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Intestinal Research 2008;6(2):95-102.
Published online December 30, 2008.
Irritable Bowel Syndrome and Immune Activation
Chang Hwan Choi, Hye Ryoung Sul
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea
과민성 장증후군과 면역 활성화
최창환, 설혜령
중앙대학교 의과대학 내과학교실
Abstract
Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and bowel habit change. Its specific pathophysiologic mechanism underlying IBS is not known; however, it is generally accepted that IBS symptoms represent dysregulation at multiple levels of the brain-gut axis. IBS symptoms are manifested by abnormal motor reactivity to various stimuli, and low sensation and pain thresholds. Recently, a variety of new findings have been reported which suggests low-grade inflammation or immune activation is present in IBS patients, including post-infectious IBS. The immune activation can generate various symptoms such as abdominal pain, bloating, and diarrhea that may result from motor dysfunction and visceral hypersensitivity. Anti-inflammatory therapy with either antibiotics or probiotics seems to be effective in reducing the symptoms of IBS. While this pathophysiologic approach to the management of IBS is in its infancy, it is evident that the immune activation deserves further attention in IBS. (Intest Res 2008;6:95-102)
Key Words: Irritable Bowel Syndrome, Immune Activation
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