Pathogenesis of Inflammatory Bowel Diseases

Masakazu Nagahori; Yasuhiro Nemoto; Mamoru Watanabe

doi:10.5217/ir.2010.8.1.9

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Review Pathogenesis of Inflammatory Bowel Diseases: Masakazu Nagahori, Yasuhiro Nemoto, Mamoru Watanabe; Intestinal Research 2010;8(1):9-17.
DOI: https://doi.org/10.5217/ir.2010.8.1.9
Published online: June 30, 2010

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

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Abstract

Our understanding of IBD pathogenesis has been increasing rapidly. The genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune system has been appreciated deeply. The interplay is also considered to be modified by specific environmental factors. This review examines the recent findings from the animal and human studies on IBD pathogenesis and the implications for future effective therapies. (Intest Res 2010;8:9-17)

Keywords: Pathogenesis; Inflammatory Bowel Diseases

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