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2 "Gut microbiome"
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Original Article
Microbiota
Exploring the link between celiac disease and obesity: a potential role of gut microbiome
Sunaina Addanki, Anastasia Mashukova, Arkene Levy
Intest Res 2025;23(2):193-201.   Published online November 8, 2024
DOI: https://doi.org/10.5217/ir.2024.00049
AbstractAbstract PDFPubReaderePub
Background/Aims
In today’s age, celiac disease (CD) is no longer solely characterized by chronic diarrhea in a malnourished child. Obesity is gradually being acknowledged as part of CD’s clinical course. Both conditions have been linked to alterations of gut microbiome. Given the difficulty of strict gluten-free diet adherence, there is a need for less restrictive adjunctive therapies. We aimed to investigate the prevalence of obesity in patients diagnosed with CD with the goal of developing new therapeutic approaches.
Methods
Baseline data from the National Institute of Health’s All of Us Research Program, was used to evaluate the relationship between CD and obesity. A retrospective cohort study was conducted where groups of individuals with CD and without CD were matched by age range and health surveys. Statistical analysis with odds ratios (OR) with 95% confidence intervals (CI) were reported.
Results
The prevalence of obesity was 32.6% in the CD group compared to 18.4% in the control group (OR, 2.111; 95% CI, 1.914–2.328; P< 0.0001). Women accounted for a greater population of patients with CD and obesity. The largest percentage of patients with CD and obesity were older than 65 years. The highest percentage of individuals in both the experimental and control groups were white, followed by African Americans.
Conclusions
Our data shows a significant association between CD and increased prevalence of obesity. These results warrant further investigation into microbial changes and dietary exposures that affect the pathogenesis of both diseases.

Citations

Citations to this article as recorded by  
  • The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2026; 41(2): 186.     CrossRef
  • Prevalence and factors associated with obesity in patients with inflammatory bowel disease (IBD) treated with infliximab and vedolizumab across the UK
    Christopher Roberts, Phoebe Hodges, Fakhirah Badrulhisham, Rebecca Smith, Jennie Clough, Claire Bewshea, Vida Cairnes, Richard Pollok, Nick Powell, Nicholas A Kennedy, Anthi Thangarajah, Tariq Ahmad, James Goodhand
    Frontline Gastroenterology.2026; : flgastro-2026-103688.     CrossRef
  • Celiac Disease and Metabolic Diseases: A Review of Emerging Connections
    Deirdre Reidy, Christopher Cao, Alexandra Rosenstock, Melissa Stoffels, Sonal Kumar, Haley M. Zylberberg
    Current Treatment Options in Gastroenterology.2025;[Epub]     CrossRef
  • 6,862 View
  • 175 Download
  • 2 Web of Science
  • 3 Crossref
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Focused Review
Microbiota
Importance of nutritional therapy in the management of intestinal diseases: beyond energy and nutrient supply
Seong-Eun Kim
Intest Res 2019;17(4):443-454.   Published online September 4, 2019
DOI: https://doi.org/10.5217/ir.2019.00075
AbstractAbstract PDFPubReaderePub
The gut is an immune-microbiome-epithelial complex. Gut microbiome-host interactions have widespread biological implications, and the role of this complex system extends beyond the digestion of food and nutrient absorption. Dietary nutrients can affect this complex and play a key role in determining gut homeostasis to maintain host health. In this article, we review various dietary nutrients and their contribution to the pathogenesis and treatment of various intestinal diseases including inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, and diverticulitis, among other such disorders. A better understanding of diet-host-gut microbiome interactions is essential to provide beneficial nutrients for gut health and to limit nutritional hazards to ensure successful nutritional management of gastrointestinal conditions in clinical practice.

Citations

Citations to this article as recorded by  
  • Nutritional risk stratification management is associated with reduced disease relapse and improved quality of life in IBD patients: a retrospective study
    Xia Li, Shuli Ma, Xuxin Zhang, Hongmei He
    Frontiers in Nutrition.2026;[Epub]     CrossRef
  • The role of nutrition in various endocrine and metabolic diseases
    Nanny Natalia Mulyani Soetedjo
    Clinical Nutrition Open Science.2025; 62: 164.     CrossRef
  • Capsule robots for the monitoring, diagnosis, and treatment of intestinal diseases
    Xiangyu Wei, Peipei Xi, Minjie Chen, Ya Wen, Hao Wu, Li Wang, Yujuan Zhu, Yile Ren, Zhifeng Gu
    Materials Today Bio.2024; 29: 101294.     CrossRef
  • TOPICAL ISSUES OF NUTRITION OF PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
    Nikishina S.S.
    "Medical & pharmaceutical journal "Pulse".2023; : 17.     CrossRef
  • An Asian perspective on irritable bowel syndrome
    Kee Wook Jung, Seung-Jae Myung
    Intestinal Research.2023; 21(2): 189.     CrossRef
  • Rectal swabs are a reliable method of assessing the colonic microbiome
    Greg Turner, Michael O’Grady, Daniel Hudson, Xochitl Morgan, Frank Frizelle, Rachel Purcell
    International Journal of Medical Microbiology.2022; 312(2): 151549.     CrossRef
  • Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations
    Shulin Fu, Yuzhen Yuan, Xinyue Tian, Linglu Zhou, Ling Guo, Dan Zhang, Jing He, Chun Peng, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong
    Veterinary Sciences.2022; 9(12): 666.     CrossRef
  • The Clinical Features of Inflammatory Bowel Disease in Patients with Obesity
    Seong Kyun Kim, Ho-Su Lee, Beom-Jun Kim, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park, Masanao Nakamura
    Canadian Journal of Gastroenterology and Hepatology.2021;[Epub]     CrossRef
  • EFFECTS OF ADOLESCENTS' NUTRITION ON THEIR QUALITY OF LIFE
    Filina I.A., Nikishina S.S., Kulakova A.S.
    "Medical & pharmaceutical journal "Pulse".2021; : 13.     CrossRef
  • Faecal Microbiota Microsphere Contributed to Relieving Gut Barrier Damage in Colitis
    Shuang Zhen, Cheng Zhao, Xin Zhao, Wu Ji, Jieshou Li
    Macromolecular Research.2020; 28(6): 644.     CrossRef
  • Dysregulation of gut microbiome is linked to disease activity of rheumatic diseases
    Yanfeng Bao, Chen Dong, Juan Ji, Zhifeng Gu
    Clinical Rheumatology.2020; 39(9): 2523.     CrossRef
  • 12,798 View
  • 419 Download
  • 9 Web of Science
  • 11 Crossref
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