher sensitivity and inclusion of milder symptoms, such as bloating, in addition to pain. In addition to careful history-taking, CBC, FOBT, and complete stool test are sufficient to identify suspected IBS patients with a higher likelihood of having organic diseases to justify colonoscopy. The diagnostic algorithm we propose was developed with a limited setting perspective while considering the evidence currently available. Well-designed and adequately funded research on, which includes a diverse population in developing countries, is crucial for developing effective diagnostic strategies for LMICs.

Funding Source

This study was supported in part by Airlangga Research Fund 2023, Universitas Airlangga.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Data Availability Statement

Not applicable.

Author Contributions

Conceptualization: Hidayat AA, Waskito LA, Miftahussurur M. Data curation: Hidayat AA, Sugihartono T. Formal analysis: Hidayat AA, Waskito LA. Funding acquisition: Miftahussurur M. Investigation: Hidayat AA. Methodology: Aftab H, Waskito LA. Project administration: Rezkitha YAA. Resources: Rezkitha YAA. Miftahussurur M. Software: Hidayat AA. Supervision: Sugihartono T, Miftahussurur M, Vilaichone RK. Validation: Vilaichone RK, Aftab H. Visualization: Hidayat AA. Writing - original draft: Hidayat AA, Waskito LA, Miftahussurur M. Writing - review & editing: Vilaichone RK, Hidayat AA, Miftahussurur M. Approval of final manuscript: all authors.

Fig. 1.
Proposed diagnostic algorithm for irritable bowel syndrome (IBS) in low- and middle-income countries. CRC, colorectal cancer; CBC, complete blood count; FOBT, fecal occult blood test; GI, gastrointestinal.
ir-2023-00199f1.jpg
Table 1.
Comparison of the Manning, Asian, Rome III, and Rome IV Criteria for Irritable Bowel Syndrome [27,28,39,40]
Manning Asian Rome III Rome IV
≥ 4 of these following: Recurrent abdominal pain, bloating, or other discomfort for ≥ 3 months associated with ≥ 1 of the following: Recurrent abdominal pain or discomfort for more than 3 days per month over the previous 3 months and associated with ≥ 2 of the following: Recurrent abdominal pain, on average, at least 1 day per week in the last 3 months, associated with ≥ 2 of the following:
· Abdominal pain that is eased after bowel movement
· Looser stools at onset of pain · Relief with defecation · Improvement in defecation · Related to defecation
· More frequent bowel movement at onset of pain · Change in stool form · Onset associated with a change in the frequency of stool · Associated with a change in the frequency of stool
· Feeling of incomplete emptying · Change in stool frequency · Onset associated with a change in form or appearance of stool · Associated with a change in the form or appearance of stool
· Mucus per rectum
· Feeling of distention
Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis
  • 1. Oka P, Parr H, Barberio B, Black CJ, Savarino EV, Ford AC. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2020;5:908–917.ArticlePubMed
  • 2. Sperber AD, Dumitrascu D, Fukudo S, et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review. Gut 2017;66:1075–1082.ArticlePubMed
  • 3. Ladep NG, Okeke EN, Samaila AA, et al. Irritable bowel syndrome among patients attending General Outpatients’ clinics in Jos, Nigeria. Eur J Gastroenterol Hepatol 2007;19:795–799.ArticlePubMed
  • 4. Schmulson M, Ortíz O, Santiago-Lomeli M, et al. Frequency of functional bowel disorders among healthy volunteers in Mexico City. Dig Dis 2006;24:342–347.ArticlePubMedPDF
  • 5. Gwee KA. Irritable bowel syndrome in developing countries: a disorder of civilization or colonization? Neurogastroenterol Motil 2005;17:317–324.ArticlePubMed
  • 6. Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology 2019;156:254–272.ArticlePubMedPMC
  • 7. Canavan C, West J, Card T. Review article: the economic impact of the irritable bowel syndrome. Aliment Pharmacol Ther 2014;40:1023–1034.ArticlePubMed
  • 8. Ladabaum U, Boyd E, Zhao WK, et al. Diagnosis, comorbidities, and management of irritable bowel syndrome in patients in a large health maintenance organization. Clin Gastroenterol Hepatol 2012;10:37–45.ArticlePubMedPMC
  • 9. Lacy BE, Patel H, Guérin A, et al. Variation in care for patients with irritable bowel syndrome in the United States. PLoS One 2016;11:e0154258.ArticlePubMedPMC
  • 10. Roshandel D, Rezailashkajani M, Shafaee S, Zali MR. A cost analysis of functional bowel disorders in Iran. Int J Colorectal Dis 2007;22:791–799.ArticlePubMedPDF
  • 11. Dean BB, Aguilar D, Barghout V, et al. Impairment in work productivity and health-related quality of life in patients with IBS. Am J Manag Care 2005;11(1 Suppl): S17–S26.PubMed
  • 12. Kanazawa M, Endo Y, Whitehead WE, Kano M, Hongo M, Fukudo S. Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Dig Dis Sci 2004;49:1046–1053.ArticlePubMed
  • 13. Kanazawa M, Drossman DA, Shinozaki M, et al. Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J). Biopsychosoc Med 2007;1:6.ArticlePubMedPMCPDF
  • 14. Drossman DA, Chang L, Schneck S, Blackman C, Norton WF, Norton NJ. A focus group assessment of patient perspectives on irritable bowel syndrome and illness severity. Dig Dis Sci 2009;54:1532–1541.ArticlePubMedPDF
  • 15. Drossman DA, Morris CB, Schneck S, et al. International survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit. J Clin Gastroenterol 2009;43:541–550.PubMedPMC
  • 16. Lacy BE, Everhart KK, Weiser KT, et al. IBS patients’ willingness to take risks with medications. Am J Gastroenterol 2012;107:804–809.ArticlePubMedPDF
  • 17. Frändemark Å, Törnblom H, Jakobsson S, Simrén M. Work productivity and activity impairment in irritable bowel syndrome (IBS): a multifaceted problem. Am J Gastroenterol 2018;113:1540–1549.ArticlePubMedPDF
  • 18. Leong SA, Barghout V, Birnbaum HG, et al. The economic consequences of irritable bowel syndrome: a US employer perspective. Arch Intern Med 2003;163:929–935.ArticlePubMed
  • 19. Spiegel BM. Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS? Nat Clin Pract Gastroenterol Hepatol 2007;4:296–297.ArticlePubMedPDF
  • 20. Spiegel BM, Farid M, Esrailian E, Talley J, Chang L. Is irritable bowel syndrome a diagnosis of exclusion? A survey of primary care providers, gastroenterologists, and IBS experts. Am J Gastroenterol 2010;105:848–858.ArticlePubMedPMCPDF
  • 21. Corsetti M, Tack J, Attara G, Sewell M. IBS Global Impact Report 2018: uncovering the true burden of irritable bowel syndrome (IBS) on people’s lives. Vancouver: Gastrointestinal Society, 2018.
  • 22. Lacy BE, Pimentel M, Brenner DM, et al. ACG Clinical Guideline: management of irritable bowel syndrome. Am J Gastroenterol 2021;116:17–44.ArticlePubMed
  • 23. Begtrup LM, Engsbro AL, Kjeldsen J, et al. A positive diagnostic strategy is noninferior to a strategy of exclusion for patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2013;11:956–962.ArticlePubMed
  • 24. Flik CE, Laan W, Smout AJ, Weusten BL, de Wit NJ. Comparison of medical costs generated by IBS patients in primary and secondary care in the Netherlands. BMC Gastroenterol 2015;15:168.ArticlePubMedPMCPDF
  • 25. Wilson GT, Walsh BT. Eating disorders in the DSM-IV. J Abnorm Psychol 1991;100:362–365.ArticlePubMed
  • 26. Lamprecht F, Sack M. Posttraumatic stress disorder revisited. Psychosom Med 2002;64:222–237.ArticlePubMed
  • 27. Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. Br Med J 1978;2:653–654.ArticlePubMedPMC
  • 28. Mearin F, Lacy BE, Chang L, et al. Bowel disorders. Gastroenterology 2016;150:1393–1407.ArticlePubMed
  • 29. Shivaji UN, Ford AC. Beliefs about management of irritable bowel syndrome in primary care: cross-sectional survey in one locality. Prim Health Care Res Dev 2015;16:263–269.ArticlePubMed
  • 30. Sood R, Gracie DJ, Law GR, Ford AC. Systematic review with meta-analysis: the accuracy of diagnosing irritable bowel syndrome with symptoms, biomarkers and/or psychological markers. Aliment Pharmacol Ther 2015;42:491–503.ArticlePubMed
  • 31. Ford AC, Chey WD, Talley NJ, Malhotra A, Spiegel BM, Moayyedi P. Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis. Arch Intern Med 2009;169:651–658.ArticlePubMed
  • 32. Halpin SJ, Ford AC. Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 2012;107:1474–1482.ArticlePubMedPDF
  • 33. Fairbrass KM, Costantino SJ, Gracie DJ, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2020;5:1053–1062.ArticlePubMed
  • 34. Irvine AJ, Chey WD, Ford AC. Screening for celiac disease in irritable bowel syndrome: an updated systematic review and meta-analysis. Am J Gastroenterol 2017;112:65–76.ArticlePubMedPDF
  • 35. Patel P, Bercik P, Morgan DG, et al. Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey. Scand J Gastroenterol 2015;50:816–823.ArticlePubMed
  • 36. Ishihara S, Yashima K, Kushiyama Y, et al. Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy. J Gastroenterol 2012;47:1084–1090.ArticlePubMedPDF
  • 37. Poon D, Law GR, Major G, Andreyev HJ. A systematic review and meta-analysis on the prevalence of non-malignant, organic gastrointestinal disorders misdiagnosed as irritable bowel syndrome. Sci Rep 2022;12:1949.ArticlePubMedPMCPDF
  • 38. Hellström PM, Benno P. The Rome IV: irritable bowel syndrome: a functional disorder. Best Pract Res Clin Gastroenterol 2019;40-41:101634.ArticlePubMed
  • 39. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006;130:1480–1491.ArticlePubMed
  • 40. Gwee KA, Bak YT, Ghoshal UC, et al. Asian consensus on irritable bowel syndrome. J Gastroenterol Hepatol 2010;25:1189–1205.ArticlePubMed
  • 41. Whitehead WE, Palsson OS, Simrén M. Irritable bowel syndrome: what do the new Rome IV diagnostic guidelines mean for patient management? Expert Rev Gastroenterol Hepatol 2017;11:281–283.ArticlePubMed
  • 42. Black CJ, Craig O, Gracie DJ, Ford AC. Comparison of the Rome IV criteria with the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care. Gut 2021;70:1110–1116.ArticlePubMed
  • 43. Yadav YS, Eslick GD, Talley NJ. Review article: irritable bowel syndrome: natural history, bowel habit stability and overlap with other gastrointestinal disorders. Aliment Pharmacol Ther 2021;54 Suppl 1:S24–S32.ArticlePubMedPDF
  • 44. Barberio B, Houghton LA, Yiannakou Y, Savarino EV, Black CJ, Ford AC. Symptom stability in Rome IV vs Rome III irritable bowel syndrome. Am J Gastroenterol 2021;116:362–371.ArticlePubMed
  • 45. Ghoshal UC, Abraham P, Bhatt C, et al. Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol 2008;27:22–28.PubMed
  • 46. Ghoshal UC, Abraham P, Bhatia SJ, et al. Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: report of the multicentric Indian irritable bowel syndrome (MIIBS) study. Indian J Gastroenterol 2013;32:369–375.ArticlePubMedPDF
  • 47. Pop LL, Mureşan IA, Dumitraşcu DL. How much bloating in the irritable bowel syndrome? Rom J Intern Med 2018;56:221–226.ArticlePubMed
  • 48. Rahman MM, Mahadeva S, Ghoshal UC. Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: a review. World J Gastroenterol 2017;23:6788–6801.ArticlePubMedPMC
  • 49. Gwee KA, Gonlachanvit S, Ghoshal UC, et al. Second Asian Consensus on irritable bowel syndrome. J Neurogastroenterol Motil 2019;25:343–362.ArticlePubMedPMC
  • 50. Quigley EM. Impact of bloating and distention in irritable bowel syndrome: have we wandered too far from the Manning creed? Clin Gastroenterol Hepatol 2009;7:7–8.ArticlePubMed
  • 51. Sperber AD, Gwee KA, Hungin AP, et al. Conducting multinational, cross-cultural research in the functional gastrointestinal disorders: issues and recommendations: a Rome Foundation working team report. Aliment Pharmacol Ther 2014;40:1094–1102.ArticlePubMed
  • 52. Aziz I, Törnblom H, Palsson OS, Whitehead WE, Simrén M. How the change in IBS criteria from Rome III to Rome IV impacts on clinical characteristics and key pathophysiological factors. Am J Gastroenterol 2018;113:1017–1025.ArticlePubMedPDF
  • 53. Palsson OS, Whitehead WE, van Tilburg MA, et al. Rome IV diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology 2016;150:1481–1491.Article
  • 54. Ghoshal UC, Rahman MM, Pratap N, et al. Comparisons of the Rome III and Rome IV criteria for diagnosis of irritable bowel syndrome in Indian and Bangladeshi communities and internal shifts in the diagnostic categories of bowel disorders of gut-brain interactions. Neurogastroenterol Motil 2023;35:e14579.PubMed
  • 55. Fukudo S, Okumura T, Inamori M, et al. Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. J Gastroenterol 2021;56:193–217.ArticlePubMedPMCPDF
  • 56. Quigley EM, Fried M, Gwee KA, et al. World Gastroenterology Organisation Global Guidelines irritable bowel syndrome: a global perspective update September 2015. J Clin Gastroenterol 2016;50:704–713.PubMed
  • 57. Black TP, Manolakis CS, Di Palma JA. “Red flag” evaluation yield in irritable bowel syndrome. J Gastrointestin Liver Dis 2012;21:153–156.ArticlePubMed
  • 58. Jellema P, van der Windt DA, Schellevis FG, van der Horst HE. Systematic review: accuracy of symptom-based criteria for diagnosis of irritable bowel syndrome in primary care. Aliment Pharmacol Ther 2009;30:695–706.ArticlePubMed
  • 59. Asghar Z, Thoufeeq M, Kurien M, et al. Diagnostic yield of colonoscopy in patients with symptoms compatible with Rome IV functional bowel disorders. Clin Gastroenterol Hepatol 2022;20:334–341.ArticlePubMed
  • 60. Whitehead WE, Palsson OS, Feld AD, et al. Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome. Aliment Pharmacol Ther 2006;24:137–146.ArticlePubMed
  • 61. Yang Q, Wei ZC, Liu N, et al. Predictive value of alarm symptoms in Rome IV irritable bowel syndrome: a multicenter cross-sectional study. World J Clin Cases 2022;10:563–575.ArticlePubMedPMC
  • 62. Tinmouth J, Lansdorp-Vogelaar I, Allison JE. Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know. Gut 2015;64:1327–1337.ArticlePubMed
  • 63. Klem F, Wadhwa A, Prokop LJ, et al. Prevalence, risk factors, and outcomes of irritable bowel syndrome after infectious enteritis: a systematic review and meta-analysis. Gastroenterology 2017;152:1042–1054.ArticlePubMedPMC
  • 64. Hamm LR, Sorrells SC, Harding JP, et al. Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome criteria. Am J Gastroenterol 1999;94:1279–1282.ArticlePubMed
  • 65. Ximénez C, Morán P, Rojas L, Valadez A, Gómez A. Reassessment of the epidemiology of amebiasis: state of the art. Infect Genet Evol 2009;9:1023–1032.ArticlePubMed
  • 66. Patel P, Bercik P, Morgan DG, et al. Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which may drive bloating. Aliment Pharmacol Ther 2015;41:449–458.ArticlePubMed
  • 67. Shafiei Z, Esfandiari F, Sarkari B, Rezaei Z, Fatahi MR, Hosseini Asl SM. Parasitic infections in irritable bowel syndrome patients: evidence to propose a possible link, based on a casecontrol study in the south of Iran. BMC Res Notes 2020;13:264.ArticlePubMedPMCPDF
  • 68. Burke KE, D’Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H. Microscopic colitis. Nat Rev Dis Primers 2021;7:39.ArticlePubMedPDF
  • 69. Phisalprapa P, Supakankunti S, Chaiyakunapruk N. Cost-effectiveness and budget impact analyses of colorectal cancer screenings in a low- and middle-income country: example from Thailand. J Med Econ 2019;22:1351–1361.ArticlePubMed
  • 70. Shaukat A, Kahi CJ, Burke CA, Rabeneck L, Sauer BG, Rex DK. ACG Clinical Guidelines: colorectal cancer screening 2021. Am J Gastroenterol 2021;116:458–479.ArticlePubMed
  • 71. Mujagic Z, Jonkers DM, Hungin AP, et al. Use of Rome criteria for the diagnosis of irritable bowel syndrome in primary care: a survey among European countries. Eur J Gastroenterol Hepatol 2017;29:651–656.ArticlePubMed
  • 72. Remes Troche JM, Bernal Reyes R, Valladares Lepine MA, Alonso Lárraga O, Gómez Escudero O, Meléndez Mena D. Gastroenterology diagnosis and treatment guidelines of irritable bowel syndrome; clinical features and diagnostic criteria. Rev Gastroenterol Mex 2009;74:58–62.PubMed
  • 73. Ortiz-Garrido O, Schmulson MJ. Los medicos en latinoamerica reportan utilizar con mayor frecuencia los mas recientes criterios de Roma III para diagnosticar sindrome de intestino irritable en la clinica. Pero conocen realmente los criterios. Rev Gastroenterol Mex 2012;77(Suppl 3): 95.
  • 74. Thompson WG, Drossman DA, Talley N. Rome III diagnostic questionnaire for the adult functional GI disorders (including alarm questions) and scoring algorithm. In: Drossman DA, Corazziari E, Delvaux M, et al. eds. Rome III: the functional gastrointestinal disorders. 3rd ed. McLean: Degnon Associates, 2006;917-951.
  • 75. Rajbhandari R, Blakemore S, Gupta N, et al. Crohn’s disease among the poorest billion: burden of Crohn’s disease in lowand lower-middle-income countries. Dig Dis Sci 2023;68:1226–1236.ArticlePubMedPMCPDF
  • 76. Oxley H. Health policy. In: Organisation for Economic Co-operation and Development (OECD), ed. Getting it right: OECD Perspectives on Policy Challenges in Mexico. Paris: OECD, 2007:99-106.

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        Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective
        Intest Res. 2024;22(3):286-296.   Published online March 26, 2024
        DOI: https://doi.org/10.5217/ir.2023.00199
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      Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective
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      Fig. 1. Proposed diagnostic algorithm for irritable bowel syndrome (IBS) in low- and middle-income countries. CRC, colorectal cancer; CBC, complete blood count; FOBT, fecal occult blood test; GI, gastrointestinal.

      Fig. 1.

      Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective
      Manning Asian Rome III Rome IV
      ≥ 4 of these following: Recurrent abdominal pain, bloating, or other discomfort for ≥ 3 months associated with ≥ 1 of the following: Recurrent abdominal pain or discomfort for more than 3 days per month over the previous 3 months and associated with ≥ 2 of the following: Recurrent abdominal pain, on average, at least 1 day per week in the last 3 months, associated with ≥ 2 of the following:
      · Abdominal pain that is eased after bowel movement
      · Looser stools at onset of pain · Relief with defecation · Improvement in defecation · Related to defecation
      · More frequent bowel movement at onset of pain · Change in stool form · Onset associated with a change in the frequency of stool · Associated with a change in the frequency of stool
      · Feeling of incomplete emptying · Change in stool frequency · Onset associated with a change in form or appearance of stool · Associated with a change in the form or appearance of stool
      · Mucus per rectum
      · Feeling of distention
      Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis
      Table 1. Comparison of the Manning, Asian, Rome III, and Rome IV Criteria for Irritable Bowel Syndrome [27,28,39,40]

      Table 1.

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