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Intest Res > Volume 10(4); 2012 > Article
Intestinal Research 2012;10(4):365-371.
DOI: https://doi.org/10.5217/ir.2012.10.4.365    Published online October 31, 2012.
Clinicopathological Characteristics of Colorectal Cancer according to Gender Difference
Dae Ho Kim, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Yoon Jong Seo
Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea
성별 차이에 따른 대장암의 임상-병리 특성
김대호, 차재명, 이정일, 주광로, 신현필, 박재준, 전정원, 임준욱, 전승정, 서윤종
경희대학교 의과대학 강동경희대병원 내과학교실
Abstract
Background/Aims
Colorectal cancer (CRC) has been one of the major causes of death and has become a major public health concern. The incidence of CRC has been increasing regardless of gender in Korea. Until now, however, the studies on gender-based clinicopathological characteristics of CRC focused on pathology have never been reported. Therefore, we aimed to evaluate the difference in clinicopathological characteristics of CRC according to gender in Korea. Methods: Medical records of 342 patients with advanced CRC who underwent surgical resection at Kyung Hee University Hospital at Gangdong from June 2006 to December 2011 were retrospectively analyzed. The data of the clinicopathological characteristics of CRC by gender difference were compared. Results: Of these 341 patients, 203 (60%) patients were male and 138 (40%) patients were female. The male preponderance was noted in all age groups for total CRC and left-sided CRC. However, for right-sided colon cancer, this male preponderance was significantly decreased with increasing age groups (P=0.025) and was finally reversed in elderly groups (age ≥60 years). The microsatellite instability represented by negative staining for hMLH1 and hMSH2 was more frequently detected in women than men (P=0.037). Conclusions: The male preponderance in right-sided colon cancer decreased with increasing age groups and finally reversed in age groups more than 60 years. Microsatellite instability with immunohistochemical staining was more frequently detected in women. However, further studies with a large number of patients are warranted on this issue. (Intest Res 2012;10:365-371)
Key Words: Colorectal Neoplasms, Gender Identity, Pathology, Microsatellite Instability
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