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IBD
Effect of resistance exercise training on Crohn’s disease patients
Konstantinos Papadimitriou
Intest Res 2021;19(3):275-281.   Published online November 20, 2020
DOI: https://doi.org/10.5217/ir.2020.00043
AbstractAbstract PDFPubReaderePub
Crohn’s disease (CD) is observed with increased levels of cytokines which cause inflammation in many parts of the digestive tract. Aerobic exercise contributes to the reduction of the intestine’s inflammation and increases the quality of life. Another type of exercise that shows research interest about its effects on CD symptoms is the resistance exercise (RE). The aim of the study was to review the influence of RE on CD patients. The study’s literature was collected from PubMed and Scholar databases. According to the results, the main phase of a RE training program must have a gradual increase of intensity (60%–80%) and resting periods of 15–30 seconds after each exercise, and 2–3 minutes between exercises. Also, CD patients who were in remission improved the muscle strength and quality of life via their participation in RE training program. However, the secretion of interleukin-6 in both CD and RE contributes in various physiological mechanisms setting a contradictory role in the effectiveness of RE at the disease’s inflammatory situation. So, the use of RE training in CD patients needs more research for safer participation.

Citations

Citations to this article as recorded by  
  • Telemedicine-based individualised aerobic exercise training in Chinese adults with inactive or mildly active inflammatory bowel disease: study protocol for a single-centre, semi-crossover randomised controlled trial
    Ying Zhou, Huiwei Liu, Xiaojian Qian, Xie Zhang, Feng Xu
    BMJ Open.2026; 16(1): e103297.     CrossRef
  • Nutritional Habits in Crohn’s Disease Onset and Management
    Konstantinos Papadimitriou, Georgia-Eirini Deligiannidou, Gavriela Voulgaridou, Constantinos Giaginis, Sousana K. Papadopoulou
    Nutrients.2025; 17(3): 559.     CrossRef
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    Shilpa Sharma
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    Zita Kovács, Péter Bacsur, Blanka Bernadett Kasza, Tamás Molnár, Andrea Domján
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    Sitong Liu, Yunting Mei, Li Huang, Xudong Liu, Yuandi Xi
    BMJ Open.2024; 14(1): e076095.     CrossRef
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    S. V. Kostyukevich, I. G. Bakulin
    Koloproktologia.2024; 23(1): 152.     CrossRef
  • Analysis of current situation and influencing factors of marital adjustment in patients with Crohn’s disease and their spouses
    Ting Pan, Danlei Chen, Zhihui Yu, Qing Liu, Yan Chen, Ailing Zhang, Fang Kong
    Medicine.2024; 103(11): e37527.     CrossRef
  • Progress in research of exercise intervention in inflammatory bowel disease
    Shao-Peng Sun, Jia-Jia Chen, Ming-Xu Zheng, Yi-Hong Fan, Bin Lv
    World Chinese Journal of Digestology.2024; 32(5): 339.     CrossRef
  • Sarcopenia as a Preoperative Risk Stratification Tool among Older Adults with Inflammatory Bowel Disease

    Advances in Geriatric Medicine and Research.2024;[Epub]     CrossRef
  • Impact of Different Nutrition Strategies on Patients with Inflammatory Bowel Disease (IBD)
    Konstantinos Papadimitriou, Sousana K. Papadopoulou
    Nutrients.2023; 15(4): 1056.     CrossRef
  • Nutritional Risk and Sarcopenia Features in Patients with Crohn’s Disease: Relation to Body Composition, Physical Performance, Nutritional Questionnaires and Biomarkers
    Konstantinos Papadimitriou, Paraskevi Detopoulou, Konstantinos Soufleris, Gavriela Voulgaridou, Despoina Tsoumana, Panagiotis Ntopromireskou, Constantinos Giaginis, Ioanna P. Chatziprodromidou, Maria Spanoudaki, Sousana K. Papadopoulou
    Nutrients.2023; 15(16): 3615.     CrossRef
  • A Repeated Cross-Sectional Pilot Study of Physical Activity, Levels of Depression and Anxiety during the COVID-19 Pandemic in Young Greek Adults
    Smaragda Skalidou, Andreas Anestis, Emmanouil Skalidis, Ourania Kontaxi, Athanasia Kyrezi, Panagiota Konstantinou, Konstantinos Papadimitriou
    Healthcare.2023; 11(18): 2493.     CrossRef
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    Jing Wang, Shuping Tong, Yuehong Niu, Bingqing Lu
    BMJ Open.2023; 13(12): e080084.     CrossRef
  • The Influence of Aerobic Type Exercise on Active Crohn’s Disease Patients: The Incidence of an Elite Athlete
    Konstantinos Papadimitriou
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  • Evaluación de actividad física como coadyuvante terapéutico para pacientes con enfermedad inflamatoria intestinal: una revisión.
    Diego Fernández-Lázaro, Nuria Hernández-Burgos, Raúl Cobreros Mielgo, Sandra García-Lázaro
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  • Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice
    Kai Aoki, Takuji Suzuki, Fang Hui, Takuro Nakano, Koki Yanazawa, Masato Yonamine, Shinichiro Fujita, Takehito Sugasawa, Yasuko Yoshida, Naomi Omi, Yasushi Kawakami, Kazuhiro Takekoshi
    Nutrients.2021; 13(5): 1735.     CrossRef
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Original Article
Functional bowel disorder
Proinflammatory cytokines in irritable bowel syndrome: a comparison with inflammatory bowel disease
Antigony Mitselou, Vasileios Grammeniatis, Anna Varouktsi, Stamatis S Papadatos, Konstantinos Katsanos, Vasiliki Galani
Intest Res 2020;18(1):115-120.   Published online January 30, 2020
DOI: https://doi.org/10.5217/ir.2019.00125
AbstractAbstract PDFPubReaderePub
Background/Aims
Irritable bowel syndrome (IBS) is a common disease often considered as a functional intestinal disorder. Inflammation in IBS is a quite intriguing theory. The aim of this study was to investigate tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 expression in inflammatory bowel disease (IBD) patients, IBS patients and normal controls.
Methods
IBS and IBD patients along with normal controls were recruited in the study. In all groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum, and rectum). IBS patients were also subcategorized according to the syndrome clinical manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis.
Results
In IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL-6 was significantly increased comparing to the aforementioned groups. In IBS patients TNF-α was increased comparing to IBD patients or controls, while IL-6 and IL-1β were similar to controls. In IBS subgroups, TNF-α was lower in diarrhea predominant IBS patients and higher constipation predominant IBS patients. Differences among IBS subgroups regarding IL-6 and IL-1β were nonsignificant.
Conclusions
IL-6 seems to be the most important proinflammatory cytokine in IBD patients, while TNF-α could play a more significant role in IBS pathogenesis.

Citations

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