Intest Res > Volume 18(2); 2020 > Article |
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FINANCIAL SUPPORT
This study was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT; 17H05802 for Hozumi K); Japan Society for the Promotion of Science (JSPS; 19K017413 for Imai J); a MEXT-Supported Program for the Strategic Research Foundation at Private University (Tokai University) for Imai Y.
AUTHOR CONTRIBUTION
Conceptualization: Hozumi K, Imai J, Yahata T. Funding acquisition: Hozumi K, Imai J. Methodology: Hozumi K, Imai J, Yahata T, Ichikawa H, Ibrahim AA, Yazawa M, Sumiyoshi H. Supervision: Ichikawa H, Inagaki Y, Matsushima M, Suzuki T, Mine T, Ando K, Miyata T. Writing original draft: Imai J, Hozumi K. All authors read and approved the final version of the manuscript.
Group |
Macroscopic score of colonic fibrosis |
|||||
---|---|---|---|---|---|---|
Adhesion | Thickness | Strictures | Dilation | Mucosal edema | Total macroscopic score | |
Ethanol (n = 10) | 0.20 ± 0.42 | 0.10 ± 0.32 | 0 | 0.20 ± 0.42 | 0.50 ± 0.42 | 1.00 ± 0.67 |
CMC (n = 10) | 0.90 ± 0.31 | 1.80 ± 0.42 | 1.80 ± 0.47 | 0.80 ± 0.42 | 0.80 ± 0.42 | 6.10 ± 0.87 |
TM5275 10 mg/kg (n = 9) | 0.74 ± 0.44 | 1.38 ± 0.72 | 1.65 ± 0.44 | 0.74 ± 0.50 | 0.74 ± 0.44 | 5.40 ± 0.60 |
TM5275 50 mg/kg (n = 10) | 0.80 ± 0.42 | 0.70 ± 0.67a,c | 0.80 ± 0.63a,c | 0.30 ± 0.48a,b | 0.50 ± 0.53a,b | 3.10 ± 0.73a,c |
Group |
Microscopic score of colonic fibrosisa |
||||
---|---|---|---|---|---|
Ulcerations | Degree of inflammation | Depth of lesions | Degree of fibrosis | Total microscopic score | |
Ethanol (n = 10) | 0.10 ± 0.32 | 0.20 ± 0.42 | 0.20 ± 0.42 | 0.30 ± 0.48 | 0.80 ± 0.63 |
CMC (n = 10) | 0.90 ± 0.31 | 1.60 ± 0.51 | 1.80 ± 0.48 | 1.90 ± 0.31 | 6.20 ± 0.63 |
TM5275 10 mg/kg (n = 9) | 0.83 ± 0.63 | 1.46 ± 0.52 | 1.56 ± 0.51 | 1.56 ± 0.50 | 5.30 ± 0.62 |
TM5275 50 mg/kg (n = 10) | 0.70 ± 0.48 | 1.30 ± 0.67 | 0.90 ± 0.56b | 0.40 ± 0.51b | 3.30 ± 0.67b |