Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease
Zhao Y, Chen B, He Y, et al. Intest Res. 2020;18(2):200-209
Crohn's disease (CD) has been reported to decrease fertility rate in relation to inflammation in the pelvis, including the fallopian tubes and ovaries, and surgery-related adhesions. However, studies on female reproductive function in patients with CD are still lacking. In this regard, AMH (Anti-Müllerian hormone), a new hormone marker that can predict ovarian reserve, an indicator of fertility, is being used. The present case-control study analyzed the risk factors that are related to impaired ovarian reserve using AMH levels in women with CD in reproductive age.
- The study included 87 patients with established CD and another 87 healthy controls with similar traits, including age, weight and height. For this study, low ovarian reserve was defined as serum AMH levels below 2 ng/mL.
- The average serum AMH level was significantly lower in CD patients when compared with control group (2.47 ± 2.08 ng/mL vs. 3.87 ± 1.96 ng/mL, respectively, P< 0.001)
- Independent risk factors associated with low ovarian reserve (serum AMH levels < 2 ng/mL) in CD patients included an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, P= 0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, P< 0.001), and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, P= 0.006) according to multivariable analysis.
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