Intestinal Research

Original Articles

Increased Risk of Asymptomatic Gallstones in Patients With Ulcerative Colitis: Jung Hoon Ha, Young Sook Park, Choon Sik Seon, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Jung Hwan Kim, Jee Hye Han, Yoon Young Jung, Sook Hee Chung; Intest Res 2015;13(2):122-127. Published online April 27, 2015; DOI: https://doi.org/10.5217/ir.2015.13.2.122

Background/Aims

The relationship between Crohn's disease and gallstones is established. However, the prevalence and risk factors for gallstones in patients with ulcerative colitis (UC) are not yet well understood. The aim of this study was to evaluate the prevalence and risk factors of gallstones in patients with UC.

Methods

This study was a retrospective single center study. A total of 87 patients with UC and 261 healthy controls were enrolled. Age, sex, and body mass index were matched. To investigate risk factors, the extent of UC, duration of disease, number of hospital admissions, and number of steroid treatments in patients with UC were evaluated.

Results

The prevalence of gallstones in patients with UC was 13.8%, whereas that in healthy controls was only 3.1% (P<0.001). For patients with UC, patients ≥50 years of age had a 3.6-times higher risk of gallstones compared to that in those <50 years of age, and the difference was statistically significant (odds ratio, 3.60; confidence interval, 1.03-12.61) in univariate analysis. There were no statistically significant disease-related risk factors for gallstones in UC patients.

Conclusions

This is the first study of gallstone prevalence in Korean UC patients. In this study, patients with UC had a higher prevalence of gallstones compared to that in well-matched healthy controls. Age seemed to be a possible risk factor, and more studies are needed. Further prospective, large-scale studies will be required to confirm the risk factors for gallstones in UC patients.

Citations

Citations to this article as recorded by

Prevalence and risk factors of gallstone disease in Korean patients with ulcerative colitis
Kwangwoo Nam, Jae Yong Lee, Sang Hyoung Park, Ha Won Hwang, Ho-Su Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Jin Hwa Park, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Intestinal Research.2025; 23(4): 455. CrossRef
Gallstone burden and risk in Korean patients with ulcerative colitis
Seong Ran Jeon
Intestinal Research.2025; 23(4): 391. CrossRef
Prevalence of Gallstones in Ulcerative Colitis and Crohn’s Disease: A Systematic Review and Meta-Analysis
Mirza M. A Baig, Shayan A Irfan, Anusha Sumbal, Ramish Sumbal, Sanjay Kumar, Junaid Ahmad, Nikhila Gandrakota, Laila Tul Qadar, Maida S Chaudhry, Azka Feroz, Muhammad Sheharyar Warraich
Cureus.2022;[Epub] CrossRef
Comorbidity in children with gallstone disease
S. Yu. Matalaeva, V. A. Shashel
Experimental and Clinical Gastroenterology.2021; 1(1): 89. CrossRef
Gallstone disease in children and comorbiditi
S. Yu. Matalayeva
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2021; 66(3): 34. CrossRef
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
International Journal of Environmental Research and Public Health.2018; 15(3): 513. CrossRef
Gallstone prevalence and risk factors in patients with ulcerative colitis in Korean population
Yo Han Jeong, Kyeong Ok Kim, Ho Chan Lee, Se Hoon Sohn, Jung Woo Lee, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Medicine.2017; 96(31): e7653. CrossRef
The Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis
Cong Dai, Min Jiang, Ming-Jun Sun
American Journal of Gastroenterology.2017; 112(7): 1165. CrossRef
Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R. Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz, John Green
PLOS ONE.2017; 12(10): e0185193. CrossRef

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Vaccination and Complementary and Alternative Medicine in Patients with Inflammatory Bowel Disease: Sung Bae Kim, Soo Jung Park, Sook Hee Chung, Kyu Yeon Hahn, Do Chang Moon, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, Won Ho Kim; Intest Res 2014;12(2):124-130. Published online April 29, 2014; DOI: https://doi.org/10.5217/ir.2014.12.2.124

Abstract PDF PubReader

Background/Aims

Vaccinations in patients with inflammatory bowel disease (IBD) are recommended to prevent infectious diseases. However, there are few reports of vaccination in IBD patients in Korea. The frequency of complementary and alternative medicine (CAM) use is high despite its uncertain effectiveness. This study aimed to identify the rates of vaccination and use of CAM in patients with IBD.

Methods

A total of 219 patients attended an education session for IBD patients held at Severance Hospital on March 23, 2013. We conducted a survey on vaccination and CAM use in IBD patients; 120 patients completed the questionnaire.

Results

The influenza vaccination rate was 44.2% and pneumococcal vaccination rate was 4.2%. Thirty-one (66%) patients were aware of the importance of vaccination. The vaccination rate was higher in patients who were aware of the importance of vaccination compared with that in patients who were unaware of the importance of vaccination (70.1% vs. 41.7%, P=0.004). The rate of CAM use was 30.0%. The most commonly used CAMs were oral products: vitamins (33.3%), red ginseng (25.0%), and probiotics (19.4%).

Conclusions

Awareness of the importance of vaccination and actual vaccination rates were low in IBD patients. Despite insufficient evidence on the effectiveness of CAMs in IBD patients, many patients used CAMs. We believe that repeated education and promotion of vaccination are important. Further large-scale studies to investigate the efficacy and safety of CAMs are warranted in patients with IBD.

Citations

Citations to this article as recorded by

Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study
Joo Kyung Kim, Jae Hee Cheon
Journal of Yeungnam Medical Science.2023; 40(1): 37. CrossRef
Adherence to Recommended Immunization Schedules in Patients with Inflammatory Bowel Disease on Biologics and Small Molecule Therapies
Mohammad Shehab, Ranim Almatar, Rawan Almohammad, Ahmad Alfadhli
Gastroenterology Insights.2023; 14(3): 383. CrossRef
SARS-CoV-2 vaccination for adult patients with inflammatory bowel disease: expert consensus statement by KASID
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
Intestinal Research.2022; 20(2): 171. CrossRef
Vaccinations and inflammatory bowel disease – a systematic review
Webber Chan, Ennaliza Salazar, Teong Guan Lim, Wan Chee Ong, Hang Hock Shim
Digestive and Liver Disease.2021; 53(9): 1079. CrossRef
SARS-CoV-2 Vaccination for Adult Patients with Inflammatory Bowel Disease: Expert Consensus Statements by KASID
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
The Korean Journal of Gastroenterology.2021; 78(2): 117. CrossRef
A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease
Lin Yang, Hua Luo, Dechao Tan, Siyuan Zhang, Zhangfeng Zhong, Shengpeng Wang, Chi Teng Vong, Yitao Wang
Phytomedicine.2021; 92: 153709. CrossRef
Insufficient vaccination and inadequate immunization rates among Korean patients with inflammatory bowel diseases
Han Hee Ryu, Kiju Chang, Nayoung Kim, Ho-Su Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Medicine.2021; 100(45): e27714. CrossRef
Complementary and alternative medicine in patients with inflammatory bowel disease: hype or evidence?
Jae Myung Cha
Intestinal Research.2020; 18(2): 141. CrossRef
Complementary and Alternative Medicine Use in Children With Inflammatory Bowel Disease
Uma P. Phatak, Arik Alper, Dinesh S. Pashankar
Journal of Pediatric Gastroenterology and Nutrition.2019; 68(2): 157. CrossRef
Prevalence and indicators of use of complementary and alternative medicine in Austrian patients with inflammatory bowel disease
Hans Peter Gröchenig, Thomas Waldhör, Thomas Haas, Heimo Wenzl, Pius Steiner, Robert Koch, Thomas Feichtenschlager, Gerald Eckhardt, Andreas Mayer, Andreas Kirchgatterer, Othmar Ludwiczek, Reingard Platzer, Pavol Papay, Johanna Gartner, Harry Fuchssteiner
European Journal of Gastroenterology & Hepatology.2019; 31(10): 1211. CrossRef
The who-when-why triangle of complementary and alternative medicine use among Portuguese IBD patients
Francisco Portela, Camila C. Dias, Paulo Caldeira, Marilia Cravo, João Deus, Raquel Gonçalves, Paula Lago, Henrique Morna, Paula Peixe, Jaime Ramos, Helena Sousa, Lurdes Tavares, Helena Vasconcelos, Fernando Magro, Paula Ministro
Digestive and Liver Disease.2017; 49(4): 388. CrossRef
Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
Molecular Medicine Reports.2017; 16(6): 9224. CrossRef
Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake
Gurtej Malhi, Amir Rumman, Reka Thanabalan, Kenneth Croitoru, Mark S. Silverberg, A. Hillary Steinhart, Geoffrey C. Nguyen
Journal of Crohn's and Colitis.2015; 9(6): 439. CrossRef
Ideal Vaccination Strategy in Inflammatory Bowel Disease
Chang Kyun Lee
The Korean Journal of Gastroenterology.2015; 65(3): 159. CrossRef

8,601 View
83 Download
14 Web of Science
14 Crossref

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