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Intest Res > Volume 11(2); 2013 > Article
Intestinal Research 2013;11(2):137-141.
DOI:    Published online April 30, 2013.
Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon
Donggeum Shin, Youngsook Park, Soojung Gong, Seonghwan Kim, Yunju Jo, Sangbong Ahn, Joonkil Han, Eunkyung Kim
Departments of Internal Medicine, Surgery and Pathology, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea
대장 신경내분비암종과 동시에 진단된 대장선암 1예
신동금, 박영숙, 공수정, 김성환, 조윤주, 안상봉, 한준길, 김은경
Neuroendocrine carcinoma of colon is a rare disease entity that is histologically poorly differentiated and immunochemically synaptophysin positive, enabling it to be confirmed by an immunohistochemical stain. Neuroendocrine carcinomas, in almost all cases, have poor prognosis due to a tendency of early metastasis and lack of standardized treatment. The concurrent diagnosis of neuroendocrine carcinoma and adenocarcinoma is extremely rare. The relation of these two disease entities is not understood. We experienced a patient with a colonic neuroendocrine carcinoma concurrent with adenocarcinoma. A 65-year-old male presented with abdominal pain. Emergent computed tomography suggested a malignant tumor of the ascending colon. Colonoscopy showed an infiltrative lesion in the ascending colon with a luminal narrowing, a large pedunculated lesion at the splenic flexure, and multiple small polyps in the descending colon. The patient underwent a right hemicolectomy including the pedunculated lesion. The pathology confirmed advanced neuroendocrine carcinoma in the ascending colon, adenocarcinoma in proximal descending colon, and multiple metastatic lymph nodes of neuroendocrine carcinomas on abdomen. The patient underwent the postoperative chemotherapy but did not tolerate it well and expired a year after diagnosis. We report this rare case with a review of the literature. (Intest Res 2013;11:137-141)
Key Words: Colonic Neoplasms, Carcinoma, Neuroendocrine, Adenocarcinoma
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