Intest Res  
Ophthalmologic manifestations in patients with inflammatory bowel disease
Hye Jin Lee1, Hyun Joo Song2, Jin Ho Jeong1, Heung Up Kim2, Sun-Jin Boo2, Soo-Young Na2
Departments of 1Ophthalmology and 2Internal Medicine, Jeju National University School of Medicine, Jeju, Korea
Correspondence to: Hyun Joo Song, Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, 15 Aran 13-gil, Jeju 63241, Korea. Tel: +82-64-754-8142, Fax: +82-64-717-1131, E-mail:
Received: August 30, 2016; Revised: November 3, 2016; Accepted: November 22, 2016; Published online: May 4, 2017.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background/Aims: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), has been reported to have various ophthalmologic manifestations. The aim of this study was to evaluate the prevalence of ophthalmologic manifestations associated with IBD in Korea. Methods: Sixty-one patients were examined between May 2013 and October 2014. We performed complete ophthalmologic examinations. Results: Findings included 36 patients with CD and 25 with UC. The mean age of the patients was 34±16 years and disease duration was 45.3±23.9 months. Ophthalmologic manifestations were positive in 44 cases. Primary complication was diagnosed in five cases, as follows; iritis in two cases, episcleritis in one case, iritis with optic neuritis in one case, and serous retinal detachment in one case, without secondary complications. The most common coincidental complication was dry eye syndrome (DES), in 35 patients (57.4%). The prevalence of DES in the control group was 21.3%. The proportion of DES in patients with IBD was significantly higher than in the control group (P =0.002). Conclusions: Ophthalmologic manifestations were high (72.1%) in IBD patients. Clinically significant primary ocular inflammation occurred in 8.2% of patients. The most common complication was DES. There was a higher rate of DES in patients with IBD compared to the control group. Evaluation of the eye should be a routine component in patients with IBD.
Keywords: Inflammatory bowel disease; Crohn disease; Colitis, ulcerative; Ophthalmology; Dry eye syndromes

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