| Predictable Factors of Early Colorectal Cancer after Colonoscopic Polypectomy |
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Jeong Rae Yoo, Hyun Joo Song, Jong Wook Beom, Soo-Young Na, Sun-Jin Boo, Eun Kwang Choi, Yoo-Kyung Cho, Heung Up Kim, Byung-Cheol Song, Chang Lim Hyun, Jo-Heon Kim2 |
1Departments of Internal Medicine and Pathology
2Jeju National University School of Medicine, Jeju, Department of Pathology, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea
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| 대장 용종절제술을 시행한 환자에서 조기 대장암의 예측 인자 |
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유정래, 송현주, 범종욱, 나수영, 부선진, 최은광, 조유경, 김흥업, 송병철, 현창림, 김조헌2 |
1제주대학교 의학전문대학원 내과학교실, 병리학교실
2가톨릭대학교 의과대학 부천성모병원 병리학교실 |
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| Abstract |
Background/Aims
Colorectal cancer is the third most common cancer and the fourth leading cause of cancer death in Korea. Colonoscopic screening with removal of adenomas is an effective strategy for reducing the incidence and mortality of colorectal cancer. This study was conducted to investigate predictable factors of early colorectal cancer (ECC) in patients with advanced adenoma (AA), tumor in situ (Tis), and submucosal (SM) cancer diagnosed after colonoscopic polypectomy. Methods: etween August 2003 and June 2012, a total of 1,001 patients who underwent colonoscopic polypectomy in Jeju National University Hospital were enrolled in this study. Results: Patients were classified into four groups; non-AA, AA, Tis, and SM cancer. Compared to the AA group, the ECC group (n=50) had large adenoma size (12.2±5.9 mm vs. 15.3±6.5 mm, P<0.01), distal location (39.3% vs. 52.0%, P=0.05) and diabetes mellitus (13.1% vs. 25.0%, P=0.04). However, age, sex, body mass index, the mean number of polyps, and morphological features (polypoid vs. nonpolypoid lesions) were not significantly different between the AA and ECC groups. In multivariate analysis, adenoma size >15 mm (odds ratio [OR], 4.49; 95% confidence interval [CI] 2.40-8.38), distal location (OR, 2.59; 95% CI, 1.33-5.05), and diabetes mellitus (OR, 2.10; 95% CI, 1.07-4.43) were significantly associated with ECC. Of the 12 patients with SM cancer, 5 underwent additional operations and had no remnant carcinoma. Conclusions: Predictable factors of ECC after colonoscopic polypectomy may be adenoma size >15 mm, distal location and diabetes mellitus. (Intest Res 2013;11:169-177) |
| Key Words:
Colorectal neoplasms, Colonoscopy |
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