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Intest Res > Volume 8(1); 2010 > Article
Intestinal Research 2010;8(1):40-47.
DOI: https://doi.org/10.5217/ir.2010.8.1.40    Published online June 30, 2010.
Clinical Course of Intestinal BehcӇet's Disease according tothe Characteristics of Ulcer in Colonoscopy
Min Cheul Kim, Sung Jae Shin, Sun Gyo Lim, Kyung Rok Lee, Hak Woo, Sang Jo Choi, Jung Soo Jo, Jung Ho Eum, Dong Youb Cha, Jae Chul Hwang, Ki Myung Lee, Kwang Jae Lee, Jin Hong Kim
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
대장내시경에서 궤양의 특성에 따른 베체트 장염의 임상경과
김민철, 신성재, 임선교, 이경록, 우 학, 최상조, 조정수, 엄중호, 차동엽, 황재철, 이기명, 이광재, 김진홍
아주대학교 의과대학 소화기내과학교실
Abstract
Background/Aims
Intestinal involvement with bleeding and perforation is one of the main causes of morbidity and mortality in patients with Behçet's disease (BD); however, the clinical course of intestinal BD has not been defined. The aim of this study was to determine the clinical course of intestinal BD based on the characteristics of ulcers visualized during colonoscopy. Methods: We retrospectively reviewed the medical records and colonoscopic findings of 41 patients with intestinal BD. All patients were classified into subgroups according to ulcer depth, size, and number, and we analyzed the clinical manifestations, subset type of BD, medications, surgical procedures, and relapse rate among the subgroups. Results: The median age at the time of diagnosis was 38 years (range, 18-74 years); 25 patients were females (M:F=1:1.56). Abdominal pain (n=40), diarrhea (n=27), and RLQ tenderness (n=21) were common symptoms. The number of complete, incomplete, and suspected types was 3, 17, and 21, respectively. In an analysis according to ulcer depth, the rate of steroid use and intestinal surgeries was more frequent in the deep ulcer group compared with the aphthous and shallow ulcer groups (50.0% vs. 0% vs. 17.6%; P=0.012; 42.9% vs. 0% vs. 23.5%: P=0.013) The rate of steroid use and relapse tended to be higher as the size of the ulcer increased; however, there was no difference in the rates of steroid use, surgeries, and relapse based on the number of intestinal ulcers. Conclusions: The prognosis was worse in patients with intestinal BD who have deeper and larger ulcers. Therefore, we suggest that such patients need to be treated aggressively. (Intest Res 2010;8:40-47)
Key Words: Intestinal Behç, et's Disease, Ulcer, Colonoscopy
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