Recent studies have identified sprue-like illness associated with the use of the antihypertensive agent olmesartan medoxomil. However, whether this condition is specific to the use of olmesartan or is associated with the use of drugs belonging to the class of “sartans” remains to be clarified. A 45-year-old woman with chronic kidney disease along with hypothyroidism and hypertension presented with chronic diarrhea and significant weight loss. Endoscopy of the upper gastrointestinal tract showed scalloping and grooving of the duodenum, and histopathological examination showed subtotal villous atrophy. She was on telmisartan for hypertension, which was discontinued. Subsequently, diarrhea ameliorated dramatically, and she regained weight. To our knowledge, this is the first study to report telmisartan-associated sprue-like enteropathy. Further, we have reviewed the cases of patients with sprue-like enteropathy caused by valsartan, irbesartan, and eprosartan.

Citations

Citations to this article as recorded by  

• Case Report: Olmesartan-Induced Enteropathy Mimicking Amyloidosis in the Setting of New Multiple Myeloma Diagnosis
  Mohamad Mahdi Osman, Moises Salgado-de la Mora, Rishaan Sharma, Abdelwahab Ahmed, Sima Fansa, Talal Massad, Hussam Kawas, Mohamed El Hag, Vitaliy Rotenberg
  Case Reports in Gastroenterology.2026; 20(1): 210.     CrossRef
• Olmesartan induced gastritis and enteropathy
  Ankur Gupta, Priyanka Jain, Latika Gupta
  Indian Journal of Gastroenterology.2024; 43(3): 684.     CrossRef
• Systematic review: Clinical phenotypes, histopathological features and prognosis of enteropathy due to angiotensin II receptor blockers
  Annalisa Schiepatti, Paolo Minerba, Michele Puricelli, Stiliano Maimaris, Giovanni Arpa, Federico Biagi, David S. Sanders
  Alimentary Pharmacology & Therapeutics.2024; 59(4): 432.     CrossRef
• Olmesartan induced enteropathy affecting the entire gastrointestinal tract: a case report
  N Van Horebeek, R Croes, A Vonck, E Colpaert
  Acta Gastro Enterologica Belgica.2023; 86(1): 95.     CrossRef
• A Case of Sprue-like Enteropathy Associated With Valsartan and Irbesartan
  Seo Yeon Yoo, Jihun Kim, Kee Wook Jung
  Journal of Neurogastroenterology and Motility.2022; 28(2): 327.     CrossRef
• The histological spectrum of ARB‐induced gastritis
  Tanner Storozuk, Ian Brown, Stephen Lagana, Maria Westerhoff, Namrata Setia, John Hart, Lindsay Alpert
  Histopathology.2022; 81(5): 653.     CrossRef
• Severe cases of sprue‐like enteropathy associated with angiotensin receptor blockers other than olmesartan
  Peter Malfertheiner, Chiara Formigoni
  GastroHep.2021; 3(2): 88.     CrossRef
• Telmisartan-induced sprue-like enteropathy: a case report
  Natalia Alzueta, Amaya Echeverría, Lorea Sanz, Carmen Fontela, Teresa Acín, Lidia Montenegro, Javier Garjón
  European Journal of Hospital Pharmacy.2020; 27(1): 49.     CrossRef
• Olmesartan Associated Enteropathy: Usefulness of Video Capsule Endoscopy in a Case With Doubtful Upper Endoscopic/Histological Picture
  Francesco Abbruzzi, Ilaria Loconte, Sonia Carparelli, Enzo Ierardi, Alfredo Di Leo, Mariabeatrice Principi
  Current Drug Safety.2020; 15(1): 65.     CrossRef
• Traitement par olmésartan et entéropathie : à propos de deux cas et revue de la littérature
  A. Sadki, M. Le Besnerais, F. Héron, I. Marie
  La Revue de Médecine Interne.2019; 40(2): 112.     CrossRef
• A simple treatment for a potentially life-threatening cause of malabsorption
  Mattia Bonzi, Elisa M. Fiorelli, Gaia Montanelli, Ludovico Furlan, Monica Solbiati
  Internal and Emergency Medicine.2019; 14(6): 967.     CrossRef
• Angiotensin II receptor blockers and gastrointestinal adverse events of resembling sprue-like enteropathy: a systematic review
  Ayesha Kamal, Christopher Fain, Angela Park, Peiqi Wang, Eduardo Gonzalez-Velez, Daniel A Leffler, Susan M Hutfless
  Gastroenterology Report.2019; 7(3): 162.     CrossRef
• Association of sprue-like enteropathy and angiotensin receptor-1 antagonists
  René R. Wenzel, Christian Datz
  Wiener klinische Wochenschrift.2019; 131(19-20): 493.     CrossRef
• Severe intestinal malabsorption associated with ACE inhibitor or angiotensin receptor blocker treatment. An observational cohort study in Germany and Italy
  Peter Malfertheiner, Claudio Ripellino, Nazarena Cataldo
  Pharmacoepidemiology and Drug Safety.2018; 27(6): 581.     CrossRef