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Intest Res > Volume 8(2); 2010 > Article
Intestinal Research 2010;8(2):151-161.
DOI:    Published online December 30, 2010.
Change of Circulating Leptin, Adiponectin, Resistin, and Visfatin Level after Treatment of Patients with Active Inflammatory Bowel Disease
Young Hwangbo, Hyo Jong Kim, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang
Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
활동기 염증성 장질환 환자의 관해 유도 치료 후 혈중 Leptin, Adiponectin, Resistin, Visfatin의 변화
황보영, 김효종, 심재준, 장재영, 동석호, 김병호, 장영운
경희대학교 의과대학 내과학교실
The aim of this study was to evaluate the change in circulating levels of adipokines, including leptin, adiponectin, resistin, and visfatin, after induction therapy of patients with active inflammatory bowel disease (IBD). Methods: We prospectively evaluated 20 patients with Crohn's disease (CD) and 14 patients with ulcerative colitis (UC) who received induction therapy. The disease activity, body mass index (BMI), and C-reactive protein (CRP) and serum adipolines levels were checked before treatment and 10 weeks after treatment. Results: After induction therapy, significant reduction of disease activity was noted in patients with CD (CD activity index, 267.9±73.7 vs. 50.8±36.5, P<0.001) and patients with UC (Mayo score, 9.8±2.2 vs. 1.4±1.6, P<0.001). The mean serum leptin, adiponectin, resistin, and visfatin levels were 4.0±2.7 ng/mL and 4.4±2.3 ng/mL (P=0.323), 27.0±20.5 Ռg/mL and 33.8±26.5Ռg/mL (P=0.084), 9.0±4.0 ng/mL and 10.2±3.2 ng/mL (P=0.108), and 4.6±3.7 ng/mL and 2.5±4.1 ng/mL (P=0.046) before and after infliximab treatment, respectively. No significant correlation between the changes in BMI, CRP level, or the clinical indices of activity and alterations of the measured adipokines was demonstrated. Conclusions: The serum levels of leptin, adiponectin, and resistin showed no significant alterations, whereas the serum visfatin level decreased significantly after induction therapy, suggesting a possible pro-inflammatory property of visfatin and a role as a marker of successful therapy of IBD. (Intest Res 2010;8:151-161)
Key Words: Inflammatory Bowel Disease, Leptin, Adiponectin, Resistin, Visfatin
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