Citations

Citations to this article as recorded by  

• Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1
  Iradj Sobhani, Nilmara De Oliveiro Alves, Cecile Charpy, Emma Bergsten, Caroline Barau, Amaury Vaysse, Mathias Chamaillard, Shatha Awaad, Aurelien Amiot, Mohammad Sadeghi, Denis Mestivier, Khashayarsha Khazaie
  BMJ Oncology.2025; 4(1): e000859.     CrossRef
• Effects of DNA methylation and its application in inflammatory bowel disease (Review)
  Francis Akanyibah, Yi Zhu, Aijun Wan, Dickson Ocansey, Yuxuan Xia, An-Ning Fang, Fei Mao
  International Journal of Molecular Medicine.2024;[Epub]     CrossRef
• Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach
  Davide Guido, Fatima Maqoud, Michelangelo Aloisio, Domenica Mallardi, Blendi Ura, Nicolò Gualandi, Massimiliano Cocca, Francesco Russo
  International Journal of Molecular Sciences.2024; 25(17): 9322.     CrossRef
• From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies
  Ehsan Gharib, Gilles A. Robichaud
  International Journal of Molecular Sciences.2024; 25(17): 9463.     CrossRef
• Inflammatory Bowel Diseases in Spain: A View from the Present to the Future
  Raquel Francés, Yuanji Fu, Christophe Desterke, Jorge Mata-Garrido
  J.2024; 7(4): 489.     CrossRef
• Epigenotoxicity: a danger to the future life
  Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
  Journal of Environmental Science and Health, Part A.2023; 58(4): 382.     CrossRef
• Evaluating the Clinical Performance of a Dual-Target Stool DNA Test for Colorectal Cancer Detection
  Zhongxin Wang, Jian Shang, Guannan Zhang, Lingjun Kong, Feng Zhang, Ye Guo, Yaling Dou, Jun Lin
  The Journal of Molecular Diagnostics.2022; 24(2): 131.     CrossRef
• Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
  Se Lim Kim, Min Woo Shin, Seung Young Seo, Sang Wook Kim
  Bioscience Reports.2022;[Epub]     CrossRef
• Personalized medicine in inflammatory bowel disease: Perspectives on Asia
  Su Hyun Park, Sang Hyoung Park
  Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
• Landscape of sialylation patterns identify biomarkers for diagnosis and prediction of response to anti-TNF therapy in crohn’s disease
  Chenglin Ye, Sizhe Zhu, Yuan Gao, Yabing Huang
  Frontiers in Genetics.2022;[Epub]     CrossRef
• The role of epigenetic modifications for the pathogenesis of Crohn's disease
  M. Hornschuh, E. Wirthgen, M. Wolfien, K. P. Singh, O. Wolkenhauer, J. Däbritz
  Clinical Epigenetics.2021;[Epub]     CrossRef
• SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling
  Dao-Pei Zou, Yang-Mei Chen, Ling-Zhao Zhang, Xiao-Hui Yuan, Yu-Jie Zhang, Adelina Inggawati, Pham Thi Kieu Nguyet, Tian-Wen Gao, Jin Chen
  Genes & Diseases.2021; 8(5): 677.     CrossRef

Overwhelming evidences supports the idea that inflammatory bowel disease (IBD) is caused by a complex interplay between genetic alterations of multiple genes and an aberrant interaction with environmental factors. There is growing evidence that epigenetic factors can play a significant part in the pathogenesis of IBD. Significant effort has been invested in uncovering genetic and epigenetic factors, which may increase the risk of IBD, but progress has been slow, and few IBD-specific factors have been detected so far. It has been known for decades that DNA methylation is the most well studied epigenetic modification, and analysis of DNA methylation is leading to a new generation of cancer biomarkers. Therefore, in this review, we summarize the role of DNA methylation alteration in IBD pathogenesis, and discuss specific genes or genetic loci using recent molecular technology advances. Here, we suggest that DNA methylation should be studied in depth to understand the molecular pathways of IBD pathogenesis, and discuss epigenetic studies of IBD that may have a significant impact on the field of IBD research.

Citations

Citations to this article as recorded by  

• From Exposure to Dysfunction: The Intestinal Toxicity of Per- and Polyfluoroalkyl Substances
  Kashi Brunetti, Giulia Serena Galletti, Elisabetta Catalani, Davide Cervia, Simona Del Quondam
  Toxics.2025; 14(1): 39.     CrossRef
• Personalized Medicine for IBD Patients
  Nina Fadeeva, Igor Khatkov, Natalia Bodunova, Oleg Knyazev, Dmitry Bordin, Asfold Parfenov, Karina Nikolskaya, Sergey Nikolaev, Konstantin Rumyantsev, Vera Polyakova, Tatiana Yanova
  BioNanoScience.2023; 13(1): 330.     CrossRef
• Epigenetic Changes and Its Intervention in Age-Related Neurodegenerative Diseases
  Nuraqila Mohd Murshid, Faridah Aminullah Lubis, Suzana Makpol
  Cellular and Molecular Neurobiology.2022; 42(3): 577.     CrossRef
• Role of diet and nutrition in inflammatory bowel disease
  Marina Moreira de Castro, Lívia Bitencourt Pascoal, Karine Mariane Steigleder, Beatriz Piatezzi Siqueira, Ligiana Pires Corona, Maria de Lourdes Setsuko Ayrizono, Marciane Milanski, Raquel Franco Leal
  World Journal of Experimental Medicine.2021; 11(1): 1.     CrossRef
• Genome-Wide Analysis of the DNA Methylation Profile Identifies the Fragile Histidine Triad (FHIT) Gene as a New Promising Biomarker of Crohn’s Disease
  Tae-Oh Kim, Dong-Il Park, Yu Han, Keunsoo Kang, Sae-Gwang Park, Hae Park, Joo Yi
  Journal of Clinical Medicine.2020; 9(5): 1338.     CrossRef
• Aberrant methylation and microRNA-target regulation are associated with downregulated NEURL1B: a diagnostic and prognostic target in colon cancer
  Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Yanli Yan, Shuai Shao, Demao Yao, Tuotuo Gong
  Cancer Cell International.2020;[Epub]     CrossRef
• Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine
  Faizan Rashid, Saeed Ahmad, Joseph Maria Kumar Irudayaraj
  Toxics.2020; 8(3): 64.     CrossRef
• Epigenetics, DNA Organization, and Inflammatory Bowel Disease
  Greeshma Ray, Michelle S Longworth
  Inflammatory Bowel Diseases.2019; 25(2): 235.     CrossRef
• Impaired nutritional status in outpatients in remission or with active Crohn's disease – classified by objective endoscopic and imaging assessments
  Marina Moreira de Castro, Ligiana Pires Corona, Lívia Bitencourt Pascoal, Bruno Lima Rodrigues, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Raquel Franco Leal, Marciane Milanski
  Clinical Nutrition ESPEN.2019; 33: 60.     CrossRef
• Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma
  Su Hwan Kim, Ji Won Kim, Kook Lae Lee, Seohui Lee, Seong-Joon Koh, Ji Bong Jeong, Byeong Gwan Kim
  The American Journal of the Medical Sciences.2018; 356(2): 141.     CrossRef
• Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
  Haiming Fang, Lian Fu, Jiajia Wang
  BioMed Research International.2018; 2018: 1.     CrossRef
• Epigenetic modulation of intestinal Na+/H+ exchanger-3 expression
  Anoop Kumar, Pooja Malhotra, Hayley Coffing, Shubha Priyamvada, Arivarasu N. Anbazhagan, Harish R. Krishnan, Ravinder K. Gill, Waddah A. Alrefai, David P. Gavin, Subhash C. Pandey, Pradeep K. Dudeja, Seema Saksena
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2018; 314(3): G309.     CrossRef
• Is there a potential role of fecal microbiota transplantation in the treatment of inflammatory bowel disease?
  Chang Soo Eun
  Intestinal Research.2017; 15(2): 145.     CrossRef
• Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer
  Otgontuya Sambuudash, Hyun-Soo Kim, Mee Yon Cho
  Yonsei Medical Journal.2017; 58(4): 749.     CrossRef
• The colon revisited or the key to wellness, health and disease
  C.A. Gonzalez-Correa, E. Mulett-Vásquez, D.A. Miranda, C.H. Gonzalez-Correa, P.A. Gómez-Buitrago
  Medical Hypotheses.2017; 108: 133.     CrossRef
• The contribution of long non-coding RNAs in Inflammatory Bowel Diseases
  Eirini Zacharopoulou, Maria Gazouli, Maria Tzouvala, Antonios Vezakis, George Karamanolis
  Digestive and Liver Disease.2017; 49(10): 1067.     CrossRef
• Epigenetic silencing of NDRG2 promotes colorectal cancer proliferation and invasion
  Sung Noh Hong, Sung Jin Kim, Eun‐Ran Kim, Dong Kyung Chang, Young‐Ho Kim
  Journal of Gastroenterology and Hepatology.2016; 31(1): 164.     CrossRef
• Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis
  Italia Loddo, Claudio Romano
  Frontiers in Immunology.2015;[Epub]     CrossRef
• The genetic architecture of inflammatory bowel disease
  Isabelle Cleynen, Séverine Vermeire
  Current Opinion in Gastroenterology.2015;[Epub]     CrossRef
• Epigenetic Modification and Its Role in Alzheimer's Disease
  Yi-Ping Zhu, Ya Feng, Te Liu, Yun-Cheng Wu
  Integrative Medicine International.2015; 2(1-2): 63.     CrossRef