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Intestinal Research 2005;3(1):11-17.
Published online June 30, 2005.
The Safety of Colonoscopy Using Sedation with Propofol
Jong Pyo Kim, Cheol Hee Park, Jae One Jung, Joon Ho Moon, Woon Geon Shin, Kyoung Oh Kim, Tae Ho Han, Kyo Sang Yoo, Sang Hoon Park, Jong Hyeok Kim, Choong Kee Park
Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea
Propofol에 의한 수면유도 대장내시경 검사법의 안정성에 대한 연구
김종표, 박철희, 정재원, 문준호, 신운건, 김경오, 한태호, 유교상, 박상훈, 김종혁, 박충기
한림대학교 의과대학 내과학교실, 성심병원
The usage of sedative agents like midazolam or propofol and a desire for efficient and safe endoscopy have contributed to changes in the practice of endoscopic sedation. The clinical efficacy and safety of propofol as premedication for outpatient colonoscopy is under evaluation in Korea. We compared propofol to low-dose midazolam for colonoscopy with conscious sedation. Methods: Outpatients undergoing colonoscopy were randomized to receive either propofol or low-dose midazolam (0.05 mg/kg). Total 92 patients were divided into 2 groups (propofol group: 51, low-dose midazolam group: 41). Induction of sedation, procedure and recovery time, patient's and doctor's satisfaction, complications were evaluated. Results: There was no significant difference between two groups in sex ratio and mean age. The changes in blood pressure, pulse rate, respiration rate and oxygen saturation were not significant in both groups. Patients receiving propofol tolerated colonoscopy much more than those with low-dose midazolam. Major complications such as hemodynamic instability or apnea did not occur in both groups. Conclusions: Propofol was safe and effective premedication for conscious sedation in colonoscopy. Propofol has several advantages over low-dose midazolam. (Intest Res 2005;3:11-17)
Key Words: Conscious sedation, Propofol, Midazolam, Colonoscopy
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