Intestinal Research

Colorectal neoplasia

Primary malignant melanoma without melanosis of the colon: Nam Hee Yi, Sang Heon Lee, Sang Heon Lee, Ji Hyun Kim, Sam Ryong Jee, Sang Yong Seol; Intest Res 2019;17(4):561-564. Published online August 5, 2019; DOI: https://doi.org/10.5217/ir.2019.00020

Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. Reported cases of PMM of the lower gastrointestinal tract typically describe anal and rectal involvement rather than colonic lesions. This report describes a rare case of a 50-year-old woman with PMM originating in the colon. The patient presented to Inje University Busan Paik Hospital with a 3-day history of blood-tinged stools. She underwent colonoscopy for a diagnosis of hematochezia. The colonoscopic examination revealed a large-sized semi-pedunculated sigmoid colon polyp with a reddish-colored mucosal surface. Endoscopic mucosal resection was performed, and the final histopathological findings were consistent with a diagnosis of malignant melanoma. Systemic work-up was performed for assessment of metastasis and to identify the primary tumor considering the high metastatic rate of gastrointestinal malignant melanoma; however, no other malignant lesion was detected. Thus, she was diagnosed with colonic PMM. She underwent laparoscopic low anterior resection and lymph node dissection and has been recurrence-free for > 2 years.

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Primary melanoma of the gastrointestinal tract
Paola De Nardi, Stefania Guida, Giuseppe Damiano, Nathalie Rizzo, Ana Maria Samanes Gajate, Silvia Teresa Riva, Giovanni Paolino, Michele Colombo, Roberta Tummineri, Franco Rongioletti, Santo Raffaele Mercuri, Arturo Chiti, Pierpaolo Sileri, Vincenzo Russ
World Journal of Gastroenterology.2026;[Epub] CrossRef
Malignant primary melanoma of the colon: a case report
Claire K Foley, Marybeth S Hughes, Charles T Hehman
Journal of Surgical Case Reports.2023;[Epub] CrossRef

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2 Crossref

IBD

Duodenal amyloidosis secondary to ulcerative colitis: Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol; Intest Res 2018;16(1):151-154. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.151

Abstract PDF PubReader ePub

Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy.

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Citations to this article as recorded by

Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review
Pianpian Xia, Deliang Liu, Feihong Deng, Dalian Ou, Mingyang Deng
Frontiers in Medicine.2025;[Epub] CrossRef
Gastrointestinal amyloidosis in a 50‐year‐old patient with miliary tuberculosis: A case report
Sameer Abdul Rauf, Hussain Haider Shah, Rahul Khatri, Mansoor Ul Haq, Tirth Dave, Javaria Parwez Ali, Syed Khizar Ali
Clinical Case Reports.2024;[Epub] CrossRef
Therapeutic effects of biological treatments on AA amyloidosis associated with inflammatory bowel disease: a case report and literature review
Marouf Alhalabi, Kamal Alaa Eddin, Ahmad Abbas
European Journal of Gastroenterology & Hepatology.2023; 35(11): 1298. CrossRef
Rheumatoid arthritis: Extra-articular manifestations and comorbidities
Fabiana Assunta Figus, Matteo Piga, Irene Azzolin, Rebecca McConnell, Annamaria Iagnocco
Autoimmunity Reviews.2021; 20(4): 102776. CrossRef
Specific Clinical and Morphological Characteristics of Amyloidosis of the Stomach and Duodenum
Z. V. Gioeva, L. M. Mikhaleva
Journal of Anatomy and Histopathology.2019; 8(1): 39. CrossRef
Morphological and Immunohistochemical Characteristics of Experimental Mandibular Fractures Healing Process
A. A. Matchin, A. A. Stadnikov, E. V. Nosov, S. Kh. Kiriakidi
Journal of Anatomy and Histopathology.2019; 8(1): 44. CrossRef
Secondary, AA, Amyloidosis
Riccardo Papa, Helen J. Lachmann
Rheumatic Disease Clinics of North America.2018; 44(4): 585. CrossRef

9,526 View
78 Download
6 Web of Science
7 Crossref

A Case of Mixed Hyperplastic-adenomatous Rectal Polyp with Composition of Invasive Adenocarcinoma: Hyo Rim Seo, Ji Hyun Kim, Soo Jin Jung, Yun Jung Choi, Choong Heon Ryu, Kwan Sik Park, Seoung In Ha, Eun Uk Jung, Sang Heon Lee, Sung Jae Park, Jung Sik Choi, Sam Ryong Jee, Youn Jae Lee, Sang Young Seol; Intest Res 2012;10(3):295-299. Published online July 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.3.295

Abstract PDF: Epithelial colon polyps are largely divided into hyperplastic and adenomatous polyps. Adenomatous polyps are premalignant lesions, whereas hyperplastic polyps are regarded as benign lesions. However, this histological classification has been blurred, as cases of malignant changes in hyperplastic polyposis, mixed hyperplastic adenomatous polyps (MHAPs), and serrated adenomas in the colon have been reported. Rare cases of MHAP have been reported, and are mainly found at the proximal colon with a relatively large size. MHAPs seem to be an intermediate stage of the hyperplastic polyp-adenoma sequence or a collision tumor. Here, we report on a case of a single polyp in the rectum diagnosed with a MHAP combined with an invasive adenocarcinoma. (Intest Res 2012;10: 0-299)

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