Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel disease (IBD) patients, and tumor tissues. However, the roles of MDSCs in IBD are not yet well understood, and there are controversies regarding their immunosuppressive functions in IBD. In addition, recent studies have suggested that endoplasmic reticulum (ER) stress in intestinal epithelial cells, especially in Paneth cells, is closely associated with the induction of IBD. However, the ER stress in MDSCs accumulated in the inflamed tissues of IBD patients is not yet fully understood. In the current review, we discuss the presence of accumulated MDSCs in the intestines of IBD patients, and further speculate on their physiological roles in the inflammatory condition with interleukin 17-producing cells, including Th17 cells. In particular, we will discuss the divergent functions of MDSCs in ER stressed intestinal environments, including their pro-inflammatory or immunosuppressive roles, based on the consideration of unfolded protein responses initiated in intestinal epithelial cells by ER stress.

Citations

Citations to this article as recorded by  

• Sulforaphane Attenuates AOM/DSS-Induced Colorectal Tumorigenesis in Mice via Inhibition of Intestinal Inflammation
  Fang Shao, Jie Pan, Yewen Xie, Jun Ding, Xiao Sun, Lei Xia, Dawei Zhu, Shizhong Wang, Chunjian Qi
  Nutrition and Cancer.2024; 76(1): 137.     CrossRef
• Local administration of myeloid-derived suppressor cells prevents progression of immune-mediated dry eye disease
  Pier Luigi Surico, Seokjoo Lee, Rohan Bir Singh, Amirreza Naderi, Shilpy Bhullar, Tomas Blanco, Yihe Chen, Reza Dana
  Experimental Eye Research.2024; 242: 109871.     CrossRef
• Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid‐derived suppressor cells
  Xiaowen Gu, Lianmei Zhang, Min Sun, Ying Zhou, Jinling Ji, YunFang Xu, Jianguo You, Zhikui Deng
  Journal of Cellular and Molecular Medicine.2024;[Epub]     CrossRef
• Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease
  Xiaoli Lou, Deyong Gao, Liyuan Yang, Yue Wang, Yanqiang Hou
  Journal of Translational Medicine.2023;[Epub]     CrossRef
• Mesenchymal Stem Cells and Myeloid-Derived Suppressor Cells Interplay in Adjuvant-Induced Arthritis Rat Model
  Faten A.M. Abo-Aziza, Basma M. Wasfy, Sanaa M.R. Wahba, Sahar S. Abd-Elhalem
  International Immunopharmacology.2023; 120: 110300.     CrossRef
• TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment
  Sifang Feng, Juan Zhao, Ting Yang, Long Li
  International Immunopharmacology.2023; 124: 110869.     CrossRef
• Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells
  Jingwei Yan, Anqi Li, Xianglin Chen, Kaixiang Cao, Mingchuan Song, Shuai Guo, Zou Li, Shuqi Huang, Ziling Li, Danghan Xu, Yong Wang, Xiaoyan Dai, Du Feng, Yuqing Huo, Jun He, Yiming Xu
  Pharmacological Research.2022; 179: 106208.     CrossRef
• Myeloid-derived suppressor cells in transplantation tolerance induction
  Peng Cao, Zejia Sun, Chang Feng, Jiandong Zhang, Feilong Zhang, Wei Wang, Yong Zhao
  International Immunopharmacology.2020; 83: 106421.     CrossRef
• Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice
  Zhanchuan Ma, Yu Zhen, Cong Hu, Huanfa Yi
  Frontiers in Immunology.2020;[Epub]     CrossRef
• Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14
  Simon H. Murch
  Medical Hypotheses.2020; 144: 110168.     CrossRef
• Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting
  Vijay Kumar
  Inflammation.2019; 42(3): 765.     CrossRef
• Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B
  William van der Touw, Kyeongah Kang, Yi Luan, Ge Ma, Sunny Mai, Lihui Qin, Guanglin Bian, Ruihua Zhang, Sathish Kumar Mungamuri, Hong-Ming Hu, Cheng Cheng Zhang, Stuart A Aaronson, Marc Feldmann, Wen-Chin Yang, Shu-Hsia Chen, Ping-Ying Pan
  The Journal of Immunology.2018; 201(6): 1727.     CrossRef
• The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis
  Junqing Zhu, Shixian Chen, Lisheng Wu, Ran Wang, Songyuan Zheng, Di Zhao, Xiangyang Wang, Juan Li
  BioMed Research International.2018; 2018: 1.     CrossRef
• Lymph node macrophages: drug-related reaction or infectious-lesion?
  Adriana Handra-Luca
  Intestinal Research.2018; 16(4): 646.     CrossRef
• TGF-Β as a Marker of Ulcerative Colitis and Disease Severity
  Marina Jovanovic, Natasa Zdravkovic, Ivan Jovanovic, Gordana Radosavljevic, Nevena Gajovic, Nebojsa Zdravkovic, Veljko Maric, Nebojsa Arsenijevic
  Serbian Journal of Experimental and Clinical Research.2018; 19(3): 229.     CrossRef
• Roles of Myeloid-Derived Suppressor Cell Subpopulations in Autoimmune Arthritis
  Min Li, Dongwei Zhu, Tingting Wang, Xueli Xia, Jie Tian, Shengjun Wang
  Frontiers in Immunology.2018;[Epub]     CrossRef
• Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
  Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
  Molecular Medicine Reports.2017; 16(6): 9224.     CrossRef
• The potential therapeutic role of myeloid-derived suppressor cells in autoimmune arthritis
  Yungang Wang, Jie Tian, Shengjun Wang
  Seminars in Arthritis and Rheumatism.2016; 45(4): 490.     CrossRef
• Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease
  Yaron Ilan
  Clinical & Translational Immunology.2016;[Epub]     CrossRef
• The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
  Chao Zhang, Shuo Wang, Cheng Yang, Ruiming Rong
  Journal of Immunology Research.2016; 2016: 1.     CrossRef
• Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice
  Yungang Wang, Jie Tian, Xinyi Tang, Ke Rui, Xinyu Tian, Jie Ma, Bin Ma, Huaxi Xu, Liwei Lu, Shengjun Wang
  Oncotarget.2016; 7(13): 15356.     CrossRef