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Intestinal Research 2006;4(2):87-94.
Published online December 30, 2006.
The Efficacy of Propofol Alone versus Midazolam Plus Propofol for Colonoscopy
Cheol Hee Park, Soung Hoon Chang, Jae One Jung, Joon Ho Moon, Woon Geon Shin, Jong Pyo Kim, Kyung Oh Kim, Taeho Hahn, Kyo-Sang Yoo, Sang Hoon Park, Jong Hyeok Kim, Choong Kee Park
Department of Internal Medicine, Hallym University College of Medicine, Anyang, Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea
수면 대장내시경에서 Propofol 단독요법과 Midazolam, Propofol 병합요법의 효과 비교 연구
박철희, 장성훈, 정재원, 문준호, 신운건, 김종표, 김경오, 한태호, 유교상, 박상훈, 김종혁, 박충기
한림대학교 의과대학 내과학교실, 건국대학교 의과대학 예방의학교실
Recent studies showed that propofol and midazolam act synergistically in combination and therefore it may be superior to sedation with propofol alone in terms of sedating efficacy. We compared the effect of propofol alone and combined use of propofol and midazolam during colonoscopy. Methods: P (propofol alone) group received propofol (2-2.5 ml/kg/hr) plus normal saline (3 ml) and MP (propofol/midazolam) group received propofol (2-2.5 ml/kg/hr) plus midazolam (3 mg). We compared followings in both groups; 1) induction and total propofol dosage 2) induction and procedure time 3) recovery time 4) satisfaction of patients and doctors 5) adverse effects. Results: Induction (9 vs. 12 ml) and total (17 vs. 22 ml) propofol dosage were lower in MP group than P group (p<0.05). Induction (3.6 vs. 5.5 min) time was shorter in MP group than P group (p<0.05). In both groups, significant difference was not observed in the change of blood pressure, heart rate, respiration rate, and peripheral blood oxygen saturation rate. Fatal adverse effect was not found in both groups. Conclusions: Combined use of propofol and midazolam is more effective sedative method than the use of propofol alone because of rapid induction and lower propofol dosage without increasing adverse effects. (Intestinal Research 2006;4:87-94)
Key Words: Colonoscopy, Conscious sedation, Midazolam, Propofol
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