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IBD/ Infection
Durability and outcomes of fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with moderate to severe inflammatory bowel disease
Raseen Tariq, Edward V Loftus Jr, Darrell Pardi, Sahil Khanna
Intest Res 2024;22(2):208-212.   Published online January 9, 2024
DOI: https://doi.org/10.5217/ir.2023.00100
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Citations to this article as recorded by  
  • Perception of fecal microbiota transplantation in patients with ulcerative colitis in Korea: a KASID multicenter study
    Jebyung Park, Sung Noh Hong, Hong Sub Lee, Jongbeom Shin, Eun Hye Oh, Kwangwoo Nam, Gyeol Seong, Hyun Gun Kim, Jin-Oh Kim, Seong Ran Jeon
    The Korean Journal of Internal Medicine.2024; 39(5): 783.     CrossRef
  • 6,421 View
  • 232 Download
  • 2 Web of Science
  • 1 Crossref
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Reviews
Microbiota
Gut microbiome and checkpoint inhibitor colitis
Kanika Sehgal, Sahil Khanna
Intest Res 2021;19(4):360-364.   Published online December 1, 2020
DOI: https://doi.org/10.5217/ir.2020.00116
AbstractAbstract PDFPubReaderePub
Immune checkpoint inhibitor therapies such as ipilimumab, are increasingly being used as a treatment option for a variety of cancers, including metastatic melanoma and have demonstrated effectively a prolonged survival. These agents have an immunological mode of action that predisposes patients to a number of immune-related adverse events, colitis being one of the most commonly encountered complications. The pathogenesis for the development of colitis is unclear, and there is a growing consensus that the ecosystem of the gastrointestinal microbiota plays a significant role. Based on this suspected connection, studies are being carried out to explore the changes in the microbiota in patients on these medications who develop colitis. Conceivably, the modulation of the gut microbiota could offer a therapeutic benefit. Fecal microbiota transplantation is one therapeutic option that is currently being investigated, though there are still more data needed to evaluate its efficacy. In this review, we recapitulate the mechanisms of action of immune checkpoint inhibitors, their adverse events, with a focus on colitis and the role gut microbiota are suspected to play, and finally discuss the microbiota modulation therapies being investigated.

Citations

Citations to this article as recorded by  
  • Ipilimumab, -omics, and head and neck cancers—update in 2025
    Robert Kucharski, Adam Kosiński, Leszek Kalinowski, Karolina Kaźmierczak-Siedlecka
    Frontiers in Immunology.2026;[Epub]     CrossRef
  • Immune-Mediated Colitis Induced by Immune Checkpoint Inhibitors: Pathophysiology, Clinical Management, and the Emerging Role of Fecal Microbiota Transplantation
    Zeljka Belosic Halle, Vedran Tomasic, Alen Biscanin, Petra Cacic, Ivona Saric, Sanda Mustapic, Josip Stojic, Kresimir Luetic, Dinko Bekic, Matej Paic, Domagoj Micetic, Irena Krznaric Zrnic, Ivna Olic, Melanija Razov Radas, Iva Skocilic, Marin Golčic, Laur
    Biomedicines.2026; 14(3): 683.     CrossRef
  • What should intensivists know about immune checkpoint inhibitors and their side effects?
    Viktor Yordanov Zlatkov Aleksandrov, Fernando Martínez Sagasti, Juncal Pérez-Somarriba Moreno, Helena Huertas Mondéjar
    Medicina Intensiva (English Edition).2025; 49(7): 502135.     CrossRef
  • The association between metformin use, immune mediated colitis and overall survival in patients treated with checkpoint inhibitor
    Malek Shatila, Carolina Colli Cruz, Linfeng Lu, Kian Abdul-baki, Elliot Baerman, Kei Takigawa, Andres Urias Rivera, Irene Jeong-Ah Lee, Sean Ngo, Gabriel Sperling, Abdullah Sagar Aleem, Raakhi Menon, Andrew Sullivan, Varun Vemulapalli, Cristina Natha, Tan
    European Journal of Cancer.2025; 221: 115405.     CrossRef
  • What should intensivists know about immune checkpoint inhibitors and their side effects?
    Viktor Yordanov Zlatkov Aleksandrov, Fernando Martínez Sagasti, Juncal Pérez-Somarriba Moreno, Helena Huertas Mondéjar
    Medicina Intensiva.2025; 49(7): 502135.     CrossRef
  • Exploring the role of inflammatory regulatory effects of probiotics as adjuvants in cancer development management with considering possible challenges: a comprehensive review
    Mehran Mahooti, Fatemeh Safaei, Faezeh Firuzpour, Elahe Abdolalipour, Davood Zare, Samira Sanami, Maliheh Safavi, Saeed Mirdamadi
    Inflammopharmacology.2025; 33(7): 3823.     CrossRef
  • Refractory Immune Checkpoint Inhibitor Colitis Treated With Biologics, Janus Kinase Inhibition, Plasma Exchange, and Fecal Microbiota Transplantation
    Jason Hearn, Getanshu Malik, Igor Stukalin, Remo Panaccione, Richard J.M. Ingram, Christopher Ma
    ACG Case Reports Journal.2025;[Epub]     CrossRef
  • Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy
    Despoina Chrysostomou, Lauren A. Roberts, Julian R. Marchesi, James M. Kinross
    Gastroenterology.2023; 164(2): 198.     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • Obesity Measured via Body Mass Index May Be Associated with Increased Incidence but Not Worse Outcomes of Immune-Mediated Diarrhea and Colitis
    Miho Kono, Malek Shatila, Guofan Xu, Yang Lu, Antony Mathew, Wasay Mohajir, Krishnavathana Varatharajalu, Wei Qiao, Anusha S. Thomas, Yinghong Wang
    Cancers.2023; 15(8): 2329.     CrossRef
  • Gut microbiome homeostasis and the future of probiotics in cancer immunotherapy
    Ankita Singh, Sharon Grace Alexander, Sunil Martin
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Gut Microbiome and Colorectal Cancer
    Tae-Geun Gweon
    The Korean Journal of Gastroenterology.2023; 82(2): 56.     CrossRef
  • Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors
    Patrick T Magahis, Steven B Maron, Darren Cowzer, Stephanie King, Mark Schattner, Yelena Janjigian, David Faleck, Monika Laszkowska
    Journal for ImmunoTherapy of Cancer.2023; 11(10): e007699.     CrossRef
  • Comments on Efficacy of a Synbiotic Containing Lactobacillus paracasei DKGF1 and Opuntia humifusa in Elderly Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
    Kwang Woo Kim
    Gut and Liver.2023; 17(6): 954.     CrossRef
  • MTA1 aggravates experimental colitis in mice by promoting transcription factor HIF1A and up-regulating AQP4 expression
    Ping Li, Dong-Ping Shi, Tao Jin, Dong Tang, Wei Wang, Liu-Hua Wang
    Cell Death Discovery.2022;[Epub]     CrossRef
  • Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
    Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Exploration of Potential Gut Microbiota-Derived Biomarkers to Predict the Success of Fecal Microbiota Transplantation in Ulcerative Colitis: A Prospective Cohort in Korea
    Gi-Ung Kang, Sowon Park, Yeongyun Jung, Jai J. Jee, Min-Sueng Kim, Seungjun Lee, Dong-Woo Lee, Jae-Ho Shin, Hong Koh
    Gut and Liver.2022; 16(5): 775.     CrossRef
  • Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives
    Cécile Torregrosa, Frédéric Chorin, Eva Ester Molina Beltran, Cindy Neuzillet, Victoire Cardot-Ruffino
    Cancers.2022; 14(21): 5402.     CrossRef
  • Microbial Modulation in Inflammatory Bowel Diseases
    Jongwook Yu, Jae Hee Cheon
    Immune Network.2022;[Epub]     CrossRef
  • Immune Checkpoint Inhibitor-Associated Colitis: From Mechanism to Management
    Liansha Tang, Jialing Wang, Nan Lin, Yuwen Zhou, Wenbo He, Jiyan Liu, Xuelei Ma
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • 9,460 View
  • 303 Download
  • 19 Web of Science
  • 20 Crossref
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IBD
Management of Clostridioides difficile infection in patients with inflammatory bowel disease
Sahil Khanna
Intest Res 2021;19(3):265-274.   Published online August 18, 2020
DOI: https://doi.org/10.5217/ir.2020.00045
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD) is a common diarrheal illness with gastrointestinal and extraintestinal manifestations and complications. The most common infectious complication associated with IBD is Clostridioides difficile infection (CDI). Active IBD predisposes to CDI due to alterations in the gut microbiome. C. difficile is a toxin producing bacterium leading to worsening of underlying IBD, increasing the risk of IBD treatment failure and an increased risk of hospitalization and surgery. Since the symptoms of CDI overlap with those of an IBD flare; it is prudent to recognize that the diagnosis of CDI is challenging and diagnostic tests (nucleic-acid and toxin-based assays) should be interpreted in context of symptoms and test performance. First line treatments for management of CDI in IBD include vancomycin or fidaxomicin. Recurrence prevention strategies should be implemented to mitigate recurrent CDI risk. One needs to monitor IBD disease progression and manage immunosuppression. The risk of recurrent CDI after a primary infection is higher in IBD compared to non-IBD patients. Microbiota restoration therapies are effective to prevent recurrent CDI in IBD patients. This review summarizes the epidemiology, pathophysiology, diagnostic testing, outcomes and management of both CDI and IBD, in CDI complicating IBD.

Citations

Citations to this article as recorded by  
  • Diagnostic challenges and treatment approaches for Clostridioides difficile infection in IBD patients
    Asghar Ali, Khalid I. AlHussaini
    Frontiers in Microbiology.2026;[Epub]     CrossRef
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    Zeng Zhang, Zhihan Yang, Shuaiming Jiang, Yukai Sun, Yuesong Jiang, Shi Huang, Jiachao Zhang
    Engineering.2026;[Epub]     CrossRef
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    Tingting Xu, Ying Xie
    Frontiers in Cellular and Infection Microbiology.2026;[Epub]     CrossRef
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    Krista Vitikainen, Merit Kase, Leo Meriranta, Pauliina Molander, Clas-Göran af Björkesten, Veli-Jukka Anttila, Perttu Arkkila
    Therapeutic Advances in Gastroenterology.2025;[Epub]     CrossRef
  • Discordance in Clinical Indicators With Sequential Fecal Microbiota Transplantation: A Case of Fulminant Clostridioides Difficile Infection
    Peter Bhandari, Reanay Berezovskiy, Salima Makhani, Valerie Gausman, Neelesh Rastogi, Sabina Braude
    ACG Case Reports Journal.2025; 12(6): e01731.     CrossRef
  • Phage therapy modulates the gut microbiome and immune responses in non-typhoidal Salmonella-induced colitis
    Md. Sharifull Islam, Ping Wei, Kaimin Zhang, Ishatur Nime, Fan Pan
    Food Research International.2025; 219: 117003.     CrossRef
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    Osama Nadeem, Muhammad Soban Imran, Nasir Siddique
    Cureus.2025;[Epub]     CrossRef
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    Ting-Chieh Huang, Tony Kou, Chia-Jung Kuo, Cheng-Hsun Chiu, Tai-Di Chen, Chien-Ming Chen, Jen-Wei Chou, Tien-Yu Huang, Chen-Wang Chang, Cheng-Tang Chiu, Ming-Yao Su, Yu-Bin Pan, Puo-Hsien Le
    Gut Pathogens.2025;[Epub]     CrossRef
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    International Journal of Molecular Sciences.2024; 25(4): 2128.     CrossRef
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    David L. Farrier, David Chiang, Amindra S. Arora
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    Linxian Zhao, Tongbo Zhang, Kai Zhang
    Frontiers in Immunology.2024;[Epub]     CrossRef
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    Jongwook Yu, Jae Hee Cheon
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  • Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
    Gabrio Bassotti, Alessandro Fruganti, Giovanni Maconi, Pierfrancesco Marconi, Katia Fettucciari
    Journal of Inflammation Research.2021; Volume 14: 7443.     CrossRef
  • 24,781 View
  • 662 Download
  • 33 Web of Science
  • 36 Crossref
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Brief Communication
Miscellaneous
Fecal microbiota transplant via colonoscopy may be preferred due to intraprocedure findings
Janice M. Cho, Laura Pestana, Ryan Pardi, Darrell S. Pardi, Sahil Khanna
Intest Res 2019;17(3):434-437.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00056
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review
    Sebastián Eustaquio Martín Pérez, Hakim Al Lal Abdel Lah, Nelson Hernández García, Umabel Aaron Reyes Carreño, Isidro Miguel Martín Pérez
    Gastrointestinal Disorders.2025; 7(1): 5.     CrossRef
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    Kevin J. McDonnell
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    Sahil Khanna, David Yoho, Daniel Van Handel, Brian J. Clark, Tahany Awad, Beth Guthmueller, Daniel Armandi, Whitfield Knapple, Nasia Safdar, Brian Baggott, Karen Simon, Paul Feuerstadt
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  • Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in Inflammatory Bowel Disease
    Raseen Tariq, Molly B Disbrow, John K Dibaise, Robert Orenstein, Srishti Saha, Dipesh Solanky, Edward V Loftus, Darrell S Pardi, Sahil Khanna
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    Niloufar Roshan, Annabel K. Clancy, Thomas J. Borody
    Infectious Diseases and Therapy.2020; 9(4): 935.     CrossRef
  • 7,371 View
  • 101 Download
  • 8 Web of Science
  • 7 Crossref
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