Intest Res  
What nutritional factors influence bone mineral density in Crohn’s disease patients?
Fernanda Gomes Coqueiro1, Raquel Rocha1, Camilla Almeida Menezes1, Mirella Brasil Lopes1, Vanessa Rosa Oliveira1, Flora Maria Lorenzo Fortes2, Genoile Oliveira Santana2,3
1Department of Sciences of Nutrition, School of Nutrition, Universidade Federal da Bahia, Salvador, 2Gastroenterology Unit, University Hospital Professor Edgard Santos, Universidade Federal da Bahia, Salvador, 3Department of Life Sciences, Universidade do Estado da Bahia, Salvador, Brazil
Correspondence to: Raquel Rocha, Department of Sciences of Nutrition, School of Nutrition, Universidade Federal da Bahia, Avenida Araújo Pinho, 32, Canela, Salvador 40110-150, Brazil. Tel: +55-71-3283-7721, Fax: +55-71-3283-7721, E-mail:
Received: September 22, 2017; Revised: January 6, 2018; Accepted: January 10, 2018; Published online: March 6, 2018.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background/Aims: Bone mineral density (BMD) is often low in patients with Crohn’s disease (CD). This study aimed to evaluate the association between nutritional factors and BMD in a group of CD patients. Methods: CD patients 18 years of age or older were included. The body mass index (BMI), waist circumference (WC) and dietary intake were evaluated during two 24-hour recalls. Bone densitometry was performed by dual-energy X-ray absorptiometry of the full body to assess body composition and of the lumbar vertebrae and femoral neck to assess BMD. Results: In the 60 patients evaluated, there was no association between BMD and disease activity or between BMD and disease duration. We observed moderate correlations between BMD in at least one of the evaluated sites and BMI, lean mass, WC, and protein, calcium, phosphorus and magnesium dietary intakes (P<0.05). In the linear regression analysis for spinal BMD, only BMI and calcium dietary intake remained associated (P<0.05). In the linear regression analysis for femoral BMD, WC and phosphorus intake continued to be significant in the final model, although they had low explanatory power for BMD (P<0.05). Conclusions: The prevalence of low BMD was high in CD patients. BMI, WC, calcium and phosphorus dietary intake were positively correlated with BMD.
Keywords: Crohn disease; Bone density; Body mass index; Waist circumference; Nutritional features

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