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Intest Res > Volume 8(2); 2010 > Article
Intestinal Research 2010;8(2):126-134.
DOI:    Published online December 30, 2010.
The Significance of Fecal Immunochemical Test to Screen for Colorectal Cancer in National Cancer Screening Program
Jun Uk Lim, Na Young Bae, Won Koung Song, Jae Myung Cha, Joung Il Lee
Departments of Internal Medicine, and Regular Nurse, East-West Neo Medical Center, Kyung Hee University College of Medicine, Seoul, Korea
국가 암검진 사업의 대장암 선별검사로 시행한 면역화학 분변잠혈검사의 의의
임준욱, 배나영, 송원경, 차재명, 이정일
경희대학교 의과대학 동서신의학병원 내과학교실, 간호부
Colorectal cancer (CRC) is one of the major causes of death and poses a major public health concern. The National CRC Screening Programme (NCSP) provides annual CRC screening using a fecal occult blood test for individuals >50 years of age since 2004. The purpose of the current study was to determine the outcomes and efficacy of a fecal immunochemical test (FIT) based on the NCSP in a quality-controlled university hospital setting. Methods: We retrospectively reviewed the medical records and a standardized questionnaire from the NCSP of 3,852 individuals who underwent a FIT between March and December 2009. All of the subjects submitted a stool specimen for a FIT, while a double-contrast barium enema or colonoscopy was performed as a confirmatory examination for FIT-positive individuals. The CRC screening rate and rate of detection colorectal adenomas, advanced adenomas, and colorectal cancers by FIT were evaluated. Results: The CRC screening rate with FIT was very high (72.3%), but the positive rate of detection by FIT was only 1.3%. The rate of detection for colorectal cancers, adenomas, and advanced adenomas by FIT was 0.08%, 0.39%, and 0.13%, respectively. The quantitative values of FIT in individuals with colorectal adenomas and cancers were significantly higher than other colorectal diseases. Men (P=0.001) and elderly individuals (P=0.039) were significantly more common in the FIT-positive group than the FIT-negative group. Approximately 28% of the subjects with FIT-positive tests did not receive a confirmatory examination. Conclusions: Although the FIT had a low rate of detection, the FIT was a useful screening tool for detection of CRC in the NCSP. It will be important to increase CRC screening rates and confirmatory examination rates. (Intest Res 2010;8:126-134)
Key Words: Colorectal Cancer, Fecal Immunochemical Test, Screening, National Colorectal Cancer Screening Programme
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