Intestinal Research

: Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study

: This issue chosen by the Editor of Intestinal Research is “Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study” performed by Park S-K, et al. 5-aminosalicylic acid (5-ASA) is currently established as a standard treatment for first-line treatment of mild-to-moderate UC. This study have reported treatment adherence, patients’ satisfaction and treatment efficacy of once daily (OD) and divided daily (DD) dosing in the Korean ulcerative colitis (UC) patients. In this study, 180 patients were randomly assigned to the OD or DD group in a 1:1 ratio. The adherence rates were not different between the OD group and DD group. The patients’ satisfaction of the OD group was higher than that of the DD group. At 1 year, 5-ASA OD dosing might have the same effect as DD for the maintenance of UC remission (91.2% and 95.5%, respectively). Read more about the adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis. In addition to this article, read other related articles listed below about 5-ASA maintain treatment and other therapeutic options for UC. Best regards,

1. Comparison of efficacies of once-daily dose multimatrix mesalazine and multiple-dose mesalazine for the maintenance of remission in ulcerative colitis: a randomized, double-blind study
Haruhiko Ogata, Akihiro Ohori, Haruo Nishino, Seiichi Mizushima, Atsushi Hagino, Toshifumi Hibi. Intest Res 2017;15(3):358-367
https://doi.org/10.5217/ir.2017.15.3.358
2. Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies
Satoshi Motoya, Mamoru Watanabe, Hyo Jong Kim, Young Ho Kim, Dong Soo Han, Hirotoshi Yuasa, Junichi Tabira, Naoki Isogawa, Shoko Arai, Isao Kawaguchi, Toshifumi Hibi. Intest Res 2018;16(2):233-245
https://doi.org/10.5217/ir.2018.16.2.233
3. Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis
Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Masamichi Kimura, Yorimitsu Koshikawa, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Hiroshi Nakase. Intest Res 2015;13(3):250-258
https://doi.org/10.5217/ir.2015.13.3.250
4. 5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis
Jun Miyoshi, Katsuyoshi Matsuoka, Atsushi Yoshida, Makoto Naganuma, Tadakazu Hisamatsu, Tomoharu Yajima, Nagamu Inoue, Susumu Okamoto, Yasushi Iwao, Haruhiko Ogata, Fumiaki Ueno, Toshifumi Hibi, Takanori Kanai. Intest Res 2018;16(4):635-640
https://doi.org/10.5217/ir.2018.00015