Intestinal Research

IBD

Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea: Ji Young Chang, Sung-Ae Jung, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim; Intest Res 2018;16(4):599-608. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00012

Background/Aims
Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination.
Methods
From May 2014 to August 2016, patients diagnosed with IBD were prospectively included and evaluated for anti-HBs antibody, anti-HBc antibody, and HBs antigen. Among the 73 patients who were confirmed with nonimmunity to HBV, 44 patients who had completed the 3-dose HBV vaccination series received a single booster vaccination, while 29 patients who had not completed the vaccinations series or were unsure of receiving the vaccination received a full vaccination series.
Results
An optimal response was obtained in 70.5% of the patients in the booster group, and 89.7% of the patients in the full vaccination group. Age younger than 26 years (odds ratio [OR], 6.01; 95% confidence interval [CI], 1.15–31.32; P=0.033) and a complete previous vaccination series (OR, 0.15; 95% CI, 0.03–0.80; P=0.026) were associated with optimal vaccine response. Previous complete vaccination series (OR, 0.11; 95% CI, 0.02–0.73; P=0.022) was the only predictive factor for lower compliance.
Conclusions
The response to the HBV vaccination was lower in patients older than 26 years and for those patients with a complete vaccination history. Since patients with a complete vaccination history also had poor compliance, serum HBV-titers should be checked more thoroughly, and a full vaccination series should be administered in cases when there is a negative response to the booster vaccination.

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Clinical Trial: Immunogenicity of Double‐Dose Versus Standard‐Dose of Hepatitis B Virus Vaccine in Inflammatory Bowel Disease
Anupam Kumar Singh, Roop Kishor Soni, Vaneet Jearth, Ashutosh Ishan Yadav, Chhagan Lal Birda, Abhirup Chatterjee, Jimil Shah, Ritin Mohindra, Amol N. Patil, Vikas Suri, Vishal Sharma, Arun Kumar Sharma, Usha Dutta
Alimentary Pharmacology & Therapeutics.2025;[Epub] CrossRef
Immunogenicity of Hepatitis B Vaccination in Patients with Ulcerative Colitis on Infliximab Is Attenuated Compared to Those on 5-Aminosalicylic Acid Therapies: A Prospective Observational Study
Mohammad Shehab, Fatema Alrashed, Munerah Alyaseen, Zainab Safar, Tunrayo Adekunle, Ahmad Alfadhli, Talat Bessissow
Vaccines.2024; 12(4): 364. CrossRef
Meta‐analysis: hepatitis B vaccination in inflammatory bowel disease
Anupam Kumar Singh, Anuraag Jena, Gaurav Mahajan, Ritin Mohindra, Vikas Suri, Vishal Sharma
Alimentary Pharmacology & Therapeutics.2022; 55(8): 908. CrossRef
Efficacy of hepatitis B vaccination in patients with ulcerative colitis: a prospective cohort study
Anurag Mishra, Amarender Singh Puri, Sanjeev Sachdeva, Ashok Dalal
Intestinal Research.2022; 20(4): 445. CrossRef
A Review of Vaccinations in Adult Patients with Secondary Immunodeficiency
Elda Righi, Tolinda Gallo, Anna Maria Azzini, Fulvia Mazzaferri, Maddalena Cordioli, Mara Merighi, Evelina Tacconelli
Infectious Diseases and Therapy.2021; 10(2): 637. CrossRef
Vaccination in the Elderly and IBD
Anthony J. Choi, Preston Atteberry, Dana J. Lukin
Current Treatment Options in Gastroenterology.2019; 17(4): 492. CrossRef

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Current status and future perspectives of capsule endoscopy: Hyun Joo Song, Ki-Nam Shim; Intest Res 2016;14(1):21-29. Published online January 26, 2016; DOI: https://doi.org/10.5217/ir.2016.14.1.21

Abstract PDF PubReader ePub

Small bowel capsule endoscopy (CE) was first introduced 15 years ago, and a large amount of literature has since been produced, focused on its indication, diagnostic yields, and safety. Guidelines that have made CE the primary diagnostic tool for small bowel disease have been created. Since its initial use in the small bowel, CE has been used for the esophagus, stomach, and colon. The primary indications for small bowel CE are obscure gastrointestinal bleeding, unexplained iron deficiency anemia, suspected Crohn's disease, small bowel tumors, nonsteroidal anti-inflammatory drug enteropathy, portal hypertensive enteropathy, celiac disease, etc. Colon CE provides an alternative to conventional colonoscopy, with possible use in colorectal cancer screening. Guidelines for optimal bowel preparation of CE have been suggested. The main challenges in CE are the development of new devices with the ability to provide therapy, air inflation for better visualization of the small bowel, biopsy sampling systems attached to the capsule, and the possibility of guiding and moving the capsule by an external motion controller. We review the current status and future directions of CE, and address all aspects of clinical practice, including the role of CE and long-term clinical outcomes.

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Advances in implantable capsule robots for monitoring and treatment of gastrointestinal diseases
Xiaofeng Wang, Hao Xu, Yanlong Ren, Ying Yuan, Fei Deng, Wei Gao, Zheng Lou, Xian-Tao Song, Hao Guo, Wei Han, Lili Wang
Materials Science and Engineering: R: Reports.2025; 163: 100943. CrossRef
Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis
Antea Krsek, Lara Baticic
Gastrointestinal Disorders.2024; 6(3): 557. CrossRef
Capsule endoscopy for small bowel bleed: Current update
Uday C. Ghoshal, Akash Roy, Mahesh K. Goenka
Indian Journal of Gastroenterology.2024; 43(5): 896. CrossRef
New endoscopic capsule vs upper gastrointestinal endoscopy in preoperative work-up of obese candidate for bariatric surgery: Relevance of a pilot study in the COVID-19 era
Giuseppe Galloro, Mario Musella, Saverio Siciliano, Giovanna Berardi, Antonio Vitiello, Nunzio Velotti, Fernando Rizzello, Paolo Gionchetti, Carlo Calabrese
Endoscopy International Open.2022; 10(02): E183. CrossRef
Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes
Nick Lung-Ngai Ting, Harry Cheuk-Hay Lau, Jun Yu
Gut.2022; 71(7): 1412. CrossRef
Iron Deficiency Anaemia and Anaemia of Inflammation in Enteropathies Caused by Commonest Small Intestine Disorders: Current Evidence
Olesja Basina, Jelena Derova, Aleksejs Derovs, Sandra Lejniece
Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences..2022; 76(5-6): 561. CrossRef
Double-headed small-bowel capsule endoscopy: Real-world experience from a multi-centre British study
DE Yung, AR Robertson, M Davie, R Sidhu, M McAlindon, I Rahman, P Patel, L Sinha, S Mason, J Brzeszczynska, S Douglas, JN Plevris, A Koulaouzidis
Digestive and Liver Disease.2021; 53(4): 461. CrossRef
Clinical Outcomes between P1 and P0 Lesions for Obscure Gastrointestinal Bleeding with Negative Computed Tomography and Capsule Endoscopy
Young Kyu Cho, Heesu Park, Jung Rock Moon, Seong Ran Jeon, Hyun Gun Kim, Tae Hee Lee, Junseok Park, Jin-Oh Kim, Joon Seong Lee, Hyeon Jeong Goong, Bong Min Ko, Suyeon Park
Diagnostics.2021; 11(4): 657. CrossRef
Application of Structural Entropy and Spatial Filling Factor in Colonoscopy Image Classification
Brigita Sziová, Szilvia Nagy, Zoltán Fazekas
Entropy.2021; 23(8): 936. CrossRef
Indicaciones, rendimiento diagnóstico y seguridad de la cápsula endoscópica de intestino delgado en pacientes mexicanos. Experiencia de un centro de tercer nivel
G. Blanco-Velasco, C. Mendoza-Segura, O.M. Solórzano-Pineda, O.V. Hernández-Mondragón, V. Paz-Flores, J.M. Blancas-Valencia
Revista de Gastroenterología de México.2020; 85(2): 140. CrossRef
Indications for small bowel capsule endoscopy and its safety and diagnostic yield in Mexican patients. Experience at a tertiary care hospital center
G. Blanco-Velasco, C. Mendoza-Segura, O.M. Solórzano-Pineda, O.V. Hernández-Mondragón, V. Paz-Flores, J.M. Blancas-Valencia
Revista de Gastroenterología de México (English Edition).2020; 85(2): 140. CrossRef
Analysis of current and future technologies of capsule endoscopy: A mini review
Brown Alexander P, Jayatissa Ahalapitiya H
Archives of Preventive Medicine.2020; : 031. CrossRef
Capsule endoscopy for small‐intestinal disorders: Current status
Naoki Hosoe, Kaoru Takabayashi, Haruhiko Ogata, Takanori Kanai
Digestive Endoscopy.2019; 31(5): 498. CrossRef
Evaluation of Gastric Disease with Capsule Endoscopy
Seung-Joo Nam, Hyun Seok Lee, Yun Jeong Lim
Clinical Endoscopy.2018; 51(4): 323. CrossRef
Rebleeding rate and risk factors in nonsteroidal anti‐inflammatory drug‐induced enteropathy
Junseok Park, Seong Ran Jeon, Jin‐Oh Kim, Hyun Gun Kim, Tae Hee Lee, Jun‐Hyung Cho, Bong Min Ko, Joon Seong Lee, Moon Sung Lee
Journal of Digestive Diseases.2018; 19(5): 279. CrossRef
The gut microbiota influences anticancer immunosurveillance and general health
Bertrand Routy, Vancheswaran Gopalakrishnan, Romain Daillère, Laurence Zitvogel, Jennifer A. Wargo, Guido Kroemer
Nature Reviews Clinical Oncology.2018; 15(6): 382. CrossRef
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A CAPENTRY Study
Hyun Seok Lee, Yun Jeong Lim, Ki Nam Shim, Chang Mo Moon, Hyun Joo Song, Jin Oh Kim, Seong Ran Jeon, Dae Young Jung, Ji Hyun Kim, Kyeong Ok Kim, Bo-In Lee
Digestive Diseases and Sciences.2017; 62(1): 180. CrossRef
Quality Indicators for Small Bowel Capsule Endoscopy
Ki-Nam Shim, Seong Ran Jeon, Hyun Joo Jang, Jinsu Kim, Yun Jeong Lim, Kyeong Ok Kim, Hyun Joo Song, Hyun Seok Lee, Jae Jun Park, Ji Hyun Kim, Jaeyoung Chun, Soo Jung Park, Dong-Hoon Yang, Yang Won Min, Bora Keum, Bo-In Lee
Clinical Endoscopy.2017; 50(2): 148. CrossRef
Role of capsule endoscopy in suspected or established Crohn's disease in real practice
Hyun Joo Jang
Intestinal Research.2017; 15(4): 431. CrossRef
Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease)
Consolato Sergi, Fan Shen, Gerd Bouma
World Journal of Gastroenterology.2017; 23(4): 573. CrossRef
Results of the first survey for the current status of inflammatory bowel disease management in Asian countries
Ji Won Kim
Intestinal Research.2016; 14(3): 199. CrossRef

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What's the Clinical Features of Colitis in Elderly People in Long-Term Care Facilities?: So Yoon Yoon, Sung-Ae Jung, Sun-Kyung Na, Jae-In Ryu, Hye-Won Yun, Min-Jin Lee, Eun-Mi Song, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim; Intest Res 2015;13(2):128-134. Published online April 27, 2015; DOI: https://doi.org/10.5217/ir.2015.13.2.128

Abstract PDF PubReader

<b>Background/Aims</b><br/>

As life expectancy has increased, the number of elderly patients who need long-term care has grown rapidly. Mortality in patients with colitis in long-term care facilities (LTCFs) is increasing. We intend to investigate the main causes of colitis in LTCFs compared to those of colitis in local communities, and to identify the clinical features and risk factors of patients with colitis in LTCFs.

Methods

We retrospectively analyzed epidemiology, medical conditions, laboratory values, diagnoses, and clinical courses of elderly patients aged ≥65 who were admitted to the Ewha Womans University hospital with colitis between January 2007 and July 2012.

Results

Patients with colitis in LTCFs (n=20) were compared with elderly patients with colitis in local communities (n=154). Fifty-five percent of colitis in LTCFs was caused by Clostridium difficile infection (CDI), 30% was due to ischemic colitis, and 15% was due to non-specific colitis. Non-specific colitis was the most common (63%) in the community group. Clinical outcomes were also significantly different between both groups: higher mortality (10.0% vs. 0.64%, P=0.021), higher requirement for intensive care units care (50.0% vs. 18.8%, P<0.01) in LTCFs group. In univariate analysis, the most significant risk factor for death in patients in LTCFs was decreased mental faculties.

Conclusions

Patients in LTCFs showed worse clinical outcomes and a much higher prevalence of CDI compared to patients from local communities. We suggest early and active evaluation, such as endoscopic examination, for differential diagnosis in patients in LTCFs.

Citations

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RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
Jung Hoon Song, You Sun Kim
Gut and Liver.2019; 13(1): 16. CrossRef
A Comprehensive Review of the Diagnosis and Pharmacological Management of Crohn’s Disease in the Elderly Population
David Kim, Sasha Taleban
Drugs & Aging.2019; 36(7): 607. CrossRef
Rapid and accurate diagnosis of Clostridium difficile infection by real-time polymerase chain reaction
Pil Hun Song, Jung Hwa Min, You Sun Kim, Soo Yeon Jo, Eun Jin Kim, Kyung Jin Lee, Jeonghun Lee, Hyun Sung, Jeong Seop Moon, Dong Hee Whang
Intestinal Research.2018; 16(1): 109. CrossRef
Acute hemorrhagic rectal ulcer syndrome: Comparison with non‐hemorrhagic rectal ulcer lower gastrointestinal bleeding
Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam‐Hoon Kim, Kyung‐Ah Kim, June Sung Lee
Journal of Digestive Diseases.2017; 18(9): 521. CrossRef
Coexisting cytomegalovirus infection in immunocompetent patients with Clostridium difficile colitis
Khee-Siang Chan, Wen-Ying Lee, Wen-Liang Yu
Journal of Microbiology, Immunology and Infection.2016; 49(6): 829. CrossRef
Clinical Outcomes in Hospitalized Patients withClostridium difficileInfection by Age Group
Ho Chan Lee, Kyeong Ok Kim, Yo Han Jeong, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
The Korean Journal of Gastroenterology.2016; 67(2): 81. CrossRef

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The Impact of Radiation Exposure on the Prevalence of Functional Dyspepsia and Irritable Bowel Syndrome in Hospital Radiation Workers: Ju Young Choi, Sung-Ae Jung, Hye Won Kang, Hye-Won Yun, Jae-In Ryu, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Kwon Yoo; Intest Res 2013;11(4):292-298. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.292

Abstract PDF

Background/Aims
Health care workers inevitably encounter many physical hazards including ionizing radiation, and have increased levels of psychological disturbance. This study was designed to investigate the prevalence of functional gastrointestinal disorders among hospital radiation workers and to determine significant factors associated with these results. Methods: Whole body radiation doses of radiation workers were evaluated using the electronic dosimeter. The prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS) were assessed by the bowel symptom questionnaire. The subjects were classified according to radiation dose, sleep quality, and psychological stress level, and the prevalence of FD and IBS was comparatively analyzed. Results: A total of 70 subjects were recruited. The prevalence of FD and IBS was 31.4% and 22.9%, respectively. The average radiation dose per exposed worker for 1 year was 0.56±0.92 mSv. By multivariate logistic regression analysis, a significant factor associated with the prevalence of FD was their high level of stress (odds ratio, 6.37; 95% confidence interval, 1.38-29.53). Between radiation workers with IBS and those without IBS, there was no significant difference in radiation exposure level, sleep quality, and stress level. There was no difference in the prevalence of IBS (40.0% vs. 15.8%, P=0.09) and FD (30.0% vs. 31.6%, P=0.92) between the relatively high-dose (total dose accumulated during the 3 years ≥9.4 mSv) and low-dose exposed group (<9.4 mSv). Conclusions: Occupational exposure to low levels of radiation does not seem to be significantly related to IBS and FD, but high stress level seems to be related to FD. (Intest Res 2013;11:292-298)

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Radiation Exposure and Functional Gastrointestinal Disease
Hyun Il Seo
Intestinal Research.2014; 12(4): 335. CrossRef

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Pregnancy Outcomes of the Patients with Inflammatory Bowel Disease in Korea: Young Wook Noh, Sung-Ae Jung, Min-Jung Kang, Ji Min Jung, Seong-Eun Kim, Ki-Nam Shim, Tae Hun Kim, Kwon Yoo; Intest Res 2010;8(1):30-39. Published online June 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.1.30

Abstract PDF: Background/Aims
It is unknown what effect inflammatory bowel disease (IBD) has on pregnancy in Korean patients. We aimed to determine the effect of IBD and its treatment on pregnancy outcomes using web-based survey. Methods: A web-based survey was conducted in three Korean internet communities for IBD patients between May and September 2008. Pregnancy and birth outcomes were examined, and the influence of IBD activity and drug therapy were analyzed. Results: Of 56 pregnancies in 36 female IBD patients, live births occurred in 60.7%, miscarriages in 10.7%, and artificial abortions in 17.8%. These results were similar to those expected for pregnant women in the general Korean population. All artificial abortions occurred in unplanned pregnancies, and 80% of those cases were due to a misunderstanding of IBD and medications. IBD was aggravated in 11.1% of the patients in remission or with mild activity and in 85.7% of patients with moderate or severe activity at the time of early pregnancy. Of 57 pregnancies in the spouses of 39 male patients, live births occurred in 78.9%, miscarriages in 8.8%, and artificial abortions in 3.5%. There was no significant influence of therapeutic medications on the natural course of pregnancies. Conclusions: Pregnancy outcomes in IBD patients appear to be similar to those of the general Korean population. A properly planned pregnancy and a comprehensive treatment course before and during pregnancy are important considerations for increasing the likelihood of a normal pregnancy in those with IBD. (Intest Res 2010;8:30-39)

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A Case of Pylephlebitis of the Inferior Mesenteric Vein and Portal Vein: Hae Sun Jung, Ki-Nam Shim, Ji Min Jung, Min-Jung Kang, Youn Ju Na, Sung Ae Jung, Kwon Yoo; Intest Res 2009;7(2):105-109. Published online December 30, 2009

Abstract PDF: Pylephlebitis is defined as septic thrombophlebitis of the portal vein or one of its tributaries. Pylephlebitis is an uncommon and often fatal complication of intra-abdominal infections, such as diverticulitis and appendicitis. The most common bacteria isolated from patients with pylephlebitis are Escherichia coli and Bacteroides fragilis. The overall mortality rate is 32%. We describe a case of septic thrombophlebitis of the main portal vein and inferior mesenteric vein successfully treated with broad-spectrum antibiotics and anticoagulants. The early diagnosis and treatment with the timely administration of antibiotics is most important for pylephlebitis. (Intest Res 2009;7:105-109)

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Expression of Matrix Metallopreoteinases and Tissue Inhibitors of Metalloproteinases in Ulcerative Colitis: Seong-Eun Kim, Sung-Ae Jung, Ki-Nam Shim, Hye Kyung Jung, Tae Hun Kim, Kwon Yoo; Intest Res 2009;7(1):32-40. Published online June 30, 2009

Abstract PDF: Background/Aims
Ulcerative colitis (UC) is characterized by chronic non-specific inflammation in the mucosa and submucosa of the colon. Degradation of the extracellular matrix (ECM) is one of the major events during this process. Matrix metalloproteinases (MMPs) are important enzymes involved in the degradation of the ECM, and the activities of MMPs are controlled by its natural inhibitor, tissue inhibitor of metalloproteinases (TIMPs). This study was performed to determine the expression of MMPs and TIMPs in patients with UC. Methods: Twenty-nine patients with UC and 5 controls were included. Colonoscopic biopsies were obtained from the cecum, ascending colon, transverse colon, sigmoid colon, and rectum in each patient. The mRNA levels of expression of MMP-2 and -9, and TIMP-1 and -2 were measured separately using reverse transcription polymerase chain reactions in the mucosal specimens from each 5 segments of the colon. Results: The mRNA expression of MMP-2 and -9, and TIMP-1 in the inflamed tissues of patients with UC was significantly increased compared to non-inflamed tissues of patients with UC and controls (p＜0.05). The mRNA expression of MMP-9 and TIMP-1 in non-inflamed tissues of patients with UC was significantly higher than that of controls (p＜0.05). In inflamed tissues of UC, the mRNA expression of MMP-2 was significantly correlated with TIMP-2, and the mRNA expression of MMP-9 was significantly correlated with TIMP-1. The MMP-2/TIMP-2 ratio was increased in inflamed tissues compared to non-inflamed tissues of patients with UC and controls (p＜0.05). Conclusions: MMP-2 and-9, and TIMP-1 are likely to contribute to the inflammatory cascade in UC. MMP-2 and-9, and TIMP-1 might be important clues to solve the pathogenesis of UC. (Intest Res 2009;7:32-40)

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Clinical Characteristics of Primary Epiploic Appendagitis: Jae Jung Park, Sung-Ae Jung, Young Wook Noh, Go Heun Kim, Hyun-mi Heo, Suh Eun Bae, Yun Jung Choi, So I Kim, Myung-Won Lee, Min Jung Kang, Ji Min Jung, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Tae-Hun Kim, Kwon Yoo, Il Hwan Moon; Intest Res 2009;7(1):47-51. Published online June 30, 2009

Abstract PDF: Background/Aims
Primary epiploic appendagitis (PEA) is a rare cause of focal abdominal pain in otherwise healthy patients. Patients with acute abdominal pain are often misdiagnosed clinically as acute appendicitis or diverticulitis. The purpose of this study was to describe the clinical presentation and characteristic computed tomography (CT) findings of PEA. Methods: We reviewed the clinical records and CT images of 23 consecutive patients in Korea who presented with acute abdominal pain between January 2005 and February 2009 and had radiologic signs of PEA. Results: Twenty-three patients (7 females and 16 males; average age, 42±14 years) were diagnosed with symptomatic PEA. Abdominal pain localized to the left (8 patients [44.5%]) and right (10 patients [55.5%]) lower quadrants as the leading symptom. CT findings specific for PEA were present in all patients except one. The symptoms resolved within 1 week (mean, 3.5 days) with or without antibiotic treatment. Conclusions: In patients with localized, sharp, acute abdominal pain not associated with other symptoms, such as nausea, vomiting, fever or atypical laboratory values, the diagnosis of PEA should be considered and the diagnosis confirmed by CT scan. (Intest Res 2009;7:47-51)

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A Case of Cystic Lymphangioma of Small Bowel Mesentery Presented with Small Bowel Volvulus: Chang Yoon Ha, Ki-Nam Shim, Min Jung Kang, Ji Min Jung, Youn Ju Na, Sung-Ae Jung, Kwon Yoo, Seog Ki Min; Intest Res 2008;6(1):76-79. Published online June 30, 2008

Abstract PDF: A cystic lymphangioma is a rare benign tumor that arises in an organ with a large number of lymphatics. It arises in patients of all ages and has variable presentations. An abdominal cystic lymphangioma most commonly occurs in the intestinal mesentery, with the retroperitoneum being the second location of choice, and it causes abdominal pain, hematochezia, intussusceptions and protein-losing enteropathy. If the cystic lymphangioma presents with symptoms, surgical excision is required for treatment and diagnosis. We report here a case of cystic lymphangioma of the small bowel mesentery that presented with a small bowel volvulus, along with a brief review of the literature. (Intest Res 2008;6:76-79)

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Expression of Matrix Metalloproteinase in Colon Adenoma and Colon Cancer: MT1-MMP and TIMP-2: Jeong Eun Shin, Sung-Ae Jung, Seong-Eun Kim, Yang-Hee Joo*, Ki-Nam Shim, Tae Hun Kim, Kwon Yoo, Il-Hwan Moon; Intest Res 2007;5(2):144-150. Published online December 30, 2007

Abstract PDF: Background/Aims
This study investigated the expression of membrane type 1-matrix metalloproteinase (MT1-MMP) and the tissue inhibitor of metalloproteinase-2 (TIMP-2) in cases of adenoma-carcinoma sequence. Methods: Thirty-two samples of colon adenoma, 11 samples of early colon cancer (ECC) and 36 samples of advanced colon cancer (ACC) were collected from colonoscopic biopsies. Normal tissues were also collected from the same subjects. The mRNA expression levels of MT1-MMP and TIMP-2 were quantified using semiquantitative RT-PCR. Results: The mRNA expression levels of MT1-MMP were greater in the ACC samples as compared to the adenoma and ECC samples (p＜0.05, respectively). However, there was no difference in the mRNA expression levels of MT1-MMP between the adenoma and ECC samples. The mRNA expression levels of TIMP-2 were greater in the ACC samples as compared to the adenoma samples (p＜0.001) but did not differ between the adenoma and ECC, and between the ECC and ACC. The expression level of MT1-MMP mRNA was positively related to lymph node metastasis (p＜0.05). However, the mRNA expression levels of MT1-MMP and TIMP-2 did not differ for colon cancer according to differentiation and modified Dukes’ stage. Conclusions: The mRNA expression levels of MT1-MMP and TIMP-2 have limitations as useful markers for malignant degeneration of colonic neoplasm and the progression of colon cancer. (Intest Res 2007;5:144-150)

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A Case of Crohn’s Disease with Psoas Abscess and Enterocutaneous Fistula: Hae Sun Jung, Ki-Nam Shim, Min-Jung Kang, Su Jung Baik, Kum Hei Ryu, Sung-Ae Jung, Kwon Yoo, Seog Ki Min; Intest Res 2007;5(2):188-191. Published online December 30, 2007

Abstract PDF: Crohn’s disease is a chronic, transmural and inflammatory disease of the gastrointestinal tract. Intraabdominal abscesses and fistulas are common complications in Crohn’s disease. However, the presence of a psoas abscess and enterocutaneous fistula in Crohn’s disease is very rare. The incidence of a psoas abscess is 0.4-4.3% and the incidence of an enterocutaneous fistula is 15-25%. Moreover, as a psoas abscess presents as a flexion contracture of the sacroiliac joint, it is apt to be misdiagnosed as arthritis, one of the common extraintestinal manifestations of Crohn’s disease. We describe here a case of a 26-year-old female who presented with pain and flexion contracture of the right sacroiliac joint. The patient was diagnosed with a psoas abscess and an enterocutaneous fistula as complications of Crohn’s disease. (Intest Res 2007;5:188-191)

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A Case of Stroke after Cessation of the Warfarin for a Colonoscopic Polypectomy: Ju Young Choi, Ki-Nam Shim, Su Jung Baik, Yoo Ri Kim, Sung-Eun Kim, Sung-Ae Jung, Kwon Yoo, Il Hwan Moon; Intest Res 2007;5(2):200-203. Published online December 30, 2007

Abstract PDF: It is not necessary to adjust anticoagulation for low-risk procedures, such as a gastroduodenoscopy or a colonoscopy with biopsy. For high-risk procedures of bleeding that include an endoscopic polypectomy and treatment of varices, warfarin should be discontinued for a few days. However, there is the risk of a thromboembolism by stopping warfarin treatment. We report a case of a 77-year-old man with atrial fibrillation, who stopped taking warfarin 4 days before a colonoscopic polypectomy, and developed an acute cerebral infarction after the procedure. (Intest Res 2007;5:200-203)

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A Case of Ileocolic Intussusception Induced by Mantle Cell Lymphoma: Kum Hei Ryu, Ki-Nam Shim, Hyun Joo Song, Yoon Ju Na, Su Jung Baik, Su Jin Yoon, Hae-Sun Jung, Hye Jung Yeom, Sung-Ae Jung, Tae Hun Kim, Kwon Yoo, Min-Sun Cho; Intest Res 2006;4(1):61-63. Published online June 30, 2006

Abstract PDF: Although the gastrointestinal tract is one of the major sites of primary extranodal malignant lymphoma, the colon and small bowel are less frequently involved than the stomach. Mantle cell lymphoma comprising only 6% of the malignant non-Hodgkin lymphomas. Mantle cell lymphoma usually distributes from the esophagus to rectum, with advanced stages of peripheral lymphadenopathy, splenomegaly, and bone marrow infiltration. We report a case of ileocolic intussusception due to ileal mantle cell lymphoma. (Intestinal Research 2006;4:61-63)

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