Intestinal Research

Original Articles

Increased Risk of Asymptomatic Gallstones in Patients With Ulcerative Colitis: Jung Hoon Ha, Young Sook Park, Choon Sik Seon, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Jung Hwan Kim, Jee Hye Han, Yoon Young Jung, Sook Hee Chung; Intest Res 2015;13(2):122-127. Published online April 27, 2015; DOI: https://doi.org/10.5217/ir.2015.13.2.122

Background/Aims

The relationship between Crohn's disease and gallstones is established. However, the prevalence and risk factors for gallstones in patients with ulcerative colitis (UC) are not yet well understood. The aim of this study was to evaluate the prevalence and risk factors of gallstones in patients with UC.

Methods

This study was a retrospective single center study. A total of 87 patients with UC and 261 healthy controls were enrolled. Age, sex, and body mass index were matched. To investigate risk factors, the extent of UC, duration of disease, number of hospital admissions, and number of steroid treatments in patients with UC were evaluated.

Results

The prevalence of gallstones in patients with UC was 13.8%, whereas that in healthy controls was only 3.1% (P<0.001). For patients with UC, patients ≥50 years of age had a 3.6-times higher risk of gallstones compared to that in those <50 years of age, and the difference was statistically significant (odds ratio, 3.60; confidence interval, 1.03-12.61) in univariate analysis. There were no statistically significant disease-related risk factors for gallstones in UC patients.

Conclusions

This is the first study of gallstone prevalence in Korean UC patients. In this study, patients with UC had a higher prevalence of gallstones compared to that in well-matched healthy controls. Age seemed to be a possible risk factor, and more studies are needed. Further prospective, large-scale studies will be required to confirm the risk factors for gallstones in UC patients.

Citations

Citations to this article as recorded by

Prevalence and risk factors of gallstone disease in Korean patients with ulcerative colitis
Kwangwoo Nam, Jae Yong Lee, Sang Hyoung Park, Ha Won Hwang, Ho-Su Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Jin Hwa Park, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Intestinal Research.2025; 23(4): 455. CrossRef
Gallstone burden and risk in Korean patients with ulcerative colitis
Seong Ran Jeon
Intestinal Research.2025; 23(4): 391. CrossRef
Prevalence of Gallstones in Ulcerative Colitis and Crohn’s Disease: A Systematic Review and Meta-Analysis
Mirza M. A Baig, Shayan A Irfan, Anusha Sumbal, Ramish Sumbal, Sanjay Kumar, Junaid Ahmad, Nikhila Gandrakota, Laila Tul Qadar, Maida S Chaudhry, Azka Feroz, Muhammad Sheharyar Warraich
Cureus.2022;[Epub] CrossRef
Comorbidity in children with gallstone disease
S. Yu. Matalaeva, V. A. Shashel
Experimental and Clinical Gastroenterology.2021; 1(1): 89. CrossRef
Gallstone disease in children and comorbiditi
S. Yu. Matalayeva
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2021; 66(3): 34. CrossRef
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
International Journal of Environmental Research and Public Health.2018; 15(3): 513. CrossRef
Gallstone prevalence and risk factors in patients with ulcerative colitis in Korean population
Yo Han Jeong, Kyeong Ok Kim, Ho Chan Lee, Se Hoon Sohn, Jung Woo Lee, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Medicine.2017; 96(31): e7653. CrossRef
The Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis
Cong Dai, Min Jiang, Ming-Jun Sun
American Journal of Gastroenterology.2017; 112(7): 1165. CrossRef
Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R. Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz, John Green
PLOS ONE.2017; 12(10): e0185193. CrossRef

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Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas: Yoon Kyung Song, Young Sook Park, Choon Sik Seon, Hye Jin Lim, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Ji Hyun Lee, Seung Chan Kim; Intest Res 2015;13(1):74-79. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.74

Abstract PDF PubReader

Background/Aims

Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.

Methods

Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.

Results

212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.

Conclusions

This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.

Citations

Citations to this article as recorded by

Association between drinking patterns and advanced colorectal adenomas
Sheng-Yan Lu, Si-Yuan Ding, Li-Yuan Cui, Jia-Yu Li, Xiao-Lei Qin, Xu Liu
World Chinese Journal of Digestology.2025; 33(7): 562. CrossRef
Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia
Kwang Woo Kim, Hyoun Woo Kang, Hosun Yoo, Yukyung Jun, Hyun Jung Lee, Jong Pil Im, Ji Won Kim, Joo Sung Kim, Seong-Joon Koh, Yong Jin Jung, Atsushi Hosui
PLOS ONE.2022; 17(12): e0279242. CrossRef
Value of combined detection of IFOBT, tumor markers, and inflammatory markers in predicting occurrence of advanced colorectal adenoma
Xu Wang, Jing-Yu Zhang, Zhong-Qing Zheng, Tao Wang, Mei-Yu Piao, Heng Liu, Jing Liu, Wen-Tian Liu
World Chinese Journal of Digestology.2021; 29(7): 347. CrossRef
Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly
Shiyu Zhang, Junyong Zhang, Yonghwan Kim, Wangyang Zhang
Healthcare.2021; 9(10): 1400. CrossRef
Associations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study
Doratha A Byrd, Suzanne E Judd, W Dana Flanders, Terryl J Hartman, Veronika Fedirko, Tanya Agurs-Collins, Roberd M Bostick
JNCI Cancer Spectrum.2020;[Epub] CrossRef
Adenoma Characteristics and the Influence of Alcohol and Cigarette Consumption on the Development of Advanced Colorectal Adenomas
Maja Čebohin, Senka Samardžić, Ksenija Marjanović, Martina Tot Vesić, Kristina Kralik, Andreja Bartulić, Dijana Hnatešen
International Journal of Environmental Research and Public Health.2020; 17(22): 8296. CrossRef
Associations of Novel Dietary and Lifestyle Inflammation Scores with Incident, Sporadic Colorectal Adenoma
Doratha A. Byrd, Suzanne Judd, W. Dana Flanders, Terryl J. Hartman, Veronika Fedirko, Roberd M. Bostick
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(11): 2300. CrossRef
Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
The Korean Journal of Internal Medicine.2019; 34(5): 998. CrossRef
Interplay of Liver Disease and Gut Microbiota in the Development of Colorectal Neoplasia
Michael W. Gleeson
Current Treatment Options in Gastroenterology.2019; 17(3): 378. CrossRef
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef
The fecal immunochemical test has high accuracy for detecting advanced colorectal neoplasia before age 50
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive and Liver Disease.2017; 49(5): 557. CrossRef
Risk Factors for False Fecal Immunochemical Test Results in Colorectal Cancer Screening
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef
Sarcopenia is associated with an increased risk of advanced colorectal neoplasia
Youn Su Park, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jae Kyung Lee, Joo Sung Kim, Seong-Joon Koh
International Journal of Colorectal Disease.2017; 32(4): 557. CrossRef
Alcoholic Liver Disease Is Associated with an Increased Risk of Gastric Cancer
Tae Hoon Ha, Byeong Gwan Kim, Donghyong Jeong, Sohee Oh, Won Kim, Yong Jin Jung, Dong Won Ahn, Ji Bong Jeong, Ji Won Kim, Kook Lae Lee, Seong-Joon Koh
Digestive Diseases and Sciences.2017; 62(1): 273. CrossRef
Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Oncotarget.2017; 8(5): 8843. CrossRef
Statin use and the risk of colorectal adenoma: A meta‐analysis
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
Journal of Gastroenterology and Hepatology.2016; 31(11): 1823. CrossRef
Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
Digestive Diseases and Sciences.2016; 61(9): 2694. CrossRef
Metabolic syndrome is a risk factor for adenoma occurrence at surveillance colonoscopy
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Medicine.2016; 95(32): e4454. CrossRef
Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
World Journal of Gastroenterology.2016; 22(10): 2981. CrossRef
Does Low Threshold Value Use Improve Proximal Neoplasia Detection by Fecal Immunochemical Test?
Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(9): 2685. CrossRef
Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
Yoon Suk Jung, Hwanseok Jung, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park, Kyuyong Choi
Journal of Gastroenterology and Hepatology.2016; 31(4): 788. CrossRef
Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?
Martin Floer, Tobias Meister
Digestion.2016; 93(3): 202. CrossRef
Risk Factors for Colorectal Cancer in Thailand
Kirati Poomphakwaen, Supannee Promthet, Krittika Suwanrungruang, Siriporn Kamsa-ard, Surapon Wiangnon
Asian Pacific Journal of Cancer Prevention.2015; 16(14): 6105. CrossRef

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Case Report

Refractory Duodenal Crohn's Disease Successfully Treated with Infliximab: You Lim Kim, Young Sook Park, Eun Kyoung Park, Dae Rim Park, Gyu Sik Choi, Sang Bong Ahn, Seong Hwan Kim, Yun Ju Jo; Intest Res 2014;12(1):66-69. Published online January 28, 2014; DOI: https://doi.org/10.5217/ir.2014.12.1.66

Abstract PDF PubReader

Crohn's disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-year-old man with Crohn's ileocolitis presented to our hospital with right upper quadrant pain. An endoscopy showed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature.

Citations

Citations to this article as recorded by

Duodenal Crohn’s disease: Case report and systematic review
Muniratu Amadu, Jonathan Soldera
World Journal of Methodology.2024;[Epub] CrossRef
An Obscure Presence of Gastroduodenal Involvement in a Newly Diagnosed Ileocolonic Crohn’s Disease Patient
Clive Jude Miranda, Murad Hayatt Ali, Muddasir Ayaz, Yousef Soofi, Thomas Christopher Mahl, Hirotada Akiho
Case Reports in Gastrointestinal Medicine.2022; 2022: 1. CrossRef
Challenges in Crohn's disease: Crohn's disease involving the duodenum
Takayuki Yamamoto, Antonino Spinelli, Paulo Gustavo Kotze
Seminars in Colon and Rectal Surgery.2020; 31(2): 100745. CrossRef
Isolated Severe Stricturing Duodenal Crohn Disease in a Pediatric Patient
Keren L. Appel, Linda Wang, Dong Xi, Vrinda Bhardwaj
JPGN Reports.2020;[Epub] CrossRef
Crohn’s disease of esophagus, stomach and duodenum
Andréa Maia Pimentel, Raquel Rocha, Genoile Oliveira Santana
World Journal of Gastrointestinal Pharmacology and Therapeutics.2019; 10(2): 35. CrossRef
Duodenal Crohn’s Disease
Amy L Lightner
Inflammatory Bowel Diseases.2018; 24(3): 546. CrossRef
The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease
S. R. Brown, N. S. Fearnhead, O. D. Faiz, J. F. Abercrombie, A. G. Acheson, R. G. Arnott, S. K. Clark, S. Clifford, R. J. Davies, M. M. Davies, W. J. P. Douie, M. G. Dunlop, J. C. Epstein, M. D. Evans, B. D. George, R. J. Guy, R. Hargest, A. B. Hawthorne,
Colorectal Disease.2018; 20(S8): 3. CrossRef
The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease
Yoshiki Nomura, Kentaro Moriichi, Mikihiro Fujiya, Toshikatsu Okumura
Clinical Journal of Gastroenterology.2017; 10(4): 289. CrossRef

10,469 View
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8 Crossref

Original Article

Cyclooxgenase-2 Expression in Chronic Inflammatory Bowel Disease: Comparing of Immunohistochemical Stain to Real-time PCR: Young Sook Park, Nam In Kim, Jun Seok Lee, Jeoung Ho Choi, Chae Young Im, Dae Won Jun, Yun Ju Jo, Seung Hwan Kim, Byung Kwan Son, Won Mee Lee, Eun Kyoung Kim; Intest Res 2008;6(2):128-134. Published online December 30, 2008

Abstract PDF: Background/Aims
This study compared the results of cyclooxygenase-2 (COX-2) expression in inflammatory bowel disease and tuberculous colitis as evident by immunochemical staining and real time polymerase chain reaction (PCR). Methods: Patients with ulcerative colitis (n=18), Crohn's disease (n=7), tuberculous colitis (n=7) and 10 normal controls were included. Biopsied colonic mucosa was simultaneously used for immunohistochemical staining and real time PCR. Results: Patients with inflammatory bowel disease and tuberculous colitis showed high COX-2 expression by both methods compared to the normal controls. In Crohn's disease patients, the real time PCR value correlated well staining grade; this correlation was not evident in ulcerative colitis patients. In real time PCR, grossly normal colonic mucosa in ulcerative colitis also showed higher expression of COX-2 than normal mucosa. Conclusions: Real time PCR value of COX-2 is more representative of inflammation state in inflammatory bowel disease than the value from immunohistochemical staining. (Intest Res 2008;6:128-134)

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