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Intestinal Research 2007;5(2):170-176.
Published online December 30, 2007.
Factors Affecting the Efficacy of Tegaserod in Patients with Chronic Constipation
Hwang Choi, Sang Heon Yoon, Won Chul Lee, Joo Sung Kim, Dong Kyung Chang, Yoon Tae Jeen, Jin Oh Kim, Dong Soo Han, Hyo Jong Kim, Sang Yong Seol, Won Ho Kim, Suk Kyun Yang, Jin Ho Kim
*Department of Internal Medicine, The Catholic University of Korea College of Medicine, Department of Preventive Medicine, The Catholic University of Korea College of Medicine
Department of Internal Medicine, Seoul National University College of Medicine
*Sungkyunkwan University College of Medicine
§Korea University College of Medicine
Soonchunhyang University College of Medicine
Hanyang University College of Medicine
*Kyunghee University College of Medicine#
*Inje University College of Medicine
††Yonsei University College of Medicine
‡‡Ulsan University College of Medicine, Seoul, Korea
만성 변비 환자에서 테가세로드의 효능에 영향을 미치는 요소
최황, 윤상헌, 이원철, 김주성, 장동경, 진윤태, 김진오, 한동수, 김효종, 설상영, 김원호, 양석균, 김진호
*가톨릭대학교 의과대학 내과학교실, 예방의학교실
서울대학교 의과대학 내과학교실
*성균관대학교 의과대학 내과학교실
§고려대학교 의과대학 내과학교실
순천향대학교 의과대학 내과학교실
한양대학교 의과대학 내과학교실
*경희대학교 의과대학 내과학교실#
*인제대학교 의과대학 내과학교실
††연세대학교 의과대학 내과학교실
‡‡울산대학교 의과대학 내과학교실
Abstract
Background/Aims
The effect of tegaserod has been found to differ for Caucasian and black patients. The aims of this study were to demonstrate the efficacy of tegaserod on bowel habits and to investigate the factors affecting the efficacy of tegaserod in Korean patients suffering from chronic constipation (CC). Methods: This was an open-label, multi-center, observational study. Analysis of covariance with repeated measures was used to determine the overall effect of treatment and was used to determine the changes in the number of complete spontaneous bowel movements (CSBM) from baseline during the 8-week treatment period. Demographic and baseline characteristics were compared between responders (3 or more CSBM at 8-weeks) and non-responders by the use of multivariate analysis. Results: A total of 1,798 patients were included in the study. Tegaserod treatment resulted in a significant increase in the mean number of CSBM per week over weeks 2-8 from baseline levels (from 1.0 to 3.1 CSBM per week, p<0.0001). Tegaserod treatment was more effective for female patients, younger patients (age less than 65 years), patients with a high Bristol score at baseline, and patients with a short duration of constipation symptoms. Conclusions: Treatment with tegaserod improved bowel movements and more effective in female patients, patients under the age of 65 years, patients with a high Bristol score at baseline, and patients with a short duration of constipation symptoms. (Intest Res 2007;5:170-176)
Key Words: Constipation, Tegaserod, Bowel Movement
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