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Intest Res > Volume 10(2); 2012 > Article
Intestinal Research 2012;10(2):176-182.
DOI:    Published online April 30, 2012.
Risk Factors for Recurrent Clostridium difficile Infection
Han Seung Ryu, Yong Sung Kim, Geom Seog Seo, Yu Min Lee, Suck Chei Choi
Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea
재발성 Clostridium difficile 감염의 위험인자
류한승, 김용성, 서검석, 이유민, 최석채
원광대학교 의과대학 내과학교실, 소화기질환연구소
Clostridium difficile infection (CDI) is a common nosocomial infection associated with substantial morbidity, mortality and increased medical care costs. Although most patients initially respond to therapy, with either metronidazole or vancomycin, about 15-20% of patients experience recurrence. The aim of this study was to analyze the risk factors related to recurrent CDI (RCDI). Methods: We retrospectively reviewed data, from patients diagnosed with CDI during admission at a university hospital between January 2000 and December 2006, for comparison with data from RCDI patients. Results: Among a total of 294 CDI patients, 32 (10.8%) had experienced RCDI. Risk factors for RCDI included anemia, congestive heart failure, respiratory infection, time between admission and CDI diagnosis, duration of antibiotic therapy prior to CDI diagnosis, tube feeding, and gastrointestinal endoscopy. Multivariate analysis revealed that tube feeding was associated with recurrence (odds ratio, 3.65; 95% confidence interval, 1.38-9.65; P=0.009). Conclusions: Patients who received tube feeding were at increased risk of RCDI. Targeting these patients for preventive strategies may contribute to a reduction in the incidence of RCDI. (Intest Res 2012;10: 0-182)
Key Words: Clostridium difficile, Recurrence, Risk Factors, Enteral Nutrition
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