Influence of anti-tumor necrosis factor-alpha therapy on pregnant women with inflammatory bowel disease and their children’s immunity |
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This issue chosen by the Editor of Intestinal Research is “Influence of anti-tumor necrosis factor-alpha (anti-TNF-α) therapy on pregnant inflammatory bowel disease (IBD) women and their children’s immunity” performed by Lee KE, et al.
Although previous studies have shown conflicting results on the safety of anti-TNF-α therapy on IBD women during pregnancy, the majority of studies suggested that the use of anti-TNF-α agents was not associated with any increase of miscarriage and neonatal complications.
This study showed that all 18 IBD women who delivered their child while receiving anti-TNF-α treatments maintained remission without any significant complications. Of these, 12 children followed the regular vaccination schedules for hepatitis B virus. Although 4 out of the 12 children (33.3%) were anti-HBs negative, all those 4 children demonstrated seroconversion after the 1 booster vaccination. None of 8 children who had live vaccinations before 6 months after birth had any specific side effects.
Read more about the influence of anti-TNF-α therapy on pregnant IBD women and their children’s immunity.
In addition to this article, read other related articles listed below about maternal and fetal outcomes in pregnant women with IBD.
Best regards,
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Related article |
- 1. Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
Ko Eun Lee, Sung-Ae Jung, Sang Hyoung Park, Chang Mo Moon, So Yeon Shim, Eun Soo Kim, Su Jin Cho, Seong-Eun Kim, Kwang Bum Cho, Suk-Kyun Yang . Intest Res. [Epub ahead of print] https://doi.org/10.5217/ir.2018.00071 - 2. Maternal and fetal outcomes in pregnant Japanese women with inflammatory bowel disease: our experience with a series of 23 cases
Naoki Minami, Minoru Matsuura, Yorimitsu Koshikawa, Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Hiroshi Nakase . Intest Res. 2017;15(1):90-96 https://doi.org/10.5217/ir.2017.15.1.90 - 3. Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus
Tomoyoshi Shibuya, Keiichi Haga, Masato Kamei, Koki Okahara, Shoko Ito, Masahito Takahashi, Osamu Nomura, Takashi Murakami, Masae Makino, Tomohiro Kodani, Dai Ishikawa, Naoto Sakamoto, Taro Osada, Tatsuo Ogihara, Sumio Watanabe, Akihito Nagahara . Intest Res. 2018;16(3):484-488 https://doi.org/10.5217/ir.2018.16.3.484 - 4. Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan
Shunsuke Komoto, Satoshi Motoya, Yuji Nishiwaki, Toshiyuki Matsui, Reiko Kunisaki, Katsuyoshi Matsuoka, Naoki Yoshimura, Takashi Kagaya, Makoto Naganuma, Nobuyuki Hida, Mamoru Watanabe, Toshifumi Hibi, Yasuo Suzuki, Soichiro Miura, Ryota Hokari . Intest Res. 2016;14(2):139-145 https://doi.org/10.5217/ir.2016.14.2.139 - 5. Concerns in pregnancy and childbirth of women with inflammatory bowel disease
Sung-Ae Jung . Intest Res. 2016;14(2):107-108 https://doi.org/10.5217/ir.2016.14.2.107
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