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Original Articles
- IBD
- Knowledge and acceptability of the Lémann Index as a tool to measure disease progression and bowel damage in Crohn’s disease: results from an international survey
- Charlotte Wong, Johan Burisch, Ryan C Ungaro, Anthony Buisson, Jérôme Lambert, Jean-Frédéric Colombel, Joana Torres, Naila Arebi
- Intest Res 2025;23(4):512-523. Published online October 28, 2025
- DOI: https://doi.org/10.5217/ir.2024.00183
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Abstract
PDF
Supplementary Material
PubReader
ePub - Background/Aims
Crohn’s disease (CD) progresses to structural bowel damage (SBD). The Lémann Index (LI) captures stricture extent/severity, penetrating disease and surgery as a SBD score, and is earmarked for future CD modification trials. Understanding knowledge gaps and perceived barriers is critical to wider adoption.
Methods
A multinational, cross-sectional study was distributed through a survey link (REDCap, Research Electronic Data Capture) to gastrointestinal professional societies with snowball sampling using 23 questionnaire items in 5 sections to determine SBD and LI knowledge, and LI acceptability. Factors associated with acceptability and perception were evaluated.
Results
Of the 107 respondents, 49 (45.8%) were female; 87 (81.3%) were from Europe. Most were inflammatory bowel disease specialists (n = 80, 74.8%) or general gastroenterologists (n = 22, 20.6%), managing > 40 CD patients per month (n = 35, 32.7%). A total of 98 (91.6%) knew about SBD; “very important” rating for clinical trials and clinical practice was 56.1% and 41.4%, respectively. A 39.3% describe LI scoring as “very difficult” or “difficult”; 33.6% reported “significant” or “a lot” of effort. Acceptability (composite scores of > 36) were significantly associated with respondents who had received LI training (P<0.001). Automated methods, intestinal ultrasound and evidence of benefit would encourage LI use in clinical trials, while additional time and automated methods would promote use in clinical practice. The top 3 perceived adoption barriers were: lack of time (60.7%), limited automated methods (47.7%) and need for dedicated radiologists (38.3%).
Conclusions
Most respondents had baseline knowledge of SBD. The LI was perceived as important for advancing future CD research and care. More training and automation will facilitate LI adoption.
- 1,248 View
- 21 Download
- IBD
- A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
- Dushyant Singh Dahiya, Asim Kichloo, Farah Wani, Jagmeet Singh, Dhanshree Solanki, Hafeez Shaka
- Intest Res 2022;20(3):342-349. Published online May 21, 2021
- DOI: https://doi.org/10.5217/ir.2021.00046
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Abstract
PDFPubReaderePub
- Background/Aims
Proinflammatory cytokines released from adipocytes can influence the development, progression, and treatment of inflammatory bowel disease (IBD), and may be associated with worse clinical outcomes.
Methods
For 2016–2018, we analyzed data from the Nationwide Inpatient Sample to identify adult (≥18 years) hospitalizations with a primary discharge diagnosis of IBD. The study sample was divided based on the presence or absence of obesity. The primary outcomes included inpatient mortality, while the secondary outcomes consisted of system-based complications and disease implications on the United States healthcare system.
Results
We identified 282,005 hospitalizations of IBD from 2016 to 2018. Of these hospitalizations, 26,465 (9.4%) had a secondary diagnosis of obesity while 255,540 (90.6%) served as controls. IBD hospitalizations with obesity had a higher mean age (47.9 years vs. 45.2 years, P<0.001), middle age (range, 40–65 years) predominance (37.7% vs. 28.9%, P<0.001), female predominance (64.1% vs. 52.5%, P<0.001) and higher proportion of patients with comorbidities compared to the non-obese cohort. White predominance was observed in both subgroups. No difference in the odds of inpatient mortality was noted between the 2 subgroups; however, IBD hospitalizations with obesity had higher mean total hospital charge ($50,126 vs. $45,001, P<0.001), longer length of stay (5.5 days vs. 4.9 days, P<0.001) and higher proportion of complications compared to the non-obese cohort.
Conclusions
Obese IBD hospitalizations had higher length of stay, total hospital charge, and complications compared to the non-obese cohort. -
Citations
Citations to this article as recorded by
- Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis
Ada Corrado, Ilaria Guadagni, Giovanna Picarelli, Angela Variola
Immunity, Inflammation and Disease.2025;[Epub] CrossRef - Metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease: prevalence, risk factors, pathophysiological pathways and clinical consequences
Elena Grueso Navarro, Alfredo J. Lucendo
Expert Review of Clinical Immunology.2025; 21(7): 875. CrossRef - Obesity-Mediated Inflammation and Its Influence on Inflammatory Bowel Disease: Pathophysiology, Clinical Impact, and Therapeutic Implications
Diego Casas-Deza, Santiago García-López, Vanesa Bernal-Monterde, Cristina Polo-Cuadro, Carmen Yagüe-Caballero, José M. Arbones-Mainar
Biomolecules.2025; 15(8): 1185. CrossRef - Efficacy of GLP-1 receptor agonists on obesity and metabolic profile in patients with inflammatory bowel disease: a systematic review and meta-analysis
Fatemeh Ojaghi Shirmard, Seyed Morteza Pourfaraji, Mahyaar Omouri-Kharashtomi, Arash Amani
BMC Gastroenterology.2025;[Epub] CrossRef - Can GLP-1 agonists be used safely in inflammatory bowel disease? A meta-analysis
Noppachai Siranart, Pannathorn Nakaphan, Patavee Pajareya, Khamik Laohasurayotin
Journal of Crohn's and Colitis.2025;[Epub] CrossRef - Glucagon-like peptide 1 receptor agonists and the clinical outcomes of inflammatory bowel disease: a systematic review and meta-analysis
Ahmed B Bayoumy, Lindsay M Clarke, Parakkal Deepak, Aakash Desai, Priya Sehgal, uri Gorelik, Haggai Bar-Yoseph, Marie Villumsen, Chris J J Mulder, Dirk J Stenvers, Maarten E Tushuizen, Nanne K H de Boer
Journal of Crohn's and Colitis.2025;[Epub] CrossRef - Recomendaciones sobre el manejo de la obesidad grave en pacientes con enfermedad inflamatoria intestinal del Grupo Español de Trabajo en Enfermedad Inflamatoria Intestinal (GETECCU), Sociedad Española de Obesidad (SEEDO), Asociación Española de Cirugía (A
Eugeni Domènech, Andreea Ciudin, José María Balibrea, Eduard Espinet-Coll, Fiorella Cañete, Lilliam Flores, Manuel Ferrer-Márquez, Román Turró, Alejandro Hernández-Camba, Yamile Zabana, Ana Gutiérrez, José María Balibrea, Manuel Barreiro-de Acosta, Javier
Gastroenterología y Hepatología.2024; 47(8): 906. CrossRef - The Rising Epidemic of Obesity in Patients with Inflammatory Bowel Disease
Jellyana Peraza, Erin Abbott, Mark Shneyderman, Asher Kornbluth, Maitreyi Raman, Stephanie Gold
Current Treatment Options in Gastroenterology.2024; 22(3): 134. CrossRef - Recommendations on the management of severe obesity in patients with inflammatory bowel disease of the Spanish Group on Crohn’s Disease and Ulcerative Colitis (GETECCU), Spanish Society of Obesity (SEEDO), Spanish Association of Surgery (AEC) and Spanish
Eugeni Domènech, Andreea Ciudin, José María Balibrea, Eduard Espinet-Coll, Fiorella Cañete, Lilliam Flores, Manuel Ferrer-Márquez, Román Turró, Alejandro Hernández-Camba, Yamile Zabana, Ana Gutiérrez, José María Balibrea, Manuel Barreiro-de Acosta, Javier
Gastroenterología y Hepatología (English Edition).2024; 47(8): 906. CrossRef - Body Mass Index Profile of Adult Patients with Inflammatory Bowel Disease in a Multicenter Study in Northeastern Brazil
Jones Lima, Carlos Brito, Lívia Celani, Marcelo Vicente Araújo, Maurilio Lucena, Graciana Vasconcelos, Gustavo Lima, Fernando Nóbrega, George Diniz, Norma Lucena-Silva, Regiane Maio, Valéria Martinelli
Clinical and Experimental Gastroenterology.2023; Volume 16: 213. CrossRef - Clinical outcomes and predictors of response for adalimumab in patients with moderately to severely active ulcerative colitis: a KASID prospective multicenter cohort study
Seung Yong Shin, Soo Jung Park, Young Kim, Jong Pil Im, Hyo Jong Kim, Kang-Moon Lee, Ji Won Kim, Sung-Ae Jung, Jun Lee, Sang-Bum Kang, Sung Jae Shin, Eun Sun Kim, You Sun Kim, Tae Oh Kim, Hyun-Soo Kim, Dong Il Park, Hyung Kil Kim, Eun Soo Kim, Young-Ho Ki
Intestinal Research.2022; 20(3): 350. CrossRef
- Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis
- 7,919 View
- 513 Download
- 10 Web of Science
- 11 Crossref
Review
- IBD
- An integrative review of physical activity in adults with inflammatory bowel disease
- Suja P Davis, Patricia B. Crane, Linda P. Bolin, Lee Ann Johnson
- Intest Res 2022;20(1):43-52. Published online January 22, 2021
- DOI: https://doi.org/10.5217/ir.2020.00049
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Abstract
PDFSupplementary MaterialPubReaderePub
- Adults with inflammatory bowel disease (IBD) search for self-management strategies to manage their symptoms and improve their quality of life (QOL). Physical activity (PA) is one of the self-management strategies widely adopted by adults with IBD. This integrative review aimed to synthesize the evidence on health outcomes of PA in adults with IBD as well as to identify the barriers to engaging in PA. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), published literature was searched to identify the articles that addressed PA in adults with IBD. Twenty-eight articles met the inclusion criteria. Many of the reviewed studies used the terms of PA and exercise interchangeably. Walking was the most common PA reported in the studies. The findings from the majority of the reviewed studies supported the benefits of moderate-intensity exercise/PA among adults with IBD. The reviewed studies noted the following positive health outcomes of PA: improvement in QOL, mental health, sleep quality, gastrointestinal symptoms, fatigue and cardiorespiratory fitness. More importantly, participation in PA reduced the risk for development of IBD and the risk for future active disease. The findings from the reviewed studies highlighted the following barriers to engage in PA: fatigue, joint pain, abdominal pain, bowel urgency, active disease and depression.
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Citations
Citations to this article as recorded by- Association between physical activity with disease activity and functional disability in patients with inflammatory bowel disease
Maud Gendard, Philippe Seksik, Carmen Stefanescu, Antoine Meyer, Maria Nachury, Stéphane Nancey, Guillaume Savoye, Matthieu Allez, David Laharie, Mélanie Serrero, Denis Franchimont, Nicolas Mathieu, Mathurin Fumery, Lucine Vuitton, Stéphane Nahon, Cyriell
Digestive and Liver Disease.2026;[Epub] CrossRef - Trends and Factors Related to Quality of Life in Patients with Inflammatory Bowel Disease
Sihyun Kim, Yu Kyung Jun, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
Gut and Liver.2025; 19(2): 236. CrossRef - Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review
Dan-Dan Wang, Shi-Guang Ren, Rui Hu, Hui-Lan Zhai, Fen Xie, Lu Jiang, Wen-Lei Huang, Xue-Qin Li
International Journal of General Medicine.2025; Volume 18: 1403. CrossRef - Validity and Reliability of the Self‐Care of Chronic Illness Inventory in Patients Living With Inflammatory Bowel Disease
Daniele Napolitano, Valentina Biagioli, Davide Bartoli, Silvia Cilluffo, Piergiorgio Martella, Alessandro Monaci, Ercole Vellone, Antonello Cocchieri
Journal of Clinical Nursing.2025; 34(11): 4642. CrossRef - A review of the link between psychological stress and inflammatory bowel disease exacerbation
Annelise Klettner, Shanhong Luo, Laura D. Coyle, Nathan Liu
Academia Mental Health and Well-Being.2025;[Epub] CrossRef - Effectiveness of an app-based walking program for obese patients with inflammatory bowel disease in Korea: a single-blind parallel-group randomized clinical trial
Young Jin Lee, Eun Ja Kwon, Da-In Park, Sang Hyoung Park, Sung Wook Hwang, Byong Duk Ye
BMC Gastroenterology.2025;[Epub] CrossRef - A Population-Based Assessment of Physical Activity and Exercise in Persons With IBD
Sydney Chochinov, Casandra Dolovich, Gia Ly, Adebanke Oketola, Samuel Narvey, Maitreyi Raman, Sandra Webber, Charles N. Bernstein
Journal of Clinical Gastroenterology.2025;[Epub] CrossRef - Patterns and Correlates of Sedentary Behavior and Physical Activity in Individuals With Crohn’s Disease: A Cross-Sectional Study
Jason J Wilson, Barry Lynch, Nathan Graham, Conor M McClean, Mark A Tully
Crohn's & Colitis 360.2025;[Epub] CrossRef - Physical activity among people with an inflammatory bowel disease: a systematic review of antecedents
Cameron Trim, Sharan Srinivasa Gopalan, Ryan Rhodes
Psychology, Health & Medicine.2025; : 1. CrossRef - Behaviour Change Considerations to Promote Physical Activity Participation among Individuals with Quiescent Inflammatory Bowel Disease: Barriers and Facilitators
Banke Oketola, Sandra Webber, Harminder Singh, Maia Kredentser, Kristin Reynolds, Gayle Restall
Advances in Rehabilitation Science and Practice.2025;[Epub] CrossRef - Qualitative Exploration of Barriers and Facilitators to Physical Activity and Exercise in Children and Adolescents With Crohn’s—Perspectives of Young People, Caregivers, and Clinicians
Zoe L. Saynor, Nadeem A. Afzal, Christopher Roberts, Kelly A. Mackintosh, Danielle Lambrick, James Faulkner, Will Freer, Elena Kurteva, Thierry Middleton, Heather Hunter
Pediatric Exercise Science.2025; : 1. CrossRef - Physical Activity and Education in the Care of IBD: The Role of the Physiotherapist—A Narrative Review
Zita Kovács, Péter Bacsur, Blanka Bernadett Kasza, Tamás Molnár, Andrea Domján
Journal of Clinical Medicine.2025; 14(23): 8602. CrossRef - Abdominally targeted physical exercises as a therapeutic intervention for inflammatory bowel diseases
Lael Werner, Rony Izhar, Morine Fibelman, Izislav Shapiro, Andrei Siderskyi, Yuri Ostrinski, Haim Leibovitzh, Nathaniel Aviv Cohen, Ayal Hirsch, Yulia Ron, Naomi Fliss Isakov, Nitsan Maharshak
Journal of Science and Medicine in Sport.2025;[Epub] CrossRef - Advances in the Application of Digital Health Technologies in the Management of Patients With Inflammatory Bowel Disease
Jing Yuan, Dandan Zhao
The American Surgeon™.2025;[Epub] CrossRef - Physical activity, sedentary behavior and risk of inflammatory bowel disease: a prospective cohort study in the UK Biobank
Siqin Xia, Jie Zhang, Zixing Zhang, Xiang Wang, Dongqing Ye, Xinyu Fang
BMC Public Health.2025;[Epub] CrossRef - The complex relationship between physical activity and fatigue with socioeconomic status, and mental health factors in individuals with inflammatory bowel disease
Casandra Dolovich, Sydney Chochinov, Gia Ly, Banke Oketola, Sam Narvey, Sydney Larance, Maitreiy Raman, Sandra C Webber, Charles N Bernstein
Journal of Crohn's and Colitis.2025;[Epub] CrossRef - Physical Activity Is Inversely Associated with Clinical Exacerbation in Patients with Crohn’s Disease in Remission: A Prospective Cohort Study
Chen Sarbagili-Shabat, Shira Zelber-Sagi, Naomi Fliss Isakov, Ayal Hirsch, Yulia Ron, Laura Sol Grinshpan, Nathaniel Aviv Cohen, Haim Leibovitzh, Tamar Thurm, Nitsan Maharshak
Digestive Diseases.2025; : 1. CrossRef - Physical exercises as an effective adjuvant therapy of IBD in remission (review)
S. V. Kostyukevich, I. G. Bakulin
Koloproktologia.2024; 23(1): 152. CrossRef - Bridging the gap: Unveiling the crisis of physical inactivity in inflammatory bowel diseases
Remus Stafie, Ana-Maria Singeap, Adrian Rotaru, Carol Stanciu, Anca Trifan
World Journal of Gastroenterology.2024; 30(10): 1261. CrossRef - Progress in research of exercise intervention in inflammatory bowel disease
Shao-Peng Sun, Jia-Jia Chen, Ming-Xu Zheng, Yi-Hong Fan, Bin Lv
World Chinese Journal of Digestology.2024; 32(5): 339. CrossRef - Unresolved conundrum of the role of physical activity in irritable bowel disease: What next?
Nilakantan Ananthakrishnan
World Journal of Gastroenterology.2024; 30(21): 2744. CrossRef - Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases
Nathalie Rohmann, Theresa Geese, Samantha Nestel, Kristina Schlicht, Corinna Geisler, Kathrin Türk, Fynn Brix, Julia Jensen-Kroll, Tobias Demetrowitsch, Corinna Bang, Andre Franke, Wolfgang Lieb, Dominik M. Schulte, Karin Schwarz, Anne-Kathrin Ruß, Arunab
BMC Medicine.2024;[Epub] CrossRef - Too Many Couch Potatoes Among Middle-Aged Inflammatory Bowel Disease Patients: Findings from the “BE-FIT-IBD-2” Study
Antonietta Gerarda Gravina, Raffaele Pellegrino, Giovanna Palladino, Annalisa Zanini, Alessandro Federico, Fabiana Zingone
Gastroenterology Insights.2024; 15(4): 963. CrossRef - Activité physique et MICI
Xavier Hébuterne
Nutrition Clinique et Métabolisme.2024; 38(4): 217. CrossRef - Chronic Abdominal Pain in Patients with Inflammatory Bowel Disease in Remission: A Continuing Challenge for Clinicians
Natasha Klemm, Sarvee Moosavi
Digestive Diseases and Sciences.2024; 69(12): 4336. CrossRef - Mechanisms of Insulin Signaling as a Potential Therapeutic Method in Intestinal Diseases
Sara Jarmakiewicz-Czaja, Aneta Sokal-Dembowska, Katarzyna Ferenc, Rafał Filip
Cells.2024; 13(22): 1879. CrossRef - Adjunct Therapies to Standard Care for IBS and IBD Patients: Digestive Symptoms Improvement and Quality of Life Optimization
Veronique Traynard
Nutrients.2024; 16(22): 3927. CrossRef - Unlocking the Power of Physical Activity in Inflammatory Bowel Disease: A Comprehensive Review
Jiajia Chen, Shaopeng Sun, Andrew S. Day
Gastroenterology Research and Practice.2024;[Epub] CrossRef - The impact of physical exercise on health-related quality of life in inflammatory bowel disease
Ayokunle T Abegunde, Daniela Goyes, Umer Farooq, Amy H Luke, Elizabeth Huggins, Richard S Cooper, Lara R Dugas
Cochrane Database of Systematic Reviews.2023;[Epub] CrossRef - Patients’ perspectives on, experience with and concerns about crohn's disease: insights from Chinese social media
Shaopeng Sun, Yunhong Hu, Heng Li, Jiajia Chen, Yijie Lou, Chunyan Weng, Lixia Chen, Bin Lv
BMC Gastroenterology.2023;[Epub] CrossRef - Fecal Calprotectin in Gastrointestinal Disease
Jennifer Murray, Klaartje B Kok, Ruth M Ayling
Clinical Chemistry.2023; 69(7): 699. CrossRef - Physical activity, quality of diet and bone mineral density in patients with inflammatory bowel disease
Alicja E. Ratajczak‐Pawłowska, Michał Michalak, Aleksandra Szymczak‐Tomczak, Anna Maria Rychter, Agnieszka Zawada, Kinga Skoracka, Agnieszka Dobrowolska, Iwona Krela‐Kaźmierczak
Journal of Human Nutrition and Dietetics.2023; 36(5): 1692. CrossRef - Physical Activity in Pediatric Inflammatory Bowel Disease: A Scoping Review
Lee Hill, Noushin Roofigari, Maria Faraz, Jelena Popov, Michal Moshkovich, Melanie Figueiredo, Emily Hartung, Meryem Talbo, Marie-Laure Lalanne-Mistrih, Mary Sherlock, Mary Zachos, Brian W. Timmons, Joyce Obeid, Nikhil Pai
Pediatric Exercise Science.2023; : 1. CrossRef - Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity: The “BE-FIT-IBD” study
Antonietta Gerarda Gravina, Raffaele Pellegrino, Tommaso Durante, Giovanna Palladino, Rossella D’Onofrio, Simone Mammone, Giusi Arboretto, Salvatore Auletta, Giuseppe Imperio, Andrea Ventura, Mario Romeo, Alessandro Federico
World Journal of Gastroenterology.2023; 29(41): 5668. CrossRef - Effects of yoga in inflammatory bowel diseases and on frequent IBD-associated extraintestinal symptoms like fatigue and depression
E. Wilke, W. Reindl, P.A. Thomann, M.P. Ebert, T. Wuestenberg, A.K. Thomann
Complementary Therapies in Clinical Practice.2021; 45: 101465. CrossRef - Physical Activity in Patients With Inflammatory Bowel Disease: A Narrative Review
Maitreyi Raman, Vidya Rajagopalan, Sandeep Kaur, Raylene A Reimer, Christopher Ma, Subrata Ghosh, Jeff Vallance
Inflammatory Bowel Diseases.2021;[Epub] CrossRef
- Association between physical activity with disease activity and functional disability in patients with inflammatory bowel disease
- 17,665 View
- 498 Download
- 32 Web of Science
- 36 Crossref
Original Article
- IBD
- The impact of corticosteroid use on inpatients with inflammatory bowel disease and positive polymerase chain reaction for Clostridium difficile
- Huei-Wen Lim, Isaiah P. Schuster, Ramona Rajapakse, Farah Monzur, Sundas Khan, Keith Sultan
- Intest Res 2019;17(2):244-252. Published online February 12, 2019
- DOI: https://doi.org/10.5217/ir.2018.00101
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Abstract
PDFPubReaderePub
- Background/Aims
Optimal management of inflammatory bowel disease (IBD) with concomitant Clostridium difficile infection (CDI) is controversial, especially when CDI diagnosis is made by polymerase chain reaction (PCR) testing, which may reflect colonization without infection.
Methods
We performed a multicenter review of all inpatients with IBD and PCR diagnosed CDI. Outcomes included length of stay, 30- and 90-day readmission, colectomy during admission and within 3 months, intensive care unit (ICU) admission, CDI relapse and death for patients who received corticosteroid (CS) after CDI diagnosis versus those that did not. Propensity-adjusted regression analysis of outcomes based on CS usage was performed.
Results
We identified 177 IBD patients with CDI, 112 ulcerative colitis and 65 Crohn’s disease. For IBD overall, CS after CDI diagnosis was associated with prolonged hospitalization (5.5 days: 95% confidence interval [CI], 1.5–9.6 days; P=0.008), higher colectomy rate within 3 months (odds ratio [OR], 5.5; 95% CI, 1.1–28.2; P=0.042) and more frequent ICU admissions (OR, 7.8; 95% CI, 1.5–41.6; P=0.017) versus no CS. CS use post-CDI diagnosis in UC patients was associated with prolonged hospitalization (6.2 days: 95% CI, 0.4– 12.0 days; P=0.036) and more frequent ICU admissions (OR, 7.4; 95% CI, 1.1–48.7; P=0.036).
Conclusions
CS use among IBD inpatients with CDI diagnosed by PCR is associated with poorer outcomes and would seem to reinforce the importance of C. difficile toxin assay to help distinguish colonization from infection. This adverse effect appears more prominent among those with UC. -
Citations
Citations to this article as recorded by- Clostridioides difficile infection in inflammatory bowel disease: a clinical review
Mengjun Tang, Chunhua Wang, Ying Xia, Jian Tang, Jiao Wang, Liang Shen
Expert Review of Anti-infective Therapy.2024; 22(5): 297. CrossRef - The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases
Alina Boeriu, Adina Roman, Crina Fofiu, Daniela Dobru
Pathogens.2022; 11(7): 819. CrossRef - Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
Intestinal Research.2022; 20(4): 431. CrossRef - KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
The Korean Journal of Gastroenterology.2021; 78(2): 105. CrossRef
- Clostridioides difficile infection in inflammatory bowel disease: a clinical review
- 10,786 View
- 176 Download
- 4 Web of Science
- 4 Crossref
Review
- IBD
- Management of inflammatory bowel disease in older persons: evolving paradigms
- Saurabh Kedia, Jimmy K. Limdi, Vineet Ahuja
- Intest Res 2018;16(2):194-208. Published online April 30, 2018
- DOI: https://doi.org/10.5217/ir.2018.16.2.194
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Abstract
PDFPubReaderePub
The incidence and prevalence of inflammatory bowel disease (IBD) is increasing, and considering the aging population, this number is set to increase further in the future. The clinical features and natural history of elderly-onset IBD have many similarities with those of IBD in younger patients, but with significant differences including a broader differential diagnosis. The relative lack of data specific to elderly patients with IBD, often stemming from their typical exclusion from clinical trials, has made clinical decision-making somewhat challenging. Treatment decisions in elderly patients with IBD must take into account age-specific concerns such as comorbidities, locomotor and cognitive function, and polypharmacy, to set realistic treatment targets in order to enable personalized treatment and minimize harm. Notwithstanding paucity of clinical data, recent studies have provided valuable insights, which, taken together with information gleaned from previous studies, can broaden our understanding of IBD. These insights may contribute to the development of paradigms for the holistic and, when possible, evidence-based management of this potentially vulnerable population and are the focus of this review.
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Citations
Citations to this article as recorded by- The Crohn's Disease Exclusion Diet Across the Lifespan, Indications and the Globe: An Expert Review Towards Personalized Therapy in Crohn's Disease
Rotem Sigall Boneh, Elena Banci, Luca Scarallo, Marta Herrador‐López, Emma P. Halmos, Dror S. Shouval, Nicolette Wierdsma, Chen Sarbagili‐Shabat, Víctor Manuel Navas‐López, Javier Martín‐de‐Carpi, Yulia Ron, Lindsey Albenberg, Henit Yanai, Franck Carbonne
JCC Plus.2026;[Epub] CrossRef - Older Adults with Inflammatory Bowel Disease Epidemiology in the United States: 2000–2021
Pojsakorn Danpanichkul, Yanfang Pang, Chawinthorn Vuthithammee, Disatorn Dejvajara, Priyata Dutta, Passisd Laoveeravat, Omar Al Ta’ani, Agnes HY. Ho, Chun Wei Pan, Nicole Shu Ying Tang, Kanokphong Suparan, Rashid N. Lui, Donghee Kim, Siew C. Ng, Gursimran
Digestive Diseases and Sciences.2025; 70(7): 2318. CrossRef - Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a meta-analysis on a global scale
Khushbu Viresh Janani, Parsa Saberian, Hardik B. Patel, Narsimha Rao Keetha, Ardalan Etemadzadeh, Anya Patel, Seyyed Mohammad Hashemi, Ehsan Amini-Salehi, Anoop Gurram
Journal of Health, Population and Nutrition.2025;[Epub] CrossRef - Elderly-onset inflammatory bowel disease in Asia: clinical characteristics and therapeutic strategies
Jiyoung Yoon, Daein Kim, You Sun Kim
Intestinal Research.2025; 23(4): 430. CrossRef - Fatigue, sarcopenia, and frailty in older adults with inflammatory bowel disease
Federica BELLONE, Alberto SARDELLA, Marco MUSCIANISI, Giorgio BASILE
Minerva Gastroenterology.2024;[Epub] CrossRef - Histology of IBD and related colitides in the elderly
Giuseppe LEONCINI, Luca REGGIANI-BONETTI, Gloria SIMONCELLI, Vincenzo VILLANACCI
Minerva Gastroenterology.2024;[Epub] CrossRef - Age over sex: evaluating gut microbiota differences in healthy Chinese populations
Jiacheng Wu, Hexiao Shen, Yongling Lv, Jing He, Xiaotian Xie, Zhiyue Xu, Pengcheng Yang, Wei Qian, Tao Bai, Xiaohua Hou
Frontiers in Microbiology.2024;[Epub] CrossRef - Clinical outcomes amongst elderly patients with inflammatory bowel disease
Vithoosharan Sivanathan, Chamara Basnayake, William Connell, Emily Wright, John Nik Ding, Ola Niewadomski, Annalise Stanley, Amy Wilson‐O'Brien, Stephanie Fry, Tamie Samyue, Mark Lust, Emma Flanagan, Alexander J. V. Thompson, Michael A. Kamm
Internal Medicine Journal.2023; 53(10): 1866. CrossRef - Non-neoplastic disorders in an aging gut: concise review
Saurabh Dawra, Pradeep Behl, Sharad Srivastava, Manish Manrai, Alok Chandra, Anupam Kumar, Ankit Kumar, Manveer Singh Tevatia
The Egyptian Journal of Internal Medicine.2023;[Epub] CrossRef - Enfermedad Inflamatoria Intestinal en el adulto mayor: Características clínicas y manejo en un hospital de referencia
Juan Eloy Paredes Méndez, Sonia Irene Pérez Junes, Henry Tomás Vargas Marcacuzco, Edith Melissa Villafuerte Méndez
Revista de Gastroenterología del Perú.2023; 43(1): 13. CrossRef - Clinical spectrum of elderly-onset inflammatory bowel disease in India
Yogesh Kumar Gupta, Arshdeep Singh, Vikram Narang, Vandana Midha, Ramit Mahajan, Varun Mehta, Dharmatma Singh, Namita Bansal, Madeline Vithya Barnaba Durairaj, Amit Kumar Dutta, Ajit Sood
Intestinal Research.2023; 21(2): 216. CrossRef - A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases
Michał Sienkiewicz, Kamila Sroka, Agata Binienda, Diana Jurk, Jakub Fichna
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