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Intest Res > Volume 8(1); 2010 > Article
Intestinal Research 2010;8(1):18-23.
DOI: https://doi.org/10.5217/ir.2010.8.1.18    Published online June 30, 2010.
The Usefulness of F18-FDG PET/CT in Detection of Colonic Neoplasm
Min Kyung Kang, Sung Pyo Hong, Ji Eun Lee, Tae Joo Jeon, Jong Woo Kim, Chang Il Kwon, Kwang Hyun Ko, Seong Gyu Hwang, Pil Won Park, Kyu Sung Rim
Digestive Disease Center and Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
대장 종양의 진단에서 F18-FDG PET/CT의 유용성
강민경, 홍성표, 이지은, 전태주, 김종우, 권창일, 고광현, 황성규, 박필원, 임규성
차의과학대학교 분당차병원 소화기센터, 핵의학과
Abstract
Background/Aims
The diagnostic value of 2-18F-fluoro-2-deoxy-D-glucose positron emi-ssion to-mo--graphy (FDG PET)/CT in the detection of colon carcinoma and adenoma was evaluated retrospectively. Methods: Between May 2007 and June 2008, 102 patients (42 males and 60 females: age range, 28-89 years) underwent both FDG PET/CT and colonoscopy in < a 3 month interval. FDG uptake on PET/CT was divided into physiologic and pathologic uptake by a nuclear medicine specialist. Pathologic confirmation was obtained in all patients. Results: Forty-three patients had no abnormal findings on both FDG PET/CT and colonoscopy. One hundred five and 59 colonic lesions were detected on FDG PET/CT and colonoscopy, respectively. Eleven of 24 lesions with pathologic FDG uptake were histologically-confirmed to be malignancies. Among 18 lesions with physiologic FDG uptake, 1 carcinoma and 1 adenoma were revealed. One carcinoma, 25 adenomas, and 11 hyperplastic polyps did not reveal FDG uptake. Interpretation of pathologic FDG uptake in the colon had a sensitivity of 84.6% and 28.2%, a specificity of 90.4% and 88.1%, a positive predictive value of 45.8% and 45.8%, and a negative predictive value of 98.4% and 77.8% for carcinomas and adenomas, respectively. Conclusions: FDG PET/CT is a very useful diagnostic method for the detection of colon cancer, but the sensitivity is low for adenomas, which may need further evaluation, such as a screening endoscopy. (Intest Res 2010;8:18-23)
Key Words: PET/CT, Colonoscopy, Colonic Neoplasms
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