Intest Res  
A case of pemphigus vulgaris associated with ulcerative colitis
Joo Wan Seo1, Jongha Park1, Jin Lee1, Mi Young Kim1, Hyun Ju Choi1, Heui Jeong Jeong1, Ji Woon Lee1, So Young Jung2, Woo Kyeong Kim3
1Division of Gastroenterology, Department of Internal Medicine, Departments of 2Dermatology, and 3Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
Correspondence to: Jongha Park, Division of Gastroenterology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea. Tel: +82-51-797-0200, Fax: +82-51-797-0298, E-mail:
Received: October 17, 2016; Revised: December 5, 2016; Accepted: January 2, 2017; Published online: May 26, 2017.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

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Pemphigus vulgaris is an autoimmune bullous disorder characterized by the production of autoantibodies against the intercellular space of the epithelium. It has rarely been reported in association with inflammatory bowel disease. Ulcerative colitis is one of the forms of inflammatory bowel disease. A 62-year-old woman who had been treated for ulcerative colitis for 16 years developed pruritic bullae on the skin of her face and body. Histological findings and direct immunofluorescence examination of the skin showed pemphigus vulgaris. She was treated with systemic steroids, mesalazine, and azathioprine. Her cutaneous lesions have remained in remission and her ulcerative colitis has remained well-controlled. The relationship between pemphigus vulgaris and ulcerative colitis is unclear. An autoimmune response has been suspected in the pathogenesis of ulcerative colitis. Pemphigus vulgaris is also associated with an autoimmune mechanism. To our knowledge, this is the first case of ulcerative colitis associated with pemphigus vulgaris reported in Korea. The association may be causal.
Keywords: Colitis, ulcerative; Pemphigus; Autoimmunity

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