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- The predictive variable regarding relapse in patients with ulcerative colitis after achieving endoscopic mucosal healing
- Takuya Yoshino, Kohei Yamakawa, Satoshi Nishimura, Koutaro Watanabe, Shujiro Yazumi
- Intest Res 2016;14(1):37-42. Published online January 26, 2016
- DOI: https://doi.org/10.5217/ir.2016.14.1.37
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Abstract
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ePub <b>Background/Aims</b><br/> Mucosal healing (MH) is a proposed therapeutic goal for patients with ulcerative colitis (UC). Whether MH is the final goal for UC, however, remains under debate. Therefore, to elucidate clinical variables predicting relapse after MH in UC could be useful for establishing further therapeutic strategy. The aim of this study is to evaluate the predictive variables for relapse in UC-patients after achieving MH.
Methods From April 2010 to February 2015, 298 UC-patients treated at Kitano Hospital were retrospectively analyzed. MH was defined as Mayo endoscopic subscore of 0 or 1. The cumulative relapse free rate after achieving MH was evaluated. Predictive variables for relapse in UC-patients were assessed by Cox regression analysis.
Results Of 298 UC-patients, 88 (29.5%) achieved MH. Of the 88 UC patients who achieved MH, 21 (23.9%) experienced UC-relapse. Based on Kaplan-Meier analysis, the cumulative relapse free rate at 1, 3, and 5 years after achieving MH was 87.9%, 70.2%, and 63.8%, respectively. The cumulative relapse free rate tended to be higher in the Mayo-0 group (76.9%) than in the Mayo-1 group (54.1%) at 5 years, although the difference was not statistically significant (
P =0.313). Cox regression analysis indicated that the use of an immunomodulator was a predictive variable for relapse in UC-patients after achieving MH (P =0.035).Conclusions Our data demonstrated that the prognosis of UC patients after achieving endoscopic MH could be based on UC refractoriness requiring an immunomodulator.
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Citations
Citations to this article as recorded by
- Deep mucosal healing in ulcerative colitis: how deep is better?
Xin Jin, Yan You, Gechong Ruan, Weixun Zhou, Ji Li, Jingnan Li
Frontiers in Medicine.2024;[Epub] CrossRef - Systematic review and meta-analysis: the advantage of endoscopic Mayo score 0 over 1 in patients with ulcerative colitis
Angelo Viscido, Marco Valvano, Gianpiero Stefanelli, Annalisa Capannolo, Chiara Castellini, Eugenia Onori, Antonio Ciccone, Filippo Vernia, Giovanni Latella
BMC Gastroenterology.2022;[Epub] CrossRef - Predicting Ulcerative Colitis Relapse in Clinical Remission With Fecal Immunochemical Occult Blood Test or Prostaglandin E-Major Urinary Metabolite
Natsuki Ishida, Tomoharu Matsuura, Yusuke Asai, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Clinical and Translational Gastroenterology.2022; 13(7): e00501. CrossRef - Further research on the clinical relevance of the ulcerative colitis colonoscopic index of severity for predicting 5-year relapse
Natsuki Ishida, Shunya Onoue, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
International Journal of Colorectal Disease.2021; 36(12): 2661. CrossRef - Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: a pooled analysis of data from two clinical trials
Toshifumi Hibi, Makoto Naganuma, Eisei Oda, Yoji Yamada, Yoshitomo Chujoh, Ryoichi Yoshihara, Mamoru Watanabe
Intestinal Research.2020; 18(1): 56. CrossRef - Incremental Benefit of Achieving Endoscopic and Histologic Remission in Patients With Ulcerative Colitis: A Systematic Review and Meta-Analysis
Hyuk Yoon, Sushrut Jangi, Parambir S. Dulai, Brigid S. Boland, Larry J. Prokop, Vipul Jairath, Brian G. Feagan, William J. Sandborn, Siddharth Singh
Gastroenterology.2020; 159(4): 1262. CrossRef - Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic remission by budesonide rectal foam
Makoto Naganuma, Fumihito Hirai, Kiyonori Kobayashi, Kenji Watanabe, Ken Takeuchi, Nobuo Aoyama, Hiroshi Nozawa, Satoshi Motoya, Toshihide Ohmori, Akio Harada, Yushi Nagai, Takayuki Abe, Yoji Yamada, Katsutoshi Inagaki, Naoki Shimizu, Takanori Kanai, Mamo
PLOS ONE.2019; 14(8): e0220413. CrossRef - Endoscopic score vs. fecal biomarkers for predicting relapse in patients with ulcerative colitis after clinical remission and mucosal healing
Takayuki Yamamoto, Takahiro Shimoyama, Satoru Umegae, Koichi Matsumoto
Clinical and Translational Gastroenterology.2018; 9(3): e136. CrossRef - European Crohn’s and Colitis Organisation Topical Review on Treatment Withdrawal [‘Exit Strategies’] in Inflammatory Bowel Disease
Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, Jarosław Kierkuś, Loris Lopetuso, Edyta Szymanska, Edouard Louis
Journal of Crohn's and Colitis.2018; 12(1): 17. CrossRef - Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
Mostafa Vaghari Tabari, Soheila Moein, Durdi Qujeq, Mehrdad Kashifard, Javaad Shokri Shirvani, Karimollah Hajian Tilaki, Gholamreza Farshidfar
Annals of Colorectal Research.2017;[Epub] CrossRef
- Deep mucosal healing in ulcerative colitis: how deep is better?
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- 10 Crossref
- Clinical features of Crohn's disease in Korean patients residing in Busan and Gyeongnam
- Eun Ji Lee, Tae Oh Kim, Geun Am Song, Jong hun Lee, Hyung Wook Kim, Sam Ryong Jee, Seun Ja Park, Hyun Jin Kim, Jong Ha Park
- Intest Res 2016;14(1):30-36. Published online January 26, 2016
- DOI: https://doi.org/10.5217/ir.2016.14.1.30
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Abstract
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<b>Background/Aims</b><br/> Crohn's disease (CD) is a chronic inflammatory bowel disease that presents with variable features and repeated disease aggravation. The incidence of CD is increasing in Korea. We evaluated the clinical features of CD in a study population in Busan and Gyeongnam, Korea.
Methods A hospital-based analysis included 619 patients diagnosed with CD between March 1986 and February 2013 from seven tertiary care hospitals in Busan and Gyeongnam. Individual case records were reviewed with regard to age at diagnosis, sex, disease location, disease behavior, and medical and surgical treatments received during the follow-up period.
Results The cumulative frequency of patients diagnosed with CD revealed a continued increase in the number of cases reported yearly. The male-to-female ratio was 2.5:1 and the median age at diagnosis was 24 years. At diagnosis, 114 (18.4%) had isolated small bowel disease, 144 (23.3%) had isolated colonic disease, and 358 patients (57.8%) presented with disease in the small bowel and colon. The number of patients presenting with stricturing or penetrating disease behavior was 291 (47%) at the final evaluation. In total, 111 (17.9%) patients underwent intestinal resections.
Conclusions A continued increase in the number of patients diagnosed with CD was found in Busan and Gyeongnam as observed in other regions. We report results similar to that of other Korean studies in terms of sex distribution, age, and location of disease.
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Citations
Citations to this article as recorded by- Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture
Jian Kang, Xize Wu, Yue Li, Shuangli Zhao, Shixuan Wang, Dongdong Yu
Frontiers in Immunology.2024;[Epub] CrossRef - Inflammatory bowel disease in Korea: epidemiology and pathophysiology
Jung Won Lee, Chang Soo Eun
The Korean Journal of Internal Medicine.2022; 37(5): 885. CrossRef - NF-kappa B activation correlates with disease phenotype in Crohn’s disease
Yoo Min Han, Jaemoon Koh, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Gernot Sellge
PLOS ONE.2017; 12(7): e0182071. CrossRef - Are there interregional differences in the epidemiology and clinical characteristics of Crohn's disease in the Asia-Pacific region?
Sinwon Lee, Byong Duk Ye
Intestinal Research.2016; 14(1): 2. CrossRef - Changing epidemiological trends of inflammatory bowel disease in Asia
Wee Khoon Ng, Sunny H. Wong, Siew C. Ng
Intestinal Research.2016; 14(2): 111. CrossRef
- Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture
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- 47 Download
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- 5 Crossref
- Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation
- Hong Jun Park, Myeong Hun Chae, Hyun-Soo Kim, Jae Woo Kim, Moon Young Kim, Soon Koo Baik, Sang Ok Kwon, Hee Man Kim, Kyong Joo Lee
- Intest Res 2015;13(4):339-345. Published online October 15, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.4.339
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> We evaluated whether colonic transit time (CTT) can predict the degree of bowel preparation in patients with chronic constipation undergoing scheduled colonoscopy in order to assist in the development of better bowel preparation strategies for these patients.
Methods We analyzed the records of 160 patients with chronic constipation from March 2007 to November 2012. We enrolled patients who had undergone a CTT test followed by colonoscopy. We defined patients with a CTT ≥30 hours as the slow transit time (STT) group, and patients with a CTT <30 hours as the normal transit time (NTT) group. Boston Bowel Preparation Scale (BBPS) scores were compared between the STT and NTT groups.
Results Of 160 patients with chronic constipation, 82 (51%) were included in the STT group and 78 (49%) were included in the NTT group. Patients with a BBPS score of <6 were more prevalent in the STT group than in the NTT group (31.7% vs. 10.3%,
P =0.001). Multivariate analysis showed that slow CTT was an independent predictor of inadequate bowel preparation (odds ratio, 0.261; 95% confidence interval, 0.107-0.634;P =0.003). The best CTT cut-off value for predicting inadequate bowel preparation in patients with chronic constipation was 37 hours, as determined by receiver operator characteristic (ROC) curve analysis (area under the ROC curve: 0.676, specificity: 0.735, sensitivity: 0.643).Conclusions Patients with chronic constipation and a CTT >30 hours were at risk for inadequate bowel preparation. CTT measured prior to colonoscopy could be useful for developing individualized strategies for bowel preparation in patients with slow CTT, as these patients are likely to have inadequate bowel preparation.
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Citations
Citations to this article as recorded by- Advanced intestinal regulation improves bowel preparation quality in patients with constipation: A systematic review and network meta-analysis
Liang Ding, JinNan Duan, Tao Yang, ChaoQiong Jin, Jun Luo, Ahuo Ma
Frontiers in Pharmacology.2023;[Epub] CrossRef - Factors affecting cecal intubation time during colonoscopy
Ke Wang, Wen-Tao Xu, Wen-Jing Kou, Xing-Shun Qi
World Chinese Journal of Digestology.2023; 31(3): 105. CrossRef - Factors affecting the quality of bowel preparation for colonoscopy in hard-to-prepare patients: Evidence from the literature
Endrit Shahini, Emanuele Sinagra, Alessandro Vitello, Rocco Ranaldo, Antonella Contaldo, Antonio Facciorusso, Marcello Maida
World Journal of Gastroenterology.2023; 29(11): 1685. CrossRef - The effect of kiwi berry (Actinidia arguta) on preventing and alleviating loperamide-induced constipation
Jiyue Zhang, Dongnan Li, Qilin Tian, Yumeng Ding, Hanqian Jiang, Guang Xin, Shunchang Cheng, Siyi Tang, Chenyu Jin, Jinlong Tian, Bin Li
Food Innovation and Advances.2023; 2(1): 1. CrossRef - A Systematic Review of Exercise Therapy for Bowel Preparation
Yuan-Yuan Zhang, Ramoo Vimala, Ping Lei Chui, Ida Normiha Hilmi
Gastroenterology Nursing.2023; 46(5): 393. CrossRef - 2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation
Young Sin Cho, Yoo Jin Lee, Jeong Eun Shin, Hye-Kyung Jung, Seon-Young Park, Seung Joo Kang, Kyung Ho Song, Jung-Wook Kim, Hyun Chul Lim, Hee Sun Park, Seong-Jung Kim, Ra Ri Cha, Ki Bae Bang, Chang Seok Bang, Sung Kyun Yim, Seung-Bum Ryoo, Bong Hyeon Kye,
Journal of Neurogastroenterology and Motility.2023; 29(3): 271. CrossRef - Taking a Long and Hard Look at Quality Predictors of Bowel Preparation for Colonoscopy
Yunho Jung
Digestive Diseases and Sciences.2023; 68(11): 4069. CrossRef - Factors Influencing the Quality of Intestinal Preparation before Colonoscopy in Special Population
瑶 童
Advances in Clinical Medicine.2023; 13(11): 17129. CrossRef - Rectal Evacuation Disorders are Associated With Poor Bowel Preparation in Patients With Chronic Constipation
Mythili P. Pathipati, Casey J. Silvernale, Kenneth G. Barshop, Jasmine B. Ha, James M. Richter, Kyle D. Staller
Journal of Clinical Gastroenterology.2022; 56(5): 438. CrossRef - Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid
Sun Hwa Kim, Eun Ran Kim, Kyunga Kim, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young‐Ho Kim
Digestive Endoscopy.2020; 32(4): 600. CrossRef - Modelling characteristics of inadequate bowel preparations for colonoscopy
Scott L. Cornella, Brian J. Wentworth, Charles Orton, Bethany J. Horton, Steven M. Powell
GastroHep.2020; 2(2): 72. CrossRef - Usefulness of Personal Bowel Habits as a Predictive Factor for Inadequate Bowel Preparation for Colonoscopy: A Prospective Questionnaire-Based Observational Study
Namyoung Paik, Eun Ran Kim, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim
Gut and Liver.2019; 13(2): 169. CrossRef - Prediction of Inadequate Bowel Preparation Using Total and Segmental Colon Transit Time in Patients with Chronic Constipation: Some Different Outcomes
Chunying Zhai, Qiyang Huang, Ningli Chai, Wengang Zhang, Enqiang Linghu
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef - Gut microbiota alterations from different Lactobacillus probiotic-fermented yoghurt treatments in slow-transit constipation
Chen-Jian Liu, Xiao-Dan Tang, Jie Yu, Hai-Yan Zhang, Xiao-Ran Li
Journal of Functional Foods.2017; 38: 110. CrossRef - The management of ‘hard-to-prepare’ colonoscopy patients
Daniele Mandolesi, Leonardo Frazzoni, Franco Bazzoli, Lorenzo Fuccio
Expert Review of Gastroenterology & Hepatology.2017; 11(8): 731. CrossRef - Bowel preparation for colonoscopy
Theodor Voiosu, Andrei Voiosu, Radu Voiosu
Current Opinion in Gastroenterology.2016; 32(5): 385. CrossRef
- Advanced intestinal regulation improves bowel preparation quality in patients with constipation: A systematic review and network meta-analysis
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- 52 Download
- 14 Web of Science
- 16 Crossref
- Clinical Features and Prognosis of Resectable Primary Colorectal Signet-Ring Cell Carcinoma
- Ho-Su Lee, Jae Seung Soh, Seohyun Lee, Jung Ho Bae, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sun A Kim, Young Soo Park, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Dong-Hoon Yang
- Intest Res 2015;13(4):332-338. Published online October 15, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.4.332
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> We attempted to investigate the prognosis of signet-ring cell carcinoma (SRC) patients who underwent curative surgery by comparing them with age-, sex-, and stage-matched non-mucinous adenocarcinoma (NMAC) patients.
Methods Between January 2003 and December 2011, 19 patients with primary SRC of the colorectum underwent curative surgery. Four SRC patients under the age of 40 were excluded, and the clinicopathological data of 15 patients (7 men; median age, 56 years) were reviewed and compared with the data of 75 NMAC patients matched by age, sex, and pathologic stage.
Results The median follow-up duration was 30.1 months for the SRC group and 43.7 months for the NMAC group (
P =0.141). Involvement of the left side of the colon (73.3% vs. 26.7%,P =0.003) and infiltrative lesions such as Borrmann types 3 and 4 (85.7% vs. 24.0%,P =0.001) were more common in the SRC group than in the NMAC group. The five-year overall survival rate was significantly lower for patients with SRC than for those with NMAC (46.0% vs. 88.7%, hazard ratio, 6.99; 95% confidence interval, 2.33-20.95,P =0.001).Conclusions Patients with even resectable primary colorectal SRC had a poorer prognosis than age-, sex-, and stage-matched colorectal NMAC patients.
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Citations
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Nan Yao, Wenqiang Li, Jiwei Wang, Hongyuan Chu, Ning Duan, Xinyu Niu, Guoyong Yu, Jun Qu
BMJ Open.2024; 14(2): e076579. CrossRef - Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma
Frederiek Nuytens, Vincent Drubay, Clarisse Eveno, Florence Renaud, Guillaume Piessen
World Journal of Gastrointestinal Oncology.2024; 16(5): 2141. CrossRef - Modeling the survival of colorectal cancer patients based on colonoscopic features in a feature ensemble vision transformer
Chung-Ming Lo, Yi-Wen Yang, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Shung-Haur Yang, Shih-Ching Chang, Huann-Sheng Wang, Yuan-Tzu Lan, Hung-Hsin Lin, Sheng-Chieh Huang, Hou-Hsuan Cheng, Jeng-Kai Jiang, Chun-Chi Lin
Computerized Medical Imaging and Graphics.2023; 107: 102242. CrossRef - Metastatic colorectal carcinoma with signet-ring cells: Clinical, histological and molecular description from an Association des Gastro-Entérologues Oncologues (AGEO) French multicenter retrospective cohort
Marion Allart, Florence Leroy, Stephano Kim, David Sefrioui, Mihane Nayeri, Aziz Zaanan, Benoit Rousseau, Meher Ben Abdelghani, Christelle de la Fouchardière, Wulfran Cacheux, Romain Legros, Samy Louafi, David Tougeron, Olivier Bouché, Nadim Fares, Guilla
Digestive and Liver Disease.2022; 54(3): 391. CrossRef - The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review
Xueting Liu, Litao Huang, Menghan Liu, Zhu Wang
Medicina.2022; 58(7): 836. CrossRef - Clinicopathological factors and survival outcomes of signet-ring cell and mucinous carcinoma versus adenocarcinoma of the colon and rectum: a systematic review and meta-analysis
Michael G. Fadel, George Malietzis, Vasilis Constantinides, Gianluca Pellino, Paris Tekkis, Christos Kontovounisios
Discover Oncology.2021;[Epub] CrossRef - Clinicopathological Features and Survival of Signet-Ring Cell Carcinoma and Mucinous Adenocarcinoma of Right Colon, Left Colon, and Rectum
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Medicine.2020; 99(14): e19420. CrossRef - Primary signet ring cell carcinoma with tubular adenoma of the rectum
Yong-Ping Yang, Ling-Yun Yu, Jian Shi, Jian-Nan Li, Xin-Yu Wang, Tong-Jun Liu
Medicine.2020; 99(26): e20985. CrossRef - Prognosis of Signet Ring Cell Carcinoma of the Colon and Rectum and their Distinction of Mucinous Adenocarcinoma with Signet Ring Cells. A Comparative Study
Luis I. Pozos-Ochoa, Leonardo S. Lino-Silva, Alberto M. León-Takahashi, Rosa A. Salcedo-Hernández
Pathology & Oncology Research.2018; 24(3): 609. CrossRef - Impact of histological subtype on the prognosis of patients undergoing surgery for colon cancer
Fabio Bagante, Gaya Spolverato, Eliza Beal, Katiuscha Merath, Qinyu Chen, Ozgür Akgül, Robert A. Anders, Timothy M. Pawlik
Journal of Surgical Oncology.2018; 117(7): 1355. CrossRef - Prognosis and value of preoperative radiotherapy in locally advanced rectal signet-ring cell carcinoma
Chun-Run Ling, Rui Wang, Mo-Jin Wang, Jie Ping, Wen Zhuang
Scientific Reports.2017;[Epub] CrossRef - The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma
Renjie Wang, Xiaoji Ma, Yaqi Li, Yiping He, Dan Huang, Sanjun Cai, Junjie Peng, Javier S Castresana
PLOS ONE.2016; 11(8): e0160527. CrossRef - Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis
Ben Huang, Mengdong Ni, Chen Chen, Yang Feng, Sanjun Cai
Gastroenterology Research and Practice.2016; 2016: 1. CrossRef
- Prognostic implications of T stage in different pathological types of colorectal cancer: an observational study using SEER population-based data
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- 52 Download
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- 14 Crossref
- Is Retroflexion Helpful in Detecting Adenomas in the Right Colon?: A Single Center Interim Analysis
- Hyun Seok Lee, Seong Woo Jeon
- Intest Res 2015;13(4):326-331. Published online October 15, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.4.326
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Colonoscopy is less effective at screening for colorectal cancer in the right side of the colon. Retroflexion during colonoscopy is expected to improve the detection rate of colorectal adenomas. The aim of the present study was to evaluate the usefulness of retroflexion in the right-sided colon.
Methods From April to November 2013, a total of 398 patients were enrolled in this study. For each patient, a cap-assisted colonoscopic examination was performed. After cecal intubation, a forward view examination from the cecum up to the hepatic flexure was performed and all identified polyps were removed. The colonoscope was reinserted to the cecum, and a careful second forward view examination of the cecum to the hepatic flexure was performed, with removal of additionally identified polyps. The colonoscope was then reinserted to the cecum and retroflexed; a third colonoscopic examination was then performed to the hepatic flexure in retroflexion with removal of additional polyps. Total polyp numbers and characteristics were compared between the two forward view examinations and the retroflexion examination.
Results A successful retroflexion was performed in 90.2% of patients. A total of 213 polyps and 143 adenomas were detected in the right-sided colon using the routine method of examining the right colon twice in forward view. An additional 35 polyps and 24 adenomas were detected on retroflexion. Of these 35 polyps, 27 (77.1%) were small-sized polyps (≤5 mm) and 24 (71.4%) were adenomas. Finding additional adenomas using the retroflexion technique was associated with older age.
Conclusions Colonoscopic retroflexion is helpful in the detection of cecum and ascending colon adenomas, especially small-sized adenomas (≤5 mm). It is particularly useful in older patients.
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Journal of Gastroenterology and Hepatology.2019; 34(9): 1504. CrossRef - Ileal intubation is not associated with higher detection rate of right-sided conventional adenomas and serrated polyps compared to cecal intubation after adjustment for overall adenoma detection rate
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Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Gastrointestinal Endoscopy.2018; 88(4): 715. CrossRef - Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies
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Yonsei Medical Journal.2017; 58(2): 347. CrossRef - Metformin use and the risk of colorectal adenoma: A systematic review and meta‐analysis
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
Journal of Gastroenterology and Hepatology.2017; 32(5): 957. CrossRef - Risk factors of missed colorectal lesions after colonoscopy
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Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Gastroenterology and Hepatology.2017; 32(5): 1003. CrossRef - Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis
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Gastrointestinal Endoscopy.2017; 86(2): 274. CrossRef - Risk Factors for False Fecal Immunochemical Test Results in Colorectal Cancer Screening
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Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef - Are Hemorrhoids Associated with False-Positive Fecal Immunochemical Test Results?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(1): 150. CrossRef - Association Between Low Relative Muscle Mass and the Risk of Colorectal Neoplasms
Yoon Suk Jung, Nam Hee Kim, Seungho Ryu, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Clinical Gastroenterology.2017; 51(10): e83. CrossRef - Metabolic syndrome is a risk factor for adenoma occurrence at surveillance colonoscopy
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Medicine.2016; 95(32): e4454. CrossRef - Asymptomatic anisakiasis of the colon incidentally diagnosed and treated during colonoscopy by retroflexion in the ascending colon
Mamiko Tsukui, Naoki Morimoto, Hidekazu Kurata, Fumiko Sunada
Journal of Rural Medicine.2016; 11(2): 73. CrossRef - Identifying the ‘Right’ colon lesion
A D Hopper, P D Mooney, A Blakeborough
Gut.2016; 65(12): 1959. CrossRef - Does Low Threshold Value Use Improve Proximal Neoplasia Detection by Fecal Immunochemical Test?
Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(9): 2685. CrossRef
- Comparison in the development of colorectal cancer after screening colonoscopy between elderly and younger population
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- 34 Download
- 21 Web of Science
- 20 Crossref
- Colonic Chicken Skin Mucosa is an Independent Endoscopic Predictor of Advanced Colorectal Adenoma
- Eun Ju Chung, Ji Young Lee, Jaewon Choe, Hye-Sook Chang, Jongcheol Kim, Dong Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Kyung-Jo Kim, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung
- Intest Res 2015;13(4):318-325. Published online October 15, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.4.318
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Chicken skin mucosa (CSM), surrounding colorectal adenoma, is an endoscopic finding with pale yellow-speckled mucosa; however, its clinical significance is unknown. This study aimed to evaluate the prevalence and clinical characteristics of CSM, and the association between colorectal carcinogenesis and CSM.
Methods This cross-sectional study was performed in 733 consecutive patients who underwent endoscopic polypectomy for colorectal adenoma after the screening of colonoscopy at the Asan Health Promotion Center between June 2009 and December 2011. The colonoscopic and pathological findings of colorectal adenoma including number, size, location, dysplasia, morphology, and clinical parameters were reviewed.
Results The prevalence of CSM was 30.7% (225 of 733 patients), and most CSM-related adenomas were located in the distal colon (93.3%). Histological analysis revealed lipid-laden macrophages in the lamina propria of the mucosa. Multivariate analyses showed that CSM was significantly associated with advanced pathology, including villous adenoma and high-grade dysplasia (odds ratio [OR], 2.078; 95% confidence interval [CI], 1.191-3.627;
P =0.010), multiple adenomas (i.e., ≥2 adenomas; OR, 1.692; 95% CI, 1.143-2.507;P =0.009), and a protruding morphology (OR, 1.493; 95% CI, 1.027-2.170;P =0.036). There were no significant differences in polyp size or clinical parameters between patients with and without CSM.Conclusions CSM-related adenoma was mainly found in the distal colon, and was associated with advanced pathology and multiple adenomas. CSM could be a potential predictive marker of the carcinogenetic progression of distally located colorectal adenomas.
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Ying-Jie Zhang, Meng-Xia Yuan, Wu Wen, Fan Li, Yi Jian, Chuan-Ming Zhang, Ye Yang, Feng-Lin Chen
World Journal of Gastrointestinal Oncology.2024; 16(3): 750. CrossRef - White spots around colorectal tumors are cancer-related findings and may aid endoscopic diagnosis: a prospective study in Japan
Kai Korekawa, Yusuke Shimoyama, Fumiyoshi Fujishima, Hiroshi Nagai, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune
Clinical Endoscopy.2024; 57(5): 637. CrossRef - Solitary juvenile polyp of the rectum with intramucosal adenocarcinoma
Kazuki Nagai, Uichiro Fuchizaki, Yoshimichi Ueda
Clinical Journal of Gastroenterology.2023; 16(4): 532. CrossRef - Chicken skin mucosa surrounding small colorectal cancer could be an endoscopic predictive marker of submucosal invasion
Ying-Jie Zhang, Wu Wen, Fan Li, Yi Jian, Chuan-Ming Zhang, Meng-Xia Yuan, Ye Yang, Feng-Lin Chen
World Journal of Gastrointestinal Oncology.2023; 15(6): 1062. CrossRef - Characteristics and potential malignancy of colorectal juvenile polyps in adults: a single-center retrospective study in China
Jie Dong, Tian-Shi Ma, Yuan-Hong Xu, Peng Li, Wan-Yuan Chen, Jiang-Feng Tu, You-Wei Chen
BMC Gastroenterology.2022;[Epub] CrossRef - Colonic Chicken Skin Mucosa Surrounding Colon Polyps Is an Endoscopic Predictive Marker for Colonic Neoplastic Polyps
Yu Mi Lee, Kyung Ho Song, Hoon Sup Koo, Choong-Sik Lee, Inseok Ko, Sang Hyuk Lee, Kyu Chan Huh
Gut and Liver.2022; 16(5): 754. CrossRef - Diagnosis and management of a solitary colorectal juvenile polyp in an adult during follow-up for ulcerative colitis: A case report
You-Wei Chen, Jiang-Feng Tu, Wen-Juan Shen, Wan-Yuan Chen, Jie Dong
World Journal of Gastroenterology.2020; 26(8): 877. CrossRef - Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma
Su Hwan Kim, Ji Won Kim, Kook Lae Lee, Seohui Lee, Seong-Joon Koh, Ji Bong Jeong, Byeong Gwan Kim
The American Journal of the Medical Sciences.2018; 356(2): 141. CrossRef - Current strategies for malignant pedunculated colorectal polyps
Adriana Ciocalteu, Dan Ionut Gheonea, Adrian Saftoiu, Liliana Streba, Nicoleta Alice Dragoescu, Tiberiu Stefanita Tenea-Cojan
World Journal of Gastrointestinal Oncology.2018; 10(12): 465. CrossRef
- Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps
- 6,476 View
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- 11 Web of Science
- 9 Crossref
- Reappraisal of Pneumoperitoneum After Percutaneous Endoscopic Gastrostomy
- Won Young Park, Tae Hee Lee, Joon Seong Lee, Su Jin Hong, Seong Ran Jeon, Hyun Gun Kim, Joo Young Cho, Jin Oh Kim, Jun Hyung Cho, Sang Wook Lee, Young Kwan Cho
- Intest Res 2015;13(4):313-317. Published online October 15, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.4.313
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Pneumoperitoneum is recognized as a benign and self-limiting finding after the insertion of a percutaneous endoscopic gastrostomy (PEG) tube, while complicated pneumoperitoneum is rarely reported. The aim of this study was to reappraise pneumoperitoneum following PEG.
Methods We retrospectively reviewed 193 patients who underwent PEG from May 2008 to May 2014. All patients had a follow-up upright chest or simple abdominal radiograph after PEG. Pneumoperitoneum was quantified by measuring the height of the air column under the diaphragm and graded as small (<2 cm), moderate (2-4 cm), or large (>4 cm). Clinically significant signs were defined as fever, abdominal tenderness or leukocytosis occurring after PEG insertion.
Results Of the 193 study patients, 9 (4.6%) had a pneumoperitoneum visualized by radiographic imaging, graded as small in 5 patients, moderate in 2 patients and large in 2 patients. Clinically significant signs were observed in 5 (55.5%) patients with fever reported in 4 patients, abdominal tenderness in 4 patients and leukocytosis in 4 patients. The time to resolution of free air was 2-18 days. Two patients (22.2%) with moderate or large pneumoperitoneum after PEG died from either pneumonia or septic shock.
Conclusions The clinical course of pneumoperitoneum after PEG is not always benign and self-limiting. These findings suggest that clinicians should not neglect a moderate or large pneumoperitoneum, particularly in patients who have an altered mental status or received antibiotics, since peritoneal irritation cannot be observed under these circumstances.
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Woo Suk Kim, Tasur Seen, Joel Baum, Aaron Walfish
Cureus.2025;[Epub] CrossRef - Clinical Practice Guideline for Percutaneous Endoscopic Gastrostomy
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
Gut and Liver.2024; 18(1): 10. CrossRef - Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients
Laura Gombošová, Jana Deptová, Ivana Jochmanová, Tatiana Svoreňová, Eduard Veseliny, Mária Zakuciová, Vladimír Haň, Alexandra Lacková, Kristína Kulcsárová, Miriama Ostrožovičová, Joaquim Ribeiro Ventosa, Lenka Trcková, Ivica Lazúrová, Matej Škorvánek
Journal of Clinical Medicine.2024; 13(3): 703. CrossRef - Clinical practice guidelines for percutaneous endoscopic gastrostomy
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
Clinical Endoscopy.2023; 56(4): 391. CrossRef - Pneumoperitoneum After Jejunostomy Tube Placement Managed by Needle Decompression: A Case Report
Khalid Al Shamousi, Masoud Salim Kashoob, Jawahir Lal, Said A Al-Busafi
Cureus.2023;[Epub] CrossRef - Clinical Practice Guideline for Percutaneous Endoscopic Gastrostomy
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
The Korean Journal of Gastroenterology.2023; 82(3): 107. CrossRef - Incidence of Pneumoperitoneum After Gastrostomy Tube Removal
Anas Mahmoud, Nizar Alyassin, Eyad Baghal, Ruhin Yuridullah, Yana Cavanagh, Matthew A Grossman
Cureus.2023;[Epub] CrossRef - Prevention and management of major complications in percutaneous endoscopic gastrostomy
Kurt Boeykens, Ivo Duysburgh
BMJ Open Gastroenterology.2021; 8(1): e000628. CrossRef - Massive Incidental Pneumoperitoneum in an Amyotrophic Lateral Sclerosis Patient
Jasmin Jaber, Nur Magadle, Lojain Arda, Francisco J Somoza-Cano
Cureus.2021;[Epub] CrossRef - Percutaneous Endoscopic Gastrostomy Tube Gone Wrong: Endoscopic Closure to the Rescue
Jahnvi Dhar, Naveen Kumar, Pankaj Gupta, Rakesh Kochhar, Jayanta Samanta
Journal of Digestive Endoscopy.2021; 12(03): 169. CrossRef - Symptomatic Pneumoperitoneum After Gastrostomy Tube Placement Managed by Pneumocentesis
Tim Brotherton, Anuj Chhaparia, Michael Presti, Gregory Sayuk, Jill Elwing
ACG Case Reports Journal.2021; 8(11): e00700. CrossRef - TWO APPROACHES TO PNEUMOPERITONEUM: SURGERY AND CONSERVATIVE
Şehmus Ölmez, Bünyamin Sarıtaş, Mesut Aydın, Banu Kara
Gastroenterology Nursing.2020; 43(4): 317. CrossRef - Diagnosis and treatment of pediatric benign pneumoperitoneum
Shou-Xing Duan, Zong-Bo Sun, Guang-Huan Wang, Jun Zhong, Wen-Hui Ou, Ma-Xian Fu, Fu-Sheng Wang, Shu-Hua Ma, Jian-Hong Li
Medicine.2017; 96(2): e5814. CrossRef - Thirty-day mortality after percutaneous gastrostomy by endoscopic versus radiologic placement: a systematic review and meta-analysis
Joo Hyun Lim, Seung Ho Choi, Changhyun Lee, Ji Yeon Seo, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Joo Sung Kim
Intestinal Research.2016; 14(4): 333. CrossRef - The role of surgery in the treatment of endoscopic complications
Peter Dixon, Gopal C. Kowdley, Steven Clark Cunningham
Best Practice & Research Clinical Gastroenterology.2016; 30(5): 841. CrossRef - Pneumoperitoneum After Percutaneous Endoscopic Gastrostomy: Does It Have Clinical Significance?
Ju Yup Lee, Kyung Sik Park
Intestinal Research.2015; 13(4): 295. CrossRef
- Behind the Ink: Unmasking Asymptomatic Micro-perforations Following Endoscopic Tattooing
- 5,676 View
- 55 Download
- 16 Web of Science
- 16 Crossref
- Institutional Board Review for Clinical Investigations on Inflammatory Bowel Diseases: A Single-Center Study
- Sinyoung Park, Yang Hee Noh, Sun Young Rha, Won Ho Kim, Jae Hee Cheon
- Intest Res 2015;13(3):274-281. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.274
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> The growing volume and the diversity of clinical research has led to related laws and regulations as well as the Institutional Review Board (IRB) approval process becoming more stringent. To conduct clinical research efficiently and while following regulations, information about the IRB approval process and feedback is important for investigators. This has yet to be studied.
Methods We included 381 gastrointestinal disease research proposals (79 with inflammatory bowel disease [IBD], and 302 with non-IBD) reviewed by the IRB of Severance Hospital between January 2009 and December 2013. We retrospectively analyzed research characteristics including research risk levels, results of initial reviews, frequencies of continuing review, numbers of IRB comments, frequencies of IRB comments, and durations from submission to approval.
Results Investigators' decisions on risk level were higher in the IBD group than in the non-IBD group (
P <0.05). Results of initial reviews, frequencies of continuing reviews, the numbers of IRB review comments, and durations from submission to approval were not different between the two groups, but IRB decisions on risk level were higher in the IBD group (P <0.05). In subgroup analysis, the number of IRB comments from initial review on informed consent forms and procedures as well were quest of more information were significantly higher in the IBD group than in the non-IBD group (P <0.001 and 0.01, respectively).Conclusions In Korea, rare diseases such as IBD require more information for the IRB process due to their distinct characteristics. IBD researchers should develop research protocols more carefully and make their research as subject-friendly as possible.
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Citations
Citations to this article as recorded by- Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management
Jihye Park, Sinyoung Park, Shin Ae Lee, Soo Jung Park, Jae Hee Cheon
The Korean Journal of Internal Medicine.2021; 36(5): 1040. CrossRef - Evaluation of Serious Adverse Event Reporting Forms for Clinical Trials: A Comparative Korean Study
Heeyoung Lee, Cholong Park, Jinwon Choi, Seongeun Jeong, Hyunin Cho, Wooseong Huh, Eunyoung Kim
Journal of Empirical Research on Human Research Ethics.2020; 15(5): 415. CrossRef - ‘Screening audit’ as a quality assurance tool in good clinical practice compliant research environments
Sinyoung Park, Chung Mo Nam, Sejung Park, Yang Hee Noh, Cho Rong Ahn, Wan Sun Yu, Bo Kyung Kim, Seung Min Kim, Jin Seok Kim, Sun Young Rha
BMC Medical Ethics.2018;[Epub] CrossRef
- Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management
- 6,663 View
- 55 Download
- 3 Web of Science
- 3 Crossref
- Efficacy of Thiopurines in Biologic-Naive Japanese Patients With Crohn's Disease: A Single-Center Experience
- Takuya Yoshino, Minoru Matsuura, Naoki Minami, Satoshi Yamada, Yusuke Honzawa, Masamichi Kimura, Yorimitsu Koshikawa, Ali Madian, Takahiko Toyonaga, Hiroshi Nakase
- Intest Res 2015;13(3):266-273. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.266
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Early use of biologics in patients with Crohn's disease (CD) improves quality of life. However, the effects of the early use of immunomodulators on long-term outcomes remain unclear. This study aimed to evaluate the effects of immunomodulators in patients with CD.
Methods Between January 2004 and December 2011, 47 biologic-naive CD patients treated with thiopurines alone for remission maintenance were analyzed. The patients were classified into 2 groups depending on the presence or absence of digestive complications. We evaluated the efficacy of and predictive factors for thiopurine use for remission maintenance.
Results The cumulative relapse rates at 24 and 60 months were 13.7% and 35.4%, respectively. Regarding patient characteristics, there was a significant difference in patient history of surgery between the non-relapse and relapse groups (
P =0.021). The cumulative relapse rate was lower in patients without a history of surgery than in those with such a history (27.2% and 52.9% at 60.0 months, respectively). Multivariate analysis suggested that the prevalence of stricturing and penetrating complications is an independent factor for relapse. The cumulative relapse rate in patients without a history of surgery was significantly lower in the non-stricturing and non-penetrating group than in the stricturing and penetrating group (11.8% at 85.0 months vs. 58.5% at 69.0 months;P =0.036).Conclusions Thiopurine use might be beneficial for the long-term maintenance of remission in biologic-naive Crohn's disease patients without digestive complications and a history of surgery.
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Mukesh Kumar Ranjan, Peeyush Kumar, Sudheer Kumar Vuyyuru, Bhaskar Kante, Sandeep K Mundhra, Rithvik Golla, Shubi Virmani, Raju Sharma, Peush Sahni, Prasenjit Das, Mani Kalaivani, Ashish Datt Upadhyay, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Journal of Crohn's and Colitis.2024; 18(2): 192. CrossRef - Efficacy of drug and endoscopic treatment of Crohn's disease strictures: A systematic review
Julien D Schulberg, Emily K Wright, Bronte A Holt, Helen E Wilding, Amy L Hamilton, Alyson L Ross, Michael A Kamm
Journal of Gastroenterology and Hepatology.2021; 36(2): 344. CrossRef - Short-term tolerability and effectiveness of methotrexate monotherapy in adult patients with Crohn’s disease: a retrospective study
Hee Seung Hong, Kyuwon Kim, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef - NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases
Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura
Intestinal Research.2017; 15(3): 328. CrossRef - Importance of Patients’ Knowledge of Their Prescribed Medication in Improving Treatment Adherence in Inflammatory Bowel Disease
Chung Hyun Tae, Sung-Ae Jung, Hye Sung Moon, Jung-A Seo, Hye Kyung Song, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Hye-Kyung Jung
Journal of Clinical Gastroenterology.2016; 50(2): 157. CrossRef
- Thiopurines Have Sustained Long-term Effectiveness in Patients with Inflammatory Bowel Disease, Which is Independent of Disease Duration at Initiation: A Propensity Score Matched Analysis
- 5,452 View
- 47 Download
- 5 Web of Science
- 5 Crossref
- Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn's Disease: an International, Multicenter, and Observational Study
- Paulo Gustavo Kotze, Antonino Spinelli, Rodolff Nunes da Silva, Ivan Folchini de Barcelos, Fábio Vieira Teixeira, Rogério Saad-Hossne, Idblan Carvalho de Albuquerque, Marcia Olandoski, Lorete Maria da Silva Kotze, Yasuo Suzuki, Akihiro Yamada, Ken Takeuchi, Matteo Sacchi, Takayuki Yamamoto
- Intest Res 2015;13(3):259-265. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.259
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Postoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn's disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice.
Methods The MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecal resection, from 7 referral centers in 3 different countries. All consecutive patients who underwent ileocecal resections between 2008 and 2012 and in whom colonoscopies had been performed up to 12 months after surgery, were included. Recurrence was defined as Rutgeerts' score ≥i2. The patients were allocated to either biological or conventional therapy after surgery, and PER rates were compared between the groups.
Results Initially, 231 patients were evaluated, and 63 were excluded. Of the 168 patients in the database, 96 received anti-tumor necrosis factor agents and 72 were treated with conventional therapy after resection. The groups were comparable regarding age, gender, and perianal disease. There was longer disease duration, more previous resections, and more open surgical procedures in patients on biologicals postoperatively. PER was identified in 25/96 (26%) patients on biological therapy and in 24/72 (33.3%) patients on conventional therapy (
P =0.310).Conclusions In this retrospective observational analysis from an international database, no difference was observed between biological and conventional therapy in preventing PER after ileocecal resections in CD patients.
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Citations
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Fadi H Mourad, Rami G Maalouf, Roni Aoun, Paulo Gustavo Kotze, Jana G Hashash
Inflammatory Bowel Diseases.2024; 30(3): 459. CrossRef - How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis
Eline M. L. van der Does de Willebois, Vittoria Bellato, Marjolijn Duijvestein, Susan van Dieren, Silvio Danese, Pierpaolo Sileri, Christianne J. Buskens, Andrea Vignali, Willem A. Bemelman
Annals of Surgery Open.2024; 5(1): e397. CrossRef - Trends in Surgical Recurrence Among Pediatric Crohn’s Disease Patients Using Administrative Claims Data
Matthew D Egberg, Xian Zhang, Michael Phillips, Michael D Kappelman
Crohn's & Colitis 360.2023;[Epub] CrossRef - Optimal strategies to prevent recrudescent Crohn's disease after resection
Natália Sousa Freitas Queiroz, Takayuki Yamamoto, Paulo Gustavo Kotze
Seminars in Colon and Rectal Surgery.2020; 31(2): 100746. CrossRef - Profile of Consecutive Fecal Calprotectin Levels in the Perioperative Period and Its Predictive Capacity for Early Endoscopic Recurrence in Crohn’s Disease
Ruiqing Liu, Zhen Guo, Lei Cao, Zhiming Wang, Jianfeng Gong, Yi Li, Weiming Zhu
Diseases of the Colon & Rectum.2019; 62(3): 318. CrossRef - Efficacy of restarting anti-tumor necrosis factor α agents after surgery in patients with Crohn's disease
Sakiko Hiraoka, Shiho Takashima, Yoshitaka Kondo, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Seiji Kawano, Keita Harada, Jun Kato, Hiroyuki Okada
Intestinal Research.2018; 16(1): 75. CrossRef - Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study
I. F. de Barcelos, P. G. Kotze, A. Spinelli, Y. Suzuki, F. V. Teixeira, I. C. de Albuquerque, R. Saad‐Hossne, L. M. da Silva Kotze, T. Yamamoto
Colorectal Disease.2017;[Epub] CrossRef - Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn’s Disease: Results from the CONNECT Study
Jee Hye Kwon, Jong Pil Im, Byong Duk Ye, Jae Hee Cheon, Hyun Joo Jang, Kang Moon Lee, You Sun Kim, Sang Wook Kim, Young Ho Kim, Geun Am Song, Dong Soo Han, Won Ho Kim, Joo Sung Kim
Gut and Liver.2016; 10(4): 595. CrossRef
- Are the New Biologics Effective in the Management of Postoperative Crohn’s Disease?
- 5,834 View
- 55 Download
- 7 Web of Science
- 8 Crossref
- Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis
- Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Masamichi Kimura, Yorimitsu Koshikawa, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Hiroshi Nakase
- Intest Res 2015;13(3):250-258. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.250
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Abstract
PDF
Supplementary MaterialPubReader <b>Background/Aims</b><br/> The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine in UC patients.
Methods This was a retrospective observational cohort analysis conducted at a single center. Between December 1998 and August 2013, 59 of 87 patients with bio-naive UC who achieved remission after induction with treatments other than biologics were enrolled. Remission maintenance with thiopurine was defined as no concomitant treatment needed other than 5-aminosalicylate without relapse. We assessed the remission-maintenance rate, mucosal healing rate, colectomy-free rate, and treatment safety in UC patients who received thiopurine as maintenance treatment.
Results The 84-month cumulative remission-maintenance and colectomy-free survival rates in the UC patients who were receiving maintenance treatment with thiopurine and 5-aminosalicylate were 43.9% and 88.0%, respectively. Of the 38 patients who underwent colonoscopy during thiopurine maintenance treatment, 23 (60.5%) achieved mucosal healing. Of the 59 patients who achieved clinical remission with thiopurine, 6 patients (10.2%) discontinued the thiopurine therapy because of adverse events.
Conclusions Our study demonstrates the long-term efficacy and safety of thiopurine treatment in patients with bio-naive UC.
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Citations
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Mukesh Kumar Ranjan, Peeyush Kumar, Sudheer Kumar Vuyyuru, Bhaskar Kante, Sandeep K Mundhra, Rithvik Golla, Shubi Virmani, Raju Sharma, Peush Sahni, Prasenjit Das, Mani Kalaivani, Ashish Datt Upadhyay, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Journal of Crohn's and Colitis.2024; 18(2): 192. CrossRef - Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis
Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai
Journal of Gastroenterology and Hepatology.2022; 37(1): 81. CrossRef - Real-World Long-Term Remission Maintenance for 10 Years With Thiopurines in Ulcerative Colitis
Satohiro Matsumoto, Hirosato Mashima
Crohn's & Colitis 360.2021;[Epub] CrossRef - Treatment of Inflammatory Bowel Disease: A Comprehensive Review
Zhaobei Cai, Shu Wang, Jiannan Li
Frontiers in Medicine.2021;[Epub] CrossRef - Optimizing the Use of Current Treatments and Emerging Therapeutic Approaches to Achieve Therapeutic Success in Patients with Inflammatory Bowel Disease
Hiroshi Nakase
Gut and Liver.2020; 14(1): 7. CrossRef - The Leading Edge of the Treatment of Inflammatory Bowel Disease
Hiroshi Nakase
Nihon Naika Gakkai Zasshi.2020; 109(6): 1145. CrossRef -
Predictive Role of
NUDT15
Variants on Thiopurine-Induced Myelotoxicity in Asian Inflammatory Bowel Disease Patients
Natalia Sutiman, Sylvia Chen, Khoon Lin Ling, Sai Wei Chuah, Wai Fook Leong, Vinayak Nadiger, Madeline Tjai, Chris San Choon Kong, Brian John Schwender, Webber Chan, Hang Hock Shim, Wee Chian Lim, Chiea Chuen Khor, Yin Bun Cheung, Balram Chowbay
Pharmacogenomics.2018; 19(1): 31. CrossRef - NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases
Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura
Intestinal Research.2017; 15(3): 328. CrossRef - Clinical Efficacy of Beclomethasone Dipropionate in Korean Patients with Ulcerative Colitis
Yoon Jee Lee, Jae Hee Cheon, Jae Hyun Kim, SunHo Yoo, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim
Yonsei Medical Journal.2017; 58(1): 144. CrossRef - Rate and Predictors of Mucosal Healing in Ulcerative Colitis Treated with Thiopurines: Results of a Multicentric Cohort Study
Caroline Prieux-Klotz, Stéphane Nahon, Aurelien Amiot, Leila Sinayoko, Carole Galéano-Cassaz, Stanislas Chaussade, Romain Coriat, Pierre Lahmek, Vered Abitbol
Digestive Diseases and Sciences.2017; 62(2): 473. CrossRef - Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
Jae Hyun Kim, Jae Hee Cheon, Yehyun Park, Hyun Jung Lee, Soo Jung Park, Tae Il Kim, Won Ho Kim
Scandinavian Journal of Gastroenterology.2016; 51(9): 1069. CrossRef - Is Long-Term Therapy With Thiopurines Effective for Maintaining Remission in Patients With Moderate-To-Severe Ulcerative Colitis?
Seong Ran Jeon, Won Ho Kim
Intestinal Research.2015; 13(3): 191. CrossRef
- Thiopurines Have Sustained Long-term Effectiveness in Patients with Inflammatory Bowel Disease, Which is Independent of Disease Duration at Initiation: A Propensity Score Matched Analysis
- 6,281 View
- 62 Download
- 12 Web of Science
- 12 Crossref
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Polymorphisms in
PRKCDBP , a Transcriptional Target of TNF-α, Are Associated With Inflammatory Bowel Disease in Korean - Jung-Wook Kim, Chang Kyun Lee, Hyo Jong Kim, Jae-Jun Shim, Jae Young Jang, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Sung-Gil Chi
- Intest Res 2015;13(3):242-249. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.242
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Emerging data indicate that polymorphic sequence variations in the tumor necrosis factor alpha (TNF-α) gene may affect its production, and be associated with the risk of inflammatory bowel disease (IBD).
PRKCDBP is a putative tumor suppressor gene and a transcriptional target of TNF-α. The aim of this case-control study is to explore the possible association of single nucleotide polymorphisms (SNPs) inPRKCDBP with the development of IBD in Koreans.Methods Genotyping analysis of four SNPs of
PRKCDBP [rs35301211 (G210A), rs11544766 (G237C), rs12294600 (C797T), and rs1051992 (T507C)] was performed on 170 ulcerative colitis (UC),131 Crohn's disease (CD) patients, and 100 unrelated healthy controls using polymerase chain reaction and restriction fragment length polymorphism.Results Heterozygous configuration of three SNPs (G210A, G237C, and C797T) was very rare in both patients and healthy controls. However, allele frequencies of the T507C SNP showed a significant difference between UC patients and controls (
P =0.037). The CC genotype of the T507C SNP was identified in 46.6% (61 of 131) of CD and 49.4% (84 of 170) of UC patients, but only in 33.0% (33 of 100) of healthy controls. Furthermore, CC homozygosity was more prevalent than TC heterozygosity in both CD and UC patients versus controls (P =0.016; gender-adjusted odds ratio [aOR], 2.16; 95% confidence interval [CI], 1.16-4.04 andP =0.009; aOR, 2.09; 95% CI, 1.193.64; respectively)Conclusions Our results suggest that the T507C SNP in
PRKCDBP , a TNF-α-inducible gene, might be associated with susceptibility to IBD (particularly UC) development in Koreans.-
Citations
Citations to this article as recorded by- Comprehensive analysis of key host gene-microbe networks in the cecum tissues of the obese rabbits induced by a high-fat diet
Yanhong Li, Xiaolan Qi, Qinrong Wang, Yan He, Zhupeng Li, Xi Cen, Limin Wei
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation
Jaesuk Yun, Mi Hee Park, Dong Ju Son, Kyung Tak Nam, Dae Bong Moon, Jung Heun Ju, Ok Kyung Hwang, Jeong Soon Choi, Tae Hoon Kim, Young Suk Jung, Dae Yeon Hwang, Sang Bae Han, Do-Young Yoon, Jin Tae Hong
Cell Death & Disease.2018;[Epub] CrossRef - The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease
Hye Won Lee, Sook Hee Chung, Chang Mo Moon, Xiumei Che, Seung Won Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Medicine.2016; 95(23): e3772. CrossRef
- Comprehensive analysis of key host gene-microbe networks in the cecum tissues of the obese rabbits induced by a high-fat diet
- 5,726 View
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- 3 Crossref
- Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells
- Hyun-Young Kim, Se-Lim Kim, Young-Ran Park, Yu-Chuan Liu, Seung Young Seo, Seong Hun Kim, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Sang Wook Kim
- Intest Res 2015;13(3):233-241. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.233
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. Balsalazide can reduce inflammatory responses via several mechanisms, including inhibition of nuclear factor-κB (NF-κB) activity. Parthenolide (PT) inhibits NF-κB and exerts promising anticancer effects by promoting apoptosis. The present investigated the antitumor effects of balsalazide, combined with PT, on NF-κB in a representative human colorectal carcinoma cell line, HCT116.
Methods We counted cells and conducted annexin-V assays and cell cycle analysis to measure apoptotic cell death. Western blotting was used investigate the levels of proteins involved in apoptosis.
Results PT and balsalazide produced synergistic anti-proliferative effects and induced apoptotic cell death. The combination of balsalazide and PT markedly suppressed nuclear translocation of the NF-κB p65 subunit and the phosphorylation of inhibitor of NF-κB. Moreover, PT and balsalazide dramatically enhanced NF-κB p65 phosphorylation. Apoptosis, through the mitochondrial pathway, was confirmed by detecting effects on Bcl-2 family members, cytochrome c release, and activation of caspase-3 and -8.
Conclusions Combination treatment with PT and balsalazide may offer an effective strategy for the induction of apoptosis in HCT116 cells.
-
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Scientific Reports.2016;[Epub] CrossRef
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- Risk Factors for Delayed Post-Polypectomy Bleeding
- Min Jung Kwon, You Sun Kim, Song I Bae, Young Il Park, Kyung Jin Lee, Jung Hwa Min, Soo Yeon Jo, Mi Young Kim, Hye Jin Jung, Seong Yeon Jeong, Won Jae Yoon, Jin Nam Kim, Jeong Seop Moon
- Intest Res 2015;13(2):160-165. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.160
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Among the many complications that can occur following therapeutic endoscopy, bleeding is the most serious, which occurs in 1.0-6.1% of all colonoscopic polypectomies. The aim of this study was to identify risk factors of delayed post-polypectomy bleeding (PPB).
Methods We retrospectively reviewed the data of patients who underwent colonoscopic polypectomy between January 2003 and December 2012. We compared patients who experienced delayed PPB with those who did not. The control-to-patient ratio was 3:1. The clinical data analyzed included polyp size, number, location, and shape, patient' body mass index (BMI), preventive hemostasis, and endoscopist experience.
Results Of 1,745 patients undergoing colonoscopic polypectomy, 21 (1.2%) experienced significant delayed PPB. We selected 63 age- and sex-matched controls. Multivariate logistic regression analysis showed that polyps >10 mm (odds ratio [OR], 2.605; 95% confidence interval [CI], 1.035-4.528;
P =0.049), a pedunculated polyp (OR, 3.517; 95% CI, 1.428-7.176;P =0.045), a polyp located in the right hemicolon (OR, 3.10; 95% CI, 1.291-5.761;P =0.013), and a high BMI (OR, 3.681; 95% CI, 1.876-8.613;P =0.013) were significantly associated with delayed PPB.Conclusions Although delayed PPB is a rare event, more caution is needed during colonoscopic polypectomies performed in patients with high BMI or large polyps, pedunculated polyps, or polyps located in the right hemicolon.
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International Journal of Gastrointestinal Intervention.2024; 13(4): 122. CrossRef - Colonic polypectomy in 2024: hot or cold?
K Ferdinande, L Desomer, D De Looze, D.J. Tate
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Aaron Yeoh, Ajitha Mannalithara, Uri Ladabaum
Clinical Gastroenterology and Hepatology.2023; 21(2): 507. CrossRef - Prophylactic clipping to prevent delayed colonic post-polypectomy bleeding: meta-analysis of randomized and observational studies
Kirles Bishay, Zhao Wu Meng, Levi Frehlich, Matthew T. James, Gilaad G. Kaplan, Michael J. Bourke, Robert J. Hilsden, Steven J. Heitman, Nauzer Forbes
Surgical Endoscopy.2022; 36(2): 1251. CrossRef - Establishment of a model for predicting delayed post-polypectomy bleeding: A real-world retrospective study
Yu Lu, Xiaoying Zhou, Han Chen, Chao Ding, Xinmin Si
Frontiers in Medicine.2022;[Epub] CrossRef - Blood group O is a risk factor for delayed post-polypectomy bleeding
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Takuya Okugawa, Tadayuki Oshima, Keisuke Nakai, Hirotsugu Eda, Akio Tamura, Ken Hara, Tomohiro Ogawa, Tomoaki Kono, Takashi Kondo, Katsuyuki Tozawa, Masashi Fukushima, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
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Oliver Bendall, Joel James, Katarzyna M Pawlak, Sauid Ishaq, J Andy Tau, Noriko Suzuki, Steven Bollipo, Keith Siau
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Faisal Kamal, Muhammad A. Khan, Salman Khan, Hemnishil K. Marella, Tamara Nelson, Zubair Khan, Dina Ahmad, Claudio Tombazzi, Mohammad K. Ismail, Colin W. Howden
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- The Use of Clips to Prevent Post-Polypectomy Bleeding: A Clinical Review
- 18,585 View
- 83 Download
- 37 Web of Science
- 33 Crossref
- Patient Descriptions of Rectal Effluents May Help to Predict the Quality of Bowel Preparation With Photographic Examples
- Hoonsub So, Sun-Jin Boo, Hyungil Seo, Ho-Su Lee, Hyojeong Lee, Sang Hyoung Park, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim, Seungbong Han, Dong-Hoon Yang
- Intest Res 2015;13(2):153-159. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.153
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Previous studies have suggested a weak correlation between self-reported rectal effluent status and bowel preparation quality. We aim to evaluate whether photographic examples of rectal effluents could improve the correlation between patient descriptions of rectal effluents and bowel preparation quality.
Methods Before colonoscopy, patients were asked to describe the nature of their last three rectal effluents. Photographic examples of rectal effluents were provided as a reference for scoring. Bowel preparation was subsequently assessed by a single endoscopist using a global preparation assessment scale. Preparation outcomes were grouped into two levels (excellent to good vs. fair to inadequate). Both univariate and multivariate logistic regression models were used to find any association between bowel preparation quality and patient characteristics.
Results A total of 138 patients completed the questionnaires. The mean age was 56.5±10.4 years. The mean sum of the last three rectal effluent scores was 5.9±2.0. Higher rectal effluent scores (odds ratio [OR], 0.82;
P =0.043) and the presence of diverticula (OR, 0.16;P <0.001) were risk factors for suboptimal preparation.Conclusions Photographic example-guided patient descriptions of rectal effluents showed a statistically significant association with bowel preparation quality. However, clinical significance seemed to be low. The presence of diverticula was an independent predictive factor for suboptimal bowel preparation quality.
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Long Chen, Xiaoyu Kang, Gui Ren, Hui Luo, Linhui Zhang, Limei Wang, Jianghai Zhao, Rongchun Zhang, Xiaoying Zhang, Lina Zhao, Yanglin Pan
Digestive and Liver Disease.2024; 56(3): 436. CrossRef - Comparison of Objectively Assessed Versus Patient-Reported Clarity of Last Rectal Effluent for the Prediction of Quality of Bowel Preparation for Colonoscopy: A Prospective, Case-Control Study
Ajay Patwa, Satish Kumar, Deepak Bhagchandani, Amit Kumar, Virendra Atam, Navneet Anil, Priya Mishra, Abhishek Singh, Archana Devi, Ajay K Pal
Cureus.2024;[Epub] CrossRef - Development and validation of a novel scoring system based on a nomogram for predicting inadequate bowel preparation
Xiaxia Zhao, Yanglin Pan, Jinyong Hao, Jie Feng, Zhongyuan Cui, Huimin Ma, Xiaojun Huang
Clinical and Translational Oncology.2024; 26(9): 2262. CrossRef - Patients' Description of Rectal Effluents Help Predict the Quality of Colonoscopy Preparation
Manuel Antonio Lescano Lescano, Rodrigo Strehl Machado, Maria Rachel Rohr, Sender Jankiel Miszputen
Journal of Coloproctology.2024; 44(02): e106. CrossRef - Superiority of a preparation‐related model for predicting inadequate bowel preparation in patients undergoing colonoscopy: A multicenter prospective study
Long Chen, Gui Ren, Hui Luo, Linhui Zhang, Limei Wang, Jianghai Zhao, Rongchun Zhang, Xiaoying Zhang, Xiaoyu Kang, Yanglin Pan
Journal of Gastroenterology and Hepatology.2022; 37(12): 2297. CrossRef - Comparison of bowel-cleansing efficacy of split-dose and same-day dose bowel preparation for afternoon colonoscopy in patients with gastrectomy: a prospective randomized study
Tae-Geun Gweon, Cheal Wung Huh, Jeong Seon Ji, Chang Hyun Kim, Jin-Jo Kim, Seung-Man Park
Surgical Endoscopy.2020; 34(10): 4413. CrossRef - Evaluating the practice of canceling colonoscopies for presumed inadequate bowel preparation
Reid L. Hopkins, David Parsons, Leonie Hoyo, Brian C. Jacobson
Gastrointestinal Endoscopy.2020; 92(2): 382. CrossRef - A Randomized Controlled Trial Comparing Colonoscopic Enema With Additional Oral Preparation as a Salvage for Inadequate Bowel Cleansing Before Colonoscopy
Hyo-Joon Yang, Dong Il Park, Soo-Kyung Park, Sunyong Kim, Taeheon Lee, Yunho Jung, Chang Soo Eun, Dong Soo Han
Journal of Clinical Gastroenterology.2019; 53(8): e308. CrossRef - Comparison of Bowel Cleansing Efficacy, Safety, Bowel Movement Kinetics, and Patient Tolerability of Same-Day and Split-Dose Bowel Preparation Using 4 L of Polyethylene Glycol: A Prospective Randomized Study
Myeongsook Seo, Tae-Geun Gweon, Cheal Wung Huh, Jeong Seon Ji, Hwang Choi
Diseases of the Colon & Rectum.2019; 62(12): 1518. CrossRef - Randomized trial comparing oral sulfate solution with 4‐L polyethylene glycol administered in a split dose as preparation for colonoscopy
Hyo‐Joon Yang, Soo‐Kyung Park, Jee Hyun Kim, Jong Pil Im, Dong Han Yeom, Geom Seog Seo, Dong Il Park
Journal of Gastroenterology and Hepatology.2017; 32(1): 12. CrossRef - Patient Description of Rectal Effluents With Photographic Examples as a Predictive Indicator for the Quality of Bowel Preparation
Hyoun Woo Kang
Intestinal Research.2015; 13(4): 362. CrossRef - Author's Reply
Hoonsub So, Seungbong Han, Dong-Hoon Yang
Intestinal Research.2015; 13(4): 364. CrossRef
- Individualized intervention based on a preparation-related prediction model improves adequacy of bowel preparation: A prospective, multi-center, randomized, controlled study
- 27,075 View
- 83 Download
- 12 Web of Science
- 12 Crossref
- Inhibitory Effect of Metformin Therapy on the Incidence of Colorectal Advanced Adenomas in Patients With Diabetes
- Yo Han Kim, Ran Noh, Sun Young Cho, Seong Jun Park, Soung Min Jeon, Hyun Deok Shin, Suk Bae Kim, Jeong Eun Shin
- Intest Res 2015;13(2):145-152. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.145
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Metformin use has been associated with decreased colorectal cancer risk and mortality among diabetic patients. Recent research suggests that metformin use may decrease the incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. This study aimed to assess the clinical effect of metformin use on the development of colorectal adenomas in diabetic patients without previous colorectal cancer.
Methods Among 604 consecutive diabetic patients who underwent colonoscopic surveillance after initial colonoscopy between January 2002 and June 2012, 240 patients without previous colorectal cancer were enrolled in this study and were divided in two groups: 151 patients receiving metformin and 89 patients not receiving metformin. Patient demographics and clinical characteristics as well as the colorectal adenoma incidence rate were retrospectively analyzed.
Results The incidence rate of total colorectal adenomas was not different according to metformin use (
P =0.349). However, the advanced adenoma incidence rate was significantly lower in the metformin group compared with the non-metformin group (relative risk [RR], 0.09;P =0.011). Metformin use was independently associated with a decreased incidence of advanced colorectal adenomas after adjustment for clinically relevant factors (RR, 0.072;P =0.016). In addition, the cumulative development rate of advanced adenomas during follow-up was significantly lower in the metformin group compared with the non-metformin group (P =0.007).Conclusions Metformin use in diabetic patients without previous colorectal cancer is associated with a lower risk of advanced colorectal adenomas.
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Digestive Diseases and Sciences.2022; 67(10): 4886. CrossRef - The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients
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Gastrointestinal Disorders.2019; 1(2): 273. CrossRef - Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes
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International Journal of Colorectal Disease.2017; 32(8): 1223. CrossRef - Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth
Eun-Kyung Kim, Jae Hee Cho, EuiJoo Kim, Yoon Jae Kim, Aamir Ahmad
PLOS ONE.2017; 12(7): e0181183. CrossRef - Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia
Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
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George K. Nimako, Zachary A. P. Wintrob, Dmitriy A. Sulik, Jennifer L. Donato, Alice C. Ceacareanu
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Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef - Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies
Nam Hee Kim, Jung Yul Suh, Jung Ho Park, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(2): 347. CrossRef - Are Hemorrhoids Associated with False-Positive Fecal Immunochemical Test Results?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(1): 150. CrossRef - Association Between Low Relative Muscle Mass and the Risk of Colorectal Neoplasms
Yoon Suk Jung, Nam Hee Kim, Seungho Ryu, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Clinical Gastroenterology.2017; 51(10): e83. CrossRef - Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Oncotarget.2017; 8(5): 8843. CrossRef - Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis
Feifei Liu, Lijing Yan, Zhan Wang, Yuanan Lu, Yuanyuan Chu, Xiangyu Li, Yisi Liu, Dongsheng Rui, Shaofa Nie, Hao Xiang
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Michael Fink
Info Onkologie.2016; 19(4): 24. CrossRef - Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Vibha Rani, Gagan Deep, Rakesh K. Singh, Komaraiah Palle, Umesh C.S. Yadav
Life Sciences.2016; 148: 183. CrossRef - Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
Digestive Diseases and Sciences.2016; 61(9): 2694. CrossRef
- Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas
- 14,264 View
- 35 Download
- 26 Web of Science
- 25 Crossref
- The Clinical Usefulness of Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy for Rectal and Perirectal Lesions
- Jae Seung Soh, Ho-Su Lee, Seohyun Lee, Jungho Bae, Hyo Jeong Lee, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim, Jeong-Sik Byeon
- Intest Res 2015;13(2):135-144. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.135
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Endoscopic ultrasound-guided fine needle aspiration and/or biopsy (EUS-FNA/B) have been used to diagnose subepithelial tumors (SETs) and extraluminal lesions in the gastrointestinal tract. Our group previously reported the usefulness of EUS-FNA/B for rectal and perirectal lesions. This study reports our expanded experience with EUS-FNA/B for rectal and perirectal lesions in terms of diagnostic accuracy and safety. We also included our new experience with EUS-FNB using the recently introduced ProCore needle.
Methods From April 2009 to March 2014, EUS-FNA/B for rectal and perirectal lesions was performed in 30 consecutive patients. We evaluated EUS-FNA/B performance by comparing histological diagnoses with final results. We also investigated factors affecting diagnostic accuracy.
Results Among 10 patients with SETs, EUS-FNA/B specimen results revealed a gastrointestinal stromal tumor in 4 patients and malignant lymphoma in 1 patient. The diagnostic accuracy of EUS-FNA/B was 50% for SETs (5/10). Among 20 patients with non-SET lesions, 8 patients were diagnosed with malignant disease and 7 were diagnosed with benign disease based on both EUS-FNA/B and the final results. The diagnostic accuracy of EUS-FNA/B for non-SET lesions was 75% (15/20). The size of lesions was the only factor related to diagnostic accuracy (
P =0.027). Two complications of mild fever and asymptomatic pneumoperitoneum occurred after EUS-FNA/B.Conclusions The overall diagnostic accuracy of EUS-FNA/B for rectal and perirectal lesions was 67% (20/30). EUS-FNA/B is a clinically useful method for cytological and histological diagnoses of rectal and perirectal lesions.
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Citations
Citations to this article as recorded by- Recurrent vaginal squamous cell carcinoma mimicking peri-rectal abscess: The role of endoscopic ultrasound
Taha Bin Arif, Tahir Shaikh
Radiology Case Reports.2025; 20(6): 2723. CrossRef - Quality indicators for EUS
Girish Mishra, Anne Marie Lennon, Nonthalee Pausawasdi, Vanessa M. Shami, Reem Z. Sharaiha, B. Joseph Elmunzer
Gastrointestinal Endoscopy.2025; 101(5): 928. CrossRef - Quality Indicators for EUS
Girish Mishra, Anne Marie Lennon, Nonthalee Pausawasdi, Vanessa M. Shami, Reem Z. Sharaiha, B. Joseph Elmunzer
American Journal of Gastroenterology.2025; 120(5): 973. CrossRef - Colonoscopic Ultrasound-Guided Fine-Needle Aspiration Using a Curvilinear Array Transducer: A Single-Center Retrospective Cohort Study
Spencer Cheng, Sergio E. Matuguma, Guilherme H. P. de Oliveira, Gustavo L.R. Silva, Henrique Cheng, Sergio A. Sánchez-Luna, Mauricio K Minata
Diseases of the Colon & Rectum.2022; 65(2): e80. CrossRef - Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)
Francesco Maione, Alessia Chini, Marco Milone, Nicola Gennarelli, Michele Manigrasso, Rosa Maione, Gianluca Cassese, Gianluca Pagano, Francesca Paola Tropeano, Gaetano Luglio, Giovanni Domenico De Palma
Diagnostics.2021; 11(5): 771. CrossRef - Long-term experience with percutaneous biopsies of pelvic lesions using CT guidance
Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jiri Spacek, Jiri Vanasek, Adam Rezac, Petr Dvorak
Science Progress.2021;[Epub] CrossRef - Prospective histological evaluation of a 20G core trap with a forward-cutting bevel needle for EUS-FNA of pancreatic lesions
Nobu Nishioka, Takeshi Ogura, Yoshitaka Kurisu, Miyuki Imanishi, Saori Onda, Wataru Takagi, Tatsushi Sano, Atsushi Okuda, Akira Miyano, Mio Amano, Kazuhide Higuchi
Surgical Endoscopy.2018; 32(10): 4125. CrossRef - Concise review on the comparative efficacy of endoscopic ultrasound-guided fine-needle aspiration vs core biopsy in pancreatic masses, upper and lower gastrointestinal submucosal tumors
Tawfik Khoury, Wisam Sbeit, Nicholas Ludvik, Divya Nadella, Alex Wiles, Caitlin Marshall, Manoj Kumar, Gilad Shapira, Alan Schumann, Meir Mizrahi
World Journal of Gastrointestinal Endoscopy.2018; 10(10): 267. CrossRef - Endoscopic ultrasound-guided fine needle aspiration of extra-rectal lesions
J. Lim, S. A. Norton, N. A. Wong, M. G. Thomas
Techniques in Coloproctology.2017; 21(5): 393. CrossRef - Application of Endoscopic Ultrasonography in the Diagnosis and Treatment of Lower Gastrointestinal Disease
Eun Young Kim
Intestinal Research.2015; 13(2): 101. CrossRef - Benign Prostatic Hyperplasia Mimicking a Symptomatic Rectal Submucosal Tumor
Seung Wook Hong, Jaeyoung Chun, Kyu Joo Park, Cheol Kwak, Joo Sung Kim
Soonchunhyang Medical Science.2015; 21(2): 164. CrossRef
- Recurrent vaginal squamous cell carcinoma mimicking peri-rectal abscess: The role of endoscopic ultrasound
- 7,346 View
- 67 Download
- 13 Web of Science
- 11 Crossref
- What's the Clinical Features of Colitis in Elderly People in Long-Term Care Facilities?
- So Yoon Yoon, Sung-Ae Jung, Sun-Kyung Na, Jae-In Ryu, Hye-Won Yun, Min-Jin Lee, Eun-Mi Song, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
- Intest Res 2015;13(2):128-134. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.128
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> As life expectancy has increased, the number of elderly patients who need long-term care has grown rapidly. Mortality in patients with colitis in long-term care facilities (LTCFs) is increasing. We intend to investigate the main causes of colitis in LTCFs compared to those of colitis in local communities, and to identify the clinical features and risk factors of patients with colitis in LTCFs.
Methods We retrospectively analyzed epidemiology, medical conditions, laboratory values, diagnoses, and clinical courses of elderly patients aged ≥65 who were admitted to the Ewha Womans University hospital with colitis between January 2007 and July 2012.
Results Patients with colitis in LTCFs (n=20) were compared with elderly patients with colitis in local communities (n=154). Fifty-five percent of colitis in LTCFs was caused by
Clostridium difficile infection (CDI), 30% was due to ischemic colitis, and 15% was due to non-specific colitis. Non-specific colitis was the most common (63%) in the community group. Clinical outcomes were also significantly different between both groups: higher mortality (10.0% vs. 0.64%,P =0.021), higher requirement for intensive care units care (50.0% vs. 18.8%,P <0.01) in LTCFs group. In univariate analysis, the most significant risk factor for death in patients in LTCFs was decreased mental faculties.Conclusions Patients in LTCFs showed worse clinical outcomes and a much higher prevalence of CDI compared to patients from local communities. We suggest early and active evaluation, such as endoscopic examination, for differential diagnosis in patients in LTCFs.
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Citations
Citations to this article as recorded by- RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
Jung Hoon Song, You Sun Kim
Gut and Liver.2019; 13(1): 16. CrossRef - A Comprehensive Review of the Diagnosis and Pharmacological Management of Crohn’s Disease in the Elderly Population
David Kim, Sasha Taleban
Drugs & Aging.2019; 36(7): 607. CrossRef - Rapid and accurate diagnosis of Clostridium difficile infection by real-time polymerase chain reaction
Pil Hun Song, Jung Hwa Min, You Sun Kim, Soo Yeon Jo, Eun Jin Kim, Kyung Jin Lee, Jeonghun Lee, Hyun Sung, Jeong Seop Moon, Dong Hee Whang
Intestinal Research.2018; 16(1): 109. CrossRef - Acute hemorrhagic rectal ulcer syndrome: Comparison with non‐hemorrhagic rectal ulcer lower gastrointestinal bleeding
Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam‐Hoon Kim, Kyung‐Ah Kim, June Sung Lee
Journal of Digestive Diseases.2017; 18(9): 521. CrossRef - Coexisting cytomegalovirus infection in immunocompetent patients with Clostridium difficile colitis
Khee-Siang Chan, Wen-Ying Lee, Wen-Liang Yu
Journal of Microbiology, Immunology and Infection.2016; 49(6): 829. CrossRef - Clinical Outcomes in Hospitalized Patients withClostridium difficileInfection by Age Group
Ho Chan Lee, Kyeong Ok Kim, Yo Han Jeong, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
The Korean Journal of Gastroenterology.2016; 67(2): 81. CrossRef
- RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
- 4,924 View
- 36 Download
- 6 Web of Science
- 6 Crossref
- Increased Risk of Asymptomatic Gallstones in Patients With Ulcerative Colitis
- Jung Hoon Ha, Young Sook Park, Choon Sik Seon, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Jung Hwan Kim, Jee Hye Han, Yoon Young Jung, Sook Hee Chung
- Intest Res 2015;13(2):122-127. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.122
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> The relationship between Crohn's disease and gallstones is established. However, the prevalence and risk factors for gallstones in patients with ulcerative colitis (UC) are not yet well understood. The aim of this study was to evaluate the prevalence and risk factors of gallstones in patients with UC.
Methods This study was a retrospective single center study. A total of 87 patients with UC and 261 healthy controls were enrolled. Age, sex, and body mass index were matched. To investigate risk factors, the extent of UC, duration of disease, number of hospital admissions, and number of steroid treatments in patients with UC were evaluated.
Results The prevalence of gallstones in patients with UC was 13.8%, whereas that in healthy controls was only 3.1% (
P <0.001). For patients with UC, patients ≥50 years of age had a 3.6-times higher risk of gallstones compared to that in those <50 years of age, and the difference was statistically significant (odds ratio, 3.60; confidence interval, 1.03-12.61) in univariate analysis. There were no statistically significant disease-related risk factors for gallstones in UC patients.Conclusions This is the first study of gallstone prevalence in Korean UC patients. In this study, patients with UC had a higher prevalence of gallstones compared to that in well-matched healthy controls. Age seemed to be a possible risk factor, and more studies are needed. Further prospective, large-scale studies will be required to confirm the risk factors for gallstones in UC patients.
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Citations
Citations to this article as recorded by- Prevalence of Gallstones in Ulcerative Colitis and Crohn’s Disease: A Systematic Review and Meta-Analysis
Mirza M. A Baig, Shayan A Irfan, Anusha Sumbal, Ramish Sumbal, Sanjay Kumar, Junaid Ahmad, Nikhila Gandrakota, Laila Tul Qadar, Maida S Chaudhry, Azka Feroz, Muhammad Sheharyar Warraich
Cureus.2022;[Epub] CrossRef - Comorbidity in children with gallstone disease
S. Yu. Matalaeva, V. A. Shashel
Experimental and Clinical Gastroenterology.2021; 1(1): 89. CrossRef - Gallstone disease in children and comorbiditi
S. Yu. Matalayeva
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2021; 66(3): 34. CrossRef - Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
International Journal of Environmental Research and Public Health.2018; 15(3): 513. CrossRef - Gallstone prevalence and risk factors in patients with ulcerative colitis in Korean population
Yo Han Jeong, Kyeong Ok Kim, Ho Chan Lee, Se Hoon Sohn, Jung Woo Lee, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Medicine.2017; 96(31): e7653. CrossRef - The Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis
Cong Dai, Min Jiang, Ming-Jun Sun
American Journal of Gastroenterology.2017; 112(7): 1165. CrossRef - Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R. Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz, John Green
PLOS ONE.2017; 12(10): e0185193. CrossRef
- Prevalence of Gallstones in Ulcerative Colitis and Crohn’s Disease: A Systematic Review and Meta-Analysis
- 5,258 View
- 41 Download
- 6 Web of Science
- 7 Crossref
- Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
- Yoon Kyung Song, Young Sook Park, Choon Sik Seon, Hye Jin Lim, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Ji Hyun Lee, Seung Chan Kim
- Intest Res 2015;13(1):74-79. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.74
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.
Methods Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.
Results 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697;
P =0.002), and multiple adenoma (OR, 1.929;P =0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P =0.003) in alcoholic liver diseases group (17 patients), 3.711 (P =0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P =0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.Conclusions This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.
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Kwang Woo Kim, Hyoun Woo Kang, Hosun Yoo, Yukyung Jun, Hyun Jung Lee, Jong Pil Im, Ji Won Kim, Joo Sung Kim, Seong-Joon Koh, Yong Jin Jung, Atsushi Hosui
PLOS ONE.2022; 17(12): e0279242. CrossRef - Value of combined detection of IFOBT, tumor markers, and inflammatory markers in predicting occurrence of advanced colorectal adenoma
Xu Wang, Jing-Yu Zhang, Zhong-Qing Zheng, Tao Wang, Mei-Yu Piao, Heng Liu, Jing Liu, Wen-Tian Liu
World Chinese Journal of Digestology.2021; 29(7): 347. CrossRef - Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly
Shiyu Zhang, Junyong Zhang, Yonghwan Kim, Wangyang Zhang
Healthcare.2021; 9(10): 1400. CrossRef - Associations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study
Doratha A Byrd, Suzanne E Judd, W Dana Flanders, Terryl J Hartman, Veronika Fedirko, Tanya Agurs-Collins, Roberd M Bostick
JNCI Cancer Spectrum.2020;[Epub] CrossRef - Adenoma Characteristics and the Influence of Alcohol and Cigarette Consumption on the Development of Advanced Colorectal Adenomas
Maja Čebohin, Senka Samardžić, Ksenija Marjanović, Martina Tot Vesić, Kristina Kralik, Andreja Bartulić, Dijana Hnatešen
International Journal of Environmental Research and Public Health.2020; 17(22): 8296. CrossRef - Associations of Novel Dietary and Lifestyle Inflammation Scores with Incident, Sporadic Colorectal Adenoma
Doratha A. Byrd, Suzanne Judd, W. Dana Flanders, Terryl J. Hartman, Veronika Fedirko, Roberd M. Bostick
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(11): 2300. CrossRef - Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
The Korean Journal of Internal Medicine.2019; 34(5): 998. CrossRef - Interplay of Liver Disease and Gut Microbiota in the Development of Colorectal Neoplasia
Michael W. Gleeson
Current Treatment Options in Gastroenterology.2019; 17(3): 378. CrossRef - Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef - The fecal immunochemical test has high accuracy for detecting advanced colorectal neoplasia before age 50
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive and Liver Disease.2017; 49(5): 557. CrossRef - Risk Factors for False Fecal Immunochemical Test Results in Colorectal Cancer Screening
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef - Sarcopenia is associated with an increased risk of advanced colorectal neoplasia
Youn Su Park, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jae Kyung Lee, Joo Sung Kim, Seong-Joon Koh
International Journal of Colorectal Disease.2017; 32(4): 557. CrossRef - Alcoholic Liver Disease Is Associated with an Increased Risk of Gastric Cancer
Tae Hoon Ha, Byeong Gwan Kim, Donghyong Jeong, Sohee Oh, Won Kim, Yong Jin Jung, Dong Won Ahn, Ji Bong Jeong, Ji Won Kim, Kook Lae Lee, Seong-Joon Koh
Digestive Diseases and Sciences.2017; 62(1): 273. CrossRef - Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Oncotarget.2017; 8(5): 8843. CrossRef - Statin use and the risk of colorectal adenoma: A meta‐analysis
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
Journal of Gastroenterology and Hepatology.2016; 31(11): 1823. CrossRef - Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
Digestive Diseases and Sciences.2016; 61(9): 2694. CrossRef - Metabolic syndrome is a risk factor for adenoma occurrence at surveillance colonoscopy
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Medicine.2016; 95(32): e4454. CrossRef - Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
World Journal of Gastroenterology.2016; 22(10): 2981. CrossRef - Does Low Threshold Value Use Improve Proximal Neoplasia Detection by Fecal Immunochemical Test?
Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(9): 2685. CrossRef - Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
Yoon Suk Jung, Hwanseok Jung, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park, Kyuyong Choi
Journal of Gastroenterology and Hepatology.2016; 31(4): 788. CrossRef - Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?
Martin Floer, Tobias Meister
Digestion.2016; 93(3): 202. CrossRef - Risk Factors for Colorectal Cancer in Thailand
Kirati Poomphakwaen, Supannee Promthet, Krittika Suwanrungruang, Siriporn Kamsa-ard, Surapon Wiangnon
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- Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia
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- Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative Colitis
- Ja Young Jung, Ji Bong Jeong, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee
- Intest Res 2015;13(1):68-73. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.68
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Ghrelin levels are known to increase in patients with ulcerative colitis (UC), but serum obestatin levels in UC patients are not well elucidated. The aim of this study was to examine the relationship between serum ghrelin and obestatin levels and disease activity in UC patients.
Methods The serum ghrelin and obestatin levels were measured in 21 UC patients (12 with active disease and 9 in remission) using enzyme-linked immunosorbent assay. The relationship between the circulating levels of these 2 hormones and disease activity was analyzed. The colonic mucosal mRNA expression of ghrelin and obestatin was measured by quantitative reverse transcription polymerase chain reaction.
Results The mean serum ghrelin values were significantly higher in patients with active disease than in patients with remission (1370.6±404.3 vs. 783.5±235.3 pg/mL,
P =0.001). Colonic mucosal mRNA expression of ghrelin was also significantly higher in patients with active disease than in patients in remission (0.805±0.214 vs. 0.481±0.356,P =0.018). However, the mean serum obestatin levels and colonic mucosal mRNA expression of obestatin were not significantly different between both groups. The circulating obestatin/ghrelin ratio was significantly lower in patients with active UC than in patients in remission (0.32±0.08 vs. 0.58±0.20,P =0.001).Conclusions The serum ghrelin levels and the obestatin/ghrelin ratio were related to the activity of UC, but serum obestatin was not related to activity of UC. The ghrelin levels and the obestatin/ghrelin ratio could serve as activity markers in patients with UC.
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Citations
Citations to this article as recorded by- Unveiling the Ghrelin and Obestatin Roles in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Assessing Their Pathogenic Implications and Biomarker Utility
Amirmohammad Khalaji, Nastaran Babajani, Zahra Amirsardari, Behrad Saeedian, Soheil Peiman, Nathan A Berger, Amir Hossein Behnoush
Inflammatory Bowel Diseases.2024; 30(4): 629. CrossRef - Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial
Sajjad Moradi, Reza Bagheri, Parsa Amirian, Mahsa Zarpoosh, Neda Cheraghloo, Alexei Wong, Mehdi Zobeiri, Mohammad Hassan Entezari
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef - “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef - Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers
Aldona Kasprzak, Agnieszka Adamek
International Journal of Molecular Sciences.2022; 23(19): 11188. CrossRef - Correlation between the tissue ghrelin presence, disease activity and laboratory parameters in ulcerative colitis patients; immunohistochemical study
Memduh Sahin, Kivilcim Eren Erdogan, Emine Tekingündüz, Gernot Zissel
PLOS ONE.2022; 17(11): e0276065. CrossRef - l-Glutamine and Physical Exercise Prevent Intestinal Inflammation and Oxidative Stress Without Improving Gastric Dysmotility in Rats with Ulcerative Colitis
Raisa de Oliveira Santos, Geovane da Silva Cardoso, Lara da Costa Lima, Mickael Laudrup de Sousa Cavalcante, Mariana Sousa Silva, Ana Karolina Martins Cavalcante, Juliana Soares Severo, Francisca Beatriz de Melo Sousa, Gabriella Pacheco, Even Herlany Pere
Inflammation.2021; 44(2): 617. CrossRef - Obestatin and Its Fragments: A New Approach to the Regulation of Body Weight under Normal and Pathological Conditions
A. V. Graf, E. E. Khirazova, M. V. Maslova, N. A. Sokolova
Moscow University Biological Sciences Bulletin.2020; 75(2): 50. CrossRef - Ghrelin and gastrointestinal wound healing. A new perspective for colorectal surgery
Humberto Fenner Lyra Junior, Igor Kunze Rodrigues, Leonardo de Lucca Schiavon, Armando José D`Acâmpora
Acta Cirurgica Brasileira.2018; 33(3): 282. CrossRef - TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal
Keyu Ren, Chunming Yong, Hao Yuan, Bin Cao, Kun Zhao, Jin Wang
Brazilian Journal of Medical and Biological Research.2018;[Epub] CrossRef - Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes
Brian D. Green, David J. Grieve
Peptides.2018; 100: 249. CrossRef - Treatment with Obestatin—A Ghrelin Gene-Encoded Peptide—Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid
Katarzyna Konarska, Jakub Cieszkowski, Zygmunt Warzecha, Piotr Ceranowicz, Anna Chmura, Beata Kuśnierz-Cabala, Krystyna Gałązka, Paweł Kowalczyk, Andrzej Miskiewicz, Thomas Jan Konturek, Michał Pędziwiatr, Artur Dembiński
International Journal of Molecular Sciences.2018; 19(6): 1643. CrossRef - Serum Adipocytokine Levels as Surrogate Markers for Disease Activity of Crohn’s Disease
Su Hwan Kim, Seung Hyeon Jang, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, You Sun Kim, Dong Soo Han, Joo Sung Kim
The American Journal of the Medical Sciences.2017; 353(5): 439. CrossRef - Function of obestatin in the digestive system
Yue-Xian Xing, Liu Yang, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Liu
Nutrition.2017; 34: 21. CrossRef - NF-kappa B activation correlates with disease phenotype in Crohn’s disease
Yoo Min Han, Jaemoon Koh, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Gernot Sellge
PLOS ONE.2017; 12(7): e0182071. CrossRef - The obestatin/ghrelin ratio and ghrelin genetics in adult celiac patients before and after a gluten-free diet, in irritable bowel syndrome patients and healthy individuals
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
European Journal of Gastroenterology & Hepatology.2017; 29(2): 160. CrossRef - Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Zane B Andrews
PLOS ONE.2017; 12(4): e0175231. CrossRef - Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes
Elaine Cowan, Kerry J Burch, Brian D Green, David J Grieve
British Journal of Pharmacology.2016; 173(14): 2165. CrossRef - Obestatin Accelerates the Healing of Acetic Acid‐Induced Colitis in Rats
Aleksandra Matuszyk, Piotr Ceranowicz, Zygmunt Warzecha, Jakub Cieszkowski, Joanna Bonior, Jolanta Jaworek, Beata Kuśnierz-Cabala, Peter Konturek, Tadeusz Ambroży, Artur Dembiński, Tanea T. Reed
Oxidative Medicine and Cellular Longevity.2016;[Epub] CrossRef - Ghrelin receptor modulates T helper cells during intestinal inflammation
M. Di Giovangiulio, N. Stakenborg, G. Bosmans, E. Meroni, G. Farro, P. J. Gomez‐Pinilla, I. Depoortere, G. E. Boeckxstaens, G. Matteoli
Neurogastroenterology & Motility.2015; 27(11): 1542. CrossRef
- Unveiling the Ghrelin and Obestatin Roles in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Assessing Their Pathogenic Implications and Biomarker Utility
- 5,616 View
- 36 Download
- 21 Web of Science
- 19 Crossref
- Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease
- Jae Hyuk Choi, Eun Soo Kim, Kwang Bum Cho, Kyung Sik Park, Yoo Jin Lee, Sang Min Lee, Yu Jin Kang, Byung Ik Jang, Kyeong Ok Kim
- Intest Res 2015;13(1):60-67. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.60
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations, data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this study was to compare clinical characteristics based on the age at diagnosis according to the Montreal Classification in Korean IBD patients.
Methods We recruited consecutive patients with IBD at two tertiary hospitals and retrospectively reviewed their medical information. Patients were divided into three groups according to their age at diagnosis: youth (<17 years), young adult (17-40 years), and middle-old (>40 years). The main clinical characteristics for comparison were the achievement of a remission state at the last follow-up visit, cumulative rate of surgery, and cumulative use of immunomodulators and tumor necrosis factor-α (TNFα) blockers during the follow-up period.
Results In total, 346 IBD patients were included (Crohn's disease [CD] 146 and ulcerative colitis 200; 36 youth, 202 young adult, and 113 middle-old). The middle-old group with CD was characterized by a predominance of uncomplicated behavior (
P =0.013) and a lower frequency of perianal disease (P =0.009). The middle-old group was associated more with a less aggressive disease course than the younger group, as shown by more frequent remission (P =0.004), being less likely to undergo surgery (P <0.001), and lower cumulative use of immunomodulators and TNFα blockers (P <0.001).Conclusions Age at diagnosis according to the Montreal Classification is an important prognostic factor for Korean IBD patients.
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Citations
Citations to this article as recorded by- Impact of age at diagnosis on long‐term prognosis in patients with intestinal Behçet's disease
Ji Young Chang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon, Jihye Park
Journal of Gastroenterology and Hepatology.2024; 39(3): 519. CrossRef - Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis
Wei Fu, Hu Fu, Weixia Ye, Yinsuo Han, Xianqiang Liu, Sirui Zhu, Hongmin Li, Rong Tang, Qin Wang
International Immunopharmacology.2021; 101: 108235. CrossRef - Earlier Anti-Tumor Necrosis Factor Therapy of Crohn’s Disease Correlates with Slower Progression of Bowel Damage
Hinaben Panchal, Mathilde Wagner, Manjil Chatterji, Bachir Taouli, Russell McBride, Jeromy R. Patterson, Ryan Ungaro, Marla Dubinsky, Judy Cho, David B. Sachar
Digestive Diseases and Sciences.2019; 64(11): 3274. CrossRef - Characteristics and management of patients with inflammatory bowel disease between a secondary and tertiary hospitals: a propensity score analysis
Ki Hwan Song, Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Sang Gyu Kwak, Hyun Seok Lee
Intestinal Research.2018; 16(2): 216. CrossRef - Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease
Yoo Min Han, Hyuk Yoon, Soo Lim, Mi-Kyung Sung, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Gut and Liver.2017; 11(3): 363. CrossRef - Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research
Shaocun Zhang, Xiaocang Cao, He Huang
Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef - Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study
Sung Wook Hwang, Jee Hyun Kim, Jong Pil Im, Byong Duk Ye, Hoon Sup Koo, Kyu Chan Huh, Jae Hee Cheon, You Sun Kim, Young Ho Kim, Dong Soo Han, Won Ho Kim, Joo Sung Kim
Journal of Gastroenterology and Hepatology.2017; 32(10): 1716. CrossRef - Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases
Young Sun Kim, Sung-Ae Jung, Kang-Moon Lee, Soo Jung Park, Tae Oh Kim, Chang Hwan Choi, Hyun Gun Kim, Won Moon, Chang Mo Moon, Hye Kyoung Song, Soo-Young Na, Suk-Kyun Yang
Intestinal Research.2017; 15(3): 338. CrossRef - Clinical Efficacy of Beclomethasone Dipropionate in Korean Patients with Ulcerative Colitis
Yoon Jee Lee, Jae Hee Cheon, Jae Hyun Kim, SunHo Yoo, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim
Yonsei Medical Journal.2017; 58(1): 144. CrossRef - Prediction of low bone mineral density in patients with inflammatory bowel diseases
Solvey Schüle, Jean‐Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas‐Queiroz, Valérie Pittet, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
United European Gastroenterology Journal.2016; 4(5): 669. CrossRef - Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
Jae Hyun Kim, Jae Hee Cheon, Yehyun Park, Hyun Jung Lee, Soo Jung Park, Tae Il Kim, Won Ho Kim
Scandinavian Journal of Gastroenterology.2016; 51(9): 1069. CrossRef - Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection
Yoo Min Han, Ji Won Kim, Seong‐Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
Journal of Gastroenterology and Hepatology.2016; 31(8): 1436. CrossRef - Clinical features of Crohn's disease in Korean patients residing in Busan and Gyeongnam
Eun Ji Lee, Tae Oh Kim, Geun Am Song, Jong hun Lee, Hyung Wook Kim, Sam Ryong Jee, Seun Ja Park, Hyun Jin Kim, Jong Ha Park
Intestinal Research.2016; 14(1): 30. CrossRef - The Positive Influences of Increasing Age at Diagnosis of Inflammatory Bowel Disease on Disease Prognostication in Asian Perspective
Raja Affendi Raja Ali
Intestinal Research.2015; 13(1): 4. CrossRef - Continuous duodenal levodopa infusion in a patient with Crohn's disease and small bowel surgery — Case report
Svetlana Tomic, Danijela Skelac, Dario Mick, Ivan Segec, Bojan Resan, Silva Butkovic Soldo
Journal of the Neurological Sciences.2015; 358(1-2): 525. CrossRef
- Impact of age at diagnosis on long‐term prognosis in patients with intestinal Behçet's disease
- 6,275 View
- 54 Download
- 15 Web of Science
- 15 Crossref
- Usefulness of the Cytomegalovirus Antigenemia Assay in Patients With Ulcerative Colitis
- Jaeyoung Chun, Changhyun Lee, Ji-eun Kwon, Sung Wook Hwang, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung, Jong Pil Im
- Intest Res 2015;13(1):50-59. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.50
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Patients with ulcerative colitis (UC) are at high risk for cytomegalovirus (CMV) reactivation. The usefulness of the CMV antigenemia assay in active UC patients has rarely been studied. We assessed whether the assay detects CMV colitis and predicts clinical outcomes in patients with UC.
Methods We retrospectively reviewed the medical records of patients hospitalized for moderate-to-severe UC from 2003 to 2012. Positive CMV antigenemia was defined as ≥1 pp65-positive cell per 2×105 polymorphonuclear neutrophils. CMV colitis was defined as the presence of inclusion bodies and/or positive immunohistochemistry in the colonic mucosa. The primary outcome was steroid refractoriness, defined as the absence of clinical improvement after intravenous high-dose steroid administration.
Results A total of 43 patients were enrolled. CMV antigenemia was detected in 12 (27.9%) patients. Positive CMV antigenemia was significantly associated with CMV colitis (
P =0.001). The sensitivity and specificity of positive CMV antigenemia for diagnosing CMV colitis were 66.7% and 87.1%, respectively. Steroid refractoriness was found in 11 of 12 (91.7%) and 12 of 31 (38.7%) patients with positive and negative CMV antigenemia, respectively (P =0.002). The independent predictors for steroid refractoriness were positive CMV antigenemia (adjusted odds ratio [OR], 7.73; 95% confidence interval [CI], 1.22-49.19;P =0.030) and a shorter duration from the diagnosis of UC (adjusted OR, 0.99; 95% CI, 0.98-0.99;P =0.025).Conclusions The CMV antigenemia assay shows low sensitivity but high specificity for detecting CMV colitis and may predict steroid-refractory UC. Early rescue therapy might be considered in UC patients positive for CMV antigenemia.
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Citations
Citations to this article as recorded by- The association between antigenemia, histology with immunohistochemistry, and mucosal PCR in the diagnosis of ulcerative colitis with concomitant human cytomegalovirus infection
Tsukasa Yamawaka, Hiroki Kitamoto, Masanori Nojima, Tomoe Kazama, Kohei Wagatsuma, Keisuke Ishigami, Shuji Yamamoto, Yusuke Honzawa, Minoru Matsuura, Hiroshi Seno, Hiroshi Nakase
Journal of Gastroenterology.2023; 58(1): 44. CrossRef - Predictive Factors of Cytomegalovirus Viremia during the Clinical Course of Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Single Center Observational Study
Makoto Harada, Ryohei Iwabuchi, Akinori Yamaguchi, Daiki Aomura, Yosuke Yamada, Kosuke Sonoda, Yutaka Kamimura, Koji Hashimoto, Yuji Kamijo
Journal of Clinical Medicine.2023; 12(1): 351. CrossRef - A quick guide to diagnosis and treatment of cytomegalovirus infection in the gut: current dilemmas
Iļja Drjagunovs, Sniedze Laivacuma, Indra Zeltiņa, Aleksejs Derovs
Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences..2022; 76(5-6): 585. CrossRef - Iranian kidney transplant recipients with COVID‐19 infection: Clinical outcomes and cytomegalovirus coinfection
Hamideh Molaei, Leila Khedmat, Eghlim Nemati, Zohreh Rostami, Seyed Hassan Saadat
Transplant Infectious Disease.2021;[Epub] CrossRef - Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis in a Patient with Low Bone Mineral Density Due to Fanconi-Bickel Syndrome
Makoto Tanaka, Mayuko Nakanishi, Hajime Miyazaki, Ryuichi Morita, Hiroki Eguchi, Yoshiya Takeda, Masanobu Katayama, Motoo Tanaka, Masamichi Bamba, Tadashi Shigematsu
Internal Medicine.2021; 60(15): 2413. CrossRef - Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy: A case report
Naoki Shijubou, Toshiyuki Sumi, Koki Kamada, Takeyuki Sawai, Yuichi Yamada, Tatsuru Ikeda, Hisashi Nakata, Yuji Mori, Hirofumi Chiba
World Journal of Clinical Cases.2021; 9(15): 3726. CrossRef - Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
Yafei Qin, Grace Wang, Dejun Kong, Guangming Li, Hongda Wang, Hong Qin, Hao Wang
Diagnostics.2021; 11(11): 1952. CrossRef - High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis
Saransh Jain, Divya Namdeo, Pabitra Sahu, Saurabh Kedia, Peush Sahni, Prasenjit Das, Raju Sharma, Vipin Gupta, Govind Makharia, Lalit Dar, Simon PL Travis, Vineet Ahuja
Intestinal Research.2021; 19(4): 438. CrossRef - Current Diagnostic and Therapeutic Approaches to Cytomegalovirus Infections in Ulcerative Colitis Patients Based on Clinical and Basic Research Data
Yoshihiro Yokoyama, Tsukasa Yamakawa, Takehiro Hirano, Tomoe Kazama, Daisuke Hirayama, Kohei Wagatsuma, Hiroshi Nakase
International Journal of Molecular Sciences.2020; 21(7): 2438. CrossRef - Ulcerative Colitis and Cytomegalovirus Infection: From A to Z
Fadi H Mourad, Jana G Hashash, Viraj C Kariyawasam, Rupert W Leong
Journal of Crohn's and Colitis.2020; 14(8): 1162. CrossRef - Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)
Alexandre Jentzer, Pauline Veyrard, Xavier Roblin, Pierre Saint-Sardos, Nicolas Rochereau, Stéphane Paul, Thomas Bourlet, Bruno Pozzetto, Sylvie Pillet
Microorganisms.2020; 8(7): 1078. CrossRef - A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology
Ali Y. Fakhreddine, Catherine T. Frenette, Gauree G. Konijeti
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef - Antiviral Treatment for Colonic Cytomegalovirus Infection in Ulcerative Colitis Patients Significantly Improved Their Surgery Free Survival
Yinghong Wang, Pankaj Aggarwal, Xiuli Liu, Haiyan Lu, Lei Lian, Xianrui Wu, Shibin Guo, Nitin Aggarwal, Bret Lashner, Bo Shen
Journal of Clinical Gastroenterology.2018; 52(4): e27. CrossRef - Cytomegalovirus Enterocolitis and Cytomegalovirus Colitis Complicating Ulcerative Colitis
Kiyotaka Okawa, Tetsuya Aoki, Wataru Ueda, Koji Sano, Hiroshi Ono, Syusuke Nakauchi
Nippon Daicho Komonbyo Gakkai Zasshi.2018; 71(10): 470. CrossRef - Approach to cytomegalovirus infections in patients with ulcerative colitis
Sung Chul Park, Yoon Mi Jeen, Yoon Tae Jeen
The Korean Journal of Internal Medicine.2017; 32(3): 383. CrossRef - Cytomegalovirus and ulcerative colitis: Place of antiviral therapy
Sylvie Pillet
World Journal of Gastroenterology.2016; 22(6): 2030. CrossRef - Targeting cytomegalovirus during ulcerative colitis flare-ups
Hiroshi Nakase, Kei Onodera
Expert Review of Gastroenterology & Hepatology.2016; 10(10): 1119. CrossRef - Risk Factors and Clinical Outcomes Associated with Cytomegalovirus Colitis in Patients with Acute Severe Ulcerative Colitis
Ho-Su Lee, Sang Hyoung Park, Sung-Han Kim, Jihun Kim, Jene Choi, Hyo Jeong Lee, Wan Soo Kim, Jeong-Mi Lee, Min Seob Kwak, Sung Wook Hwang, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Ki
Inflammatory Bowel Diseases.2016; 22(4): 912. CrossRef - When is an Assay of Cytomegalovirus Antigenemia Useful in Detecting Cytomegalovirus Colitis?
Kyeong Ok Kim
Intestinal Research.2015; 13(2): 182. CrossRef - A Clinical Significance of Assessing Cytomegalovirus Infection Status in Patients With Ulcerative Colitis
Sooyun Chang, Jae Hee Cheon
Intestinal Research.2015; 13(1): 2. CrossRef - Author's Reply
Jaeyoung Chun, Jong Pil Im
Intestinal Research.2015; 13(2): 184. CrossRef - Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis
Saifun Nahar
World Journal of Gastroenterology.2015; 21(44): 12667. CrossRef
- The association between antigenemia, histology with immunohistochemistry, and mucosal PCR in the diagnosis of ulcerative colitis with concomitant human cytomegalovirus infection
- 5,875 View
- 67 Download
- 22 Web of Science
- 22 Crossref
-
Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 (
Cdx2 ) Transgenic Mice - Hirotsugu Sakamoto, Takashi Asahara, Osamu Chonan, Norikatsu Yuki, Hiroyuki Mutoh, Shunji Hayashi, Hironori Yamamoto, Kentaro Sugano
- Intest Res 2015;13(1):39-49. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.39
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Caudal-related homeobox 2 (
Cdx2 ) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in theCdx2 transgenic mouse stomach. Atrophic gastritis and intestinal metaplasia commonly lead to gastric achlorhydria, which predisposes the stomach to bacterial overgrowth. In the present study, we determined the differences in gut microbiota between normal andCdx2 transgenic mice, using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Methods Twelve normal (control) and 12
Cdx2 transgenic mice were sacrificed, and the gastric, jejunal, ileac, cecal and colonic mucosa, and feces were collected. To quantitate bacterial microbiota, we used real-time qRTPCR with 16S rRNA gene-targeted, species-specific primers.Results The total numbers of bacteria in the gastric, jejunal, ileac, cecal, and colonic mucosa of the
Cdx2 transgenic mice were significantly higher than those of the normal mice. TheBacteroides fragilis group and alsoPrevotella were not detected in the stomach of the normal mice, although they were detected in theCdx2 transgenic mice. Moreover, theClostridium coccoides group,Clostridium leptum subgroup,Bacteroides fragilis group, andPrevotella were not detected in the jejunum or ileum of the normal mice, although they were detected in theCdx2 transgenic mice. The fecal microbiota of the normal mice was similar to that of theCdx2 transgenic mice.Conclusions Our results showed the differences in composition of gut microbiota between normal and
Cdx2 transgenic mice, which may be caused by the development of gastric achlorhydria and intestinal metaplasia inCdx2 transgenic mice.-
Citations
Citations to this article as recorded by- Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer
Maofu Zhang, Jialin Zhong, Yanyun Shen, Zhongyang Song
Frontiers in Pharmacology.2025;[Epub] CrossRef - Long non-coding RNAs as the pivotal regulators of epithelial mesenchymal transition through WNT/β-catenin signaling pathway in tumor cells
Faezeh Tolue Ghasaban, Meysam Moghbeli
Pathology - Research and Practice.2024; 263: 155683. CrossRef - In vitro and in vivo evaluation of Lactobacillus strains and comparative genomic analysis of Lactobacillus plantarum CGMCC12436 reveal candidates of colonise-related genes
Ying Shi, Jianxin Zhao, Lee Kellingray, Hao Zhang, Arjan Narbad, Qixiao Zhai, Wei Chen
Food Research International.2019; 119: 813. CrossRef - Down-regulated expression of LINC00518 prevents epithelial cell growth and metastasis in breast cancer through the inhibition of CDX2 methylation and the Wnt signaling pathway
Hong-Bin Wang, Hong Wei, Jin-Song Wang, Lin Li, An-Yue Chen, Zhi-Gao Li
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2019; 1865(3): 708. CrossRef - Transgenic and gene knockout mice in gastric cancer research
Yannan Jiang, Yingyan Yu
Oncotarget.2017; 8(2): 3696. CrossRef
- Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer
- 6,032 View
- 65 Download
- 5 Web of Science
- 5 Crossref
- Double-Balloon Enteroscopy in Elderly Patients: Is It Safe and Useful?
- Dae Han Choi, Seong Ran Jeon, Jin-Oh Kim, Hyun Gun Kim, Tae Hee Lee, Woong Cheul Lee, Byung Soo Kang, Jun-Hyung Cho, Yunho Jung, Wan Jung Kim, Bong Min Ko, Joo Young Cho, Joon Seong Lee, Moon Sung Lee
- Intest Res 2014;12(4):313-319. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.313
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Providers may be hesitant to perform double-balloon enteroscopy (DBE) in the elderly because the increased number of co-morbidities in this population poses a greater risk of complications resulting from sedation. There are limited data on the use of DBE in the elderly. Here, we assessed the safety and efficacy of DBE in the elderly compared to those in younger patients.
Methods We retrospectively analyzed the medical records of 158 patients who underwent 218 DBEs. Patients were divided into an elderly group (age ≥65 years; mean 71.4±5.4; n=34; 41 DBEs) and a younger group (age <65 years; mean 39.5±13.5; n=124; 177 DBEs).
Results In both groups, the most common indication for DBE was obscure gastrointestinal bleeding. Mucosal lesions (33.3% vs. 60.9%;
P =0.002) were the most common finding in both groups, followed by tumors (30.8% vs. 14.1%;P =0.036). The elderly were more likely to receive interventional therapy (51.3% vs. 23.5%;P =0.001). The diagnostic yield of DBE was slightly higher in the elderly group (92.3% vs. 86.5%;P =0.422), but was not statistically significant. The therapeutic success rate of DBE was 100% in the elderly group compared to 87.5% in the younger group (P =0.536). The overall DBE complication rate was 1.8% overall, and this rate did not differ significantly between the groups (2.6% vs. 1.7%;P =0.548).Conclusions DBE is safe and effective in the elderly, and has a high diagnostic yield and high therapeutic success rate.
-
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Rebecca K Grant, Alexander R Robertson, Kirsty A Lennon, Eksha Gupta, Ursula E Walton, Ross J Porter, Niall T Burke, Solomon Ong, Atul Anand, Sarah Douglas, Alice Corbett, William M Brindle, Rahul Kalla, John N Plevris
Frontline Gastroenterology.2025; 16(1): 30. CrossRef - Outcomes of Double Balloon-Enteroscopy in Elderly vs. Adult Patients: A Retrospective 16-Year Single-Centre Study
Margherita Trebbi, Cesare Casadei, Silvia Dari, Andrea Buzzi, Mario Brancaccio, Valentina Feletti, Alessandro Mussetto
Diagnostics.2023; 13(6): 1112. CrossRef - Enteroscopy in the Elderly: Review of Procedural Aspects, Indications, Yield, and Safety
Ana Catarina Ribeiro Gomes, Rolando Pinho, Adélia Rodrigues, Ana Ponte, João Carvalho
GE - Portuguese Journal of Gastroenterology.2020; 27(1): 18. CrossRef - Device assisted enteroscopy in the elderly — A systematic review and meta-analysis
Stefania Chetcuti Zammit, David S. Sanders, Reena Sidhu
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J.J.E. García-Correa, J.J. Ramírez-García, L.F. García-Contreras, C. Fuentes-Orozco, L. Irusteta-Jiménez, L.R. Michel-Espinoza, A.S. Carballo Uribe, J.A. Torres Chávez, A. González-Ojeda
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Hyun Joo Song, Ki-Nam Shim
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- Clinical outcomes in frail elderly patients undergoing small-bowel capsule endoscopy
- 12,840 View
- 40 Download
- 19 Web of Science
- 16 Crossref
- Is the Environment of the Endoscopy Unit a Reservoir of Pathogens?
- Eun Sung Choi, Jae Hyuk Choi, Jung Min Lee, Sang Min Lee, Yoo Jin Lee, Yu Jin Kang, Eun Soo Kim, Kwang Bum Cho, Kyung Sik Park, Byoung Kuk Jang, Jae Seok Hwang, Woo Jin Chung, Nam Hee Ryoo, Seong Woo Jeon, Min Kyu Jung
- Intest Res 2014;12(4):306-312. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.306
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Given the characteristic procedures involved in the endoscopy unit, the spread of pathogens is much more frequent in this unit than in other environments. However, there is a lack of data elucidating the existence of pathogens in the endoscopy unit. The aim of this study was to detect the presence of possible pathogens in the endoscopy unit.
Methods We performed environmental culture using samples from the endoscopy rooms of 2 tertiary hospitals. We used sterile cotton-tipped swabs moistened with sterile saline to swab the surfaces of 197 samples. Then, we cultured the swab in blood agar plate. Samples from the colonoscopy room were placed in thioglycollate broth to detect the presence of anaerobes. After 2 weeks of culture period, we counted the colony numbers.
Results The most commonly contaminated spots were the doctor's keyboard, nurse's cart, and nurse's mouse. The common organisms found were non-pathogenic bacterial microorganisms
Staphylococcus ,Micrococcus , andStreptococcus spp.. No definite anaerobe organism was detected in the colonoscopy room.Conclusions Although the organisms detected in the endoscopy unit were mainly non-pathogenic organisms, they might cause opportunistic infections in immunocompromised patients. Therefore, the environment of the endoscopy room should be managed appropriately; moreover, individual hand hygiene is important for preventing possible hospital-acquired infections.
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Citations
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Hiroshi Takayama, Toshitatsu Takao, Ryo Masumura, Yoshikazu Yamaguchi, Ryo Yonezawa, Hiroya Sakaguchi, Yoshinori Morita, Takashi Toyonaga, Kazutaka Izumiyama, Yuzo Kodama
Internal Medicine.2023; 62(2): 153. CrossRef - What’s on your keyboard? A systematic review of the contamination of peripheral computer devices in healthcare settings
Nicole Ide, Bianca K Frogner, Cynthia M LeRouge, Patrick Vigil, Matthew Thompson
BMJ Open.2019; 9(3): e026437. CrossRef - Addressing Bacterial Surface Contamination in Radiology Work Spaces
Alexander Harvin, Kyle VanMiddlesworth, Jonathan Botstein, Robert Hazelrigg, Jeanne Hill, Paul Thacker
Journal of the American College of Radiology.2016; 13(10): 1271. CrossRef
- Speech Recognition System Generates Highly Accurate Endoscopic Reports in Clinical Practice
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Long-Term Clinical Outcome of
Clostridium difficile Infection in Hospitalized Patients: A Single Center Study - Young Seok Doh, You Sun Kim, Hye Jin Jung, Young Il Park, Jin Won Mo, Hyun Sung, Kyung Jin Lee, Young Ki Seo, Jeong Seop Moon, Seong Woo Hong
- Intest Res 2014;12(4):299-305. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.299
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Antibiotic usage and increasingly aging populations have led to increased incidence of
Clostridium difficile infection (CDI) in worldwide. Recent studies in Korea have also reported increasing CDI incidence; however, there have been no reports on the long-term outcomes of CDI. We therefore investigated the long-term clinical outcomes of patients with CDI, including delayed recurrence, associated risk factors and mortality.Methods Hospitalized patients diagnosed with CDI at Seoul Paik Hospital between January 2007 and December 2008 were included. Their medical records were retrospectively investigated. 'Delayed recurrence' was defined as a relapse 8 weeks after a successful initial treatment. Multivariate logistic regression analysis was performed to identify risk factors for the delayed recurrence. Kaplan-Meier curves were used to analyze mortality rates.
Results A total of 120 patients were enrolled; among them, 87 were followed-up for at least 1 year, with a mean follow-up period of 34.1±25.1 months. Delayed recurrence was observed in 17 patients (19.5%), and significant risk factors were age (over 70 years,
P =0.049), nasogastric tube insertion (P =0.008), and proton pump inhibitor or H2-blocker treatments (P =0.028). The 12- and 24-month mortality rates were 24.6% and 32.5%, respectively. No deaths were directly attributed to CDI.Conclusions Delayed recurrence of CDI was not rare, occurring in 19.5% of the study population. Although CDI-related mortality was not reported, 2-year (32.5%) mortality rate of CDI patients implies that a CDI diagnosis may predict severe morbidity and poor prognosis of the underlying disease.
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Citations
Citations to this article as recorded by-
Global, regional, and national burdens of
Clostridioides difficile
infection over recent decades: a trend analysis informed by the Global Burden of Disease Study
Jianmei Zhou, Jie Zhu, Pengyue Zhang, Chunhui Tao, Xiaodan Hong, Zhenhua Zhang, Yuan Pin Hung, Bobby G. Warren
Microbiology Spectrum.2025;[Epub] CrossRef - Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study
Tessel M. van Rossen, Yvette H. van Beurden, Johannes A. Bogaards, Andries E. Budding, Chris J.J. Mulder, Christina M.J.E. Vandenbroucke-Grauls
BMC Infectious Diseases.2024;[Epub] CrossRef - Clinical characteristics and outcomes of Clostridioides difficile infection in the intensive care unit: a KASID multi-centre study
J.E. Baek, I.H. Choi, Y.W. Cho, J. Kim, Y.J. Lee, M.C. Kim, K.O. Kim, Y-S. Cho
Journal of Hospital Infection.2023; 139: 106. CrossRef - Predictive Factors for Death among Patients with Clostridium difficile Infection – A Single Center Experience Study
Vlad A. Ionescu, Camelia C. Diaconu, Raluca S. Costache, Florentina Gheorghe, Andreea G. Andronesi, Gina Gheorghe
Romanian Journal of Military Medicine.2023; 126(4): 492. CrossRef - Review of the Impact of Biofilm Formation on Recurrent Clostridioides difficile Infection
Daira Rubio-Mendoza, Adrián Martínez-Meléndez, Héctor Jesús Maldonado-Garza, Carlos Córdova-Fletes, Elvira Garza-González
Microorganisms.2023; 11(10): 2525. CrossRef - The evaluation of fecal microbiota transplantation vs vancomycin in a Clostridioides difficile infection model
Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Applied Microbiology and Biotechnology.2022; 106(19-20): 6689. CrossRef - Fecal Microbiota Transplantation May Be the Best Option in Treating Multiple Clostridioides difficile Infection: A Network Meta-Analysis
Fanni Dembrovszky, Noémi Gede, Zsolt Szakács, Péter Hegyi, Szabolcs Kiss, Nelli Farkas, Zsolt Molnár, Marcell Imrei, Dóra Dohos, Zoltán Péterfi
Infectious Diseases and Therapy.2021; 10(1): 201. CrossRef - A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI
Tinghua Li, Lin Lyu, Yan Zhang, Ke Dong, Qingtian Li, Xiaokui Guo, Yongzhang Zhu
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Casey Morgan Luc, Danyel Olson, David B. Banach, Paula Clogher, James Hadler
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Tessel M. van Rossen, Laura J. van Dijk, Martijn W. Heymans, Olaf M. Dekkers, Christina M. J. E. Vandenbroucke-Grauls, Yvette H. van Beurden
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef - RBX7455, a Non-frozen, Orally Administered Investigational Live Biotherapeutic, Is Safe, Effective, and Shifts Patients’ Microbiomes in a Phase 1 Study for Recurrent Clostridioides difficile Infections
Sahil Khanna, Darrell S Pardi, Courtney Jones, William D Shannon, Carlos Gonzalez, Ken Blount
Clinical Infectious Diseases.2021; 73(7): e1613. CrossRef - Epidemiology of community-acquired and recurrent Clostridioides difficile infection
Yichun Fu, Yuying Luo, Ari M Grinspan
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef - Long term outcomes of Hospital-Identified Clostridium Difficile Infection (HICDI): A retrospective cohort analysis of adult patients in a teaching hospital
Pandhem Samarasimha R, Michael David, Singh Manoj Y
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Kuan-Sheng Wu, Ling-Shan Syue, Aristine Cheng, Ting-Yu Yen, Hsien-Meng Chen, Yu-Hsin Chiu, Yu-Lung Hsu, Chun-Hsiang Chiu, Ting-Yi Su, Wan-Lin Tsai, Wei-Yu Chen, Chung-Hao Huang, Huei-Min Hung, Ling-Ju Huang, Hong-Jie Kuo, Pei-Chin Lin, Ching-Hsiang Yang,
Journal of Microbiology, Immunology and Infection.2020; 53(2): 191. CrossRef - Fecal Microbiota Transplantation in Recurrent Clostridium Difficile Infection: Is it Superior to Other Conventional Methods?
Zayar Lin, Zafar Iqbal, Juan Fernando Ortiz, Sawleha Arshi Khan, Nusrat Jahan
Cureus.2020;[Epub] CrossRef - RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
Jung Hoon Song, You Sun Kim
Gut and Liver.2019; 13(1): 16. CrossRef - Nasogastric tube and outcomes of Clostridium difficile infection: A systematic review and meta‐analysis
Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Parkpoom Phatharacharukul, Wisit Cheungpasitporn
Journal of Evidence-Based Medicine.2018; 11(1): 40. CrossRef - Rapid and accurate diagnosis of Clostridium difficile infection by real-time polymerase chain reaction
Pil Hun Song, Jung Hwa Min, You Sun Kim, Soo Yeon Jo, Eun Jin Kim, Kyung Jin Lee, Jeonghun Lee, Hyun Sung, Jeong Seop Moon, Dong Hee Whang
Intestinal Research.2018; 16(1): 109. CrossRef - Retrospective analysis of long-term gastrointestinal symptoms after Clostridium difficile infection in a nonelderly cohort
Tamar F. Barlam, Rene Soria-Saucedo, Omid Ameli, Howard J. Cabral, Warren A. Kaplan, Lewis E. Kazis, Abhishek Deshpande
PLOS ONE.2018; 13(12): e0209152. CrossRef - The risk of Clostridium difficile associated diarrhea in nasogastric tube insertion: A systematic review and meta-analysis
Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Parkpoom Phatharacharukul, Wisit Cheungpasitporn, Kiran Nakkala
Digestive and Liver Disease.2016; 48(5): 468. CrossRef - Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication
Yu Mi Lee, Kyu Chan Huh, Soon Man Yoon, Byung Ik Jang, Jeong Eun Shin, Hoon Sup Koo, Yunho Jung, Sae Hee Kim, Hee Seok Moon, Seung Woo Lee
Gut and Liver.2016; 10(2): 250. CrossRef - Proton Pump Inhibitors Should be Used with Caution in Critically Ill Patients to Prevent the Risk of Clostridium difficile Infection
Jung Hwa Min, You Sun Kim
Gut and Liver.2016; 10(4): 493. CrossRef - An Unusual Case of Proctitis and Rectal Abscess due to Irritants byArtemisia asiaticaSmoke (Ssukjwahun)
Seunghyup Kim, You Sun Kim, Seo Hyun Kim, Dong Hoon Lee, Se Jun Park, Seo Young Yun, Dae Young Kim, Jeonghun Lee, Jeong Seop Moon
The Korean Journal of Gastroenterology.2016; 67(4): 212. CrossRef - Risk of Clostridium difficile Infection with the Use of a Proton Pump Inhibitor for Stress Ulcer Prophylaxis in Critically Ill Patients
Youngouk Ro, Chang Soo Eun, Hyun Soo Kim, Ji Yeoun Kim, Young Jae Byun, Kyo-Sang Yoo, Dong Soo Han
Gut and Liver.2016; 10(4): 581. CrossRef - Risk Factors for Delayed Recurrence ofClostridium difficileInfection
Ji Won Kim
Intestinal Research.2014; 12(4): 266. CrossRef
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Global, regional, and national burdens of
Clostridioides difficile
infection over recent decades: a trend analysis informed by the Global Burden of Disease Study
- 6,905 View
- 60 Download
- 22 Web of Science
- 25 Crossref
- Does Carotid Intima-Media Thickness Increase in Patients With Inflammatory Bowel Disease?
- Kyeong Ok Kim, Byung Ik Jang, Si Hyung Lee
- Intest Res 2014;12(4):293-298. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.293
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Mesenteric microvascular thrombosis has been implicated as a contributing factor to the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to assess the possibility of subclinical atherosclerosis in patients with IBD by measuring their carotid intima-media thickness (c-IMT).
Methods Thirty-eight patients with IBD who were followed-up for at least 3 years participated. Patients with a history of cardiovascular disease and known risk factors for atherosclerosis were excluded. As a control group, 38 healthy patients matched for age and gender without atherosclerosis risk factors were included. Carotid ultrasonography was performed in all patients and controls. Patient baseline characteristics and laboratory parameters were recorded to evaluate atherosclerosis risk factors.
Results The mean age of patients with IBD was 38.5±6.62 years. Twenty-three patients with IBD were diagnosed with ulcerative colitis and the other 15 cases were diagnosed with Crohn's disease. The median duration of disease was 52.0 months. Serologic markers such as erythrocyte sedimentation rate, C-reactive protein (CRP), and cholesterol levels differed significantly, however, there was no significant difference in c-IMT between patients with IBD and those in the control group (0.53±0.10 mm vs. 0.53±0.07;
P =0.85). Multivariate analysis revealed that body mass index, CRP, disease duration, and age were significantly correlated with c-IMT in patients with IBD.Conclusions The results of the current study did not show an increase in c-IMT in patients with IBD. Further studies that include more subjects and a longer follow-up period will be necessary in order to evaluate the risk of atherosclerosis in Korean patients with IBD.
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Citations
Citations to this article as recorded by- Ocular endothelial dysfunction in pediatric inflammatory bowel disease
Giovanni Di Nardo, Mariachiara Di Pippo, Letizia Zenzeri, Maurizio Mennini, Marisa Piccirillo, Silvia Furio, Giovanna Quatrale, Melania Evangelisti, Pasquale Parisi, Livia Lucchini, Alessandro Ferretti, Maria Pia Villa, Gianluca Scuderi, David Sarzi Amadè
Journal of Pediatric Gastroenterology and Nutrition.2024; 78(6): 1297. CrossRef - Endothelial Dysfunction and Arterial Stiffness in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Hao Wu, Meihua Xu, Hong Hao, Michael A. Hill, Canxia Xu, Zhenguo Liu
Journal of Clinical Medicine.2022; 11(11): 3179. CrossRef - Subclinical Atherosclerosis in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis
Guo-Cui Wu, Rui-Xue Leng, Qi Lu, Yin-Guang Fan, De-Guang Wang, Dong-Qing Ye
Angiology.2017; 68(5): 447. CrossRef - Usefulness of Measuring Serum Procalcitonin Levels in Patients with Inflammatory Bowel Disease
Sook Hee Chung, Hye Won Lee, Seung Won Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Gut and Liver.2016; 10(4): 574. CrossRef - Endothelial dysfunction in inflammatory bowel diseases: Pathogenesis, assessment and implications
Dorota Cibor
World Journal of Gastroenterology.2016; 22(3): 1067. CrossRef
- Ocular endothelial dysfunction in pediatric inflammatory bowel disease
- 5,304 View
- 38 Download
- 5 Web of Science
- 5 Crossref
- Safety and Efficacy of Adalimumab for Patients With Moderate to Severe Crohn's Disease: The Taiwan Society of Inflammatory Bowel Disease (TSIBD) Study
- Chen-Wang Chang, Shu-Chen Wei, Jen-Wei Chou, Tzu-Chi Hsu, Chiao-Hsiung Chuang, Ching-Pin Lin, Wen-Hung Hsu, Hsu-Heng Yen, Jen-Kou Lin, Yi-Jen Fang, Horng-Yuan Wang, Hung-Hsin Lin, Deng Cheng Wu, Yen Hsuan Ni, Cheng-Yi Wang, Jau-Min Wong
- Intest Res 2014;12(4):287-292. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.287
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Only moderate to severe Crohn's Disease (CD) patients without a satisfactory conventional therapy effect are eligible to get reimbursement from the National Health Insurance of Taiwan for using adalimumab. These are more stringent criteria than in many Western countries and Japan and Korea. We aim to explore the efficacy of using adalimumab in CD patients under such stringent criteria.
Methods A retrospective analysis was conducted in nine medical centers in Taiwan and we collected the results of CD patients receiving adalimumab from Sep 2009 to Mar 2014. The clinical characteristics, response measured by CDAI (Crohn's Disease Activity Index), adverse events and survival status were recorded and analyzed. CR-70, CR-100, and CR-150 were defined as attaining a CDAI decrease of 70, 100 or 150 points compared with baseline.
Results A total of 103 CD patient records were used in this study. Sixty percent of these patients received combination therapy of adalimumab together with immunomodulators. CR-70 was 68.7%, 74.5% and 88.4% after week 4, 8 and 12 of treatment, respectively. The steroid-free rate, complications and survival were 47.6%, 9.7% and 99% of patients, respectively. In considering the mucosal healing, only 25% patients achieve mucosal healing after treatment for 6 to 12 months. Surgery was still needed in 16.5% of patients. Combination treatment of adalimumab with immunomodulators further decreased the level of CDAI at week 8 when compared with the monotherapy.
Conclusions Even under the stringent criteria for using adalimumab, the response rate was comparable to those without stringent criteria.
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- Long-Term Clinical Outcomes of Korean Patient With Crohn's Disease Following Early Use of Infliximab
- Nam Hee Kim, Yoon Suk Jung, Chang Mo Moon, Shin Yeong Lee, Eun Ran Kim, Young Ho Kim, Chang Kyun Lee, Suck Ho Lee, Jae Hak Kim, Kyu Chan Huh, Soon Man Yoon, Hyun Joo Song, Sun-Jin Boo, Hyun Joo Jang, You Sun Kim, Kang-Moon Lee, Jeong Eun Shin, Dong Il Park
- Intest Res 2014;12(4):281-286. Published online October 27, 2014
- DOI: https://doi.org/10.5217/ir.2014.12.4.281
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Several recent studies have reported that the early use of infliximab (IFX) improves the prognosis of Crohn's disease (CD). However, no data are available from Asian populations, as the forementioned studies have all been conducted in Western countries. The aim of the current study was to evaluate the impact of early use of IFX on the prognosis of Korean patients with CD.
Methods Patients with a diagnosis of CD established between July 1987 and January 2012 were investigated in 12 university hospitals in Korea. Because insurance coverage for IFX treatment began in August 2005, patients were assigned to either of 2 groups based on diagnosis date. The first group included patients diagnosed from July 1987 to December 2005, and the second from January 2006 to January 2012. We compared the cumulative probabilities of operation and reoperation between the two groups using the Kaplan-Meier method and a log-rank test.
Results Of the 721 patients investigated, 443 (61.4%) comprized the second group. Although the cumulative probabilities of immunosuppressant (
P <0.001) and IFX use (P <0.001) after diagnosis were significantly higher in the second group, there were no significant differences in cumulative probabilities of operation (P =0.905) or reoperation (P =0.418) between two groups.Conclusions The early use of IFX did not reduce CD-related surgery requirements in Korean patients with CD. These study results suggest that the early use of IFX may have little impact on the clinical outcome of CD in Korean patients in the setting of a conventional step-up algorithm.
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