Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID)
Kang-Moon Lee, You Sun Kim, Geom Seog Seo, Tae Oh Kim, Suk-Kyun Yang,
Intest Res. 2015;13(3):193-207.   Published online 2015 Jun 9     DOI: https://doi.org/10.5217/ir.2015.13.3.193
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