| Sonic Hedgehog Expression in Colorectal Neoplasms |
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Hye Seung Han, Sun-Young Lee, Moo Kyung Seong, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Choon Jo Jin, Tae Sook Hwang |
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Departments of Pathology, Internal Medicine and Surgery†, Konkuk University School of Medicine, Seoul, Korea
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| 대장 종양에서의 Sonic Hedgehog 단백의 발현 |
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한혜승, 이선영, 성무경, 김정환, 성인경, 박형석, 진춘조, 황태숙 |
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건국대학교 의학전문대학원 병리학교실, 내과학교실 |
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| Abstract |
Background/Aims
Dysregulation of the hedgehog pathway has been implicated in regeneration and carcinogenesis, leading to the expression of the sonic hedgehog (Shh) protein in gastrointestinal neoplasms. The expression of Shh in colon neoplasms and paired normal colonic mucosa was therefore investigated. Methods: Forty-four colon cancers and 73 colon adenomas that were removed by surgical colectomy or colon polypectomy between August 2005 and August 2006 were included. Colorectal neoplasms and the adjacent normal colon tissue were examined by immunohistochemistry using rabbit polyclonal Shh antibody. Results: Expression of Shh was up-regulated in adenomas and adenocarcinomas of the colon compared to normal colon tissues (p＜0.001). The degree of Shh expression was not associated with the size, shape, or, location of the tumor, or as the age and gender of the patient. In normal colonic epithelium, Shh was expressed at the apex of the crypts and in a few basally-located cells. Conclusions: Higher levels of Shh expression in colonic adenoma and adenocarcinoma suggest that Shh is required during epithelial proliferation in the colon. Hedgehog signaling is likely to be associated with early tumorigenesis in colonic neoplasms. (Intest Res 2008;6:19-24) |
| Key Words:
Hedgehog, Colorectal Neoplasms, Adenocarcinoma, Adenoma |
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