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Original Article
- IBD
- Sarcopenia is common in ulcerative colitis and correlates with disease activity
- Pardhu B Neelam, Rimesh Pal, Pankaj Gupta, Anupam K Singh, Jimil Shah, Harshal S Mandavdhare, Harjeet Singh, Aravind Sekar, Sanjay K Bhadada, Usha Dutta, Vishal Sharma
- Intest Res 2024;22(2):162-171. Published online January 22, 2024
- DOI: https://doi.org/10.5217/ir.2023.00090
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Abstract
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Supplementary Material
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ePub - Background/Aims
Association of sarcopenia with disease severity in ulcerative colitis (UC) is not clearly defined. We planned to estimate the prevalence of sarcopenia in patients with UC as per the revised definition and its relation with the disease severity.
Methods
A cross-sectional assessment of sarcopenia in patients with UC was performed. Disease activity was graded according to complete Mayo score. Hand grip strength was assessed with Jamar hand dynamometer, muscle mass using a dual energy X-ray absorptiometry scan, and physical performance with 4-m walk test. Sarcopenia was defined as a reduction of both muscle mass and strength. Severe sarcopenia was defined as reduced gait speed in presence of sarcopenia.
Results
Of 114 patients (62 males, mean age: 36.49±12.41 years), 32 (28%) were in remission, 46 (40.4%) had mild-moderate activity, and 36 (31.6%) had severe UC. Forty-three patients (37.7%) had probable sarcopenia, 25 (21.9%) had sarcopenia, and 14 (12.2%) had severe sarcopenia. Prevalence of sarcopenia was higher in active disease (2 in remission, 6 in active, and 17 in severe, P<0.001). Of 14 with severe sarcopenia, 13 had severe UC while 1 had moderate UC. On multivariate analysis, lower body mass index and higher Mayo score were associated with sarcopenia. Of 37 patients with acute severe colitis, 16 had sarcopenia. Requirement of second-line therapy was similar between patients with and without sarcopenia. On follow-up (median: 18 months), there was a non-significant higher rate of major adverse events in those with sarcopenia (47.4% vs. 33.8%, P=0.273).
Conclusions
Sarcopenia and severe sarcopenia in UC correlate with the disease activity. -
Citations
Citations to this article as recorded by
- Prevalence and outcome of sarcopenia in patients with inflammatory bowel disease: a follow-up study
Vikram Dharap, Devendra Desai, Philip Abraham, Tarun Gupta, Pavan Dhoble, Nirad Mehta, Jagdish Modhe
Intestinal Research.2026; 24(1): 141. CrossRef - Nutrition in achalasia cardia—A neglected frontier
Urvashi Rana, Harshal S. Mandavdhare
Indian Journal of Gastroenterology.2026; 45(5): 801. CrossRef - Shared molecular features and potential diagnostic biomarkers between ulcerative colitis and sarcopenia: an integrative bioinformatics analysis with preliminary experimental validation
Beiying Deng, Yinghui Liu, Pengzhan He, Nian Wang, Lin Xu, Jingjing Ma
Frontiers in Immunology.2026;[Epub] CrossRef - Cross-talk of gut-bone-muscle: osteosarcopenia in experimental colitis models
Shilpa Sharma
Laboratory Animal Research.2026;[Epub] CrossRef - Sarcopenia as a prognostic marker in inflammatory bowel disease: Implications for endoscopic outcomes and loss of response to biologic therapy—A systematic review with narrative synthesis
Thomas Fuchs, Vanessa Stadlbauer
Inflammatory Bowel Diseases.2026;[Epub] CrossRef - Sarcopenia in patients with active ulcerative colitis: associations with serum metabolites and gut microbiota
Wei Wei, Pengguang Yan, Fang Wang, Qiong Wang, Chunwei Li, Xiaoyin Bai, Yu Zhang, Yuanyuan Bao, Jingnan Li, Kang Yu
Frontiers in Nutrition.2026;[Epub] CrossRef - Prevalence and diagnostic variability of sarcopenia in India: A systematic review and meta-analysis
Mogan Kaviprawin, Gnanaprakash Gurusamy, Carolin Elizabeth George, Alexander Thomas, Mohan Babu Saminathan, Lalithambigai Kathiresan, Deepa C., Aswathy P., Aravind P. Gandhi, Shanmuganathan Rajasekaran
The Indian Journal of Medical Research.2026; 164: 423. CrossRef - Sarcopenia in Inflammatory Bowel Disease: Prevalence, Mechanisms, Detection, Adverse Clinical Impact and Targetable Care Gaps—A Narrative Review Supported by a Structured Literature Search
Alexandra-Ioana Vasilachi-Lulache, Petruta Violeta Filip, Cosmin Alexandru Ciora, Eugen-Florin Georgescu, Laura Sorina Diaconu, Anca Roxana Băleanu, Corina Silvia Pop
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Solène Dermine, Thomas Bazin, Fatimé Adam Hassan, Johanna Bettolo, Lore Billiauws, Justine Bourdillel, Clément Bresteau, Olivier Corcos, Myriam El khatib, Ashiq Mohamed Gouse, Coralie Hutinet, Alexandre Nuzzo, Francisca Joly
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Young Joo Yang, Seong Ran Jeon
The Korean Journal of Internal Medicine.2025; 40(2): 181. CrossRef - Impact of body mass index on clinical outcomes in intestinal Behçet’s disease
Daye Park, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
The Korean Journal of Internal Medicine.2025; 40(4): 606. CrossRef - Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease
Shilpa Sharma
Intestinal Research.2025; 23(3): 254. CrossRef - Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence
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JGH Open.2024;[Epub] CrossRef - Utility of SARC‐F for screening for sarcopenia in ulcerative colitis
Pardhu B. Neelam, Vishal Sharma
Nutrition in Clinical Practice.2024; 39(5): 1270. CrossRef - Response to “Utility of SARC‐F for screening for sarcopenia in ulcerative colitis”
Ilkay Ergenc, Chasan Ismail Basa, Alper Uzum, Sevval Sahin, Haluk Tarık Kani, Rahmi Aslan, Aslı Tufan, Özgür Kasımay, Özlen Atuğ, Yeşim Özen Alahdab
Nutrition in Clinical Practice.2024; 39(5): 1272. CrossRef - Sarcopenia and low prognostic nutritional index as markers of disease activity in patients with inflammatory bowel disease and predictors of poor outcome: a cohort longitudinal study
Mirella Sherif, Rabab Fouad, Tamer Elbaz, Maryse Awadalla, Omnia Tantawi, Mohamed Negm, Dalia Abd El-kareem, Ibrahim Naguib, Hany Shehab, Hedy A. Badary
Egyptian Rheumatology and Rehabilitation.2024;[Epub] CrossRef
- Prevalence and outcome of sarcopenia in patients with inflammatory bowel disease: a follow-up study
- 10,613 View
- 321 Download
- 13 Web of Science
- 16 Crossref
Brief Communication
- Infection
- Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India
- Harshal S Mandavdhare, Jimil Shah, Kaushal K Prasad, Roshan Agarwala, Vikas Suri, Savita Kumari, Usha Dutta, Vishal Sharma
- Intest Res 2019;17(1):149-152. Published online October 16, 2018
- DOI: https://doi.org/10.5217/ir.2018.00111
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Citations
Citations to this article as recorded by- ECCO consensus on management of inflammatory bowel disease in low- and middle-income countries
Alaa El-Hussuna, Almuthe Christina Hauer, Tarkan Karakan, Valerie Pittet, Henit Yanai, Jalpa Devi, Jesus K Yamamoto-Furusho, Ali Reza Sima, Hailemichael Desalegn, Mutaz Idrees Sultan, Vishal Sharma, Hany Shehab, Lamya Mrabti, Natalia Queiroz, Anuraag Jena
Journal of Crohn’s and Colitis.2026;[Epub] CrossRef - Unusual gastrointestinal histoplasmosis with jejunal perforation in a 57-year-old patient from Bogotá: Case report
Diana-Marcela Gaviria-Delgado , Natalia Olaya, Laura Cristina Nocua-Báez
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Bassey E. Ekeng, Asa E. Itam-Eyo, Iriagbonse I. Osaigbovo, Adilia Warris, Rita O. Oladele, Felix Bongomin, David W. Denning
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Faisal Inayat, Gul Nawaz, Arslan Afzal, Maleeha Ajmal, Marjan Haider, Muhammad Sarfraz, Zaka Ul Haq, Sobaan Taj, Rizwan Ishtiaq
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Chirag Patel, Patricia Le, Malik Salman, Stephen Cavalieri, Joyce Kovar
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Berta Oliveras, Marc Albert, Carme López, Esther Fort, Laia Peries, Laia Gutiérrez, David Busquets, Hugo Uchima, Xavier Aldeguer, Virginia Piñol
Clinical Journal of Gastroenterology.2021; 14(2): 690. CrossRef - A case of gastrointestinal histoplasmosis with esophageal involvement
Mathew Finniss, Paul Lewis, James Myers, Lamis Ibrahim, Paras Patel
Clinical Journal of Gastroenterology.2020; 13(2): 173. CrossRef - Ileocecal thickening: Clinical approach to a common problem
Roshan Agarwala, Abhi K Singh, Jimil Shah, Harshal S Mandavdhare, Vishal Sharma
JGH Open.2019; 3(6): 456. CrossRef
- ECCO consensus on management of inflammatory bowel disease in low- and middle-income countries
- 11,711 View
- 199 Download
- 8 Web of Science
- 8 Crossref
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