Intestinal Research

Original Article

IBD

Ustekinumab for anti-tumor necrosis factor refractory pediatric ulcerative colitis: a promising approach towards endoscopic healing: Rahiya Rehman, Muhammad Safwan Riaz, Dyadin Esharif, Phinnara Has, Michael Herzlinger, Jason Shapiro, Shova Subedi; Intest Res 2024;22(3):351-356. Published online February 6, 2024; DOI: https://doi.org/10.5217/ir.2023.00091

Background/Aims
To describe the role of ustekinumab in inducing remission and endoscopic healing in anti-tumor necrosis factor α nonresponsive pediatric ulcerative colitis patients at a tertiary care inflammatory bowel disease center.
Methods
A retrospective chart review was performed on patients with ulcerative colitis receiving ustekinumab. Primary outcome was steroidfree clinical remission at follow-up. Secondary outcomes were biochemical remission and endoscopic healing.
Results
Ten children were analyzed; 7 (70%) had ulcerative colitis, and 3 (30%) had inflammatory bowel disease unspecified with colitis. Median follow-up period was 56 weeks. Nine patients (90%) achieved steroid-free clinical remission and biochemical remission. Seven patients had follow-up colonoscopies, out of which 6 (86%) achieved endoscopic remission, while 1 (14%) underwent colectomy. Out of the 3 patients without a follow-up colonoscopy, fecal calprotectin levels downtrended to < 150 mg/kg in 2 patients and < 400 mg/kg in 1 patient from baseline level of > 2,000 mg/kg.
Conclusions
Ustekinumab appears efficacious in achieving not only clinical and biochemical remission but also has promising role in inducing endoscopic healing end point in patients who fail other biologics.

Citations

Citations to this article as recorded by

Positionspapier der Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE) zum zulassungsüberschreitenden Gebrauch von für Erwachsene mit CED zugelassenen Biologika und Signalinhibitoren bei Kindern und Jugendlichen
Jan Däbritz, Martin Classen, Kathrin Krohn, Andreas Krahl, Stephan Buderus, Elke Lainka, Jan de Laffolie, Carsten Posovszky
Zeitschrift für Gastroenterologie.2025; 63(03): 255. CrossRef
New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review
Valeria Dipasquale, Claudio Romano
Healthcare.2025; 13(8): 923. CrossRef
Monoclonal antibodies against pediatric ulcerative colitis: a review of clinical progress
Debora Curci, Marianna Lucafò, Giuliana Decorti, Gabriele Stocco
Expert Opinion on Biological Therapy.2024; 24(10): 1133. CrossRef

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286 Download
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Focused Review

IBD

Clinical aspects and treatments for pediatric inflammatory bowel disease: Jin Soo Moon; Intest Res 2019;17(1):17-23. Published online January 9, 2019; DOI: https://doi.org/10.5217/ir.2018.00139

Abstract PDF PubReader ePub

The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Newer drugs such as antitumor necrosis factor-α have been known to make a difference in treating pediatric IBD. Recent studies suggested that the patients with high risk factors might have some benefits from earlier use of biologics. To achieve treatment goals such as relieving symptoms, optimizing growth, and improving quality of life while minimizing drug toxicity, more research is needed to develop tools for risk stratification in the use of biologics for pediatric IBD.

Citations

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Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice
Shijia Pan, Yuan Guo, Wen Yu, Jia Zhang, Xiaoxiao Qiao, Letong Li, Pengfei Xu, Yonggong Zhai
International Journal of Molecular Sciences.2023; 24(3): 2602. CrossRef
Saudi Arabia consensus guidance for the diagnosis and management of adults with inflammatory bowel disease
Mahmoud H. Mosli, Hajer Y. Almudaiheem, Turki AlAmeel, Shakir A. Bakkari, Othman R. Alharbi, Khalidah A. Alenzi, Amr M. Khardaly, Maha A. AlMolaiki, Bedor A. Al-Omari, Rayan G. Albarakati, Ahmed H. Al-Jedai, Omar I. Saadah, Majid A. Almadi, Badr Al-Baward
Saudi Journal of Gastroenterology.2023; 29(Suppl 1): S1. CrossRef
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Kyung-Joo Kim, Suhyun Kyung, Hui Jin, Minju Im, Jae-won Kim, Hyun Su Kim, Se-Eun Jang
Journal of Microbiology and Biotechnology.2023; 33(8): 1057. CrossRef
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Zachary Green, Ella Mayberry, James John Ashton, R Mark Beattie, Alison Evans, Amar Wahid, Martin Oliver Edwards
BMJ Open.2023; 13(12): e078675. CrossRef
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Jooyoung Jang, Sung Hee Lee, In Sook Jeong, Jinmin Cho, Hyun Jin Kim, Seak Hee Oh, Dae Yeon Kim, Ho-Su Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Kyung Mo Kim
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220 Download
15 Web of Science
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Case Report

Behçet's disease with multiple splenic abscesses in a child: Kyung In Lim, Dong Hwa Yang, Eell Ryoo; Intest Res 2017;15(3):422-428. Published online June 12, 2017; DOI: https://doi.org/10.5217/ir.2017.15.3.422

Abstract PDF PubReader ePub

We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated with Behçet's disease. The patient visited Gachon University Gil Hospital with fever, abdominal pain, and acute watery and bloody diarrhea, and reported a 2-year history of chronic abdominal pain and intermittent watery diarrhea. He was treated with antibiotics at a local clinic for fever and cervical lymph node swelling. Additionally, he had recurrent stomatitis. A colonoscopy showed multiple well-demarcated ulcerations throughout the colon, and abdominal computed tomography showed multiple splenic abscesses. Pathergy and HLA-B51 tests were positive. Investigations did not reveal any infectious organisms in the aspirate obtained via ultrasound-guided fine needle aspiration. After steroid treatment, all symptoms and multiple aseptic splenic abscesses resolved. However, oral ulcers, genital ulcers, and abdominal pain recurred after tapering the steroids. Infliximab treatment improved the patient's symptoms. However, 5 months after the treatment, the symptoms recurred. The treatment was changed to include adalimumab. Subsequently, the patient's symptoms resolved and colonoscopic findings improved. No recurrence was noted after 3 months of follow-up.

Citations

Citations to this article as recorded by

Aseptic Abscess of the Spleen as an Antecedent Manifestation of Behçet’s Disease
Mohamed Jazeer, Diroji Antony, Mayurathan Pakkiyaretnam
Cureus.2023;[Epub] CrossRef
Treatment with Biologic Drugs in Pediatric Behçet’s Disease: A Comprehensive Analysis of the Published Data
Ezgi Deniz Batu, Seher Sener, Veysel Cam, Nuray Aktay Ayaz, Seza Ozen
BioDrugs.2023; 37(6): 813. CrossRef
Case report: Aseptic splenic abscesses in childhood-onset systemic lupus erythematosus
Shobashenee Sritharan, Peter Sie-Teck Lau, Kamilah Manan, Anand Mohan
Frontiers in Pediatrics.2023;[Epub] CrossRef
Successful management of a case of intestinal Behçet’s disease with a splenic abscess by intensified immunosuppressive therapy without splenectomy
Noriko Sato, Fumiya Yamaide, Ryohei Shibata, Taiji Nakano, Akiko Yamaide, Takeshi Saito, Naoki Shimojo
Modern Rheumatology Case Reports.2022; 6(2): 266. CrossRef
Adalimumab in the treatment of pediatric Behçet’s disease: case-based review
Dimitri Poddighe, Zaure Mukusheva, Kaisar Dauyey, Maikesh Assylbekova
Rheumatology International.2019; 39(6): 1107. CrossRef

8,010 View
64 Download
6 Web of Science
5 Crossref

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