Intestinal Research

Original Article

Colorectal neoplasia

Clinical significance of carcinoembryonic antigen in peritoneal fluid detected during operation in stage I–III colorectal cancer patients: Jae Hyun Kim, Seunghun Lee, Seung Hyun Lee, Byung Kwon Ahn, Sung Uhn Baek, Won Moon, Seun Ja Park; Intest Res 2018;16(3):467-474. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.467

<b>Background/Aims</b><br/>

Early diagnosis of peritoneal metastases in patients with colorectal cancer (CRC) can influence patient prognosis. The aim of this study was to identify the clinical significance of carcinoembryonic antigen (CEA) in peritoneal fluid detected during operation in stage I–III CRC patients.

Methods

Between April 2009 and April 2015, we reviewed medical records from a total of 60 stage I–III CRC patients who had peritoneal fluid collected during operation. Patients who had positive cytology in the assessment of peritoneal fluid were excluded. We evaluated the values of CEA in peritoneal fluid (pCEA) to predict the long-term outcomes of these patients using Kaplan-Meier curves and Cox regression models.

Results

The median follow-up duration was 37 months (interquartile range, 21–50 months). On receiver operating characteristic analysis, pCEA had the largest area under the curve (0.793; 95% confidence interval, 0.635–0.950; P=0.001) with an optimal cutoff value of 26.84 (sensitivity, 80.0%; specificity, 76.6%) for predicting recurrence. The recurrence rate was 8.1% in patients with low pCEA (<26.84 ng/mL, n=37), and 52.2% in patients with high pCEA (≥26.84 ng/mL, n=23). In multivariate Cox regression analysis, high pCEA (≥26.84 ng/mL) was a risk factor for poor cancer-free survival (CFS) in stage I–III patients.

Conclusions

In this study, we determined that high pCEA (≥26.84 ng/mL) detected during operation was helpful for the prediction of poor CFS in patients with stage I–III CRC.

Citations

Citations to this article as recorded by

Research Progress of Drainage Fluid Biomarkers in Predicting Anastomotic Leakage after Colorectal Surgery
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Advances in Clinical Medicine.2025; 15(02): 1772. CrossRef
Evaluation of peritoneal Carcinoembryonic Antigen as a survival prognostic factor in gastric cancer patients: a single western center experience
Nicola Natalizi, Elisabetta Marino, Luigina Graziosi, Annibale Donini
Updates in Surgery.2023; 75(5): 1211. CrossRef
Prognostic Significance of Preoperative Serum Carcinoembryonic Antigen Varies with Lymph Node Metastasis Status in Colorectal Cancer
Jing Jia, MinZhe Li, Wenhao Teng, Lin Wang, Weidong Zang, Jun Xiao, Ying Chen, Dan Zhao
Journal of Oncology.2021; 2021: 1. CrossRef

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2 Web of Science
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Case Report

Obstructive ileus caused by phlebosclerotic colitis: Seung Hyun Lee, Jong Wook Kim, Se Jin Park, Ju Yeol Heo, Woo Hyun Paik, Won Ki Bae, Nam-Hoon Kim, Kyung-Ah Kim, June Sung Lee; Intest Res 2016;14(4):369-374. Published online October 17, 2016; DOI: https://doi.org/10.5217/ir.2016.14.4.369

Abstract PDF PubReader

A 57-year-old man with chronic kidney disease and a history of using numerous herbal medications visited Inje University Ilsan Paik Hospital for abdominal pain and vomiting. An abdominal radiograph showed diffuse small bowel distension containing multiple air-fluid levels and extensive calcifications along the colon. Computed tomography showed colon wall thickening with diffuse calcification along the colonic mesenteric vein and colonic wall. Colonoscopy, performed without bowel preparation, showed bluish edematous mucosa from the transverse to the distal sigmoid colon, with multiple scar changes. At the mid transverse colon, a stricture was noted and the scope could not pass through. A biopsy of the stricture site revealed nonspecific changes. The patient was diagnosed with phlebosclerotic colitis. After the colonoscopy, the obstructive ileus spontaneously resolved, and the patient was discharged without an operation. Currently, after 2 months of follow-up, the patient has remained asymptomatic. Herein, we report the rare case of an obstructive ileus caused by phlebosclerotic colitis with a colon stricture.

Citations

Citations to this article as recorded by

Phlebosclerotic colitis with long-term herbal medicine use
Nguyen Dinh Minh, Nguyen Duy Hung, Pham Thu Huyen, Nguyen Thanh Van Anh, Nguyen Sy Lanh, Pham Quynh Anh, Nguyen Minh Duc
Radiology Case Reports.2022; 17(5): 1696. CrossRef
Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan
Yutaka Shimada, Makoto Fujimoto, Tatsuya Nogami, Hidetoshi Watari
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Phlebosclerotic colitis
Wenguo Chen, Huatuo Zhu, Hongtan Chen, Guodong Shan, Guoqiang Xu, Lihua Chen, Fei Dong
Medicine.2018; 97(43): e12824. CrossRef
Exclusive Phlebosclerosis of Submucosal Veins Leading to Ischemic Necrosis and Perforation of the Large Bowel: First European Case
Sebastian Klein, Denise Buchner, De-hua Chang, Reinhard Büttner, Uta Drebber, Jochen W.U. Fries
Case Reports in Gastroenterology.2018; 12(1): 137. CrossRef

6,746 View
60 Download
2 Web of Science
4 Crossref

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