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Intestinal Research 2004;2(2):58-64.
Published online December 22, 2004.
Expression of Human T cell-activating CXC Chemokines in inflammatory bowel disease
Byeong Gwan Kim, Ji Won Kim, Ji Bong Jeong, Geum Yeon Kwak, Kook Lae Lee, Young Soo Park, Na Young Kim, Dong Ho Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Song
1Department of Internal Medicine, Seoul National University Boramae Hospital, Department of Internal Medicine, Seoul National University Bundang Hospital
2Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea
염증성 장질환에서 Human T cell-activating CXC Chemokine의 발현
김병관, 김지원, 정지봉, 곽금연, 이국래, 박영수, 김나영, 이동호, 김주성, 정현채, 송인성
1서울대학교 보라매병원, 서울대학교 분당병원
2서울대학교 의과대학 내과학교실
Abstract
Background/Aims
Colonic epithelial cells are increasingly recognized as playing an important role in host defense against microorganisms in the intestinal lumen and in inflammatory responses. When human intestinal epithelial cells are stimulated with proinflammatory cytokines or infected with microbial pathogens, they up-regulate a program of proinflammatory genes whose products are chemoattractant neutrophils and monocytes. However, little is known about the regulated production of T-cell chemoattractants by the intestinal epithelium. Methods: We studied chemokine (IP-10, Mig, I-TAC) expression of the human colonic mucosa by using enzyme-linked immunosorbent assay. Results: Expression of T-cell chemokine (IP-10, Mig, I-TAC) was increased in the mucosa of patients with Crohn's disease and ulcerative colitis. The production level of T-cell chemokine (IP-10, Mig, I-TAC) was decreased in the mucosa of patients with Crohn's disease after remission. Conclusions: Our finding indicated that under inflammatory conditions, mucosal T-cell chemokine production increased and attracted inflammatory cells. This result suggests that, at least in an inflammatory process, T-cell chemokine (IP-10, Mig, I-TAC) play a role in the pathogenesis of inflammatory bowel disease. (Intestinal Research 2004;2:58-64)
Key Words: Inflammatory bowel disease, IP-10, Mig, I-TAC
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