Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Search

Page Path
HOME > Search
1 "Skin manifestations"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review
Inflammatory bowel diseases
Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases
Jung Min Kim, Jae Hee Cheon
Intest Res 2020;18(3):249-264.   Published online April 18, 2020
DOI: https://doi.org/10.5217/ir.2019.00128
AbstractAbstract PDFPubReaderePub
A considerable number of patients with inflammatory bowel disease (IBD) experience extraintestinal manifestations (EIMs), which can present either before or after IBD diagnosis. Unraveling the pathogenic pathways of EIMs in IBD is challenging because of the lack of reliable criteria for diagnosis and difficulty in distinguishing EIMs from external pathologies caused by drugs or other etiologies. Optimizing treatment can also be difficult. Early diagnosis and management of EIM revolve around multidisciplinary teams, and they should have the resources necessary to make and implement appropriate decisions. In addition, specialists of the affected organs should be trained in IBD treatment. Furthermore, patient awareness regarding the extraintestinal symptoms of IBD is of paramount importance for improving patient understanding of disease and health outcomes. Herein, we review the pathogenesis and clinical perspectives of EIMs in IBD.

Citations

Citations to this article as recorded by  
  • Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis
    Min Zhong, Hongjin An, Huatian Gan
    Scientific Reports.2025;[Epub]     CrossRef
  • Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review
    Sia Shin, Siqi Chen, Kangzhe Xie, Suehad Abou Duhun, Tamara Ortiz-Cerda
    Redox Report.2025;[Epub]     CrossRef
  • The causal impact of genetically predicted inflammatory bowel disease on extraintestinal manifestations: a mendelian randomization study
    Xingcan Fan, Anqi He, Kaiyu Li, Maorun Zhang, Qi Zhang, Wanyi Xiao, Gang Liu
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Risk of malignancies and chemopreventive effect of statin, metformin, and aspirin in Korean patients with ulcerative colitis: a nationwide population-based study
    Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park
    Intestinal Research.2025; 23(2): 129.     CrossRef
  • Asociación entre colitis ulcerativa y embolia pulmonar: caso clínico
    Edwar Jassir Rozo Ortíz, Javier Orlando Barón Barón, Ledmar Jovanny Vargas Rodriguez, Karina Briceño Díaz, Dania Fabiola Pérez Gómez
    Revista colombiana de Gastroenterología.2025; 40(1): 104.     CrossRef
  • Pyoderma gangrenosum, peripheral ulcerative keratitis, and oral ulcers in a patient with inflammatory bowel disease
    Amanda T. Chung, Roy Luister C. Acos, John Paulo L. Recio, Giselle Marie S. Tioleco-Ver, Belen L. Dofitas
    JAAD Case Reports.2025; 61: 78.     CrossRef
  • Strain-specific responses to dextran sulfate sodium-induced ulcerative colitis in BALB/c and C57BL/6 mice: Comparative analysis of local versus extra-intestinal manifestations
    Priyanka Tiwari, Gopabandhu Jena
    Inflammation Research.2025;[Epub]     CrossRef
  • Prevalence and risk factors of gallstone disease in Korean patients with ulcerative colitis
    Kwangwoo Nam, Jae Yong Lee, Sang Hyoung Park, Ha Won Hwang, Ho-Su Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Jin Hwa Park, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
    Intestinal Research.2025; 23(4): 455.     CrossRef
  • Inflammatory bowel diseases (IBDs): a cross-sectional analysis of the psychological and biological mechanisms underlying intestinal and extra-intestinal symptoms—GastroPsy study protocol
    Alberto Caruso, Giovanni Latella, Dina Di Giacomo, Marco Cavicchioli, Federica Galli
    BMJ Open.2025; 15(11): e103374.     CrossRef
  • JAK inhibitors in the management of extra-intestinal manifestations in inflammatory bowel disease
    Fotios S. Fousekis, André Jefremow, Konstantinos H. Katsanos, Markus F. Neurath, Raja Atreya
    Therapeutic Advances in Gastroenterology.2025;[Epub]     CrossRef
  • Long-term remission of severe refractory scleritis associated with ulcerative colitis after proctocolectomy: a case report and literature review
    Kazuki Kurimura, Reiko Kunisaki, Katsuki Yaguchi, Shunsuke Shibui, Misa Onishi, Serina Haruyama, Yoshinori Nakamori, Kenichiro Toritani, Hideaki Kimura, Shin Maeda
    Clinical Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Pomegranate seed oil mitigates liver and kidney damage in an experimental colitis model: Modulation of NF-κB activation and apoptosis
    Açelya Gül Koyuncu, Alev Cumbul, Elvan Yilmaz Akyüz, Müge Kopuz Alvarez Noval
    Prostaglandins & Other Lipid Mediators.2024; 171: 106804.     CrossRef
  • Screening of silent inflammatory bowel disease in seronegative spondyloarthritis patients: Fecal calprotectin, ileo-colonoscopy and histopathology assessment
    Shaimaa Badran, Andrew Saweres, Hadeel GamalEldeen, Mohamed B. Hashem, Dalia Abdel-kareem, Fatma H. Abdelraouf, Wafaa Gaber, Tamer Elbaz
    The Egyptian Rheumatologist.2024; 46(1): 6.     CrossRef
  • Leaky gut, circulating immune complexes, arthralgia, and arthritis in IBD: coincidence or inevitability?
    Xi-ya Jin, Dan-dan Li, Wei Quan, Yang Chao, Bin Zhang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Effect of ustekinumab on extraintestinal manifestations in patients with Crohn’s disease or ulcerative colitis
    D. I. Abdulganieva, D. D. Mukhametova
    Meditsinskiy sovet = Medical Council.2024; (8): 135.     CrossRef
  • Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment
    Ilaria Faggiani, Jacopo Fanizza, Ferdinando D’Amico, Mariangela Allocca, Alessandra Zilli, Tommaso Lorenzo Parigi, Alberto Barchi, Silvio Danese, Federica Furfaro
    Biomedicines.2024; 12(8): 1839.     CrossRef
  • Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn’s Disease and Ocular Involvement
    Amer F. Alsoudi, Karen M. Wai, Euna Koo, Ryan A. McConnell, Nathan H. Pham, Brian K. Do, Cassie A. Ludwig, Andrea L. Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy
    Ocular Immunology and Inflammation.2024; 32(10): 2486.     CrossRef
  • The Leaky Gut and Human Diseases: “Can’t Fill the Cup if You Don’t Plug the Holes First”
    Debora Compare, Costantino Sgamato, Alba Rocco, Pietro Coccoli, Carmen Ambrosio, Gerardo Nardone
    Digestive Diseases.2024; 42(6): 548.     CrossRef
  • Long‐term clinical outcomes of intestinal Behçet's disease: A 30‐year cohort study at a tertiary hospital in South Korea
    Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2023; 38(3): 386.     CrossRef
  • Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study
    Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park
    Intestinal Research.2023; 21(2): 252.     CrossRef
  • The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders
    Gretchen A Lam, Hala Albarrak, Cassidy J McColl, Alaina Pizarro, Harsha Sanaka, Adrian Gomez-Nguyen, Fabio Cominelli, Andre Paes Batista da Silva
    Inflammatory Bowel Diseases.2023; 29(7): 1153.     CrossRef
  • Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-Tumor Necrosis Factor-Alpha Therapy
    So Jung Han, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Yonsei Medical Journal.2023; 64(2): 111.     CrossRef
  • Are the risks of colorectal cancer and biliary cancer really increased if patients with ulcerative colitis have primary sclerosing cholangitis?
    Jung Wook Lee, Won Moon
    Intestinal Research.2023; 21(2): 171.     CrossRef
  • The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
    Yu Kyung Jun, Da-Ae Yu, Yoo Min Han, Soo Ran Lee, Seong-Joon Koh, Hyunsun Park
    Dermatology and Therapy.2023; 13(7): 1465.     CrossRef
  • Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease
    You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
    Intestinal Research.2023; 21(4): 420.     CrossRef
  • Novel Histone Deacetylase 6 Inhibitor Confers Anti-inflammatory Effects and Enhances Gut Barrier Function
    Jae-Young Lee, Hyun Woo Ma, Ji Hyung Kim, I Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon
    Gut and Liver.2023; 17(5): 766.     CrossRef
  • Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease
    Kwang Woo Kim, Hyoun Woo Kang
    Intestinal Research.2023; 21(4): 413.     CrossRef
  • Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn’s Disease
    Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I Seul Park, Jae Hee Cheon, Duk Hwan Kim
    Gut and Liver.2023; 17(6): 905.     CrossRef
  • Effectiveness and safety of adalimumab in patients with intestinal Behçet’s disease: a real-world prospective observational study in South Korea
    Jongwook Yu, Sung Jae Shin, Yune-Jung Park, Hyung Wook Kim, Bo-In Lee, Byong Duk Ye, Geun-Tae Kim, Sung Kook Kim, Joo Sung Kim, Young-Ho Kim, Seonjeong Jeong, Jae Hee Cheon
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice
    Jahidul Islam, Afifah Zahra Agista, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso, Yusuke Ohsaki, Takuya Koseki, Michio Komai, Hitoshi Shirakawa
    The Journal of Nutritional Biochemistry.2022; 99: 108855.     CrossRef
  • Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease
    Kyeong Ok Kim
    The Korean Journal of Gastroenterology.2022; 79(1): 4.     CrossRef
  • Is primary sclerosing cholangitis with inflammatory bowel disease different between patients in the East and West?
    Yong Eun Park
    Intestinal Research.2022; 20(2): 157.     CrossRef
  • A Review of Extraintestinal Manifestations & Medication-Induced Myocarditis and Pericarditis in Pediatric Inflammatory Bowel Disease
    Kevin Cesa, Catherine Cunningham, Tyler Harris, Whitney Sunseri
    Cureus.2022;[Epub]     CrossRef
  • Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
    Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang
    Gut and Liver.2022; 16(4): 555.     CrossRef
  • Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
    Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park
    The Ewha Medical Journal.2022; 45(2): 35.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    Intestinal Research.2022; 20(4): 431.     CrossRef
  • A Review of Ophthalmic Complications in Inflammatory Bowel Diseases
    Wiktoria Pytrus, Katarzyna Akutko, Tomasz Pytrus, Anna Turno-Kręcicka
    Journal of Clinical Medicine.2022; 11(24): 7457.     CrossRef
  • Atopic dermatitis does not increase the risk of inflammatory bowel disease: A nationwide cohort study
    Yu‐Ching Weng, Chao‐Kuei Juan, Hsiu J. Ho, Yi‐Ling Chang, Chun‐Ying Wu, Yi‐Ju Chen
    The Journal of Dermatology.2021; 48(2): 168.     CrossRef
  • Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease
    You-Jung Ha, Hyo Jin Kim, Eugene Lee, Ji Hye Park, Young Soo Park, Yun Jong Lee, Yusuhn Kang, Hyuk Yoon
    The Korean Journal of Internal Medicine.2021; 36(4): 868.     CrossRef
  • Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet’s disease from Crohn’s disease
    Jihye Park, Daeun Jeong, Youn Wook Chung, Seunghan Han, Da Hye Kim, Jongwook Yu, Jae Hee Cheon, Ji-Hwan Ryu
    Scientific Reports.2021;[Epub]     CrossRef
  • Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management
    Gerhard Rogler, Abha Singh, Arthur Kavanaugh, David T. Rubin
    Gastroenterology.2021; 161(4): 1118.     CrossRef
  • Pancreatic Associated Manifestations in Pediatric Inflammatory Bowel Diseases
    Ugo Cucinotta, Claudio Romano, Valeria Dipasquale
    Genes.2021; 12(9): 1372.     CrossRef
  • KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    The Korean Journal of Gastroenterology.2021; 78(2): 105.     CrossRef
  • Epidemiology and diagnosis of inflammatory bowel diseases
    Kang-Moon Lee
    Journal of the Korean Medical Association.2021; 64(9): 579.     CrossRef
  • Current status of inflammatory bowel diseases in Korea
    Suk-Kyun Yang
    Journal of the Korean Medical Association.2021; 64(9): 572.     CrossRef
  • A review of ophthalmic manifestations of inflammatory bowel disease and associated treatments
    Priya Janardhana, Saad Al-Kadhi
    Current Opinion in Ophthalmology.2021; 32(6): 549.     CrossRef
  • Etiopathogenic and Clinical Aspects in Inflammatory Bowel Disease – Literature Review
    Petronela Nicoleta Seritean Isac, Diana Popescu, Tudor Marcel Genes, Minerva Codruta Badescu, Ioana Irina Rezus, Nicoleta Dima, Ana Roxana Rusu Ganceanu, Elena Rezus, Ciprian Rezus
    Journal of Interdisciplinary Medicine.2021; 6(3): 132.     CrossRef
  • Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
    Giuseppe Cicero, Silvio Mazziotti
    Intestinal Research.2021; 19(4): 365.     CrossRef
  • Anti-inflammatory properties of Escherichia coli Nissle 1917 in a murine colitis model
    Jihye Park, Da Hye Kim, Soochan Kim, Hyun Woo Ma, I Seul Park, Mijeong Son, Ji Hyung Kim, Yoojin Shin, Seung Won Kim, Jae Hee Cheon
    Intestinal Research.2021; 19(4): 478.     CrossRef
  • Ficus pandurata Hance Inhibits Ulcerative Colitis and Colitis‐Associated Secondary Liver Damage of Mice by Enhancing Antioxidation Activity
    Weibo Dai, Xinyi Zhan, Weijie Peng, Xin Liu, Weiwen Peng, Quanxi Mei, Xianjing Hu, Kai Wang
    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Liver-side of inflammatory bowel diseases: Hepatobiliary and drug-induced disorders
    Stefano Mazza, Sara Soro, Maria Chiara Verga, Biagio Elvo, Francesca Ferretti, Fabrizio Cereatti, Andrea Drago, Roberto Grassia
    World Journal of Hepatology.2021; 13(12): 1828.     CrossRef
  • Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease
    Istvan Fedor, Eva Zold, Zsolt Barta
    Journal of Clinical Medicine.2021; 10(24): 5984.     CrossRef
  • 25,254 View
  • 515 Download
  • 52 Web of Science
  • 53 Crossref
Close layer

Intest Res : Intestinal Research
Close layer
TOP