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Intest Res > Volume 8(1); 2010 > Article
Intestinal Research 2010;8(1):75-79.
DOI:    Published online June 30, 2010.
Postradiation Malignant Fibrous Histiocytoma of the Colon: A Case Report
Jin Young Yoon, Do Kyung Kim, Jae Hee Cheon, Chang Mo Moon, Jae Jun Park, Joo Won Chung, Eun Young Kim, Tae Hoon Kim, Chan Joo Lee, Eun Young Park, Sang Hoon Shin, Sung Pil Hong, Tae Il Kim, Nam Kyu Kim, Ho Guen Kim, Won Ho Kim
*Department of Internal Medicine
Institute of Gastroenterology
Departments of Pathology
§and Surgery, Yonsei University College of Medicine, Seoul, Korea
대장에 발생한 방사선속발 악성 섬유 조직구종
윤진영, 김도경, 천재희, 문창모, 박재준, 정주원, 김은영, 김태훈, 이찬주, 박은영, 신상훈*, 홍성필, 김태일, 김남규, 김호근, 김원호
*연세대학교 의과대학 내과학교실
Post-radiation soft tissue sarcomas are recognized as rare complications of radiation therapy. The most common type of post-radiation soft tissue sarcoma is a malignant fibrous histiocytoma (MFH), which originates from mesenchymal cells with a predominance of histiocytes and fibroblasts. The two most common sites of occurrence for post-radiation soft tissue sarcomas are the chest wall and pelvic cavity. Post-radiation colorectal MFHs are extremely rare and all of the reported cases of post-radiation sarcomas have occurred >3 years after radiation therapy. Recently, we managed a case of colorectal MFH which developed in a 48-year-old male who had undergone a low anterior resection for rectal adenocarcinoma and had received chemoradiotherapy as adjuvant treatment. Twelve months after radiotherapy, a 4 cm mass was detected 8 cm superior to the anastomosis site on colonoscopic examination. A soft tissue sarcoma was suspected on pathologic examination of the biopsy specimen. Therefore, he underwent a Hartmann's operation and the final pathologic finding revealed MFH with a storiform pattern of tumor cells composed of pleomorphic, multinucleated giant cells. This is the first case of MFH that had a latency period <3 years (i.e., 1 year) between the time of radiotherapy and diagnosis. (Intest Res 2010;8:75-79)
Key Words: Neoplasm, Radiation Induced, Histiocytoma, Malignant Fibrous, Sarcoma
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