Intest Res  
Fecal microbiota transplantation for refractory Crohn’sdisease
Seon Ho Bak1, Hyun Ho Choi2, Jinhee Lee1, Mi Hee Kim1, Youn Hee Lee1, Jin Su Kim1, Young-Seok Cho1
1Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul,
2Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea
Correspondence to: Young-Seok Cho, Department of Internal Medicine,Seoul St. Mary’s Hospital, College of Medicine, The Catholic University ofKorea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea. Tel: +82-2-2258-6021, Fax: +82-2-2258-2038, E-mail: yscho@catholic.ac.kr
Received: August 23, 2015; Revised: December 10, 2015; Accepted: December 21, 2015; Published online: March 3, 2017.
© Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Approximately one-third of patients with Crohn’s disease do not respond to conventional treatments, and some experiencesignificant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are acommon feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immunesystem, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation,aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn’s colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.
Keywords: Crohn disease; Fecal microbiota transplantation; Dysbiosis; Biologic therapy


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