Mucosal surface of the intestinal tract is continuously exposed to a large number of microorganisms. To manage the substantial microbial exposure, epithelial surfaces produce a diverse arsenal of antimicrobial proteins (AMPs) that directly kill or inhibit the growth of microorganisms. Thus, AMPs are important components of innate immunity in the gut mucosa. They are frequently expressed in response to colonic inflammation and infection. Expression of many AMPs, including human β-defensin 2-4 and cathelicidin, is induced in response to invasion of pathogens or enteric microbiota into the mucosal barrier. In contrast, some AMPs, including human α-defensin 5-6 and human β-defensin 1, are constitutively expressed without microbial contact or invasion. In addition, specific AMPs are reported to be associated with inflammatory bowel disease (IBD) due to altered expression of AMPs or development of autoantibodies against AMPs. The advanced knowledge for AMPs expression in IBD can lead to its potential use as biomarkers for disease activity. Although the administration of exogenous AMPs as therapeutic strategies against IBD is still at an early stage of development, augmented induction of endogenous AMPs may be another interesting future research direction for the protective and therapeutic purposes. This review discusses new advances in our understanding of how intestinal AMPs protect against pathogens and contribute to pathophysiology of IBD.

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• A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability
  Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez, Xiang Gao, Andrew L. Goodman
  Cell Host & Microbe.2025; 33(2): 200.     CrossRef
• MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut
  Marina Chulkina, Hanh Tran, Gabriela Uribe, Steven Bruce McAninch, Christina McAninch, Ashley Seideneck, Bing He, Matthew Lanza, Kamil Khanipov, Georgiy Golovko, Don W. Powell, Emily R. Davenport, Irina V. Pinchuk
  Cell Reports.2025; 44(5): 115553.     CrossRef
• Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
  Shari Garrett, Yongguo Zhang, Yinglin Xia, Jun Sun
  Engineering.2024; 35: 241.     CrossRef
• Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus
  Irmak Dik, Burak Dik, Öznur Tufan, Ayşe Er
  Fundamental & Clinical Pharmacology.2024; 38(4): 695.     CrossRef
• Role of antimicrobial peptides in gastrointestinal diseases: Recent advances
  Xia Xu, Yan-Bo Yu
  World Chinese Journal of Digestology.2024; 32(12): 865.     CrossRef
• Importance of Fecal Microbiota Transplantation and Molecular Regulation as Therapeutic Strategies in Inflammatory Bowel Diseases
  Olga Brusnic, Adrian Boicean, Sorin-Radu Fleacă, Blanca Grama, Florin Sofonea, Corina Roman-Filip, Iulian Roman-Filip, Adelaida Solomon, Sabrina Bîrsan, Horatiu Dura, Corina Porr, Cristian Adrian, Danusia Onisor
  Nutrients.2024; 16(24): 4411.     CrossRef
• A COMBINATION REVIEW ON EFFECT OF CITRUS JUICE AND METRONIDAZOLE IN INFLAMMATORY BOWEL DISEASE
  Deeksha, Shalini Saini, Meenakshi Bhatt
  International Journal of Research -GRANTHAALAYAH.2023;[Epub]     CrossRef
• Oral Delivery of Mouse β-Defensin 14 (mBD14)-Producing Lactococcus lactis NZ9000 Attenuates Experimental Colitis in Mice
  Haizhi Tian, Jiahong Li, Xiaopei Chen, Zhengnan Ren, Xiaohua Pan, Weining Huang, Madhav Bhatia, Li-Long Pan, Jia Sun
  Journal of Agricultural and Food Chemistry.2023; 71(13): 5185.     CrossRef
• Alterations in fecal β-defensin-3 secretion as a marker of instability of the gut microbiota
  Zarwa Saqib, Giada De Palma, Jun Lu, Michael Surette, Premysl Bercik, Stephen Michael Collins
  Gut Microbes.2023;[Epub]     CrossRef
• COVID-19 and its Therapeutics: Special Emphasis on Mesenchymal Stem Cells Based Therapy
  Yogesh Kumar Verma, Ranjan Verma, Nishant Tyagi, Amanpreet Behl, Subodh Kumar, Gurudutta U. Gangenahalli
  Stem Cell Reviews and Reports.2021; 17(1): 113.     CrossRef
• Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease
  Paulina Krawiec, Elżbieta Pac-Kożuchowska
  Journal of Inflammation Research.2021; Volume 14: 163.     CrossRef
• Protective effects of potential probiotic Lactobacillus rhamnosus (MTCC-5897) fermented whey on reinforcement of intestinal epithelial barrier function in a colitis-induced murine model
  Harpreet Kaur, Taruna Gupta, Suman Kapila, Rajeev Kapila
  Food & Function.2021; 12(13): 6102.     CrossRef
• Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
  Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak
  Cells.2021; 10(11): 2991.     CrossRef
• Detection of Marker Associated with CTC in Colorectal Cancer in Mononuclear Cells of Patients with Benign Inflammatory Intestinal Diseases
  Johanna Born, Alexander Hendricks, Charlotte Hauser, Jan-Hendrik Egberts, Thomas Becker, Christian Röder, Susanne Sebens
  Cancers.2021; 14(1): 47.     CrossRef
• Mucosal expression of defensin-5, soluble phospholipase A2 and lysozyme in the intestine in a rat model of acute liver failure and its relationship to intestinal bacterial translocation
  Silin Chen, Xiaopeng Li, Ming Li, Qing Mei, Juanjun Huang, Zhenping Wu, Lunli Zhang
  Gastroenterología y Hepatología.2020; 43(6): 293.     CrossRef
• High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures
  Jiani Wang, Christina Ortiz, Lindsey Fontenot, Ying Xie, Wendy Ho, S. Anjani Mattai, David Q. Shih, Hon Wai Koon, Pal Bela Szecsi
  PLOS ONE.2020; 15(4): e0231796.     CrossRef
• Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics
  Nehal Adel Abdelsalam, Ahmed Tarek Ramadan, Marwa Tarek ElRakaiby, Ramy Karam Aziz
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Mucosal expression of defensin-5, soluble phospholipase A2 and lysozyme in the intestine in a rat model of acute liver failure and its relationship to intestinal bacterial translocation
  Silin Chen, Xiaopeng Li, Ming Li, Qing Mei, Juanjun Huang, Zhenping Wu, Lunli Zhang
  Gastroenterología y Hepatología (English Edition).2020; 43(6): 293.     CrossRef
• Mesenchymal Stromal Cells as Potential Antimicrobial for Veterinary Use—A Comprehensive Review
  Keith A. Russell, Livia C. Garbin, Jonathan M. Wong, Thomas G. Koch
  Frontiers in Microbiology.2020;[Epub]     CrossRef
• Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice
  Seong-Joon Koh, Youn-I Choi, Yuri Kim, Yoo-Sun Kim, Sang Woon Choi, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee
  European Journal of Nutrition.2019; 58(4): 1603.     CrossRef
• Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk
  Ajaz A. Bhat, Srijayaprakash Uppada, Iman W. Achkar, Sheema Hashem, Santosh K. Yadav, Muralitharan Shanmugakonar, Hamda A. Al-Naemi, Mohammad Haris, Shahab Uddin
  Frontiers in Physiology.2019;[Epub]     CrossRef
• Gene and Mirna Regulatory Networks During Different Stages of Crohn’s Disease
  Sare Verstockt, Gert De Hertogh, Jan Van der Goten, Bram Verstockt, Maaike Vancamelbeke, Kathleen Machiels, Leentje Van Lommel, Frans Schuit, Gert Van Assche, Paul Rutgeerts, Marc Ferrante, Séverine Vermeire, Ingrid Arijs, Isabelle Cleynen
  Journal of Crohn's and Colitis.2019; 13(7): 916.     CrossRef
• Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction
  Gabriela Pinget, Jian Tan, Bartlomiej Janac, Nadeem O. Kaakoush, Alexandra Sophie Angelatos, John O'Sullivan, Yen Chin Koay, Frederic Sierro, Joel Davis, Shiva Kamini Divakarla, Dipesh Khanal, Robert J. Moore, Dragana Stanley, Wojciech Chrzanowski, Lauren
  Frontiers in Nutrition.2019;[Epub]     CrossRef
• Duodenal expression of antimicrobial peptides in dogs with idiopathic inflammatory bowel disease and intestinal lymphoma
  M. Nakazawa, S. Maeda, M. Omori, K. Kaji, N. Yokoyama, T. Nakagawa, J.K. Chambers, K. Uchida, K. Ohno, T. Yonezawa, N. Matsuki
  The Veterinary Journal.2019; 249: 47.     CrossRef
• Integrative Analysis of Transcriptomic and Proteomic Profiling in Inflammatory Bowel Disease Colon Biopsies
  Liang Jin, Li Li, Chenqi Hu, Jesus Paez-Cortez, Yingtao Bi, Michael Macoritto, Sherry Cao, Yu Tian
  Inflammatory Bowel Diseases.2019; 25(12): 1906.     CrossRef
• Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells
  Reza Esfandiyari, Raheleh Halabian, Elham Behzadi, Hamid Sedighian, Ramezan Jafari, Abbas Ali Imani Fooladi
  Heliyon.2019; 5(10): e02652.     CrossRef
• Intestinal barrier integrity and inflammatory bowel disease: Stem cell‐based approaches to regenerate the barrier
  Fredrik E.O. Holmberg, Jannie Pedersen, Peter Jørgensen, Christoffer Soendergaard, Kim B. Jensen, Ole H. Nielsen
  Journal of Tissue Engineering and Regenerative Medicine.2018; 12(4): 923.     CrossRef
• Growth characteristics of Chlamydia trachomatis in human intestinal epithelial Caco-2 cells
  Ildikó Lantos, Dezső P Virok, Tímea Mosolygó, Zsolt Rázga, Katalin Burián, Valéria Endrész
  Pathogens and Disease.2018;[Epub]     CrossRef
• The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria
  Olivia Benguettat, Rouba Jneid, Julie Soltys, Rihab Loudhaief, Alexandra Brun-Barale, Dani Osman, Armel Gallet, Karel Talavera
  PLOS Pathogens.2018; 14(9): e1007279.     CrossRef
• P17, an Original Host Defense Peptide from Ant Venom, Promotes Antifungal Activities of Macrophages through the Induction of C-Type Lectin Receptors Dependent on LTB4-Mediated PPARγ Activation
  Khaddouj Benmoussa, Hélène Authier, Mélissa Prat, Mohammad AlaEddine, Lise Lefèvre, Mouna Chirine Rahabi, José Bernad, Agnès Aubouy, Elsa Bonnafé, Jérome Leprince, Bernard Pipy, Michel Treilhou, Agnès Coste
  Frontiers in Immunology.2017;[Epub]     CrossRef
• Lessons to be learned from serum biomarkers in psoriasis and IBD – the potential role in SpA
  Maureen C. Turina, Robert Landewé, Dominique Baeten
  Expert Review of Clinical Immunology.2017; 13(4): 333.     CrossRef
• Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia
  Junbae Jee, Reena Mourya, Pranavkumar Shivakumar, Lin Fei, Michael Wagner, Jorge A. Bezerra, Gianfranco D. Alpini
  PLOS ONE.2017; 12(8): e0182089.     CrossRef
• Metronidazole-induced encephalopathy in a patient with Crohn's disease
  Jihye Kim, Jaeyoung Chun, Jae Yong Park, Seung Wook Hong, Joo Young Lee, Jin Woo Kang, Seongjun Hwang, Sang-Bae Ko, Jong Pil Im, Joo Sung Kim
  Intestinal Research.2017; 15(1): 124.     CrossRef
• Intestinal stem cells and intestinal homeostasis in health and in inflammation: A review
  Alexander L.A. Bloemendaal, Nicolas C. Buchs, Bruce D. George, Richard J. Guy
  Surgery.2016; 159(5): 1237.     CrossRef
• Antimicrobial peptides and wound healing: biological and therapeutic considerations
  Maria Luisa Mangoni, Alison M. McDermott, Michael Zasloff
  Experimental Dermatology.2016; 25(3): 167.     CrossRef
• The Roles of Cathelicidin LL-37 in Inflammatory Bowel Disease
  Lihua Sun, Wensheng Wang, Weidong Xiao, Hua Yang
  Inflammatory Bowel Diseases.2016; 22(8): 1986.     CrossRef
• A glance at … dietary emulsifiers, the human intestinal mucus and microbiome, and dietary fiber
  Michael J. Glade, Michael M. Meguid
  Nutrition.2016; 32(5): 609.     CrossRef
• Antimicrobial and antiviral effects of human defensins: pathogenetic value and prospective application to medicinal therapy
  Vladimir I Vaschenko, Vladimir N Vil’yaninov, Petr D Shabanov
  Reviews on Clinical Pharmacology and Drug Therapy.2016; 14(2): 3.     CrossRef
• Cross-Regulation of Innate and Adaptive Immunity: A New Perspective for the Pathogenesis of Inflammatory Bowel Disease
  Da Yeon Oh, Seong-Joon Koh
  Gut and Liver.2015;[Epub]     CrossRef
• Epigenetic Alterations in Inflammatory Bowel Disease and Cancer
  Joo Mi Yi, Tae Oh Kim
  Intestinal Research.2015; 13(2): 112.     CrossRef