Intestinal Research

Letters to the Editor

Miscellaneous

JAK inhibitor, a new player for treatment-refractory microscopic colitis: Anne Druez, Simon Travis, Jean-François Rahier; Intest Res 2023;21(3):411-412. Published online July 4, 2023; DOI: https://doi.org/10.5217/ir.2023.00030

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Endoscopic findings of immune checkpoint inhibitor-related gastrointestinal adverse events
Min Kyu Kim, Sung Wook Hwang
Clinical Endoscopy.2024; 57(6): 725. CrossRef

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108 Download
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Review

IBD

Artificial intelligence in inflammatory bowel disease: implications for clinical practice and future directions: Harris A. Ahmad, James E. East, Remo Panaccione, Simon Travis, James B. Canavan, Keith Usiskin, Michael F. Byrne; Intest Res 2023;21(3):283-294. Published online April 20, 2023; DOI: https://doi.org/10.5217/ir.2023.00020

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Inflammatory bowel disease encompasses Crohn’s disease and ulcerative colitis and is characterized by uncontrolled, relapsing, and remitting course of inflammation in the gastrointestinal tract. Artificial intelligence represents a new era within the field of gastroenterology, and the amount of research surrounding artificial intelligence in patients with inflammatory bowel disease is on the rise. As clinical trial outcomes and treatment targets evolve in inflammatory bowel disease, artificial intelligence may prove as a valuable tool for providing accurate, consistent, and reproducible evaluations of endoscopic appearance and histologic activity, thereby optimizing the diagnosis process and identifying disease severity. Furthermore, as the applications of artificial intelligence for inflammatory bowel disease continue to expand, they may present an ideal opportunity for improving disease management by predicting treatment response to biologic therapies and for refining the standard of care by setting the basis for future treatment personalization and cost reduction. The purpose of this review is to provide an overview of the unmet needs in the management of inflammatory bowel disease in clinical practice and how artificial intelligence tools can address these gaps to transform patient care.

Citations

Citations to this article as recorded by

Deep Learning Model Using Stool Pictures for Predicting Endoscopic Mucosal Inflammation in Patients With Ulcerative Colitis
Jung Won Lee, Dongwon Woo, Kyeong Ok Kim, Eun Soo Kim, Sung Kook Kim, Hyun Seok Lee, Ben Kang, Yoo Jin Lee, Jeongseok Kim, Byung Ik Jang, Eun Young Kim, Hyeong Ho Jo, Yun Jin Chung, Hanjun Ryu, Soo-Kyung Park, Dong-Il Park, Hosang Yu, Sungmoon Jeong
American Journal of Gastroenterology.2025; 120(1): 213. CrossRef
The Histological Detection of Ulcerative Colitis Using a No-Code Artificial Intelligence Model
Yuichiro Hamamoto, Michihiro Kawamura, Hiroki Uchida, Kazuhiro Hiramatsu, Chiaki Katori, Hinako Asai, Shigeki Shimizu, Satoshi Egawa, Kyotaro Yoshida
International Journal of Surgical Pathology.2024; 32(5): 890. CrossRef
Could histologic healing be a new treatment target in patients with ulcerative colitis?
Soyoung Kim, Sang Hyoung Park
The Korean Journal of Internal Medicine.2024; 39(1): 2. CrossRef
Machine learning in the assessment and management of acute gastrointestinal bleeding
Gaurav Bhaskar Nigam, Michael F Murphy, Simon P L Travis, Adrian J Stanley
BMJ Medicine.2024; 3(1): e000699. CrossRef
The Role of Artificial Intelligence in the Diagnosis and Treatment of Ulcerative Colitis
Petar Uchikov, Usman Khalid, Nikola Vankov, Maria Kraeva, Krasimir Kraev, Bozhidar Hristov, Milena Sandeva, Snezhanka Dragusheva, Dzhevdet Chakarov, Petko Petrov, Bistra Dobreva-Yatseva, Ivan Novakov
Diagnostics.2024; 14(10): 1004. CrossRef
Artificial intelligence and endo-histo-omics: new dimensions of precision endoscopy and histology in inflammatory bowel disease
Marietta Iacucci, Giovanni Santacroce, Irene Zammarchi, Yasuharu Maeda, Rocío Del Amor, Pablo Meseguer, Bisi Bode Kolawole, Ujwala Chaudhari, Antonio Di Sabatino, Silvio Danese, Yuichi Mori, Enrico Grisan, Valery Naranjo, Subrata Ghosh
The Lancet Gastroenterology & Hepatology.2024; 9(8): 758. CrossRef
Summary of the best evidence on self-management support schemes for patients with inflammatory bowel disease based on mobile health systems
Chenfei Ren, Yunxian Zhou, Qian Cai, Mi Zhou
DIGITAL HEALTH.2024;[Epub] CrossRef
Deep Learning-Based Real-Time Organ Localization and Transit Time Estimation in Wireless Capsule Endoscopy
Seung-Joo Nam, Gwiseong Moon, Jung-Hwan Park, Yoon Kim, Yun Jeong Lim, Hyun-Soo Choi
Biomedicines.2024; 12(8): 1704. CrossRef
The Role of Artificial Intelligence and Big Data for Gastrointestinal Disease
Nicholas Mathew Holt, Michael Francis Byrne
Gastrointestinal Endoscopy Clinics of North America.2024;[Epub] CrossRef
Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD
Rodrigo V Motta, Vipin Gupta, Karen Hartery, Paul Bassett, Simon J Leedham, Roger W Chapman, Simon PL Travis, Emma L Culver, James E. East
Endoscopy International Open.2024; 12(11): E1285. CrossRef
Potential Oral Microbial Markers for Differential Diagnosis of Crohn’s Disease and Ulcerative Colitis Using Machine Learning Models
Sang-Bum Kang, Hyeonwoo Kim, Sangsoo Kim, Jiwon Kim, Soo-Kyung Park, Chil-Woo Lee, Kyeong Ok Kim, Geom-Seog Seo, Min Suk Kim, Jae Myung Cha, Ja Seol Koo, Dong-Il Park
Microorganisms.2023; 11(7): 1665. CrossRef

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Original Article

Inflammatory bowel diseases

Real-time data monitoring for ulcerative colitis: patient perception and qualitative analysis: Alissa Walsh, Lawrence Matini, Christopher Hinds, Vanashree Sexton, Oliver Brain, Satish Keshav, John Geddes, Guy Goodwin, Gary Collins, Simon Travis, Michele Peters; Intest Res 2019;17(3):365-374. Published online May 31, 2019; DOI: https://doi.org/10.5217/ir.2018.00173

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Background/Aims
TrueColours ulcerative colitis (TCUC) is a comprehensive web-based program that functions through email, providing direct links to questionnaires. Several similar programs are available, however patient perspectives are unexplored.
Methods
A pilot study was conducted to determine feasibility, usability and patient perceptions of real-time data collection (daily symptoms, fortnightly quality of life, 3 monthly outcomes). TCUC was adapted from a web-based program for patients with relapsing-remitting bipolar disorder, using validated UC indices. A semi-structured interview was developed and audio-recorded face-to-face interviews were conducted after 6 months of interaction with TCUC. Transcripts were coded in NVivo11, a qualitative data analysis software package. An inductive approach and thematic analysis was conducted.
Results
TCUC was piloted in 66 patients for 6 months. Qualitative analysis currently defies statistical appraisal beyond “data saturation,” even if it has more influence on clinical practice than quantitative data. A total of 28 face-to-face interviews were conducted. Six core themes emerged: awareness, control, decision-making, reassurance, communication and burden of treatment. There was a transcending overarching theme of patient empowerment, which cut across all aspects of the TCUC experience.
Conclusions
Patient perception of the impact of real-time data collection was extremely positive. Patients felt empowered as a product of the self-monitoring format of TCUC, which may be a way of improving self-management of UC whilst also decreasing the burden on the individual and healthcare services.

Citations

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Investigating Patient Perspectives on Using eHealth Technologies for the Self-Management of Inflammatory Bowel Disease: Mixed Methods Study
Sander Hermsen, Danielle Tump, Eva Wentink, Marjolijn Duijvestein
Journal of Medical Internet Research.2024; 26: e53512. CrossRef
The body as an obstacle and the “other”. How patients with chronic inflammatory bowel diseases view their body, self and the good life
Anke Erdmann, Christoph Rehmann-Sutter, Florian Schrinner, Claudia Bozzaro
BMC Medical Ethics.2024;[Epub] CrossRef
Development of the Escalation of Therapy or Intervention (ETI) Calculator for Patients with Ulcerative Colitis Using ePROMs
Lawrence Matini, Thomas P Chapman, Ramona Kantschuster, Jean Wilson, Adib Tarafdar, Moheez Hussain, Kaiyang Song, Daniel M Simadibrata, Pavetha Seeva, Lydia White, Jessica Slater, Andrey Kormilitzin, Gary Collins, Simon P L Travis, Alissa Walsh
Journal of Crohn's and Colitis.2023; 17(11): 1744. CrossRef
Deep learning model for distinguishing Mayo endoscopic subscore 0 and 1 in patients with ulcerative colitis
Ji Eun Kim, Yoon Ho Choi, Yeong Chan Lee, Gyeol Seong, Joo Hye Song, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Soo-Yong Shin
Scientific Reports.2023;[Epub] CrossRef
Patient-reported Outcomes: the ICHOM Standard Set for Inflammatory Bowel Disease in Real-life Practice Helps Quantify Deficits in Current Care
Darren Wong, Lawrence Matini, Andrey Kormilitzin, Ramona Kantschuster, Daniel Martin Simadibrata, Sara Lyden, Jean Wilson, Oliver A Brain, Rebecca Palmer, Tim Ambrose, Jack Satsangi, Matthew South, John Geddes, Keith Bodger, Simon P L Travis, Alissa Walsh
Journal of Crohn's and Colitis.2022; 16(12): 1874. CrossRef
Analysis of the Current Situation of Teaching and Learning of Ideological and Political Theory Courses by Deep Learning
Jin Chao, Yijiang Zhang, Arpit Bhardwaj
Computational Intelligence and Neuroscience.2022; 2022: 1. CrossRef
Ulcerative Colitis Narrative Global Survey Findings: Communication Gaps and Agreements Between Patients and Physicians
David T Rubin, Ailsa Hart, Remo Panaccione, Alessandro Armuzzi, Ulla Suvanto, J Jasper Deuring, John Woolcott, Joseph C Cappelleri, Kathy Steinberg, Laura Wingate, Stefan Schreiber
Inflammatory Bowel Diseases.2021; 27(7): 1096. CrossRef
Telehealth and mobile health interventions in adults with inflammatory bowel disease: A mixed‐methods systematic review
Suja P. Davis, Megan Suzanne Hardin Ross, Reuben Adatorwovor, Holly Wei
Research in Nursing & Health.2021; 44(1): 155. CrossRef
COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
Richard H. Hunt, James E. East, Angel Lanas, Peter Malfertheiner, Jack Satsangi, Carmelo Scarpignato, Gwilym J. Webb
Digestive Diseases.2021; 39(2): 119. CrossRef
The True Colours Remote Symptom Monitoring System: A Decade of Evolution
Sarah M Goodday, Lauren Atkinson, Guy Goodwin, Kate Saunders, Matthew South, Clare Mackay, Mike Denis, Chris Hinds, Mary-Jane Attenburrow, Jim Davies, James Welch, William Stevens, Karen Mansfield, Juulia Suvilehto, John Geddes
Journal of Medical Internet Research.2020; 22(1): e15188. CrossRef
Developments and challenges of e-health strategies for people with inflammatory bowel disease
Pearl Avery
British Journal of Healthcare Management.2020; 26(3): 73. CrossRef
Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases
Jung Min Kim, Jae Hee Cheon
Intestinal Research.2020; 18(3): 249. CrossRef
The UK IBD Registry COVID-19 Risk Tool; Patient Generated Data Can Improve the Hospital Record
Nicholas A. Kennedy, Naila Arebi, Keith Bodger, Vida Cairnes, R. Fraser Cummings, Liz Dobson, Stephen Grainger, Paul Harrow, A. Barney Hawthorne, Gareth-Rhys Jones, Alexandra Kent, Shaji Sebastian, Christian Selinger, Gareth J. Walker, Lisa Younge, Stuart
SSRN Electronic Journal .2020;[Epub] CrossRef

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Reviews

IBD

Improving the quality of care for inflammatory bowel disease: Byong Duk Ye, Simon Travis; Intest Res 2019;17(1):45-53. Published online November 20, 2018; DOI: https://doi.org/10.5217/ir.2018.00113

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Great strides have been achieved in the development of quality-of-care measures and standards for inflammatory bowel disease (IBD) over the last decade. The central structural component of care in IBD revolves around the multidisciplinary team, which should be equipped with the necessary resources to operate and implement decisions. Process measures have been defined by interest groups and can be adapted into process tools for the delivery of care for various patient subgroups and clinical scenarios. The emerging treat-to-target approach to IBD management may be used to achieve optimal long-term and holistic patient-centred outcomes, such as survival, control of inflammation and disease progression, symptomatic remission, quality of life and complications. Other important quality-of-care outcome measures for IBD include disutility of care, healthcare utilization and other patient-reported outcomes such as nutritional status and impact of fistulae. The current challenge for healthcare providers and health systems is the integration of quality-of-care structures and processes into clinical practice, and the consistent delivery of updated evidence-based quality IBD care to various patient populations by individual health care providers. Finally, the awareness and appreciation for quality of care in IBD is increasing in Asia, and Asian healthcare institutions should be encouraged to take the lead in improving the quality of care in IBD.

Citations

Citations to this article as recorded by

Improving access to inflammatory bowel disease care in Canada: The patient experience
Shehzeen Lalani, Holly Mathias, Courtney Heisler, Noelle Rohatinsky, Raza M Mirza, Olga Kits, Sandra Zelinsky, Geoffrey Nguyen, Peter L Lakatos, Sharyle Fowler, Kevin Rioux, Jennifer L Jones
Journal of Health Services Research & Policy.2025; 30(1): 12. CrossRef
Identification and prioritization of patient-centred strategies to enhance IBD-related care for older adults: a modified Delphi approach
Noelle Rohatinsky, Natasha Tooke, Sharyle Fowler, Christian Rueda-Clausen, Dirk Morrison, Judith Winchester, Juan-Nicolás Peña-Sánchez
Journal of the Canadian Association of Gastroenterology.2024; 7(5): 384. CrossRef
Person-Centered Coordinated Care Experience of People With Long-Term Conditions in the Balearic Islands Measured by the P3CEQ
Gabriel Mercadal-Orfila, Salvador Herrera-Pérez, Núria Piqué, Francesc Mateu-Amengual, Pedro Ventayol-Bosch, Maria Antonia Maestre-Fullana, Joaquin Ignacio Serrano-López de las Hazas, Francisco Fernández-Cortés, Francesc Barceló- Sansó, Santiago Rios
Health Services Insights.2024;[Epub] CrossRef
Empowering inflammatory bowel disease patients with at-home remote disease and therapeutic drug monitoring
Graham Johnson
Gastrointestinal Nursing.2024; 22(7): 337. CrossRef
Holistic healthcare in inflammatory bowel disease: time for patient-centric approaches?
Padhmanand Sudhakar, Judith Wellens, Bram Verstockt, Marc Ferrante, João Sabino, Séverine Vermeire
Gut.2023; 72(1): 192. CrossRef
The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission
Johan Burisch, Mirabella Zhao, Selwyn Odes, Peter De Cruz, Severine Vermeire, Charles N Bernstein, Gilaad G Kaplan, Dana Duricova, Dan Greenberg, Hans O Melberg, Mamoru Watanabe, Hyeong Sik Ahn, Laura Targownik, Valérie E H Pittet, Vito Annese, KT Park, K
The Lancet Gastroenterology & Hepatology.2023; 8(5): 458. CrossRef
The 2023 Impact of Inflammatory Bowel Disease in Canada: Access to and Models of Care
Holly Mathias, Noelle Rohatinsky, Sanjay K Murthy, Kerri Novak, M Ellen Kuenzig, Geoffrey C Nguyen, Sharyle Fowler, Eric I Benchimol, Stephanie Coward, Gilaad G Kaplan, Joseph W Windsor, Charles N Bernstein, Laura E Targownik, Juan-Nicolás Peña-Sánchez, K
Journal of the Canadian Association of Gastroenterology.2023; 6(Supplement): S111. CrossRef
Der IBD-Control-Fragebogen: Deutsche Übertragung und Validierung des standardisierten Fragebogens zur Messung des Outcomes aus Patientensicht bei chronisch entzündlichen Darmerkrankungen
Annabell Müller, Selina Simone Bilger, Andreas Göldi, Gunther Meinlschmidt, Florian Rueter, Alexander Kappes, Petr Hruz, Christoph Andreas Meier, Jan Hendrik Niess
Zeitschrift für Gastroenterologie.2022; 60(06): 911. CrossRef
High Risk of Fractures Within 7 Years of Diagnosis in Asian Patients With Inflammatory Bowel Diseases
Hyung Jin Ahn, Ye-Jee Kim, Ho-Su Lee, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beom-Jun Kim, Sang Hyoung Park
Clinical Gastroenterology and Hepatology.2022; 20(5): e1022. CrossRef
Appendiceal Orifice Inflammation Is Associated with Lower Rate of Complete Endoscopic Remission in Patients with Ulcerative Colitis
Chang Kyo Oh, Han Hee Lee, Jin Su Kim, Bo-In Lee, Young-Seok Cho
Journal of Personalized Medicine.2022; 12(5): 748. CrossRef
Risk of Hepatitis B Virus (HBV) Reactivation in Patients with Immune-Mediated Inflammatory Diseases Receiving Biologics: Focus on the Timing of Biologics after Anti-HBV Treatment
Soo Min Ahn, Jonggi Choi, Byong Duk Ye, Suk-Kyun Yang, Ji Seon Oh, Yong‑Gil Kim, Chang-Keun Lee, Bin Yoo, Sang Hyoung Park, Seokchan Hong
Gut and Liver.2022; 16(4): 567. CrossRef
Clinical Remission and Psychological Management are Major Issues for the Quality of Life in Pediatric Crohn Disease
Anne Gourdonneau, Léa Bruneau, Frank M. Ruemmele, Lorenzo Norsa, Armelle Takeda, Catherine Le Gall, Haude Clouzeau, Laurent Rebouissoux, Alain Dabadie, Laure Bridoux‐Henno, Julie Rebeuh, Nadège Thomassin, Jérôme Viala, Stéphanie Willot, Anne Breton, Stéph
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Trends in hospitalizations and mortality for inflammatory bowel disease from a nationwide database study between 2008 and 2018
Asim Kichloo, Zain El-amir, Dushyant Singh Dahiya, Farah Wani, Hafeez Shaka
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Classification According to Subjectivity of Inflammatory Bowel Disease Patients Using Q Methodology
Jun Lee
The Korean Journal of Gastroenterology.2021; 78(1): 1. CrossRef
Subjective Needs and Thoughts for the Treatment of Patients with Inflammatory Bowel Disease: Applying Q Methodology
Yong Eun Park, Jin Lee, Jongha Park, Joon Hyuk Choi, Nae Yun Heo, Seung Ha Park, Yoon Kyoung Lee, Tae Oh Kim
The Korean Journal of Gastroenterology.2021; 78(1): 37. CrossRef
Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management
Jihye Park, Sinyoung Park, Shin Ae Lee, Soo Jung Park, Jae Hee Cheon
The Korean Journal of Internal Medicine.2021; 36(5): 1040. CrossRef
Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park
BMC Gastroenterology.2021;[Epub] CrossRef
Prevention and management of viral hepatitis in inflammatory bowel disease: a clinical practice guideline by the Korean Association for the Study of Intestinal Diseases
Soo-Kyung Park, Chang Hwan Choi, Jaeyoung Chun, Heeyoung Lee, Eun Sun Kim, Jae Jun Park, Chan Hyuk Park, Bo-In Lee, Yunho Jung, Dong-Il Park, Do Young Kim, Hana Park, Yoon Tae Jeen
Intestinal Research.2020; 18(1): 18. CrossRef
Nationwide improvement in outcomes of emergency admission for ulcerative colitis in England, 2005‐2013
Mustafa Shawihdi, Susanna Dodd, Constantinos Kallis, Pete Dixon, Ruth Grainger, Stuart Bloom, Fraser Cummings, Mike Pearson, Keith Bodger
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IBD

What's app? Electronic health technology in inflammatory bowel disease: Alissa Walsh, Simon Travis; Intest Res 2018;16(3):366-373. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.366

Abstract PDF PubReader ePub

Electronic health (eHealth) data collection is increasingly used in many chronic illnesses, to track pattern of disease. eHealth systems have the potential to revolutionize care. Inflammatory bowel disease (IBD) is a paradigm for such an approach: this is a chronic disease that usually affects young and technologically literate patient population, who are motivated to be involved in their own care. A range of eHealth technologies are available for IBD. This review considers the strengths and weaknesses of 7 platforms that focus on patient-provider interaction. These have been developed in Denmark, United States, the Netherlands, and the United Kingdom, demonstrating an international interest in this form of technology and interaction. Not only do these technologies aim to improve care but they also have the potential to collect large amounts of information. Information includes demographics and patient reported outcomes (symptoms, quality of life), quality of care (steroid use, among other metrics) and outcomes such as hospitalization. These data could inform quality improvement programmes to improve their focus. eHealth technology is also open to machine learning to analyze large data sets, through which personalized algorithms may be developed.

Citations

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Validation of the IBD-Control Questionnaire across different sociodemographic and clinical subgroups: secondary analysis of a nationwide electronic survey
Gerum G Gebeyehu, Frederick Taylor, Liz Dobson, J R Fraser Cummings, Stuart Bloom, Nicholas A Kennedy, Paul Christiansen, Keith Bodger
Journal of Crohn's and Colitis.2024; 18(2): 275. CrossRef
Investigating Patient Perspectives on Using eHealth Technologies for the Self-Management of Inflammatory Bowel Disease: Mixed Methods Study
Sander Hermsen, Danielle Tump, Eva Wentink, Marjolijn Duijvestein
Journal of Medical Internet Research.2024; 26: e53512. CrossRef
How can pharmacists better support patients with chronic diseases? The patient perspective
Lakesha Butler, Steven Zona, Aarti A. Patel, Christine Brittle, Lisa Shea
Journal of the American Pharmacists Association.2023; 63(6): 1776. CrossRef
Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives
Konstantinos Papamichael, Waqqas Afif, David Drobne, Marla C Dubinsky, Marc Ferrante, Peter M Irving, Nikolaos Kamperidis, Taku Kobayashi, Paulo G Kotze, Jo Lambert, Nurulamin M Noor, Xavier Roblin, Giulia Roda, Niels Vande Casteele, Andres J Yarur, Naila
The Lancet Gastroenterology & Hepatology.2022; 7(2): 171. CrossRef
Telemedicine based on patient-reported outcomes in management of patients with inflammatory bowel disease in a real-life setting – a before and after cohort study
Charlotte W. Appel, Sarah Christine Pedersen, Amalie Søgaard Nielsen, Birgit Furstrand Larsen
Scandinavian Journal of Gastroenterology.2022; 57(7): 825. CrossRef
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Amalie Søgaard Nielsen, Lisa Hanna, Birgit Furstrand Larsen, Charlotte W Appel, Richard H Osborne, Lars Kayser
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The International Association of Dental Traumatology ToothSOS mobile app: A 2‐year report
Anahat Khehra, Nestor Cohenca, Zafer C. Cehreli, Liran Levin
Dental Traumatology.2021; 37(1): 145. CrossRef
Telehealth and mobile health interventions in adults with inflammatory bowel disease: A mixed‐methods systematic review
Suja P. Davis, Megan Suzanne Hardin Ross, Reuben Adatorwovor, Holly Wei
Research in Nursing & Health.2021; 44(1): 155. CrossRef
Real-life pilot study on the impact of the telemedicine platform EasyMICI–MaMICI® on quality of life and quality of care in patients with inflammatory bowel disease
Guillaume Bonnaud, Audrey Haennig, Romain Altwegg, Bénédicte Caron, Lucile Boivineau, Camille Zallot, Cyrielle Gilleta de Saint-Joseph, Jacques Moreau, Florent Gonzalez, Didier Reynaud, Patrick Faure, Philippe Aygalenq, Jean Marc Combis, Laurent Peyrin-Bi
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Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives
Florian Tran, Jan Henrik Schirmer, Ilka Ratjen, Wolfgang Lieb, Philip Helliwell, Johan Burisch, Juliane Schulz, Florian Schrinner, Charlot Jaeckel, Ulf Müller-Ladner, Stefan Schreiber, Bimba F. Hoyer
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Researching Interventions to Improve Medication Adherence in Ulcerative Colitis Patients
Mila Palma Pacheco, Flora Maria Lorenzo Fortes, Raquel Rocha dos Santos, Genoile Oliveira Santana Silva
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Mobile app requirements for patients with rare liver diseases: A single center survey for the ERN RARE-LIVER‬‬‬
Darius F. Rüther, Marcial Sebode, Ansgar W. Lohse, Sarah Wernicke, Erwin Böttinger, Christian Casar, Felix Braun, Christoph Schramm
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Patient Experience and Satisfaction with an e-Health Care Management Application for Inflammatory Bowel Diseases
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Developments and challenges of e-health strategies for people with inflammatory bowel disease
Pearl Avery
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Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic
Nicholas A Kennedy, Richard Hansen, Lisa Younge, Joel Mawdsley, R Mark Beattie, Shahida Din, Christopher A Lamb, Philip J Smith, Christian Selinger, Jimmy Limdi, Tariq H Iqbal, Alan Lobo, Rachel Cooney, Oliver Brain, Daniel R Gaya, Charles Murray, Richard
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Crohn’s Colitis Care (CCCare): bespoke cloud-based clinical management software for inflammatory bowel disease
Krupa Krishnaprasad, Alissa Walsh, Jakob Begun, Sally Bell, David Carter, Rachel Grafton, Alexandra Sechi, Karen Sewell, Anna McMahon, Susan Connor, Graham Radford-Smith, Jane M. Andrews
Scandinavian Journal of Gastroenterology.2020; 55(12): 1419. CrossRef
Exploring the Challenges of Implementing a Web-Based Telemonitoring Strategy for Teenagers With Inflammatory Bowel Disease: Empirical Case Study
Alie Dijkstra, Anke Heida, Patrick Ferry van Rheenen
Journal of Medical Internet Research.2019; 21(3): e11761. CrossRef
Digital Health Apps in the Clinical Care of Inflammatory Bowel Disease: Scoping Review
Andrew Lukas Yin, David Hachuel, John P Pollak, Ellen J Scherl, Deborah Estrin
Journal of Medical Internet Research.2019; 21(8): e14630. CrossRef

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Original Article

Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn's disease: Kai-Chun Wu, Zhi Hua Ran, Xiang Gao, Minhu Chen, Jie Zhong, Jian-Qiu Sheng, Michael A Kamm, Simon Travis, Kori Wallace, Nael M Mostafa, Marisa Shapiro, Yao Li, Roopal B Thakkar, Anne M Robinson; Intest Res 2016;14(2):152-163. Published online April 27, 2016; DOI: https://doi.org/10.5217/ir.2016.14.2.152

Abstract PDF Supplementary Material PubReader ePub

<b>Background/Aims</b><br/>

This was a Phase 2 study (NCT02015793) to evaluate the pharmacokinetics, safety, and efficacy of adalimumab in Chinese patients with Crohn's disease (CD).

Methods

Thirty, adult Chinese patients with CD (CD Activity Index [CDAI] 220–450; high-sensitivity [hs]-C-reactive protein [CRP] ≥3 mg/L) received double-blind adalimumab 160/80 mg or 80/40 mg at weeks 0/2, followed by 40 mg at weeks 4 and 6. An open-label extension period occurred from weeks 8–26; patients received 40 mg adalimumab every other week. Serum adalimumab concentration and change from baseline in fecal calprotectin (FC) were measured during the double-blind period. Clinical remission (CDAI <150), response (decrease in CDAI ≥70 points from baseline), and change from baseline in hs-CRP were assessed through week 26. Nonresponder imputation was used for missing categorical data and last observation carried forward for missing hs-CRP/FC values. No formal hypothesis was tested. Adverse events were monitored.

Results

Mean adalimumab serum concentrations during the induction phase were 13.9–18.1 µg/mL (160/80 mg group) and 7.5−9.5 µg/mL (80/40 mg group). During the double-blind period, higher remission/response rates and greater reductions from baseline in hs-CRP and FC were observed with adalimumab 160/80 mg compared to that with 80/40 mg. Adverse event rates were similar among all treatment groups.

Conclusions

Adalimumab serum concentrations in Chinese patients with CD were comparable to those observed previously in Western and Japanese patients. Clinically meaningful remission rates and improvement in inflammatory markers were achieved with both dosing regimens; changes occurred rapidly with adalimumab 160/80 mg induction therapy. No new safety signals were reported.

Citations

Citations to this article as recorded by

Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn’s disease
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