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Intest Res > Volume 10(4); 2012 > Article
Intestinal Research 2012;10(4):392-396.
DOI: https://doi.org/10.5217/ir.2012.10.4.392    Published online October 31, 2012.
A Case of Cholangiocarcinoma and Colorectal Cancer Diagnosed Simultaneously in a Patient with Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis
Eun Yeong Kim, Hyo Jong Kim, Chang Kyun Lee, Choul Ki Park, Hee Jae Hyun, Yeon Ju Kim, Kyung Yup Kim
Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea
원발성 경화성 담관염이 동반된 궤양성 대장염 환자에서 담관암 및 대장암이 동시에 진단된 1예
김은영, 김효종, 이창균, 박철기, 현희재, 김연주, 김경엽
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) accompanied by a risk to develop colorectal dysplasia and cancer. Primary sclerosing cholangitis (PSC) is strongly associated with UC and there are some distinguishing clinical features between UC patients with PSC (UC-PSC) and UC patients without PSC. The most important feature is that UC patients with concomitant PSC are at a significantly increased risk of developing colorectal dysplasia or cancer. Furthermore, it has been suggested that patients with UC and PSC are also at an increased risk of cholangiocarcinoma. We report a case of cholangiocarcinoma and colorectal cancer diagnosed simultaneously in a patient with UC and concurrent PSC. He was diagnosed with UC and PSC 13 years ago and had been treated irregularly. Surveillance colonoscopy and biopsies were performed and one of the biopsied specimen confirmed adenocarcinoma. He underwent abdominal computed tomography (CT) because of the abnormal liver function test and the CT showed cholangiocarcinoma. To the best of our knowledge, this is the first case report of a UC-PSC with cholangiocarcinoma and colorectal cancer at the same time in Korea. (Intest Res 2012;10:392-396)
Key Words: Primary sclerosing cholangitis, Cholangiocarcinoma, Ulcerative colitis, Colorectal cancer
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