Intest Res 2018; 16(3): 338-345  https://doi.org/10.5217/ir.2018.16.3.338
Intestinal microbiota, chronic inflammation, and colorectal cancer
Chan Hyuk Park, Chang Soo Eun, Dong Soo Han
Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea
Correspondence to: Dong Soo Han, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, 153 Gyeongchun-ro, Guri 11923, Korea. Tel: +82-31-560-2226, Fax: +82-31-553-7369, E-mail: hands@hanyang.ac.kr
Received: March 25, 2018; Revised: May 3, 2018; Accepted: May 3, 2018; Published online: July 11, 2018.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In addition to genetic and epigenetic factors, various environmental factors, including diet, play important roles in the development of colorectal cancer (CRC). Recently, there is increasing interest in the intestinal microbiota as an environmental risk factor for CRC, because diet also influences the composition of the intestinal microbiota. The human intestinal microbiota comprises about 100 trillion microbes. This microbiome thrives on undigested dietary residues in the intestinal lumen and produces various metabolites. It is well known that the dietary risk factors for CRC are mediated by dysbiosis of the intestinal microbiota and their metabolites. In this review, we describe the bacterial taxa associated with CRC, including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, Escherichia coli, and butyrate-producing bacteria. We also discuss the host-diet interaction in colorectal carcinogenesis.
Keywords: Microbiota; Colorectal neoplasms; Carcinogenesis; Inflammation


This Article

e-submission

Archives

Official Journal of

Indexed/Covered by