Intest Res  
Magnetic resonance enterography predicts the prognosis of Crohn’s disease
Ji Hoon Lee1, Yong Eun Park1, Nieun Seo2, Hyun Jung Lee1, Soo Jung Park1, Tae Il Kim1, Won Ho Kim1, Joon Seok Lim2*, Jae Hee Cheon1,3*
1Department of Internal Medicine and Institute of Gastroenterology, 2Department of Radiology, Research Institute of Radiological Science, and 3Brain Korea21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Jae Hee Cheon, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Tel: +82-2-2228-1990, Fax: +82-2-393-6884, E-mail: GENIUSHEE@yuhs.ac
Joon Seok Lim, Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Tel: +82-2-2228-7400, Fax: +82-2-393-3035, E-mail: JSLIM1@yuhs.ac
*These authors contributed equally to this study.
Received: August 25, 2017; Revised: October 16, 2017; Accepted: October 19, 2017; Published online: January 30, 2018.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims: Magnetic resonance enterography (MRE) has emerged as an important tool in the diagnosis and follow-up of Crohn’s disease (CD). The aim of this study was to evaluate whether MRE findings could predict the prognosis of CD. Methods: In this retrospective study, a total of 173 patients with clinical remission of CD (n=61) or active CD (n=112) were identified. The outcomes of clinical relapse, admission, surgery, and need for other medications according to the MRE findings were evaluated. Results: The presence of active inflammation on MRE was observed in 93 (83%) patients with clinically active CD and in 44 (72.1%) patients with clinical remission of CD, without a statistically significant difference (P=0.091). In multivariate analysis, active inflammation on MRE increased the risk for clinical relapse (hazard ratio [HR], 6.985; 95% confidence interval [CI], 1.024−47.649) in patients with clinical remission of CD. In patients with clinically active CD, active inflammation on MRE increased the risk for CD-related hospitalization (HR, 2.970; 95% CI, 1.006−8.772). Conclusions: The presence of active inflammation on MRE was significantly associated with poor prognosis both in patients with clinical remission of CD and in those with active CD.
Keywords: Magnetic resonance enterography; Prognosis; Crohn disease


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