Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a lifelong disease that manifests with chronic intestinal inflammation, sequential fibrosis, and an increased risk of colitis-associated colon cancer (CAC). The combined effects of genetic, immunological, environmental, and microbial factors render it difficult to determine the specific mechanism underlying the induction and perpetuation of IBD. Various animal models of IBD have contributed enormously to the understanding of IBD pathogenesis in terms of genomics, transcriptomics, proteomics, microbiome, and drug development of novel therapeutics. Although comprehensive research on IBD has been enabled by advanced technologies, such as genetically engineered models, there is a great need to develop relevant in vivo models of colitis and fibrosis. Here, we review 4 categories of animal models of acute and chronic intestinal inflammation, fibrosis, and CAC: chemically induced, genetically engineered, T cell transfer, and spontaneous gene mutation models.
Citations
Citations to this article as recorded by
Refined photobiomodulation therapy ameliorates inflammatory bowel disease via modulation of immune pathways and gut microbiota Lee So Maeng, Jung Hwan Yoon, Bom Yee Chung, Kyung Jin Seo, Hae Kyung Lee, Moon Gyu Chung, Won Sang Park, Hiun Suk Chae Journal of Photochemistry and Photobiology B: Biology.2026; 274: 113330. CrossRef
COVID-19 Infection in a Patient With Sigmoid Diverticulitis: Viral Diverticulitis or Incidental Association? Maria J Araujo, Victor A Sato, Precil D Neves, Erico S Oliveira, Leonardo V Pereira, Sara Mohrbacher, Alessandra M Bales, Luciana L Nardotto, Marcella M Frediani, Andrea Santos Galvão, Wares F Medeiros, Américo L Cuvello-Neto, Pedro R Chocair Cureus.2026;[Epub] CrossRef
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways Fangmei Ling, Yidong Chen, Junrong Li, Mingyang Xu, Gengqing Song, Lei Tu, Huan Wang, Shuang Li, Liangru Zhu Inflammatory Bowel Diseases.2025; 31(1): 11. CrossRef
Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig Advanced Healthcare Materials.2025;[Epub] CrossRef
Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production Haitao Xiao, Tianhang Xing, Miao Qiu, Guangtao Zhang, Gongli Yang, Wenke Chen, Die Hu, Deao Xue, Jiao Peng, Bin Du Journal of Advanced Research.2025; 76: 639. CrossRef
Fructosyl-mangiferin ameliorates dextran sulfate sodium-induced colitis in mice via the STAT3/M1/Th17 axis Penghong Xu, Yuping Qian, Guo Xu, Jianlin Chu, Bingfang He Phytomedicine.2025; 139: 156475. CrossRef
S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity Huaping Zheng, Jingjing Yu, Luhua Gao, Kexin Wang, Zheng Xu, Zhen Zeng, Kun Zheng, Xiaoju Tang, Xiaowen Tian, Qing Zhao, Jie Zhao, Huajing Wan, Zhongwei Cao, Kang Zhang, Jingqiu Cheng, Jürgen Brosius, Hu Zhang, Wei Li, Wei Yan, Zhenhua Shao, Fengming Luo, Nature Communications.2025;[Epub] CrossRef
Groundwater Nitrate Contamination and its Effect on Human Health: A Review Indra Jeet Chaudhary, Ratna Chauhan, Sanjay Sarjerao Kale, Suresh Gosavi, Dheeraj Rathore, Vinay Dwivedi, Sunita Singh, Virendra Kumar Yadav Water Conservation Science and Engineering.2025;[Epub] CrossRef
Standardization of a Preclinical Colon Cancer Model in Male and Female BALB/c Mice: Macroscopic and Microscopic Characterization from Pre-Neoplastic to Tumoral Lesions Elizabeth Correa, Juan Pablo Rendón, Vanesa Bedoya-Betancur, Juliana Montoya, Julian Muñoz Duque, Tonny W. Naranjo Biomedicines.2025; 13(4): 939. CrossRef
Metabolic Disorders and Inflammatory Bowel Diseases Hye Kyung Hyun, Jae Hee Cheon Gut and Liver.2025; 19(3): 307. CrossRef
A review on ulcerative colitis induction models and the protective mechanism of carbon quantum dots as a novel anti-inflammatory and anti-ulcer agent Mohammad Beiranvand, Gholamreza Dehghan Discover Pharmaceutical Sciences.2025;[Epub] CrossRef
Oral–gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol Hyun Sik Kim, Bo-Hyung Kim, Bora Nam, Shin Ju Oh, Soo-Kyung Park, Sang Won Lee, Jae-Yun Lee, Sungsin Jo, Yeon-Ah Lee, June-Young Lee, Dong Il Park, Tae-Hwan Kim, Chang Kyun Lee BMJ Open.2025; 15(8): e092075. CrossRef
Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease Alda Cassia Alves da Silva, Juliana Soares Severo, Brenda Lois Barros dos Santos, Heron Silva Soares, Jorddam Almondes Martins, Rodrigo Soares Pereira Lima, Kalinne Kelly Lima Gadelha, Francisco Leonardo Torres-Leal, Paulo Correia-de-Sá, Pedro Jorge Calda World Journal of Gastroenterology.2025;[Epub] CrossRef
From AI-Assisted In Silico Computational Design to Preclinical In Vivo Models: A Multi-Platform Approach to Small Molecule Anti-IBD Drug Discovery Joya Datta Ripa, Sarfaraz Ali, Matt Field, John Smithson, Phurpa Wangchuk Pharmaceuticals.2025; 18(10): 1536. CrossRef
A Comprehensive Narrative Review of Potential Gastrointestinal Adverse Effects From Micro(nano) Plastic Exposure Priyata Dutta, Sana Rabeeah, Alejandra Vargas, Edward C. Oldfield, David A. Johnson Clinical Gastroenterology and Hepatology.2025;[Epub] CrossRef
Effect of Gut Microbiota Alteration on Colorectal Cancer Progression in an In Vivo Model: Histopathological and Immunological Evaluation Juliana Montoya Montoya, Elizabeth Correa Gómez, Jorge Humberto Tabares Guevara, Julián Camilo Arango Rincón, Tonny Williams Naranjo Preciado Current Issues in Molecular Biology.2025; 48(1): 15. CrossRef
Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products Tenzin Jamtsho, Karma Yeshi, Matthew J. Perry, Alex Loukas, Phurpa Wangchuk Pharmaceuticals.2024; 17(3): 283. CrossRef
Strategies for targeting cytokines in inflammatory bowel disease Markus F. Neurath Nature Reviews Immunology.2024; 24(8): 559. CrossRef
Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles Saji Uthaman, Shadi Parvinroo, Ansuja Pulickal Mathew, Xinglin Jia, Belen Hernandez, Alexandra Proctor, Karuna Anna Sajeevan, Ariel Nenninger, Mary-Jane Long, In-Kyu Park, Ratul Chowdhury, Gregory J. Phillips, Michael J. Wannemuehler, Rizia Bardhan ACS Nano.2024; 18(19): 12117. CrossRef
Targeting cyclooxygenase-2 for chemoprevention of inflammation-associated intestinal carcinogenesis: An update Kyung-Soo Chun, Eun-Hee Kim, Do-Hee Kim, Na-Young Song, Wonki Kim, Hye-Kyung Na, Young-Joon Surh Biochemical Pharmacology.2024; 228: 116259. CrossRef
Lactobacillus paracasei Jlus66 relieves DSS-induced ulcerative colitis in a murine model by maintaining intestinal barrier integrity, inhibiting inflammation, and improving intestinal microbiota structure Fazheng Yu, Xiaoxu Wang, Honglin Ren, Jiang Chang, Jian Guo, Zhaoqi He, Ruoran Shi, Xueyu Hu, Yuanyuan Jin, Shiying Lu, Yansong Li, Zengshan Liu, Pan Hu European Journal of Nutrition.2024; 63(6): 2185. CrossRef
Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study Kijae Jo, Kwang Woo Kim, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim, Seong-Joon Koh Intestinal Research.2024; 22(4): 453. CrossRef
Interventional Effects of Lactobacillus plantarum Hfy04 Isolated from Naturally Fermented Yak Yogurt on Oxazolone-Induced Colitis in BALB/c Mice Haitao Zheng, Xiaoli Ping, Ruizi Wu, Cen Lei, Huijia Mao, Yanni Pan, Yongpeng He, Xin Zhao International Journal of Pharmacology.2024; 20(5): 817. CrossRef
Inhibition of myeloperoxidase by food-derived peptides: A review of current research and future prospects Fai-Chu Wong, Yit-Lai Chow, Sheri-Ann Tan, Lingmin Tian, Weibin Bai, Tsun-Thai Chai Food Bioscience.2024; 60: 104458. CrossRef
Deciphering Microbial Composition in Patients with Inflammatory Bowel Disease: Implications for Therapeutic Response to Biologic Agents Orazio Palmieri, Fabrizio Bossa, Stefano Castellana, Tiziana Latiano, Sonia Carparelli, Giuseppina Martino, Manuel Mangoni, Giuseppe Corritore, Marianna Nardella, Maria Guerra, Giuseppe Biscaglia, Francesco Perri, Tommaso Mazza, Anna Latiano Microorganisms.2024; 12(7): 1260. CrossRef
Protective effect of freeze-dried extract of Persicaria bistorta Samp. on acetic acid-induced colitis model in rats: Involvement of nitric oxide and opioid system Niusha Esmaealzadeh, Amirhossein Abdolghaffari, Maryam Baeeri, Maede Hasanpour, Mehrdad Iranshahi, Cristina Santarcangelo, Mahdi Gholami, Roodabeh Bahramsoltani Inflammopharmacology.2024; 32(6): 3845. CrossRef
Advances in Vascular Diagnostics using Magnetic Particle Imaging (MPI) for Blood Circulation Assessment Marisa O Pacheco, Isabelle K Gerzenshtein, Whitney L Stoppel, Carlos M Rinaldi‐Ramos Advanced Healthcare Materials.2024;[Epub] CrossRef
Immunomodulatory Effects of a Probiotic Mixture: Alleviating Colitis in a Mouse Model through Modulation of Cell Activation Markers and the Gut Microbiota Hye-Myung Ryu, S. M. Shamsul Islam, Bushra Riaz, Hasan M. Sayeed, Bunsoon Choi, Seonghyang Sohn International Journal of Molecular Sciences.2024; 25(16): 8571. CrossRef
Immuno-therapeutic and prophylactic potential of Trichinella spiralis antigens for inflammatory bowel diseases Majed H. Wakid, Walaa A. El Kholy, Muslimah N. Alsulami, Eman S. El-Wakil Food and Waterborne Parasitology.2024; 37: e00248. CrossRef
Development of a novel complex inflammatory bowel disease mouse model: Reproducing human inflammatory bowel disease etiologies in mice Sun-Min Seo, Na-Won Kim, Eun-Seon Yoo, Ji-Hun Lee, Ah-Reum Kang, Han-Bi Jeong, Won-Yong Shim, Dong-Hyun Kim, Young-Jun Park, Kieun Bae, Kyong-Ah Yoon, Yang-Kyu Choi, Pradeep Dudeja PLOS ONE.2024; 19(11): e0311310. CrossRef
Gut Microbiome and Colorectal Cancer Tae-Geun Gweon The Korean Journal of Gastroenterology.2023; 82(2): 56. CrossRef
Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease Hoyul Lee, Jae-Han Jeon, Eun Soo Kim Frontiers in Immunology.2023;[Epub] CrossRef
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and both disorders affect individuals throughout life. Despite every extensive effort, the interplay among genetic factors, immunological factors, environmental factors and intestinal microbes is still completely unrevealed. Animal models are indispensable to find out mechanistic details that will facilitate better preclinical setting to target specific components involved in the pathogenesis of IBD. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, not only IBD but also colon cancer, obesity, psoriasis as well as allergic disorders, in both human and animal models. Advanced technologies including cell-specific and inducible knockout systems, which are recently employed to mouse IBD models, have further enhanced the ability of developing new therapeutic strategies for IBD. Furthermore, data from these mouse models highlight the critical involvement of dysregulated immune responses and impaired colonic epithelial defense system in the pathogenesis of IBD. In this review, we will explain from the history of animal models of IBD to the recent reports of the latest compounds, therapeutic strategies, and approaches tested on IBD animal models.
Citations
Citations to this article as recorded by
DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering Oliver Sandys, Pieter C. F. Stokkers, Anje A. te Velde Digestive Diseases and Sciences.2025; 70(1): 49. CrossRef
Eleven Grand Challenges for Inflammatory Bowel Disease Genetics and Genomics Greg Gibson, John D Rioux, Judy H Cho, Talin Haritunians, Akshaya Thoutam, Maria T Abreu, Steven R Brant, Subra Kugathasan, Jacob L McCauley, Mark Silverberg, Dermot McGovern Inflammatory Bowel Diseases.2025; 31(1): 272. CrossRef
Biofabrication and simulation techniques for gut-on-a-chip Ke Wang, Yushen Wang, Junlei Han, Zhixiang Liang, Wenhong Zhang, Xinyu Li, Jun Chen, Li Wang Biofabrication.2025; 17(2): 022011. CrossRef
Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibitor for the treatment of inflammatory bowel disease Jie Hu, Juan Liu, Fengming Zou, Xixiang Li, Hongwei Yu, Beilei Wang, Li Wang, Jun Tang, Xilu Hou, Qian Gao, Jiaoxue Wang, Xing He, Yanjie Chen, Hezhong Yan, Jing Liu, Aoli Wang, Wenchao Wang, Qingsong Liu International Immunopharmacology.2025; 159: 114839. CrossRef
Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway Ruo Wang, Bing Feng, Qigu Yao, Qiaoling Pan, Jiong Yu, Chaoxu Liu, Jinhai Wang, Lanjuan Li, Hongcui Cao, Jue Xie Communications Biology.2025;[Epub] CrossRef
MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation Yingying Lin, Yuqi Wang, Yuning Zhang, Yao Lu, Juan Chen, Yongting Luo, Jian He, Qingfeng Luo, Heng Quan, Weiru Yu, Yujia Luo, Peng Xue, Yi Xue, Xiaoya Lin, Rui Ding, Lining Chen, Yiran Wang, Zenghui Xia, Liang Zhao, Hao Zhang, Ran Wang, Qingyu Wang, Xifa Exploration.2025;[Epub] CrossRef
Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis Xiaojie Fang, Jiahao Yang, Liu Yang, Yiyou Lin, Yanyan Li, Xin Yin, Xiaobing Dou, Chenyun Miao Frontiers in Immunology.2025;[Epub] CrossRef
Improved efficacy and long‐term protective effects of CXCR4/IL10 bioengineered mesenchymal stromal cells in a model of inflammatory bowel disease Mercedes Lopez‐Santalla, Marta C. Ordoñez‐Velasco, Maria Fernandez‐Garcia, Miriam Hernando‐Rodriguez, Juan A. Bueren, Rosa M. Yañez, Marina I. Garin Bioengineering & Translational Medicine.2025;[Epub] CrossRef
Ethanolic Extract of Kinkeliba (Combretum micranthum), Rich in Phenolic Compounds Mitigates DSS-Induced Ulcerative Colitis in C57BL/6 Mice via Antioxidation and Microbiota Regulation Ibrahima Mamadou Sall, Dan Cristian Vodnar, Gheorghe Adrian Martău, Meriem Aziez, Alina Diana Haşaş, Dragoş Hodor, Alexandru Flaviu Tăbăran International Journal of Molecular Sciences.2025; 26(23): 11299. CrossRef
Continued JAK inhibitor treatment on the risk of recurrent herpes zoster reactivation in patients with immune-mediated inflammatory diseases: A nationwide population-based study in South Korea Young-Eun Kim, Ye-Jee Kim, Dae Hyun Jeong, Seonok Kim, Min Jee Kim, Hyeon Hwa Kim, Kyung-Wook Jo, Sang Hyoung Park, Seokchan Hong Seminars in Arthritis and Rheumatism.2024; 65: 152362. CrossRef
Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model Chunhua Yang, Didier Merlin Inflammatory Bowel Diseases.2024; 30(5): 844. CrossRef
An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease Shanshan Tie, Yannan Chen, Mingqian Tan Food Frontiers.2024; 5(2): 474. CrossRef
Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products Tenzin Jamtsho, Karma Yeshi, Matthew J. Perry, Alex Loukas, Phurpa Wangchuk Pharmaceuticals.2024; 17(3): 283. CrossRef
Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice Natticha Sumneang, Komsak Pintha, Sarawut Kongkarnka, Maitree Suttajit, Napapan Kangwan Molecules.2024; 29(9): 1940. CrossRef
Sacroiliitis in inflammatory bowel disease on abdominal computed tomography: prevalence, misses, and associated factors DK Kim, K-C Lee, JK Kim Scandinavian Journal of Rheumatology.2024; 53(4): 248. CrossRef
Dopamine β-hydroxylase shapes intestinal inflammation through modulating T cell activation Qiaoling Sun, Heng Li, Jing Lv, Weilin Shi, Yanfeng Bai, Ke Pan, Alice Chen Cellular Immunology.2024; 401-402: 104839. CrossRef
Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention Hong Huang, Gejing Li, Yini He, Jing Chen, Jianye Yan, Qin Zhang, Liqing Li, Xiong Cai Frontiers in Immunology.2024;[Epub] CrossRef
Advances in Vascular Diagnostics using Magnetic Particle Imaging (MPI) for Blood Circulation Assessment Marisa O Pacheco, Isabelle K Gerzenshtein, Whitney L Stoppel, Carlos M Rinaldi‐Ramos Advanced Healthcare Materials.2024;[Epub] CrossRef
Modelling the innate immune system in microphysiological systems Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. Hickman Lab on a Chip.2024; 24(15): 3604. CrossRef
Bioinspired and bioderived nanomedicine for inflammatory bowel disease Rafaela Gazzi, Rita Gelli, Simone Aleandri, Marianna Carone, Paola Luciani WIREs Nanomedicine and Nanobiotechnology.2024;[Epub] CrossRef
Target potential of miRNAs in ulcerative colitis: what do we know? Peeyush Kumar, Saurabh Kedia, Vineet Ahuja Expert Opinion on Therapeutic Targets.2024; 28(10): 829. CrossRef
Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease Rucha Chandwaskar, Rajdeep Dalal, Saurabh Gupta, Aishwarya Sharma, Deepak Parashar, Vivek K. Kashyap, Jagdip Singh Sohal, Subhash K. Tripathi Scandinavian Journal of Immunology.2024;[Epub] CrossRef
MiRNA-Based Therapies for the Treatment of Inflammatory Bowel Disease: What Are We Still Missing? Tommaso Innocenti, Elisabetta Bigagli, Erica Nicola Lynch, Andrea Galli, Gabriele Dragoni Inflammatory Bowel Diseases.2023; 29(2): 308. CrossRef
Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee Cellular and Molecular Gastroenterology and Hepatology.2023; 15(2): 439. CrossRef
Korean clinical practice guidelines on biologics for moderate to severe Crohn’s disease Seong-Joon Koh, Sung Noh Hong, Soo-Kyung Park, Byong Duk Ye, Kyeong Ok Kim, Jeong Eun Shin, Yong Sik Yoon, Hong Sub Lee, Sung Hoon Jung, Miyoung Choi, Soo-Young Na, Chang Hwan Choi, Joo Sung Kim Intestinal Research.2023; 21(1): 43. CrossRef
Potential of Gut Microbe-Derived Extracellular Vesicles to Differentiate Inflammatory Bowel Disease Patients from Healthy Controls Min Heo, Young Soo Park, Hyuk Yoon, Nam-Eun Kim, Kangjin Kim, Cheol Min Shin, Nayoung Kim, Dong Ho Lee Gut and Liver.2023; 17(1): 108. CrossRef
Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review Jung Yoon Jang, Eunok Im, Nam Deuk Kim International Journal of Molecular Sciences.2023; 24(3): 1954. CrossRef
Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study Joo Kyung Kim, Jae Hee Cheon Journal of Yeungnam Medical Science.2023; 40(1): 37. CrossRef
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi Intestinal Research.2023; 21(1): 148. CrossRef
miRNA Molecules—Late Breaking Treatment for Inflammatory Bowel Diseases? Ioanna Aggeletopoulou, Athanasia Mouzaki, Konstantinos Thomopoulos, Christos Triantos International Journal of Molecular Sciences.2023; 24(3): 2233. CrossRef
Succinate metabolism and its regulation of host-microbe interactions Yi-han Wei, Xi Ma, Jiang-chao Zhao, Xiu-qi Wang, Chun-qi Gao Gut Microbes.2023;[Epub] CrossRef
A westernized diet changed the colonic bacterial composition and metabolite concentration in a dextran sulfate sodium pig model for ulcerative colitis Farhad M. Panah, Katrine D. Nielsen, Gavin L. Simpson, Anna Schönherz, Andreas Schramm, Charlotte Lauridsen, Tina S. Nielsen, Ole Højberg, Marlene Fredborg, Stig Purup, Nuria Canibe Frontiers in Microbiology.2023;[Epub] CrossRef
pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs, Marie-Laure Rives The Journal of Pharmacology and Experimental Therapeutics.2023; 386(1): 35. CrossRef
The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis Yu Kyung Jun, Da-Ae Yu, Yoo Min Han, Soo Ran Lee, Seong-Joon Koh, Hyunsun Park Dermatology and Therapy.2023; 13(7): 1465. CrossRef
Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022 Cuilan Huang, Wujuan Hao, Xuyang Wang, Renmin Zhou, Qiong Lin Frontiers in Microbiology.2023;[Epub] CrossRef
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279 Silvana Leit, Jeremy Greenwood, Samantha Carriero, Sayan Mondal, Robert Abel, Mark Ashwell, Heather Blanchette, Nicholas A. Boyles, Mark Cartwright, Alan Collis, Shulu Feng, Phani Ghanakota, Geraldine C. Harriman, Vinayak Hosagrahara, Neelu Kaila, Rosanna Journal of Medicinal Chemistry.2023; 66(15): 10473. CrossRef
Novel Histone Deacetylase 6 Inhibitor Confers Anti-inflammatory Effects and Enhances Gut Barrier Function Jae-Young Lee, Hyun Woo Ma, Ji Hyung Kim, I Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon Gut and Liver.2023; 17(5): 766. CrossRef
Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease Kwang Woo Kim, Hyoun Woo Kang Intestinal Research.2023; 21(4): 413. CrossRef
Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn’s Disease Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I Seul Park, Jae Hee Cheon, Duk Hwan Kim Gut and Liver.2023; 17(6): 905. CrossRef
Immortalized Canine Adipose-Derived Mesenchymal Stem Cells Maintain the Immunomodulatory Capacity of the Original Primary Cells Yuyo Yasumura, Takahiro Teshima, Tomokazu Nagashima, Masaki Michishita, Takashi Takano, Yoshiaki Taira, Ryohei Suzuki, Hirotaka Matsumoto International Journal of Molecular Sciences.2023; 24(24): 17484. CrossRef
Animal models of inflammatory bowel disease: category and evaluation indexes Changlin Wen, Dan Chen, Rao Zhong, Xi Peng Gastroenterology Report.2023;[Epub] CrossRef
Recent development in zebrafish model for bioactivity and safety evaluation of natural products Fang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng, Ren-You Gan Critical Reviews in Food Science and Nutrition.2022; 62(31): 8646. CrossRef
Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai Journal of Gastroenterology and Hepatology.2022; 37(1): 81. CrossRef
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1 Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, Chulho Choi, Gabriela Dower, Kathleen A. Farley, Margaret Fleming, Andrew Flick, Richard K. Frisbie, Justin Hall, David Hepworth, Hannah Jones, John D. Knafels, Steve Kortum, Frank E. Lovering, Jo Journal of Medicinal Chemistry.2022; 65(1): 757. CrossRef
Copper oxide nanoparticles synthesized from Trichosanthes kirilowii ameliorates the DSS-induced acute colitis in mice through the suppression of inflammatory responses Xuefeng Jiang, Yu Sun, Tahani Awad Alahmadi, Velu Manikandan, Thamaraiselvan Rengarajan, Yuyang Zhao Journal of King Saud University - Science.2022; 34(3): 101817. CrossRef
Screening and Evaluation of Probiotics for Reducing Intestinal Inflammation 雅君 陈 Hans Journal of Food and Nutrition Science.2022; 11(01): 44. CrossRef
Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress Qian Chen, Ya-Li Zhang, Zi-Wei Zhang, Yu-Jun Chen, Ying-Jue Tang, Dan Qiao, Yan-Cheng Dai, Zhi-Peng Tang, Lu sa Mota da Silva Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef
Reactive Oxygen Species-Responsive Polyether Micelle Nanomaterials for Targeted Treatment of Ulcerative Colitis Xin-Xin Zhao, Shan-Bo Ma, Jin-Peng Wen, Da-Tao Hu, Ju-Shan Gao, Qiao Peng, Yu-Chen Zhang, Jin-Qing Wang, Ke Wang, Xiao-Peng Shi Journal of Biomedical Nanotechnology.2022; 18(1): 120. CrossRef
Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1 Olga Hartwig, Brigitta Loretz, Adrien Nougarede, Dorothée Jary, Eric Sulpice, Xavier Gidrol, Fabrice Navarro, Claus-Michael Lehr Journal of Controlled Release.2022; 345: 646. CrossRef
Asymptomatic sacroiliitis detected by magnetic resonance enterography in patients with Crohn's disease: prevalence, association with clinical data, and reliability among radiologists in a multicenter study of adult and pediatric population Lorenzo Cereser, Giovanni Zancan, Ivan Giovannini, Carmelo Cicciò, Ilaria Tinazzi, Angela Variola, Matteo Bramuzzo, Flora Maria Murru, Marco Marino, Annarita Tullio, Salvatore De Vita, Rossano Girometti, Alen Zabotti Clinical Rheumatology.2022; 41(8): 2499. CrossRef
Update on the epidemiology of inflammatory bowel disease in Asia: where are we now? Sang Hyoung Park Intestinal Research.2022; 20(2): 159. CrossRef
Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice Wenli Huang, Zeyuan Deng, Ling Lu, Yaoming Ouyang, Shuyuan Zhong, Ting Luo, Yawei Fan, Liufeng Zheng Food & Function.2022; 13(10): 5739. CrossRef
Mesenchymal stem cell treatment for enteric neuropathy in the Winnie mouse model of spontaneous chronic colitis Ainsley M. Robinson, Rhian Stavely, Sarah Miller, Rajaraman Eri, Kulmira Nurgali Cell and Tissue Research.2022; 389(1): 41. CrossRef
Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn’s Disease Recurrence Jongwook Yu, Hye Kyung Hyun, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon Gut and Liver.2022; 16(3): 414. CrossRef
Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway Se Lim Kim, Min Woo Shin, Seung Young Seo, Sang Wook Kim Bioscience Reports.2022;[Epub] CrossRef
Ulcerative Colitis and Patient’s Quality of Life, Especially in Early Stage Jung Won Lee Gut and Liver.2022; 16(3): 317. CrossRef
Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function Mijeong Son, I Seul Park, Soochan Kim, Hyun Woo Ma, Ji Hyung Kim, Tae Il Kim, Won Ho Kim, Jaeyong Han, Seung Won Kim, Jae Hee Cheon Frontiers in Immunology.2022;[Epub] CrossRef
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs) Xue Yuan, Yong Chen, Minghai Tang, Yuhan Wei, Mingsong Shi, Yingxue Yang, Yanting Zhou, Tao Yang, Jiang Liu, Kongjun Liu, Dexin Deng, Chufeng Zhang, Lijuan Chen Journal of Medicinal Chemistry.2022; 65(13): 9312. CrossRef
Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang Gut and Liver.2022; 16(4): 555. CrossRef
The Common and Unique Pattern of Microbiome Profiles among Saliva, Tissue, and Stool Samples in Patients with Crohn’s Disease Seung Yong Shin, Sounkou Kim, Ji Won Choi, Sang-Bum Kang, Tae Oh Kim, Geom Seog Seo, Jae Myung Cha, Jaeyoung Chun, Yunho Jung, Jong Pil Im, Ki Bae Bang, Chang Hwan Choi, Soo-Kyung Park, Dong Il Park Microorganisms.2022; 10(7): 1467. CrossRef
Medication Adherence in Korean Patients with Inflammatory Bowel
Disease and Its Associated Factors Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park The Ewha Medical Journal.2022; 45(2): 35. CrossRef
Inflammatory bowel disease in Korea: epidemiology and pathophysiology Jung Won Lee, Chang Soo Eun The Korean Journal of Internal Medicine.2022; 37(5): 885. CrossRef
Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs Soo-Young Na, You Sun Kim The Korean Journal of Internal Medicine.2022; 37(5): 906. CrossRef
Improvement in Medication Adherence after Pharmacist Intervention Is Associated with Favorable Clinical Outcomes in Patients with Ulcerative Colitis Jae Song Kim, Min Jung Geum, Eun Sun Son, Yun Mi Yu, Jae Hee Cheon, Kyeng Hee Kwon Gut and Liver.2022; 16(5): 736. CrossRef
Exploration of Potential Gut Microbiota-Derived Biomarkers to Predict the Success of Fecal Microbiota Transplantation in Ulcerative Colitis: A Prospective Cohort in Korea Gi-Ung Kang, Sowon Park, Yeongyun Jung, Jai J. Jee, Min-Sueng Kim, Seungjun Lee, Dong-Woo Lee, Jae-Ho Shin, Hong Koh Gut and Liver.2022; 16(5): 775. CrossRef
Clinical applications and optimization of patient-derived organoids in intestinal diseases Tae Il Kim Organoid.2022; 2: e22. CrossRef
Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Ge Gut and Liver.2022; 16(6): 907. CrossRef
Comparison between Pediatric Crohn’s Disease and Ulcerative Colitis at Diagnosis in Korea: Results from a Multicenter, Registry-Based, Inception Cohort Study Sowon Park, Ben Kang, Seung Kim, Sujin Choi, Hyo Rim Suh, Eun Sil Kim, Ji Hyung Park, Mi Jin Kim, Yon Ho Choe, Yeoun Joo Lee, Jae Hong Park, Eell Ryoo, Hong Koh, Byung-Ho Choe Gut and Liver.2022; 16(6): 921. CrossRef
Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease Yohei Ohashi Autophagy.2021; 17(12): 3897. CrossRef
Prevention of dextran sulfate sodium-induced mouse colitis by the fungal protein Ling Zhi-8viapromoting the barrier function of intestinal epithelial cells Yu-Huan Chen, Jenn-Yeu Shin, Hsiu-Mei Wei, Chi-Chien Lin, Linda C. H. Yu, Wei-Ting Liao, Dz-Chi Chen, Ching-Liang Chu Food & Function.2021; 12(4): 1639. CrossRef
Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome Sonia Marinho, Matilde Illanes, Javier Ávila-Román, Virginia Motilva, Elena Talero Biomolecules.2021; 11(2): 162. CrossRef
Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease Chufeng Zhang, Wenyan Qi, Yong Li, Minghai Tang, Tao Yang, Kongjun Liu, Yong Chen, Dexin Deng, Mingli Xiang, Lijuan Chen Journal of Medicinal Chemistry.2021; 64(4): 1966. CrossRef
Modeling microbe-host interaction in the pathogenesis of Crohn’s disease Mohamed Ahmed, Amira Metwaly, Dirk Haller International Journal of Medical Microbiology.2021; 311(3): 151489. CrossRef
Therapeutic Effects of Probiotic Minas Frescal Cheese on the Attenuation of Ulcerative Colitis in a Murine Model Bárbara F. Cordeiro, Juliana L. Alves, Giovanna A. Belo, Emiliano R. Oliveira, Marina P. Braga, Sara H. da Silva, Luisa Lemos, Jonas T. Guimarães, Ramon Silva, Ramon S. Rocha, Gwénaël Jan, Yves Le Loir, Marcia Cristina Silva, Mônica Q. Freitas, Erick A. E Frontiers in Microbiology.2021;[Epub] CrossRef
Increased Interleukin-10 Expression by the Inhibition of Ca2+-Activated K+ Channel KCa3.1 in CD4+CD25+ Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model Susumu Ohya, Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito The Journal of Pharmacology and Experimental Therapeutics.2021; 377(1): 75. CrossRef
Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease You-Jung Ha, Hyo Jin Kim, Eugene Lee, Ji Hye Park, Young Soo Park, Yun Jong Lee, Yusuhn Kang, Hyuk Yoon The Korean Journal of Internal Medicine.2021; 36(4): 868. CrossRef
Epithelial Regeneration Ability of Crohn’s Disease Assessed Using Patient-Derived Intestinal Organoids Chansu Lee, Sung-Noh Hong, Eun-Ran Kim, Dong-Kyung Chang, Young-Ho Kim International Journal of Molecular Sciences.2021; 22(11): 6013. CrossRef
Drug delivery to the inflamed intestinal mucosa – targeting technologies and human cell culture models for better therapies of IBD Olga Hartwig, Maryam A. Shetab Boushehri, Karim S. Shalaby, Brigitta Loretz, Alf Lamprecht, Claus-Michael Lehr Advanced Drug Delivery Reviews.2021; 175: 113828. CrossRef
Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational stud Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Chang Sik Yu Stem Cell Research & Therapy.2021;[Epub] CrossRef
Chronic Abdominal Pain in IBD Research Initiative: Unraveling Biological Mechanisms and Patient Heterogeneity to Personalize Treatment and Improve Clinical Outcomes Andrés Hurtado-Lorenzo, Gerard Honig, Sarah Alandra Weaver, Paul B Larkin, Caren Heller Crohn's & Colitis 360.2021;[Epub] CrossRef
Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice Sushmita Negi, Sheetal Saini, Nikunj Tandel, Kiran Sahu, Ravi P.N. Mishra, Rajeev K. Tyagi Cells.2021; 10(8): 1847. CrossRef
Succinate-treated macrophages attenuate dextran sodium sulfate colitis in mice I Seul Park, Mijeong Son, Hyun Woo Ma, Jihyung Kim, Da Hye Kim, Seung Won Kim, Jae Hee Cheon Intestinal Research.2021; 19(3): 349. CrossRef
Treatment of inflammatory bowel diseases: focusing on biologic agents and new therapies Hyo Yeop Song, Geom Seog Seo Journal of the Korean Medical Association.2021; 64(9): 605. CrossRef
Intestinal microbiota and inflammatory bowel diseases Chang Soo Eun Journal of the Korean Medical Association.2021; 64(9): 588. CrossRef
Expression of Th17/Treg Cells in Peripheral Blood and Related Cytokines of Patients with Ulcerative Colitis of Different Syndrome Types and Correlation with the Disease Jianhua Yu, Shu Wang, Hongsheng Yuan, Tingyue Qiao, Miao Bao, Songwen Tan Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
Improving the Efficacy of Mesenchymal Stem/Stromal-Based Therapy for Treatment of Inflammatory Bowel Diseases Mercedes Lopez-Santalla, Marina Inmaculada Garin Biomedicines.2021; 9(11): 1507. CrossRef
EPIDEMIOLOGIC ASPECTS OF INFLAMMATORY BOWEL DISEASE IN THE WESTERN REGION OF MINAS GERAIS STATE Kamila Rosa MARTINS, Joniel Mendes de ARAÚJO, Álefe Cardoso CRUZ, Anderson LUIZ-FERREIRA Arquivos de Gastroenterologia.2021; 58(3): 377. CrossRef
Anti-inflammatory properties of Escherichia coli Nissle 1917 in a murine colitis model Jihye Park, Da Hye Kim, Soochan Kim, Hyun Woo Ma, I Seul Park, Mijeong Son, Ji Hyung Kim, Yoojin Shin, Seung Won Kim, Jae Hee Cheon Intestinal Research.2021; 19(4): 478. CrossRef
Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis Emiko Mizoguchi, Takayuki Sadanaga, Toshiyuki Okada International Journal of Translational Medicine.2021; 1(3): 187. CrossRef
The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability Sarah Stiegeler, Kevin Mercurio, Miruna Alexandra Iancu, Sinéad C. Corr Cells.2021; 10(12): 3358. CrossRef
The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe? Min Zou, Qi-Shan Zeng, Jiao Nie, Jia-Hui Yang, Zhen-Yi Luo, Hua-Tian Gan Frontiers in Immunology.2021;[Epub] CrossRef
Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review Ji Young Chang, Jae Hee Cheon Precision and Future Medicine.2021; 5(4): 151. CrossRef
Genetics and epigenetics of IBD Vito Annese Pharmacological Research.2020; 159: 104892. CrossRef
Secondary causes of inflammatory bowel diseases Yezaz A Ghouri, Veysel Tahan, Bo Shen World Journal of Gastroenterology.2020; 26(28): 3998. CrossRef
High‐dose dietary supplementation with zinc prevents gut inflammation: Investigation of the role of metallothioneins and beyond by transcriptomic and metagenomic studies Benoît Foligné, Fanny George, Annie Standaert, Anne Garat, Sabine Poiret, Véronique Peucelle, Stéphanie Ferreira, Hélène Sobry, Ghaffar Muharram, Anca Lucau‐Danila, Catherine Daniel The FASEB Journal.2020; 34(9): 12615. CrossRef