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Original Article
- IBD
- Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity
- Alex Barnes, Jane M Andrews, Sutapa Mukherjee, Robert V Bryant, Peter Bampton, Robert J. Fraser, Réme Mountifield
- Intest Res 2024;22(1):104-114. Published online November 1, 2023
- DOI: https://doi.org/10.5217/ir.2023.00028
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Abstract
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Supplementary Material
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ePub - Background/Aims
Insomnia is common in people with chronic medical conditions, such as inflammatory bowel disease (IBD), and is readily treatable through cognitive behavioral therapy for insomnia. This study aimed to describe the associations with insomnia in people with IBD and its relationship to IBD-related disability.
Methods
An online questionnaire was administered through 3 tertiary IBD centers, social media, and Crohn’s Colitis Australia. The questionnaire included the Insomnia Severity Index (ISI), a validated assessment of insomnia. Measures of anxiety, depression, physical activity, and disability were also included. IBD activity was assessed using validated patient reported scores. A multivariate model was constructed for clinically significant insomnia and ISI scores. Subpopulations of Crohn’s disease and ulcerative colitis were considered.
Results
In a cohort of 670 respondents the median age was 41 years (range, 32–70 years), with the majority female (78.4%), the majority had Crohn’s disease (57.3%). Increasingly severe disability was associated with worse insomnia score. Clinically significant insomnia was associated with clinically active IBD, abdominal pain, anxiety, and depression, in a multivariate model. In an ulcerative colitis population, Simple Clinical Colitis Activity Index components of general well-being and urgency were associated with worse ISI score in a model including depression and anxiety. In those with Crohn’s disease, the multivariate model included Harvey Bradshaw Index score in addition to depression and anxiety.
Conclusions
Insomnia is common in people with IBD and is associated with increased disability. Abdominal pain and mental health conditions should prompt consideration for screening for insomnia and referral for cognitive behavioral therapy for insomnia. -
Citations
Citations to this article as recorded by
- The IBD Clinic of Tomorrow: Holistic, Patient-Centric, and Value-based Care
Benjamin Click, Raymond K. Cross, Miguel Regueiro, Laurie Keefer
Clinical Gastroenterology and Hepatology.2025; 23(3): 419. CrossRef - Chronic Poor Sleep is Associated with Increased Disease Activity in Patients with Ulcerative Colitis: Prospective Observational Study in Japan
Hideaki Oyama, Rintaro Moroi, Atsushi Sakuma, Yusuke Shimoyama, Hiroshi Nagai, Takeo Naito, Hisashi Shiga, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune
Journal of Crohn's and Colitis.2025;[Epub] CrossRef - Association between depression and anxiety with the risk and flare of inflammatory bowel disease: a systematic review and meta-analysis
Guowei Gong, Cong Xu, Zhenxia Zhang, Yuzhong Zheng
Internal and Emergency Medicine.2025; 20(1): 35. CrossRef - The impact of sleep quality on the prognosis of inflammatory bowel disease commonly overlooked by gastroenterologists
Ji Young Chang
Intestinal Research.2024; 22(1): 5. CrossRef - Sleep quality is associated with reduced quality of life in inflammatory bowel disease through its interaction with pain
Alex Barnes, Robert V Bryant, Sutapa Mukherjee, Paul Spizzo, Réme Mountifield
JGH Open.2024;[Epub] CrossRef - Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review
Wei-wei Tan, Zi-xuan Liu, Xiao-Yan Liu, Wei-bing Zhang, Lie Zheng, Ya-Li Zhang, Yan-Cheng Dai
Pain and Therapy.2024; 13(6): 1447. CrossRef - Impact of Inflammatory Bowel Disease on Patient’s Quality of Life – A Review
Kamila Duszyńska, Karol Dolepski, Alicja Góral, Krystian Żuk, Michał Czachajda
Journal of Health Study and Medicine.2024; 2024(1): 185. CrossRef
- The IBD Clinic of Tomorrow: Holistic, Patient-Centric, and Value-based Care
- 4,607 View
- 280 Download
- 6 Web of Science
- 7 Crossref
Brief Communication
- IBD
- Novel inflammatory bowel disease (IBD) specific electronic medical record allows scalable auditing of IBD severity, therapy and complications to show the current unmet need in IBD care
- Alex Barnes, David Carter, Patricia Kaazan, Alissa Walsh, Susan Connor, Jane M Andrews
- Intest Res 2022;20(4):506-508. Published online April 26, 2022
- DOI: https://doi.org/10.5217/ir.2022.00003
- 3,682 View
- 375 Download
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