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Published online April 23, 2019.
Influence of anti-tumor necrosis factor-alpha therapy on pregnant women with inflammatory bowel disease and their children’s immunity
This issue chosen by the Editor of Intestinal Research is “Influence of anti-tumor necrosis factor-alpha (anti-TNF-α) therapy on pregnant inflammatory bowel disease (IBD) women and their children’s immunity” performed by Lee KE, et al.
Although previous studies have shown conflicting results on the safety of anti-TNF-α therapy on IBD women during pregnancy, the majority of studies suggested that the use of anti-TNF-α agents was not associated with any increase of miscarriage and neonatal complications.
This study showed that all 18 IBD women who delivered their child while receiving anti-TNF-α treatments maintained remission without any significant complications. Of these, 12 children followed the regular vaccination schedules for hepatitis B virus. Although 4 out of the 12 children (33.3%) were anti-HBs negative, all those 4 children demonstrated seroconversion after the 1 booster vaccination. None of 8 children who had live vaccinations before 6 months after birth had any specific side effects.
Read more about the influence of anti-TNF-α therapy on pregnant IBD women and their children’s immunity.
In addition to this article, read other related articles listed below about maternal and fetal outcomes in pregnant women with IBD.

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