Intestinal Research

Original Articles

IBD/ Endoscopy

Adequacy of sigmoidoscopy as compared to colonoscopy for assessment of disease activity in patients of ulcerative colitis: a prospective study: Sameet Tariq Patel, Anuraag Jena, Sanjay Chandnani, Shubham Jain, Pankaj Nawghare, Saurabh Bansal, Harsh Gandhi, Rishikesh Malokar, Jay Chudasama, Prasanta Debnath, Seemily Kahmei, Rima Kamat, Sangeeta Kini, Qais Q Contractor, Pravin M Rathi; Intest Res 2024;22(3):310-318. Published online May 16, 2024; DOI: https://doi.org/10.5217/ir.2023.00174

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Patients of ulcerative colitis (UC) on follow-up are routinely evaluated by sigmoidoscopy. There is no prospective literature to support this practice. We assessed agreement between sigmoidoscopy and colonoscopy prospectively in patients with disease extent beyond the sigmoid colon.
Methods
We conducted a prospective observational study at a tertiary care institute for agreement between sigmoidoscopy and colonoscopy. We assessed endoscopic activity using the Mayo Endoscopic Score (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and histological activity using the Nancy Index (NI), Robarts Histopathology Index (RHI), and Simplified Geboes Score (SGS).
Results
Sigmoidoscopy showed a strong agreement with colonoscopy for MES and UCEIS with a kappa (κ) of 0.96 and 0.94 respectively. The misclassification rate for MES and UCEIS was 3% and 5% respectively. Sigmoidoscopy showed perfect agreement (κ = 1.00) with colonoscopy for assessment of the presence of endoscopic activity in the colon using MES ≥ 1 as activity criteria and strong agreement (κ = 0.93) using MES > 1 as activity criteria. Sigmoidoscopy showed strong agreement with colonoscopy for assessment of the presence of endoscopic activity using UCEIS (κ = 0.92). Strong agreement was observed between sigmoidoscopy and colonoscopy using NI (κ = 0.86), RHI (κ = 1.00), and SGS (κ = 0.92) for the detection of histological activity. The misclassification rate for the detection of histological activity was 2%, 0%, and 1% for NI, RHI, and SGS respectively.
Conclusions
Sigmoidoscopy showed strong agreement with colonoscopy for endoscopic and histologic disease activity. Sigmoidoscopy is adequate for assessment of disease activity in patients with UC during follow-up evaluation.

Citations

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Sigmoidoscopy is sufficient to assess endoscopic response to therapy in pediatric ulcerative colitis: A cohort study
Shira Yuval Bar‐Asher, Esther Orlanski‐Meyer, Ibrahim Shamasnah, Dotan Yogev, Dan Turner
Journal of Pediatric Gastroenterology and Nutrition.2026; 82(1): 98. CrossRef
Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffith
Journal of Pediatric Gastroenterology and Nutrition.2026; 82(3): 867. CrossRef
ECCO consensus on management of inflammatory bowel disease in low- and middle-income countries
Alaa El-Hussuna, Almuthe Christina Hauer, Tarkan Karakan, Valerie Pittet, Henit Yanai, Jalpa Devi, Jesus K Yamamoto-Furusho, Ali Reza Sima, Hailemichael Desalegn, Mutaz Idrees Sultan, Vishal Sharma, Hany Shehab, Lamya Mrabti, Natalia Queiroz, Anuraag Jena
Journal of Crohn’s and Colitis.2026;[Epub] CrossRef
Comments on “Adequacy of sigmoidoscopy as compared to colonoscopy for assessment of disease activity in patients of ulcerative colitis: a prospective study”
Sidharth Harindranath
Intestinal Research.2025; 23(2): 225. CrossRef

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Microbiota

Evaluation of commercial probiotic lactic cultures against biofilm formation by Cronobacter sakazakii: Anubhav Jamwal, Kavita Sharma, Rajni Chauhan, Saurabh Bansal, Gunjan Goel; Intest Res 2019;17(2):192-201. Published online December 3, 2018; DOI: https://doi.org/10.5217/ir.2018.00106

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Cronobacter sakazakii, an emergent pathogen is considered as a major concern to infants and neonates fed on reconstituted powdered infant milk formula. In conjunction with many other factors, biofilm forming capacity adds to its pathogenic potential. In view of the facts that infants are at highest risk to C. sakazakii infections, and emerging antibiotic resistance among pathogens, it is imperative to evaluate probiotic cultures for their efficacy against C. sakazakii. Therefore, pure probiotic strains were isolated from commercial probiotic products and tested for their antimicrobial and anti-biofilm activities against C. sakazakii.
Methods
A total of 6 probiotic strains were tested for their antibiotic susceptibility followed by antimicrobial activity using cell-free supernatant (CFS) against C. sakazakii. The inhibitory activity of CFS against biofilm formation by C. sakazakii was determined using standard crystal violet assay and microscopic observations.
Results
All the probiotic strains were sensitive to ampicillin, tetracycline, vancomycin and carbenicillin whereas most of the strains were resistant to erythromycin and novobiocin. Four of the 6 probiotic derived CFS possessed antimicrobial activity against C. sakazakii at a level of 40 μL. A higher biofilm inhibitory activity (>80%) was observed at initial stages of biofilm formation with weaker activity during longer incubation upto 48 hours (50%–60%).
Conclusions
The study indicated the efficacy of isolated commercial probiotics strains as potential inhibitor of biofilm formation by C. sakazakii and could be further explored for novel bioactive molecules to limit the emerging infections of C. sakazakii.

Citations

Citations to this article as recorded by

2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum
Jingfang Du, Hong Yang
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Huilong Xin, Zhe Cai, Jiahui Hao, Jing An, Yi Li, Min Wen, Zhaojun Jia
Advanced Healthcare Materials.2025;[Epub] CrossRef
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Isabela Sguilla Rotta, Sthefânia Dalva da Cunha Rezende, Hugo Felix Perini, Marcos Vinicius da Silva, Felipe Alves de Almeida, Uelinton Manoel Pinto, Alessandra Barbosa Ferreira Machado, Aline Dias Paiva
Frontiers in Microbiology.2025;[Epub] CrossRef
A review of structure-activity relationship, enzymatic and genetic modulation of exopolysaccharides from lactic acid bacteria
Jingyan Zhang, Tao Hu, Qingshen Sun
Food Science and Human Wellness.2025; 14(8): 9250368. CrossRef
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Akua Gyamfi, Randolf Benle, Michael Konney Laryea, Mercy Badu, Lawrence Sheringham Borquaye
Chemistry Africa.2025; 8(10): 5165. CrossRef
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Yang Du, Lijia Wang, Jingru Xu, Shitong Zhao, Jinquan Li, Renwei Wu
Food Bioscience.2025; 74: 108026. CrossRef
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Arezou Rouhi, Fereshteh Falah, Marjan Azghandi, Behrooz Alizadeh Behbahani, Seyed Ali Mortazavi, Farideh Tabatabaei-Yazdi, Alireza Vasiee
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Souraya Sakoui, Reda Derdak, Oana Lelia Pop, Dan Cristian Vodnar, Fatimazahra Jouga, Bernadette-Emőke Teleky, Boutaina Addoum, Elemér Simon, Ramona Suharoschi, Abdelaziz Soukri, Bouchra El Khalfi
Foods.2024; 13(4): 586. CrossRef
Determination of Antioxidant and Antimicrobial Activities of Cell-Free Supernatant (CFSKC27L) and Exopolysaccharide (EPSKC27L) obtained from Ligilactobacillus salivarius KC27L
Kübra Çelik, Zehranur Yuksekdag, Berat Çınar Acar, Filiz Kara
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Limosilactobacillus fermentum MYSY8, a Potential Probiotic Isolate from Fermented Rice Beverage for the Control of Microsporum canis
Padur Ramachandra Vanitha, Divyashree Shivakumar, Shruthi Basavaraj, Adithi Gunduraj, Dhanuja Janardanachar, Deepthi BV, Marikunte Yanjarappa Sreenivasa
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Exploration of Antibiofilm Activities of Pediococci Strains Against Diarrheal Multi-Drug Resistant E.coli Strains
Gunjan Sadera, Anjali Jaglan, Ashwani Kumar, Teresa Requena, Rakesh Kumar, Aparna Parmar, Gunjan Goel
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Multivariate analysis of structural and functional properties of fibres from apple pomace using different extraction methods
Rusli Fidriyanto, Brij Pal Singh, K. M. Manju, Yantyati Widyastuti, Gunjan Goel
Food Production, Processing and Nutrition.2023;[Epub] CrossRef
Antifungal activity of probiotic strain Lactiplantibacillus plantarum MYSN7 against Trichophyton tonsurans
P. R. Vanitha, Rakesh Somashekaraiah, S. Divyashree, Indranil Pan, M. Y. Sreenivasa
Frontiers in Microbiology.2023;[Epub] CrossRef
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Rajni Chauhan, Savita Kumari, Gunjan Goel, Wamik Azmi
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Antibacterial and Antibiofilm Effect of Cell-Free Supernatant of Lactobacillus brevis KCCM 202399 Isolated from Korean Fermented Food against Streptococcus mutans KCTC 5458
Jong Ha Kim, Hye Ji Jang, Na-Kyoung Lee, Hyun-Dong Paik
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Selection of a Potential Synbiotic against Cronobacter sakazakii
ALFRED KE, VALERIA R. PARREIRA, JEFFREY M. FARBER, LAWRENCE GOODRIDGE
Journal of Food Protection.2022; 85(9): 1240. CrossRef
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Microorganisms.2020; 8(10): 1510. CrossRef

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